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Michael E. Williams
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Journal Articles

Dysregulation of Transcription Machinery Drives the Acquisition of BTK Inhibitor and Venetoclax Treatment Resistance in Mantle Cell Lymphoma

Jing Gao, Kevin Qiu, Kallesh Danappa Jayappa, Qing Yin, Michelle Wang, Allen Hu, Danielle C Llaneza, Loryn L Blackburn, Jeffrey W Craig, Bijal D Shah, Craig A. Portell, Michael E Williams, Chongzhi Zang, Jianguo Tao
Journal: Blood
Blood (2024) 144 (Supplement 1): 6220.
https://doi.org/10.1182/blood-2024-204223
Published: 2024
Journal Articles

Combinatorial Therapy of CDK9 Inhibitor with CD19 CAR-T to Reciprocally Overcome Therapy Resistance and Enhance Treatment Efficacies Against Aggressive B-Cell Lymphomas

Qing Yin, Michelle Wang, Allen Hu, Jing Gao, Danielle C Llaneza, Loryn L Blackburn, Jeffrey W Craig, Bijal D Shah, Craig A. Portell, Michael E Williams, Jianguo Tao
Journal: Blood
Blood (2024) 144 (Supplement 1): 6219.
https://doi.org/10.1182/blood-2024-204209
Published: 2024
Journal Articles

Real World First-Line Treatment Strategies and Outcomes in TP53 Mutated and Unmutated Mantle Cell Lymphoma

Jie Wang, Jihao Zhou, Yucai Wang, Javier L. Munoz, Kevin G. Shim, Muhamad Alhaj Moustafa, Firas Baidoun, Kaitlin Annunzio, Narendranath Epperla, Michael McLane, Yasmin H. Karimi, Binh Luu, Stephen E Spurgeon, Cheryl Chang, Zihan Wan, Diamone Gathers, Emily R. King, Marcus P. Watkins, Nancy L. Bartlett, Christine E. Ryan, Genevieve M Gerhard, Philippe Armand, Ann S. LaCasce, Vedha Vaddaraju, Danielle S Wallace, Vaishalee P Kenkre, Chase Junge, Natalie Grover, Jorge A Florindez, Reem Karmali, Alexander V. Stanisic, Chen Zhang, Parameswaran Venugopal, Grace Ying, Caitlin Gribbin, Jia Ruan, Navika D Shukla, Sonali M. Smith, Viktoriya Zelikson, Michael E. Williams, Stefan K. Barta, Omar Elghawy, Jake Schade, Rohini Navalekar, Matthew Matasar, Andrew M Evens, Alexey V. Danilov, Timothy S. Fenske
Journal: Blood
Blood (2024) 144 (Supplement 1): 4406.
https://doi.org/10.1182/blood-2024-194601
Published: 2024
Journal Articles

Pembrolizumab in Combination with Epigenetic Therapy Is Safe and Active in Heavily Treated Patients with Peripheral T-Cell Lymphoma (PTCL) and Cutaneous T-Cell Lymphoma (CTCL): Preliminary Results from the Embolden Trial

Nathan Roberts, John Lister, N. Nora Bennani, Salvia Jain, Tammy Battaglia, Emily C. Ayers, Craig A. Portell, Michael E. Williams, Prem Batchala, Ipsita Pal, Owen A. O'Connor, John Sanil Manavalan, Enrica Marchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 9425–9426.
https://doi.org/10.1182/blood-2022-170181
Published: 2022
Journal Articles

Phase 1 Study of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates, in Adult Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Jennifer Kimberly Lue, Don A. Stevens, Michael E. Williams, Jason Westin, Reggie Ewesuedo, Alice McDonald, Sagar Agarwal, Patrick Henrick, Rachelle Perea, Jared Gollob
Journal: Blood
Blood (2022) 140 (Supplement 1): 12143–12144.
https://doi.org/10.1182/blood-2022-170151
Published: 2022
Journal Articles

Nanoliposomal C6-Ceramide Exhibits Synergistic Anti-Cancer Activity with a Small Molecule Agonist of PP2A in Chronic Lymphocytic Leukemia

Kallesh D. Jayappa, Luke R. Vass, Caroline Farrington, Anuradha Illendula, Susan Walker, Michael E. Williams, Craig A. Portell, Todd Fox, Goutham Narla, Mark Kester
Journal: Blood
Blood (2022) 140 (Supplement 1): 7816–7817.
https://doi.org/10.1182/blood-2022-168086
Published: 2022
Journal Articles

Ibrutinib improves survival compared with chemotherapy in mantle cell lymphoma with central nervous system relapse

Clinical Trials & Observations
Chiara Rusconi, Chan Y. Cheah, Toby A. Eyre, David Tucker, Pavel Klener, Eva Giné, Lara Crucitti, Cristina Muzi, Sara Iadecola, Gabriele Infante, Sophie Bernard, Rebecca L. Auer, Chiara Pagani, Monika Duglosz-Danecka, Heidi Mocikova, Tom van Meerten, Emanuele Cencini, Ana Marin-Niebla, Michael E. Williams, Piera Angelillo, Paolo Nicoli, Annalisa Arcari, Lucia Morello, Donato Mannina, Orsola Vitagliano, Roberto Sartori, Annalisa Chiappella, Roberta Sciarra, Piero M. Stefani, Martin Dreyling, John F. Seymour, Carlo Visco
Journal: Blood
Blood (2022) 140 (17): 1907–1916.
https://doi.org/10.1182/blood.2022015560
Published: 2022
Includes: Supplemental data
Journal Articles

Novel Hemorrhagic Dermatologic Toxicity Associated with Bruton's Tyrosine Kinase Inhibitor Therapy

Nicholas J Schmidt, Jr., Krista Isaac, Michael E. Williams, Richard Flowers, Alina Zufall, Krishna Patel
Journal: Blood
Blood (2021) 138 (Supplement 1): 4528.
https://doi.org/10.1182/blood-2021-146587
Published: 2021
Journal Articles

Antibody and T-Cell Responses to Covid-19 mRNA Vaccines in Patients with B-Cell Lymphomas and Chronic Lymphocytic Leukemia (CLL)

Emily C. Ayers, Jeffrey Wilson, Glenda Canderan, Behnam Keshavarz, Judith Woodfolk, Craig A. Portell, Michael E. Williams
Journal: Blood
Blood (2021) 138 (Supplement 1): 1335.
https://doi.org/10.1182/blood-2021-146165
Published: 2021
Journal Articles

Long Term Follow up of the Resort Study (E4402): A Randomized Phase III Study Comparing Two Different Rituximab Dosing Strategies for Low Tumor Burden Follicular Lymphoma

Brad S. Kahl, Fangxin Hong, Christopher Peterson, Lode J. Swinnen, Thomas M. Habermann, Stephen J Schuster, Matthias Weiss, Paul A S Fishkin, W. Christopher Ehmann, Timothy S. Fenske, Michael E. Williams
Journal: Blood
Blood (2021) 138 (Supplement 1): 815.
https://doi.org/10.1182/blood-2021-152976
Published: 2021
Journal Articles

Mantle cell lymphoma continues to surprise, and inform!

Michael E. Williams
Journal: Blood
Blood (2021) 137 (23): 3158–3160.
https://doi.org/10.1182/blood.2020010622
Published: 2021
Journal Articles

Modulation of the Tumor Suppressor Protein PP2A Using a Small Molecule Agonist Overcomes Multi-Drug Resistance through Mitochondrial Permeability Transition Pore (MPTP) Dependent Induction of Apoptosis in Chronic Lymphocytic Leukemia

Kallesh D. Jayappa, PhD, Caroline Farrington, PhD, Vicki L. Gordon, BS, Shekhar Saha, PhD, Christopher Morris, BS, Krista M. Isaac, MD, Timothy P. Bender, PhD, Michael E. Williams, MD, Craig A. Portell, MD, Goutham Narla, MD PhD, Michael J. Weber, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15–17.
https://doi.org/10.1182/blood-2020-138954
Published: 2020
Journal Articles

Multi-Institution Phase I/Ib Continual Re-Assessment Study to Identify the Optimal Dose of of Ibrutinib (IBR) and Venetoclax (VEN) in Relapsed or Refractory Mantle Cell Lymphoma (MCL)

Craig A. Portell, MD, Nolan A Wages, PhD, Brad S. Kahl, MD, Lihua E Budde, MD PhD, Robert W. Chen, MD, Jonathon B. Cohen, MDMS, Gina Petroni, PhD, Michael E. Williams, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1535.
https://doi.org/10.1182/blood-2019-128788
Published: 2019
Journal Articles

A Multi-Drug Tolerant Phenotype Is Induced By Diverse Microenvironmental Agonists in Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

Kallesh D. Jayappa, DVM, PhD, Konrad J. Cios, BSc (2019), Vicki L. Gordon, BSc, Puja C. Arora, MD, Timothy P. Bender, PhD, Michael E. Williams, MD, Craig A. Portell, MD, Michael J. Weber, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4120.
https://doi.org/10.1182/blood-2018-99-119521
Published: 2018
Journal Articles

Drug Combinations Co-Targeting Myeloid Cell Leukemia-1 (Mcl-1) Protein Can Overcome Microenvironmentally-Induced Multi-Drug Tolerance in Non-Hodgkin Lymphomas

Kallesh D. Jayappa, DVM, PhD, Craig A. Portell, MD, Vicki L. Gordon, BSc, Goutham Narla, MD PhD, Timothy P. Bender, PhD, Michael E. Williams, MD, Michael J. Weber, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2649.
https://doi.org/10.1182/blood-2018-99-116759
Published: 2018
Journal Articles

Single Institution Experience of Gastrointestinal Involvement of Diffuse Large B- Cell Lymphoma: Presentation, Outcomes and Patterns of Treatment Failure

Puja C. Arora, MD, Victor M. Orellana-Noia, MD, Abeer Alfaraj, MBBS, Wenzinger Christopher, MD, Sandra Monson, PhD, Gina Petroni, PhD, Craig A. Portell, MD, Michael E. Williams, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2982.
https://doi.org/10.1182/blood-2018-99-117651
Published: 2018
Journal Articles

Initial Report of a Multi-Institution Phase I/Ib Study of Ibrutinib with Venetoclax in Relapsed or Refractory Mantle Cell Lymphoma

Craig A. Portell, MD, Robert W Chen, MD, Nolan Wages, PhD, Jonathon B. Cohen, MD, Michael J. Weber, PhD, Gina Petroni, PhD, Brad S. Kahl, MD, Michael E Williams, MD
Journal: Blood
Blood (2016) 128 (22): 2958.
https://doi.org/10.1182/blood.V128.22.2958.2958
Published: 2016
Journal Articles

Extrinsic Factors in the In Vivo Macroenvironment Generate Phenotypic Resistance to BTK/Bcl-2 Targeted Therapies in Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

Kallesh D. Jayappa, DVM, PhD, Craig A. Portell, MD, Vicki L Gordon, BS, Brian J Capaldo, PhD, Stefan Bekiranov, PhD, Julia D Wulfkuhle, Rosa I Gallagher, Emanuel F. Petricoin, PhD, Timothy P. Bender, PhD, Michael E. Williams, MD, Michael J. Weber, PhD
Journal: Blood
Blood (2016) 128 (22): 754.
https://doi.org/10.1182/blood.V128.22.754.754
Published: 2016
Journal Articles

Major Bleeding with Ibrutinib: More Than Expected

Paul R Kunk, MD, Joesph Mock, MD, Michael E. Devitt, MD, Surabhi Palkimas, Pharm D., Jeremy Sen, Pharm D., Craig A. Portell, MD, Michael E. Williams, MD
Journal: Blood
Blood (2016) 128 (22): 3229.
https://doi.org/10.1182/blood.V128.22.3229.3229
Published: 2016
Journal Articles

Postibrutinib outcomes in patients with mantle cell lymphoma

Clinical Trials & Observations
Peter Martin, Kami Maddocks, John P. Leonard, Jia Ruan, Andre Goy, Nina Wagner-Johnston, Simon Rule, Ranjana Advani, David Iberri, Tycel Phillips, Stephen Spurgeon, Eliana Kozin, Katherine Noto, Zhengming Chen, Wojciech Jurczak, Rebecca Auer, Ewa Chmielowska, Stephan Stilgenbauer, Johannes Bloehdorn, Craig Portell, Michael E. Williams, Martin Dreyling, Paul M. Barr, Selina Chen-Kiang, Maurizio DiLiberto, Richard R. Furman, Kristie A. Blum
Journal: Blood
Blood (2016) 127 (12): 1559–1563.
https://doi.org/10.1182/blood-2015-10-673145
Published: 2016