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Journal Articles

CRISPR/Cas9 Library Screens Identified Atp2a2 As an In Vivo Specific Tumor Suppressor in Myeloid Neoplasms

Ruka Shimura, Moe Tamura, Keita Yamamoto, Kohei Iida, Shuhei Asada, Emi Sugimoto, E. Christine Pietsch, Barbara A. Weir, Ramona Crescenzo, Glenn S. Cowley, Ricardo M. Attar, Ulrike Philippar, Satoshi Yamasaki, Taisei Hirouchi, Kaoru Uchimaru, Toshio Kitamura, Susumu Goyama

Blood (2024) 144 (Supplement 1): 949.

https://doi.org/10.1182/blood-2024-206816

Published: 2024

Journal Articles

Development of an Antibody-Drug Conjugate Targeting CADM1 in Adult T-Cell Leukemia/Lymphoma

Aki Tanabe, Yoshiaki Takahashi, Anna Yui, Makoto Nakakido, Tomohiro Nasu, Mami Uemura, Kenta Tezuka, Kaoru Uchimaru, Atae Utsunomiya, Tetsuro Matano, Takuo Mizukami, Toshiki Watanabe, Kouhei Tsumoto, Kazumi Nakano

Blood (2024) 144 (Supplement 1): 1405.

https://doi.org/10.1182/blood-2024-198569

Published: 2024

Journal Articles

Integrating Genomic & Transcriptomic Features for Noninvasive Detection, Characterization, and Monitoring of T-Cell Lymphomas

Blood (2024) 144 (Supplement 1): 454.

https://doi.org/10.1182/blood-2024-206518

Published: 2024

Journal Articles

Durable Clinical Impacts and Mechanisms of Action and Resistance in EZH1/2-Targeting Epigenetic Therapy

Blood (2022) 140 (Supplement 1): 756–757.

https://doi.org/10.1182/blood-2022-159275

Published: 2022

Journal Articles

Highly Sensitive Detection Method Reveals Significant Anti-Tumor Activity of Valemetostat in Patients with Relapsed/Refractory Adult T Cell Leukemia

Gensuke Takayama, Yoshiyuki Hizukuri, Tomoyuki Fujioka, Kazuyuki Hashimoto, Kazumi Ito, Hironori Yamada, Makoto Yamagishi, Makoto Nakashima, Yutaka Suzuki, Yasuhito Nannya, Kaoru Uchimaru, Shinji Tsutsumi

Blood (2022) 140 (Supplement 1): 9304–9305.

https://doi.org/10.1182/blood-2022-165922

Published: 2022

Journal Articles

Genomic Analysis of Therapy-Related Myeloid Neoplasms and Tracking of the Founder Clone By Circulating Tumor DNA

Kanya Kondoh, MD, Kazuaki Yokoyama, MD PhD, Nozomi Yusa, Mika Ito, Eigo Shimizu, Sousuke Nakamura, MD, Miho Ogawa, MD, Tomomi Takei, MD, Asako Kobayashi, Rika Kasajima, PhD, Yuka Wada, Rui Yamaguchi, PhD, Seiya Imoto, PhD, Tokiko Nagamura-Inoue, MD PhD, Kaoru Uchimaru, MD, PhD, Satoru Miyano, PhD, Arinobu Tojo, MD PhD

Blood (2019) 134 (Supplement_1): 5393.

https://doi.org/10.1182/blood-2019-127611

Published: 2019

Journal Articles

The Presence and Possible Role of Virus-Host Chimeric Transcripts in Adult T-Cell Leukemia-Lymphoma

Hiroo Katsuya, MD, Paola Miyazato, PhD, Saiful Islam, Benjy Jek Yang Tan, MD, Yuki Inada, Misaki Matsuo, Takaharu Ueno, Masahito Tokunaga, MD PhD, Hiroyuki Hata, MD PhD, Makoto Yamagishi, PhD, Jun-Ichi Fujisawa, Toshiki Watanabe, MD, PhD, Kaoru Uchimaru, MD, PhD, Atae Utsunomiya, MD, Shinya Kimura, MD PhD, Yorifumi Satou, MD PhD

Blood (2019) 134 (Supplement_1): 2779.

https://doi.org/10.1182/blood-2019-124361

Published: 2019

Journal Articles

EZH1/2, SWI/SNF, and MLL2 Dependent Heterochromatin Formation and Abnormal Transcriptome in Hematological Malignancies

Makoto Yamagishi, PhD, Dai Fujikawa, PhD, Makoto Hori, Daisuke Honma, PhD, Nobuaki Adachi, PhD, Seiichiro Kobayashi, MD, PhD, Masako Iwanaga, MD PhD MPH, Atae Utsunomiya, MD, Seiji Okada, MD, PhD, Kunihiro Tsukasaki, MD PhD, Kensei Tobinai, MD PhD, Kazushi Araki, D.V.M., PhD, Toshiki Watanabe, MD, PhD, Kaoru Uchimaru, MD, PhD

Blood (2017) 130 (Supplement 1): 1200.

https://doi.org/10.1182/blood.V130.Suppl_1.1200.1200

Published: 2017

Journal Articles

Proof of Merit in New Diet Therapy Against Adult T-Cell Leukemia/Lymphoma: Applying Specific Amino Acid Dependency of Leukemia/Lymphoma Cells

Tomohiro Ishigaki, MD PhD, Yuki Taya, MD PhD, Satoshi Yamazaki, PhD, Seiichiro Kobayashi, MD PhD, Nobuhiro Ohno, MD, Kaoru Uchimaru, MD PhD, Arinobu Tojo, MD PhD, Hiromitsu Nakauchi, MD PhD

Blood (2016) 128 (22): 1765.

https://doi.org/10.1182/blood.V128.22.1765.1765

Published: 2016

Journal Articles

Exploratory Introduction of Cognitive Computing to Clinical Sequencing in Hematological Malignancies

Blood (2016) 128 (22): 5262.

https://doi.org/10.1182/blood.V128.22.5262.5262

Published: 2016

Journal Articles

Treatment and Prognosis in Patients with Adult T-Cell Leukemia-Lymphoma (ATL): A Nationwide Survey in Japan

Yoshitaka Imaizumi, MD, PhD, Masako Iwanaga, MD, PhD, Kisato Nosaka, MD, PhD, Shigeki Ito, MD, PhD, Kenji Ishitsuka, MD, PhD, Atae Utsunomiya, MD, PhD, Yoshiki Tokura, MD, PhD, Takeaki Tomoyose, MD, PhD, Kazuya Shimoda, MD, PhD, Kensei Tobinai, MD, PhD, Toshiki Watanabe, MD, PhD, Kaoru Uchimaru, MD, PhD, Kunihiro Tsukasaki, MD

Blood (2016) 128 (22): 5936.

https://doi.org/10.1182/blood.V128.22.5936.5936

Published: 2016

Journal Articles

Development and Molecular Analysis of Synthetic Lethality By Targeting EZH1 and EZH2 in Non-Hodgkin Lymphomas

Makoto Yamagishi, PhD, Makoto Hori, Dai Fujikawa, PhD, Daisuke Honma, PhD, Nobuaki Adachi, PhD, Takeo Ohsugi, D.V.M., PhD, Kazumi Nakano, PhD, Makoto Nakashima, Seiichiro Kobayashi, MD, PhD, Masako Iwanaga, MD, PhD, Atae Utsunomiya, MD, PhD, Seiji Okada, MD, PhD, Kunihiro Tsukasaki, MD, Kensei Tobinai, MD, PhD, Kazushi Araki, D.V.M., PhD, Toshiki Watanabe, MD, PhD, Kaoru Uchimaru, MD PhD

Blood (2016) 128 (22): 462.

https://doi.org/10.1182/blood.V128.22.462.462

Published: 2016

Journal Articles

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

Dai Fujikawa, Shota Nakagawa, Makoto Hori, Naoya Kurokawa, Ai Soejima, Kazumi Nakano, Tadanori Yamochi, Makoto Nakashima, Seiichiro Kobayashi, Yuetsu Tanaka, Masako Iwanaga, Atae Utsunomiya, Kaoru Uchimaru, Makoto Yamagishi, Toshiki Watanabe

Blood (2016) 127 (14): 1790–1802.

https://doi.org/10.1182/blood-2015-08-662593

Published: 2016

Includes: Supplemental data

Journal Articles

Current Clinico-Epidemiological Characteristics of Adult T-Cell Leukemia-Lymphoma (ATL) Based on the 11th Nationwide Survey in Japan

Kisato Nosaka, MD PhD, Masako Iwanaga, MD, PhD, Kenichi Ishizawa, MD, PhD, Yoji Ishida, MD, PhD, Kaoru Uchimaru, MD, PhD, Kenji Ishitsuka, MD, PhD, Masahiro Amano, MD,PhD, Takashi Ishida, MD PhD, Yoshitaka Imaizumi, MD, Naokuni Uike, MD, PhD, Atae Utsunomiya, MD, PhD, Koichi Ohshima, MD PhD, Kazuhiro Kawai, MD, PhD, Junji Tanaka, MD, PhD, Yoshiki Tokura, MD, PhD, Kensei Tobinai, MD PhD, Toshiki Watanabe, MD, PhD, Kunihiro Tsukasaki, MD, PhD

Blood (2015) 126 (23): 5034.

https://doi.org/10.1182/blood.V126.23.5034.5034

Published: 2015

Journal Articles

Polycomb-Dependent Epigenetic Landscape in Adult T Cell Leukemia (ATL); Providing Proof of Concept for Targeting EZH1/2 to Selectively Eliminate the HTLV-1 Infected Population

Makoto Yamagishi, PhD, Dai Fujikawa, Daisuke Honma, PhD, Nobuaki Adachi, PhD, Shota Nakagawa, Makoto Hori, Naoya Kurokawa, Ai Soejima, Kazumi Nakano, PhD, Tadanori Yamochi, PhD, Makoto Nakashima, Seiichiro Kobayashi, MD, PhD, Yuetsu Tanaka, MD, PhD, Masako Iwanaga, MD, PhD, Atae Utsunomiya, MD, PhD, Kaoru Uchimaru, MD, PhD, Kunihiro Tsukasaki, MD, PhD, Kazushi Araki, D.V.M., PhD, Toshiki Watanabe, MD, PhD

Blood (2015) 126 (23): 572.

https://doi.org/10.1182/blood.V126.23.572.572

Published: 2015

Journal Articles

BRAF-V600E Mutation on Circulating Cell-Free DNA Is a Promising Biomarker of High-Risk Adult Langerhans Cell Histiocytosis

Masayuki Kobayashi, MD, Nobuhiro Ohno, MD PhD, Tomofusa Fukuyama, MD PhD, Toyotaka Kawamata, MD PhD, Kaoru Uchimaru, MD PhD, Arinobu Tojo, MD PhD

Blood (2014) 124 (21): 3209.

https://doi.org/10.1182/blood.V124.21.3209.3209

Published: 2014

Journal Articles

Comprehensive Analysis of Surface Antigens on Adult T-Cell Leukemia/Lymphoma (ATL) Cells and Search for ATL-Initiating Cell Markers

Tomohiro Ishigaki, MD, Seiichiro Kobayashi, MD PhD, Nobuhiro Ohno, MD PhD, Nobuaki Nakano, MD, Atae Utsunomiya, MD PhD, Satoshi Yamazaki, PhD, Nobukazu Watanabe, MD PhD, Kaoru Uchimaru, MD PhD, Arinobu Tojo, MD PhD, Hiromitsu Nakauchi, MD PhD

Blood (2014) 124 (21): 1674.

https://doi.org/10.1182/blood.V124.21.1674.1674

Published: 2014

Journal Articles

Leukemic T Cells Are Specifically Enriched In a Unique CD3 dim CD7 low Subpopulation of CD4 + T Cells In Acute-Type Adult T Cell Leukemia

Yamin Tian, MD, Seiichiro Kobayashi, MD, PhD, Nobuhiro Ohno, MD, Masamichi Isobe, MD, Mayuko Tsuda, MD, Yuji Zaike, Nobukazu Watanabe, MD, PhD, Kenzaburo Tani, MD, PhD, Arinobu Tojo, MD, PhD, Kaoru Uchimaru, MD, PhD

Blood (2010) 116 (21): 4144.

https://doi.org/10.1182/blood.V116.21.4144.4144

Published: 2010

Journal Articles

Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan

Blood (2010) 116 (8): 1211–1219.

https://doi.org/10.1182/blood-2009-12-257410

Published: 2010

Includes: Supplemental data

Journal Articles

Large Scale Selective Ex Vivo Expansion of CD4 + CD25 + FOXP3 + Regulatory T Cells from Peripheral Blood.

Tokiko Nagamura-Inoue, MD, PhD, Kazuo Ogami, Kazuaki Yokoyama, Kiyoko Izawa, Seiichiro Kobayashi, Shin Nakayama, Ikuo Ishige, Yusuke Inoue, Jun Ooi, Kaoru Uchimaru, Satoshi Takahashi, Arinobu Tojo

Blood (2008) 112 (11): 2344.

https://doi.org/10.1182/blood.V112.11.2344.2344

Published: 2008

NARROW

CRISPR/Cas9 Library Screens Identified Atp2a2 As an In Vivo Specific Tumor Suppressor in Myeloid Neoplasms

Development of an Antibody-Drug Conjugate Targeting CADM1 in Adult T-Cell Leukemia/Lymphoma

Integrating Genomic & Transcriptomic Features for Noninvasive Detection, Characterization, and Monitoring of T-Cell Lymphomas

Durable Clinical Impacts and Mechanisms of Action and Resistance in EZH1/2-Targeting Epigenetic Therapy

Highly Sensitive Detection Method Reveals Significant Anti-Tumor Activity of Valemetostat in Patients with Relapsed/Refractory Adult T Cell Leukemia

Genomic Analysis of Therapy-Related Myeloid Neoplasms and Tracking of the Founder Clone By Circulating Tumor DNA

The Presence and Possible Role of Virus-Host Chimeric Transcripts in Adult T-Cell Leukemia-Lymphoma

EZH1/2, SWI/SNF, and MLL2 Dependent Heterochromatin Formation and Abnormal Transcriptome in Hematological Malignancies

Proof of Merit in New Diet Therapy Against Adult T-Cell Leukemia/Lymphoma: Applying Specific Amino Acid Dependency of Leukemia/Lymphoma Cells

Exploratory Introduction of Cognitive Computing to Clinical Sequencing in Hematological Malignancies

Treatment and Prognosis in Patients with Adult T-Cell Leukemia-Lymphoma (ATL): A Nationwide Survey in Japan

Development and Molecular Analysis of Synthetic Lethality By Targeting EZH1 and EZH2 in Non-Hodgkin Lymphomas

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

Current Clinico-Epidemiological Characteristics of Adult T-Cell Leukemia-Lymphoma (ATL) Based on the 11th Nationwide Survey in Japan

Polycomb-Dependent Epigenetic Landscape in Adult T Cell Leukemia (ATL); Providing Proof of Concept for Targeting EZH1/2 to Selectively Eliminate the HTLV-1 Infected Population

BRAF-V600E Mutation on Circulating Cell-Free DNA Is a Promising Biomarker of High-Risk Adult Langerhans Cell Histiocytosis

Comprehensive Analysis of Surface Antigens on Adult T-Cell Leukemia/Lymphoma (ATL) Cells and Search for ATL-Initiating Cell Markers

Leukemic T Cells Are Specifically Enriched In a Unique CD3 dim CD7 low Subpopulation of CD4 + T Cells In Acute-Type Adult T Cell Leukemia

Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan

Large Scale Selective Ex Vivo Expansion of CD4 + CD25 + FOXP3 + Regulatory T Cells from Peripheral Blood.

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American Society of Hematology

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