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Journal Articles

The PP2A-B56α Heterocomplex Regulates Response to Venetoclax Plus Azacitidine Treatment in AML

Silvia Romero-Murillo, Irene Peris, Nerea Marcotegui, Carmen Vicente, Maria D. Odero, Goutham Narla
Journal: Blood
Blood (2023) 142 (Supplement 1): 2784.
https://doi.org/10.1182/blood-2023-174496
Published: 2023
Journal Articles

Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation

Irene Peris, Silvia Romero-Murillo, Elena Martínez-Balsalobre, Caroline C. Farrington, Elena Arriazu, Nerea Marcotegui, Marta Jiménez-Muñoz, Cristina Alburquerque-Prieto, Andrea Torres-López, Vicente Fresquet, Jose A. Martínez-Climent, Maria C. Mateos, Maria L. Cayuela, Goutham Narla, Maria D. Odero, Carmen Vicente
Journal: Blood
Blood (2023) 141 (9): 1047–1059.
https://doi.org/10.1182/blood.2022016466
Published: 2023
Includes: Supplemental data
Journal Articles

Nanoliposomal C6-Ceramide Exhibits Synergistic Anti-Cancer Activity with a Small Molecule Agonist of PP2A in Chronic Lymphocytic Leukemia

Kallesh D. Jayappa, Luke R. Vass, Caroline Farrington, Anuradha Illendula, Susan Walker, Michael E. Williams, Craig A. Portell, Todd Fox, Goutham Narla, Mark Kester
Journal: Blood
Blood (2022) 140 (Supplement 1): 7816–7817.
https://doi.org/10.1182/blood-2022-168086
Published: 2022
Journal Articles

Modulation of the Tumor Suppressor Protein PP2A Using a Small Molecule Agonist Overcomes Multi-Drug Resistance through Mitochondrial Permeability Transition Pore (MPTP) Dependent Induction of Apoptosis in Chronic Lymphocytic Leukemia

Kallesh D. Jayappa, PhD, Caroline Farrington, PhD, Vicki L. Gordon, BS, Shekhar Saha, PhD, Christopher Morris, BS, Krista M. Isaac, MD, Timothy P. Bender, PhD, Michael E. Williams, MD, Craig A. Portell, MD, Goutham Narla, MD PhD, Michael J. Weber, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15–17.
https://doi.org/10.1182/blood-2020-138954
Published: 2020
Journal Articles

PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

Mario Scarpa, PhD, Prerna Singh, MS, Shivani Kapoor, MS, Jonelle K. Lee, MS, Sandrine Niyongere, MD, Goutham Narla, MD PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1276.
https://doi.org/10.1182/blood-2019-129011
Published: 2019
Journal Articles

Drug Combinations Co-Targeting Myeloid Cell Leukemia-1 (Mcl-1) Protein Can Overcome Microenvironmentally-Induced Multi-Drug Tolerance in Non-Hodgkin Lymphomas

Kallesh D. Jayappa, DVM, PhD, Craig A. Portell, MD, Vicki L. Gordon, BSc, Goutham Narla, MD PhD, Timothy P. Bender, PhD, Michael E. Williams, MD, Michael J. Weber, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2649.
https://doi.org/10.1182/blood-2018-99-116759
Published: 2018
Journal Articles

Small Molecule Activators of Protein Phosphatase 2A (SMAPs) Cause c-Myc Degradation and Tumor Growth Suppression in Preclinical Models of Lymphoid Malignancies

Molly M Gallogly, MDPhD, Eric Yuan, MPhil, Sahar Mazhar, BA, Caroline Farrington, BA, Goutham Narla, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2819.
https://doi.org/10.1182/blood.V130.Suppl_1.2819.2819
Published: 2017
Journal Articles

Direct-Acting Small Molecule Activators of PP2A (SMAPs) in Myeloid Malignancies: Understanding Mechanisms of Cytotoxicity to Inform Rational Combinatorial Therapeutic Strategies

Christopher B Ryder, Goutham Narla, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2517.
https://doi.org/10.1182/blood.V130.Suppl_1.2517.2517
Published: 2017
Journal Articles

Ribosomal protein S19 expression during erythroid differentiation

Lydie Da Costa, Goutham Narla, Thiébaut-Noel Willig, Luanne L. Peters, Marilyn Parra, Jason Fixler, Gil Tchernia, Narla Mohandas
Journal: Blood
Blood (2003) 101 (1): 318–324.
https://doi.org/10.1182/blood-2002-04-1131
Published: 2003