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David Bearss
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Journal Articles

The novel allosteric NEK7 inhibitor ofirnoflast (HT-6184) demonstrates robust and sustained hematologic response in subjects with IPSS-R very low, low or intermediate risk myelodysplastic syndrome (MDS) and symptomatic anemia

Free
Varun Bafna, Sandip Shah, Arijit Nag, Prof. Uttam Kumar Nath, Chandran Nair, Ramesh Uppada, Devan Bursey, Andrea Groen, Victoria Allgood, Alan List, Stephen Anthony, David Bearss
Journal: Blood
Blood (2025) 146 (Supplement 1): 5622.
https://doi.org/10.1182/blood-2025-5622
Published: 2025
Journal Articles

Ofirnoflast, a novel inflammasome inhibitor, rewires transcriptional programs and shows clinical and preclinical efficacy in myeloid neoplasms

Free
Divij Verma, Rahul Sanawar, Samarpana Chakraborty, Emma Rabinovich, Kith Pradhan, Srabani Sahu, Christopher Selverian, Rongbao Zhao, Surendra Neupane, Colette Prophete, Lidiane Torres, Stephen Anthony, Margit Janat-Amsbury, Alexis Mollard, Shanisha Gordon-Mitchell, Aditi Shastri, Shanye Yin, Eric Padron, Alan List, David Bearss, Amit Verma
Journal: Blood
Blood (2025) 146 (Supplement 1): 323.
https://doi.org/10.1182/blood-2025-323
Published: 2025
Journal Articles

TP53 exon 7 (c.742C>T; p. Arg248Trp) vaf suppression by novel oral allosteric NEK7 inhibitor in a patient with low-risk myelodysplastic syndrome in A phase 2 clinical trial

Free
Devan Bursey, Victoria Allgood, Andrea Groen, Jeremiah Bearss, Stephen Anthony, David Bearss
Journal: Blood
Blood (2025) 146 (Supplement 1): 7379.
https://doi.org/10.1182/blood-2025-7379
Published: 2025
Journal Articles

Targeting NLRP3 with ofirnoflast, alone or in combination with semaglutide, ameliorates inflammatory anemia associated with obesity-induced inflammation in rodent models

Free
Benjamin Bearss, Jared Bearss, Chadwick Davis, Devan Bursey, William Burnett, Alexis Mollard, Jeremiah Bearss, Stephen Anthony, Margit Janat-Amsbury, David Bearss
Journal: Blood
Blood (2025) 146 (Supplement 1): 1127.
https://doi.org/10.1182/blood-2025-1127
Published: 2025
Journal Articles

The novel allosteric NEK7 inhibit ofirnoflast (HT-6184) reduces oxidized mitochondrial DNA in patients with low-risk myelodysplastic syndrome

Free
Devan Bursey, Victoria Allgood, Andrea Groen, Jeremiah Bearss, Stephen Anthony, David Bearss
Journal: Blood
Blood (2025) 146 (Supplement 1): 2093.
https://doi.org/10.1182/blood-2025-2093
Published: 2025
Journal Articles

The novel allosteric NEK7 inhibitor ofirnoflast (HT-6184) suppresses IL-8 and other pro-inflammatory cytokines in patients with low-risk myelodysplastic syndrome and symptomatic anemia

Free
Devan Bursey, Victoria Allgood, Andrea Groen, Jeremiah Bearss, Margit Janat-Amsbury, Stephen Anthony, David Bearss
Journal: Blood
Blood (2025) 146 (Supplement 1): 2092.
https://doi.org/10.1182/blood-2025-2092
Published: 2025
Journal Articles

Ofirnoflast suppresses heme-induced inflammation, representing a novel therapeutic strategy for hemolytic anemias

Free
Benjamin Bearss, Jared Bearss, Devan Bursey, Alexis Mollard, Jeremiah Bearss, William Burnett, Chadwick Davis, Margit Janat-Amsbury, David Bearss, Stephen Anthony
Journal: Blood
Blood (2025) 146 (Supplement 1): 1151.
https://doi.org/10.1182/blood-2025-1151
Published: 2025
Journal Articles

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

Free
Lisa S. Chen, Sanjeev Redkar, David Bearss, William G. Wierda, Varsha Gandhi
Journal: Blood
Blood (2009) 114 (19): 4150–4157.
https://doi.org/10.1182/blood-2009-03-212852
Published: 2009
Includes: Supplemental data
Journal Articles

Fetal Hemoglobin Induction in Baboons (P. Anubis) Following Admistration of a Novel Decitabine Dinucleotide (S110) Compound.

Free
Donald Lavelle, PhD, Kestis Vaitkus, B.S., Virryan Banzon, M.S., Maria Hankewych, B.S., Pasit Phiasivongsva, Ph.D., Sanjeev Redkar, Ph.D., Sarath Kanekal, Ph.D., David Bearss, Ph.D., Chongtie Shi, Ph.D., Roger Inloes, Ph.D., Joseph DeSimone, Ph.D.
Journal: Blood
Blood (2007) 110 (11): 571.
https://doi.org/10.1182/blood.V110.11.571.571
Published: 2007