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Vicente Fresquet
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Journal Articles

Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation

Irene Peris, Silvia Romero-Murillo, Elena Martínez-Balsalobre, Caroline C. Farrington, Elena Arriazu, Nerea Marcotegui, Marta Jiménez-Muñoz, Cristina Alburquerque-Prieto, Andrea Torres-López, Vicente Fresquet, Jose A. Martínez-Climent, Maria C. Mateos, Maria L. Cayuela, Goutham Narla, Maria D. Odero, Carmen Vicente
Journal: Blood
Blood (2023) 141 (9): 1047–1059.
https://doi.org/10.1182/blood.2022016466
Published: 2023
Includes: Supplemental data
Journal Articles

Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- and high-risk myeloma

Clinical Trials & Observations
Ibai Goicoechea, Noemi Puig, Maria-Teresa Cedena, Leire Burgos, Lourdes Cordón, María-Belén Vidriales, Juan Flores-Montero, Norma C. Gutierrez, Maria-Jose Calasanz, Maria-Luisa Martin Ramos, David Lara-Astiaso, Amaia Vilas-Zornoza, Diego Alignani, Idoia Rodriguez, Sarai Sarvide, Daniel Alameda, Juan José Garcés, Sara Rodriguez, Vicente Fresquet, Jon Celay, Ramón Garcia-Sanz, Joaquin Martinez-Lopez, Albert Oriol, Rafael Rios, Jesus Martin-Sanchez, Rafael Martinez-Martinez, Josep Sarra, Miguel-Teodoro Hernandez, Javier de la Rubia, Isabel Krsnik, Jose-Maria Moraleda, Luis Palomera, Joan Bargay, Jose-Angel Martinez-Climent, Alberto Orfao, Laura Rosiñol, Maria-Victoria Mateos, Juan-José Lahuerta, Joan Blade, Jesús San Miguel, Bruno Paiva
Journal: Blood
Blood (2021) 137 (1): 49–60.
https://doi.org/10.1182/blood.2020006731
Published: 2021
Includes: Supplemental data
Journal Articles

Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma

Vicente Fresquet, Melissa Rieger, Carlo Carolis, Maria J. García-Barchino, Jose A. Martinez-Climent
Journal: Blood
Blood (2014) 123 (26): 4111–4119.
https://doi.org/10.1182/blood-2014-03-560284
Published: 2014
Includes: Supplemental data
Journal Articles

Downregulation of FOXP1 is required during germinal center B-cell function

Ainara Sagardoy, Jose I. Martinez-Ferrandis, Sergio Roa, Karen L. Bunting, María Angela Aznar, Olivier Elemento, Rita Shaknovich, Lorena Fontán, Vicente Fresquet, Ignacio Perez-Roger, Eloy F. Robles, Linde De Smedt, Xavier Sagaert, Ari Melnick, Jose A. Martinez-Climent
Journal: Blood
Blood (2013) 121 (21): 4311–4320.
https://doi.org/10.1182/blood-2012-10-462846
Published: 2013
Includes: Supplemental data
Journal Articles

A Novel Pro-Survival Function of Cyclin-D1 Underlies Its Oncogenic Role and Potential as a Therapeutic Target In Mantle Cell Lymphoma

Elena Beltran, PhD, Vicente Fresquet, PhD, Javier Martinez-Useros, Jose A. Richter-Larrea, PhD, Ainara Sagardoy, PhD, Izaskun Sesma, Luciana L. Almada, PhD, Santiago Montes-Moreno, MD, Stefan Gesk, MD, Reiner Siebert, Prof., Dr., med., MaJose Calasanz, PhD, Felipe Prosper, MD, Miguel A. Piris, MD, Martin E. Fernandez-Zapico, MD, Jose A Martinez-Climent, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 769.
https://doi.org/10.1182/blood.V116.21.769.769
Published: 2010
Journal Articles

Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma

Jose A. Richter-Larrea, Eloy F. Robles, Vicente Fresquet, Elena Beltran, Antonio J. Rullan, Xabier Agirre, Maria José Calasanz, Carlos Panizo, Jose A. Richter, Jesus M. Hernandez, Jose Roman-Gomez, Felipe Prosper, Jose A. Martinez-Climent
Journal: Blood
Blood (2010) 116 (14): 2531–2542.
https://doi.org/10.1182/blood-2010-02-268003
Published: 2010
Includes: Supplemental data
Journal Articles

Epigenetic Silencing of BIM Mediates Chemotherapy Resistance of Patients with Burkitt Lymphoma That Can Be Overcome by Therapeutic Reactivation of BIM in Mouse and Human Lymphoma Models

Jose A. Richter, MSc, Antonio Rullan, Elena Beltran, MSc, Xabier Agirre, PhD, M.a José Calasanz, PhD, Jose Roman-Gomez, MD, Carlos Panizo, MD, Jesus M Hernandez, MD, PhD, Felipe Prosper, MD, Vicente Fresquet, PhD, Jose A. Martinez-Climent, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 607.
https://doi.org/10.1182/blood.V112.11.607.607
Published: 2008
Journal Articles

Gene Expression and Proteomic Profiling Predict Therapeutic Response to ABT-737 in Human and Mouse Models of Mantle Cell Lymphoma

Elena Beltran, MSc, Vicente Fresquet, PhD, Jose A Richter, MSc, Miguel A. Piris, MD, Reiner Siebert, MD, Jose A. Martinez-Climent, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 608.
https://doi.org/10.1182/blood.V112.11.608.608
Published: 2008
Journal Articles

Splenic Marginal Zone Lymphoma Shows a Distinct Pattern of DNA Copy Number Aberrations That Correlates with Tumor Characteristics and Predicts Disease Outcome.

Jose A. Martinez-Climent, MD, PhD, Cristina Robledo, MSc, Manuela Mollejo, MD, Anton Parker, MD, Juan L. Garcia, PhD, Carlos Panizo, MD, Lorena Fontan, PhD, Vicente Fresquet, PhD, Ellen D. Remstein, MD, Sara Mould, MD, Ahmet Dogan, MD, Mark Law, MD, Isabel Marugan, MD, Maria J. Terol, MD, Esperanza Vizcarra, MD, David Graham Oscier, MD, Miguel A. Piris, MD, Jose M. Hernandez-Rivas, MD
Journal: Blood
Blood (2006) 108 (11): 2422.
https://doi.org/10.1182/blood.V108.11.2422.2422
Published: 2006
Journal Articles

Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas

Cinta Mestre-Escorihuela, Fanny Rubio-Moscardo, Jose A. Richter, Reiner Siebert, Joan Climent, Vicente Fresquet, Elena Beltran, Xabier Agirre, Isabel Marugan, Miguel Marín, Andreas Rosenwald, Kei-ji Sugimoto, Luise M. Wheat, E. Loraine Karran, Juan F. García, Lydia Sanchez, Felipe Prosper, Louis M. Staudt, Daniel Pinkel, Martin J. S. Dyer, Jose A. Martinez-Climent
Journal: Blood
Blood (2006) 109 (1): 271–280.
https://doi.org/10.1182/blood-2006-06-026500
Published: 2006
Includes: Supplemental data