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Toshio Kitamura
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Journal Articles

PCYT1A Is a Metabolic Vulnerability in Monocytic Acute Myeloid Leukemia

Jakushin Nakahara, Keita Yamamoto, Tomohiro Yabushita, Takumi Chinen, Kei Ito, Yutaka Takeda, Daiju Kitagawa, Toshio Kitamura, Susumu Goyama
Journal: Blood
Blood (2024) 144 (Supplement 1): 2913.
https://doi.org/10.1182/blood-2024-202832
Published: 2024
Journal Articles

Machine Learning-Based Predictive Modeling Maximizes the Efficacy of mTOR/TP53 Co-Targeting Therapy Against Acute Myeloid Leukemia

Jingmei Li, Emi Sugimoto, Keita Yamamoto, Yutong Dai, Sung-Joon Park, Kenta Nakai, Toshio Kitamura, Susumu Goyama
Journal: Blood
Blood (2024) 144 (Supplement 1): 272.
https://doi.org/10.1182/blood-2024-206818
Published: 2024
Journal Articles

CRISPR/Cas9 Library Screens Identified Atp2a2 As an In Vivo Specific Tumor Suppressor in Myeloid Neoplasms

Ruka Shimura, Moe Tamura, Keita Yamamoto, Kohei Iida, Shuhei Asada, Emi Sugimoto, E. Christine Pietsch, Barbara A. Weir, Ramona Crescenzo, Glenn S. Cowley, Ricardo M. Attar, Ulrike Philippar, Satoshi Yamasaki, Taisei Hirouchi, Kaoru Uchimaru, Toshio Kitamura, Susumu Goyama
Journal: Blood
Blood (2024) 144 (Supplement 1): 949.
https://doi.org/10.1182/blood-2024-206816
Published: 2024
Journal Articles

SETDB1 Suppresses Interferon Responses and NK Cell-Mediated Immunosurveillance Specifically in Monocytic AML

Yu-Hsuan Chang, Keita Yamamoto, Takeshi Fujino, Teh-Wei Wang, Emi Sugimoto, Wenyu Zhang, Tomohiro Yabushita, E. Christine Pietsch, Barbara A. Weir, Ramona Crescenzo, Glenn S. Cowley, Ricardo M. Attar, Ulrike Philippar, Yutaka Enomoto, Yoichi Imai, Toshio Kitamura, Susumu Goyama
Journal: Blood
Blood (2023) 142 (Supplement 1): 713.
https://doi.org/10.1182/blood-2023-177531
Published: 2023
Journal Articles

Mitotic Perturbation Is a Key Mechanism of Action of Decitabine in Myeloid Tumor Treatment

Tomohiro Yabushita, Takumi Chinen, Atsuya Nishiyama, Shuhei Asada, Keita Yamamoto, Naru Sato, Yutaka Enomoto, Yosuke Tanaka, Keiko Katoh, Kaori Saitoh, Takamasa Ishikawa, Hitoshi Sato, Tomoyoshi Soga, Yasuhito Nannya, Makoto Nakanishi, Daiju Kitagawa, Toshio Kitamura, Susumu Goyama
Journal: Blood
Blood (2022) 140 (Supplement 1): 8776–8777.
https://doi.org/10.1182/blood-2022-168499
Published: 2022
Journal Articles

Impaired Osteoblastic Differentiation of MSCs Suppresses Normal Hematopoiesis in MDS

Yasutaka Hayashi, MDPhD, Kimihito Cojin Kawabata, MD PhD, Yosuke Tanaka, PhD, Yasufumi Uehara, MDPhD, Shigeru Kiryu, MD PhD, Yasunori Ota, MD PhD, Yusuke Yoshioka, PhD, Yo Mabuchi, PhD, Tatsuki Sugiyama, MDPhD, Keiko Mikami, MSc, Moe Tamura, MSc, Tsuyoshi Fukushima, MD PhD, Shuhei Asada, MDPhD, Reina Takeda, MDPhD, Yuya Kunisaki, MD PhD, Tomofusa Fukuyama, MD PhD, Susumu Goyama, MD PhD, Kazuaki Yokoyama, MD PhD, Arinobu Tojo, MD PhD, Yoshio Katayama, MD PhD, Fumio Arai, PhD, Takashi Nagasawa, MDPhD, Takahiro Ochiya, PhD, Daichi Inoue, MDPhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-142284
Published: 2020
Journal Articles

HHEX promotes myeloid transformation in cooperation with mutant ASXL1

Reina Takeda, Shuhei Asada, Sung-Joon Park, Akihiko Yokoyama, Hans Jiro Becker, Akinori Kanai, Valeria Visconte, Courtney Hershberger, Yasutaka Hayashi, Taishi Yonezawa, Moe Tamura, Tsuyoshi Fukushima, Yosuke Tanaka, Tomofusa Fukuyama, Akiko Matsumoto, Satoshi Yamasaki, Kenta Nakai, Satoshi Yamazaki, Toshiya Inaba, Tatsuhiro Shibata, Daichi Inoue, Hiroaki Honda, Susumu Goyama, Jaroslaw P. Maciejewski, Toshio Kitamura
Journal: Blood
Blood (2020) 136 (14): 1670–1684.
https://doi.org/10.1182/blood.2019004613
Published: 2020
Includes: Supplemental data
Journal Articles

Mutant ASXL1 Disrupts Paraspeckle Formation through Aberrant Interaction with Nono in Hematopoietic Cells

Yamamoto Keita, MD, Susumu Goyama, MD PhD, Shuhei Asada, MD PhD, Takeshi Fujino, MD, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, MD, Ayana Kon, MD PhD, Yasuhito Nannya, MD PhD, Seishi Ogawa, MD PhD, Reina Onoguchi, PhD, Nobuyoshi Akimitsu, PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2514.
https://doi.org/10.1182/blood-2019-125472
Published: 2019
Journal Articles

The Ubiquitin Ligase DTX2 Promotes Nuclear Export of RUNX1 and Inhibits RUNX1-Dependent Leukemogenesis

Taishi Yonezawa, MSc, Hirotaka Takahasi, PhD, Tatsuya Sawasaki, PhD, Toshio Kitamura, MD PhD, Susumu Goyama, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1252.
https://doi.org/10.1182/blood-2019-126264
Published: 2019
Journal Articles

Homeobox Transcription Factor Hhex Promotes Myeloid Leukemia in Cooperation with Mutant ASXL1

Reina Takeda, MD, Shuhei Asada, MD PhD, Sung-Joon Park, PhD, Akihiko Yokoyama, PhD, Akinori Kanai, PhD, Valeria Visconte, PhD, Courtney Hershberger, BS, Yasutaka Hayashi, MD PhD, Taishi Yonezawa, MSc, Moe Tamura, Tomofusa Fukuyama, MD PhD, Akiko Matsumoto, Satoshi Yamasaki, PhD, Kenta Nakai, PhD, Toshiya Inaba, MD PhD, Tatsuhiro Shibata, MD PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Susumu Goyama, MD PhD, Jaroslaw P. Maciejewski, MD PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2525.
https://doi.org/10.1182/blood-2019-126663
Published: 2019
Journal Articles

Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation

Shuhei Asada, MD PhD, Susumu Goyama, MD PhD, Reina Takeda, MD, Keita Yamamoto, MD, Hiroko Kozuka-Hata, PhD, Masaaki Oyama, PhD, Daichi Inoue, MD PhD, Hiroaki Honda, MD PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 731.
https://doi.org/10.1182/blood-2019-125959
Published: 2019
Journal Articles

Mutant ASXL1 Promotes Expansion of the Phenotypic Hematopoietic Stem Cell Compartment

Takeshi Fujino, MD, Susumu Goyama, MD PhD, Yuki Sugiura, PhD, Daichi Inoue, MD PhD, Satoshi Yamasaki, PhD, Akiko Matsumoto, Naru Sato, MD, Hironobu Morinaga, PhD, Shiori Shikata, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, PhD, Shuhei Asada, MD PhD, Tsuyoshi Fukushima, MD PhD, Hiroaki Honda, MD PhD, Emi K Nishimura, MD PhD, Tatsuhiro Shibata, MD PhD, Makoto Suematsu, MD PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 821.
https://doi.org/10.1182/blood-2019-127904
Published: 2019
Journal Articles

Chromatin Architecture Modulation in B-Cell Acute Lymphoblastic Leukemia Carrying DUX4 Fusions

Yosuke Tanaka, MD, Masahito Kawazu, MD PhD, Satoshi Inoue, PhD, Shinya Kojima, Ueno Toshihide, PhD, Toshiaki Uno, Moe Tamura, Susumu Goyama, MD PhD, Toshio Kitamura, MD PhD, Shinichi Morishita, PhD, Hiroyuki Mano, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1240.
https://doi.org/10.1182/blood-2019-125207
Published: 2019
Journal Articles

Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma

Hiroshi Higuchi, Natsuko Yamakawa, Ken-Ichi Imadome, Takashi Yahata, Ryutaro Kotaki, Jun Ogata, Masatoshi Kakizaki, Koji Fujita, Jun Lu, Kazuaki Yokoyama, Kazuki Okuyama, Ai Sato, Masako Takamatsu, Natsumi Kurosaki, Syakira Mohamad Alba, Azran Azhim, Ryouichi Horie, Toshiki Watanabe, Toshio Kitamura, Kiyoshi Ando, Takao Kashiwagi, Toshimitsu Matsui, Akinao Okamoto, Hiroshi Handa, Masahiko Kuroda, Naoya Nakamura, Ai Kotani
Journal: Blood
Blood (2018) 131 (23): 2552–2567.
https://doi.org/10.1182/blood-2017-07-794529
Published: 2018
Includes: Supplemental data
Journal Articles

ASXL1 mutations gain a function

Toshio Kitamura
Journal: Blood
Blood (2018) 131 (3): 274–275.
https://doi.org/10.1182/blood-2017-12-816595
Published: 2018
Journal Articles

Mutant ASXL1 Cooperates with BAP1 to Promote Myeloid Leukemogenesis

Shuhei Asada, MD, Susumu Goyama, MD PhD, Daichi Inoue, MD PhD, Reina Takeda, MD, Masahito Kawazu, Hiroyuki Mano, MDPhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 562.
https://doi.org/10.1182/blood.V130.Suppl_1.562.562
Published: 2017
Journal Articles

A p53-MDM2 Interaction Inhibitor, DS-5272, Inhibits the Development of MLL-Fusion Leukemia with the Assistance of Tumor Immunity

Susumu Goyama, MD PhD, Yasutaka Hayashi, XiaoXiao Liu, Shiori Shikata, Yosuke Tanaka, Tomofusa Fukuyama, MD PhD, Akiko Matsumoto, Satoshi Yamasaki, Tatsuhiro Shibata, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 796.
https://doi.org/10.1182/blood.V130.Suppl_1.796.796
Published: 2017
Journal Articles

RARB Translocations in Acute Promyelocytic Leukemia without Rara translocation

Motohiro Kato, MD, Tomoo Osumi, MD, Shinichi Tsujimoto, MD, Moe Tamura, Meri Uchiyama, Kazuhiko Nakabayashi, Kohji Okamura, Daisuke Tomizawa, MD PhD, Akihiro Watanabe, Hiroyuki Takahashi, Tsukasa Hori, MD PhD, Shohei Yamamoto, MD PhD, Kazuko Hamamoto, Masahiro Migita, Hiroko Ogata-Kawata, Toru Uchiyama, Hiroe Kizawa, Hitomi Ueno-Yokohata, Ryota Shirai, Masanori Yoshida, Masafumi Seki, MD,PhD, Kentaro Oki, MD PhD, Junko Takita, MD PhD, Seishi Ogawa, MD PhD, Toshio Kitamura, MD PhD, Kimikazu Matsumoto, Kenichiro Hata, MD PhD, Susumu Goyama, MD PhD, Nobutaka Kiyokawa, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 104.
https://doi.org/10.1182/blood.V130.Suppl_1.104.104
Published: 2017
Journal Articles

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

Susumu Goyama, MD PhD, Shiori Shikata, Yasutaka Hayashi, Yuto Izawa, Janet Schibler, Hiroyuki Iwamura, Dphil, Motoki Saito, PhD, Satoshi Kofuji, Kazutaka Sumita, Atsuo T Sasaki, James C. Mulloy, PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2016) 128 (22): 750.
https://doi.org/10.1182/blood.V128.22.750.750
Published: 2016
Journal Articles

Protease-Activated Receptor 1 (PAR-1) Inhibits Proliferation but Enhances Leukemia Stem Cell Activity in Acute Myeloid Leukemia

Susumu Goyama, MD PhD, Mahesh Shrestha, Janet Schibler, Leah Rosenfeldt, Whitney Miller, Eric O'Brien, Benjamin Mizukawa, MD, Toshio Kitamura, MD PhD, Joseph S. Palumbo, MD, James C. Mulloy, PhD
Journal: Blood
Blood (2016) 128 (22): 2730.
https://doi.org/10.1182/blood.V128.22.2730.2730
Published: 2016