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Journal Articles

Docirbrutinib (AS-1763), a novel non-COVALENT BTK inhibitor, demonstrates efficacy in BTK inhibitor-resistant mutant cells

Free
Tokiko Asami, Hitomi Fujiwara, Hiroko Endo, Natalia Timofeeva, Mariko Hatakeyama, Fumio Nakajima, Kyoko Miyamoto, Akinori Arimura, Yu Nishioka, Nitin Jain, Varsha Gandhi, Masaaki Sawa
Journal: Blood
Blood (2025) 146 (Supplement 1): 5077.
https://doi.org/10.1182/blood-2025-5077
Published: 2025
Journal Articles

Pirtobrutinib, venetoclax, and obinutuzumab for patients with richter transformation: A phase 2 trial

Free
Nitin Jain, Niranjan Khaire, Mahesh Swaminathan, Alessandra Ferrajoli, Jan Burger, Vishruth Shah, Kelly Chien, Gautam Borthakur, Koichi Takahashi, Naveen Pemmaraju, Prithviraj Bose, Jo Ishizawa, Beenu Thakral, Naveen Garg, Hyunsoo Hwang, Wei Qiao, Cameron Garcia, Anna Evangelio, Ana Ayala, Guillermo Garcia-Manero, Deepa Sampath, Varsha Gandhi, Michael Keating, Hagop Kantarjian, William Wierda
Journal: Blood
Blood (2025) 146 (Supplement 1): 89.
https://doi.org/10.1182/blood-2025-89
Published: 2025
Journal Articles

Time-limited pirtobrutinib, venetoclax, and obinutuzumab combination in first-line chronic lymphocytic leukemia

Free
Nitin Jain, Alessandra Ferrajoli, Mahesh Swaminathan, Jan Burger, Vanthana Bharathi, Wei-Ying Jen, Himachandana Atluri, Alex Bataller, Elias Jabbour, Tapan Kadia, Gautam Borthakur, Koichi Takahashi, Kelly Chien, Musa Yilmaz, Naveen Pemmaraju, Naval Daver, Fadi Haddad, Yesid Alvarado Valero, Jo Ishizawa, Guillermo Montalban-Bravo, Cameron Noorbakhsh, Dhruv Kumar, Naveen Garg, Hyunsoo Hwang, Wei Qiao, Cameron Garcia, Anna Evangelio, Ana Ayala, Guillermo Garcia-Manero, Deepa Sampath, Varsha Gandhi, Michael Keating, Hagop Kantarjian, William Wierda
Journal: Blood
Blood (2025) 146 (Supplement 1): 680.
https://doi.org/10.1182/blood-2025-680
Published: 2025
Journal Articles

Docirbrutinib (AS-1763), a novel non-COVALENT pan-mutant BTK inhibitor, demonstrates durable clinical responses in patients with previously treated B-cell malignancies: Data from an ongoing Phase 1b study

Free
Nitin Jain, Catherine Coombs, James D'Olimpio, Nirav Shah, Jacqueline Barrientos, Seung Tae Lee, Danielle Brander, John Nemunaitis, Andrew Gillis-Smith, Shuo Ma, Shirou Kirita, Koji Yoshida, Masaaki Sawa, Kyoko Miyamoto, Akinori Arimura, William Wierda, Varsha Gandhi, Javier Pinilla-Ibarz
Journal: Blood
Blood (2025) 146 (Supplement 1): 3892.
https://doi.org/10.1182/blood-2025-3892
Published: 2025
Journal Articles

Genomic Determinants of Response and Resistance to Pirtobrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia

Open Access
Clinical Trials & Observations
Jennifer R. Brown, Bastien Nguyen, Sai Prasad Desikan, Helen Won, Shady I. Tantawy, Samuel C McNeely, Narasimha Marella, Hetal S Randeria, Lauren M Hanson, Andrew Parker, Salome Calado Botelho, Jennifer A. Woyach, Krish Patel, Constantine S Tam, Toby A. Eyre, Chan Y Cheah, Nirav N Shah, Paolo Ghia, Wojciech Jurczak, Minna Balbas, Binoj Chandrasekharan Nair, Paolo B. Abada, Chunxiao Wang, Denise Wang, Lindsey Elizabeth Roeker, Varsha Gandhi, William G. Wierda
Journal: Blood
Blood blood.2024027009.
https://doi.org/10.1182/blood.2024027009
Published: 2025
Includes: Supplemental data
Journal Articles

Impact of Docirbrutinib (AS-1763) Treatment in CLL: Preclinical Data and Early Clinical Biomarkers

Free
Natalia Timofeeva, Breana Herrera, Shady I. Tantawy, Hitomi Fujiwara, Lizbeth Loza, Mariko Hatakeyama, Tokiko Asami, Hiroshi Ohmoto, Kyoko Miyamoto, Yu Nishioka, Akinori Arimura, Masaaki Sawa, Nitin Jain, Varsha Gandhi
Journal: Blood
Blood (2024) 144 (Supplement 1): 1850.
https://doi.org/10.1182/blood-2024-210788
Published: 2024
Journal Articles

Combined Pirtobrutinib, Venetoclax, and Obinutuzumab As First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL)

Free
Nitin Jain, Alessandra Ferrajoli, Mahesh Swaminathan, Patrick K. Reville, Jan A. Burger, Vanthana Bharathi, Himachandana Atluri, Hua-Jay J Cherng, Alex Bataller, Elias Jabbour, Tapan M. Kadia, Gautam Borthakur, Koichi Takahashi, Kelly S. Chien, Musa Yilmaz, Naveen Pemmaraju, Naval Daver, Fadi G. Haddad, Yesid Alvarado Valero, Jo Ishizawa, Guillermo Montalban-Bravo, Naveen Garg, Hyunsoo Hwang, Wei Qiao, Cameron Garcia, Anna Evangelio, Ana Ayala, Deepa Sampath, Varsha Gandhi, Michael J. Keating, Hagop M. Kantarjian, William G. Wierda
Journal: Blood
Blood (2024) 144 (Supplement 1): 1011.
https://doi.org/10.1182/blood-2024-211454
Published: 2024
Journal Articles

Preliminary Results from a Phase 1b Study of Non-Covalent Pan-Mutant BTK Inhibitor Docirbrutinib (AS-1763) in Patients with Previously Treated B-Cell Malignancies

Free
Nitin Jain, Catherine C. Coombs, James D'Olimpio, Nirav N. Shah, Jacqueline C. Barrientos, Seung Tae Lee, Andrew Gillis-Smith, Shuo Ma, Shirou Kirita, Masaaki Sawa, Kyoko Miyamoto, Akinori Arimura, William G. Wierda, Varsha Gandhi, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 1866.
https://doi.org/10.1182/blood-2024-208549
Published: 2024
Journal Articles

Trial in Progress: A Phase 1b Study of AS-1763, an Oral, Potent and Selective Noncovalent BTK Inhibitor, in Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

Free
Nitin Jain, James D'Olimpio, Andew gillis-Smith, Seung Tae Lee, Nirav N. Shah, Javier Pinilla-Ibarz, Catherine C. Coombs, Jacqueline C. Barrientos, Shuo Ma, Masaaki Sawa, Kyoko Miyamoto, Akinori Arimura, Varsha Gandhi, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 3288.
https://doi.org/10.1182/blood-2023-182568
Published: 2023
Journal Articles

Investigation into Intraclonal Heterogeneity of CXCR4 Dim CD5 Bright Chronic Lymphocytic Leukemia Cells Identifies Distinct Activation Signatures

Free
Anita Ng, Andrew Shih, Martina Cardillo, Kristin Lynn Sticco, Houman Khalili, Lita Crichton, William Plunkett, Varsha Gandhi, Nicholas Chiorazzi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3259.
https://doi.org/10.1182/blood-2023-187957
Published: 2023
Journal Articles

Characterization and Preclinical Evaluation of AS-1763, an Oral, Potent and Selective Noncovalent BTK Inhibitor, in Chronic Lymphocytic Leukemia

Free
Shady I. Tantawy, Natalia Timofeeva, Hitomi Fujiwara, Mariko Hatakeyama, Breana Herrera, Lizbeth Loza, Tokiko Asami, Hiroshi Ohmoto, Kyoko Miyamoto, Yu Nishioka, Akinori Arimura, Masaaki Sawa, Nitin Jain, Varsha Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1453.
https://doi.org/10.1182/blood-2023-189659
Published: 2023
Journal Articles

Genomic Evolution and Resistance during Pirtobrutinib Therapy in Covalent BTK-Inhibitor (cBTKi) Pre-Treated Chronic Lymphocytic Leukemia Patients: Updated Analysis from the BRUIN Study

Free
Jennifer R. Brown, Sai Prasad Desikan, Bastien Nguyen, Helen Won, Shady I. Tantawy, Samuel McNeely, Narasimha Marella, Kevin Ebata, Jennifer A. Woyach, Krish Patel, Constantine S. Tam, Toby A. Eyre, Chan Y. Cheah, Nirav N. Shah, Paolo Ghia, Wojciech Jurczak, Minna Balbas, Binoj Nair, Paolo Abada, Chunxiao Wang, Ying (Denise) Wang, Lindsey E. Roeker, Varsha Gandhi, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 326.
https://doi.org/10.1182/blood-2023-180143
Published: 2023
Journal Articles

Pyrimidine Starvation Is a Targetable Cancer Vulnerability: Mechanisms of Nucleotide Homeostasis

Free
Jelena Milosevic, Johannes Elferich, Kashish Chetal, Mary Ayres, Varsha Gandhi, Ruslan Sadreyev, Nikolaus Grigorieff, Shobha Vasudevan, David Sykes
Journal: Blood
Blood (2023) 142 (Supplement 1): 4113.
https://doi.org/10.1182/blood-2023-186615
Published: 2023
Journal Articles

Combined Ibrutinib and Venetoclax for First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL): 5-Year Follow-up Data

Free
Nitin Jain, Michael J. Keating, Philip A. Thompson, Alessandra Ferrajoli, Jayastu Senapati, Jan A. Burger, Gautam Borthakur, Mahesh Swaminathan, Koichi Takahashi, Zeev Estrov, Marina Y. Konopleva, Koji Sasaki, Tapan M. Kadia, Naveen Pemmaraju, Naval Daver, Elias Jabbour, Courtney D. DiNardo, Yesid Alvarado Valero, Musa Yilmaz, Prithviraj Bose, Maro Ohanian, Rashmi Kanagal-Shamanna, Keyur Patel, Jeffrey L. Jorgensen, Sa A. Wang, Sameh Nassar, Naveen Garg, Hyunsoo Hwang, Xuemei Wang, Nichole Cruz, Ana Ayala, William Plunkett, Hagop M. Kantarjian, Varsha Gandhi, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 4635.
https://doi.org/10.1182/blood-2023-189711
Published: 2023
Journal Articles

Ibrutinib, Fludarabine, Cyclophosphamide and Obinutuzumab (iFCG) for Firstline Treatment of Patients with CLL with Mutated IGHV and without Del(17p)/ TP53 Mutation: Six-Year Follow-up Analyses

Free
Nitin Jain, Philip Thompson, Akhil Jain, Jan A. Burger, Alessandra Ferrajoli, Jayastu Senapati, Koichi Takahashi, Mahesh Swaminathan, Zeev Estrov, Gautam Borthakur, Prithviraj Bose, Tapan M. Kadia, Naveen Pemmaraju, Koji Sasaki, Divyam Bansal, Marina Y. Konopleva, Elias Jabbour, Naveen Garg, Xuemei Wang, Rashmi Kanagal-Shamanna, Keyur P. Patel, Wei Wang, Sa A. Wang, Jeffrey L. Jorgensen, Wanda Lopez, Ana Ayala, William Plunkett, Varsha Gandhi, Hagop M. Kantarjian, Susan M. O'Brien, Michael J. Keating, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 3267.
https://doi.org/10.1182/blood-2023-188084
Published: 2023
Journal Articles

Combined Ibrutinib and Venetoclax for First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL): 4-Year Follow-up Data

Free
Nitin Jain, Michael J. Keating, Philip A. Thompson, Alessandra Ferrajoli, Jayastu Senapati, Jan A. Burger, Gautam Borthakur, Koichi Takahashi, Zeev E. Estrov, Marina Konopleva, Koji Sasaki, Tapan M. Kadia, Naveen Pemmaraju, Naval Daver, Elias Jabbour, Courtney D. DiNardo, Yesid Alvarado, Musa Yilmaz, Prithviraj Bose, Maro Ohanian, Rashmi Kanagal-Shamanna, Keyur Patel, Jeffrey L. Jorgensen, Sa A Wang, Sameh Nassar, Naveen Garg, Hyunsoo Hwang, Xuemei Wang, Nichole Cruz, Ana Ayala, William Plunkett, Hagop Kantarjian, Varsha Gandhi, William G. Wierda
Journal: Blood
Blood (2022) 140 (Supplement 1): 234–237.
https://doi.org/10.1182/blood-2022-170850
Published: 2022
Journal Articles

Pharmacological Profiling of Cells from Patients with Chronic Lymphocytic Leukemia (CLL) Treated with Pirtobrutinib

Free
Shady I. Tantawy, Burcu Aslan, Lisa S Chen, Lakesla Iles, Philip A. Thompson, Nitin Jain, William G. Wierda, Varsha Gandhi
Journal: Blood
Blood (2022) 140 (Supplement 1): 501–502.
https://doi.org/10.1182/blood-2022-171119
Published: 2022
Journal Articles

Effects of Glutaminase Inhibition on Venetoclax, Ibrutinib, and AZD-5991 Resistance in Chronic Lymphocytic Leukemia Cell Lines

Free
Natalia Timofeeva, Varsha Gandhi, Marina Konopleva, Mary Ayres
Journal: Blood
Blood (2022) 140 (Supplement 1): 9862–9864.
https://doi.org/10.1182/blood-2022-170746
Published: 2022
Journal Articles

DHODH: A Promising New Therapeutic Target in Pediatric T-ALL

Free
Amy N Sexauer, Gabriela Alexe, Varsha Gandhi, Kimberly Stegmaier, David Sykes
Journal: Blood
Blood (2022) 140 (Supplement 1): 7795–7797.
https://doi.org/10.1182/blood-2022-167569
Published: 2022
Journal Articles

Combined Ibrutinib and Venetoclax for First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL): Focus on Long-Term MRD Results

Free
Nitin Jain, Michael J. Keating, Philip A. Thompson, Alessandra Ferrajoli, Jan A. Burger, Gautam Borthakur, Koichi Takahashi, Zeev E. Estrov, Koji Sasaki, Tapan M. Kadia, Marina Konopleva, Yesid Alvarado, Musa Yilmaz, Courtney D. DiNardo, Prithviraj Bose, Maro Ohanian, Naveen Pemmaraju, Elias J. Jabbour, Rashmi Kanagal-Shamanna, Keyur Patel, Wei Wang, Jeffrey L. Jorgensen, Sa A Wang, Naveen Garg, Xuemei Wang, Chongjuan Wei, Nichole Cruz, Ana Ayala, William Plunkett, Hagop Kantarjian, Varsha Gandhi, William G. Wierda
Journal: Blood
Blood (2021) 138 (Supplement 1): 3720.
https://doi.org/10.1182/blood-2021-154454
Published: 2021