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Ken-Ichi Imadome
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Journal Articles

The hepatic niche leads to aggressive natural killer cell leukemia proliferation through the transferrin–transferrin receptor 1 axis

Kazuaki Kameda, Ryo Yanagiya, Yuji Miyatake, Joaquim Carreras, Hiroshi Higuchi, Hiromichi Murayama, Takashi Ishida, Asahi Ito, Shinsuke Iida, Noriko Fukuhara, Hideo Harigae, Yuki Fujioka, Naoto Takahashi, Hidenori Wada, Fumihiro Ishida, Hideyuki Nakazawa, Rei Ishihara, Yuki Murakami, Hiroyuki Tagawa, Tadashi Matsuura, So Nakagawa, Sadahiro Iwabuchi, Shinichi Hashimoto, Ken-Ichi Imadome, Naoya Nakamura, Kenichi Ishizawa, Yoshinobu Kanda, Kiyoshi Ando, Ai Kotani
Journal: Blood
Blood (2023) 142 (4): 352–364.
https://doi.org/10.1182/blood.2022018597
Published: 2023
Includes: Supplemental data
Journal Articles

Phase II Study of a JAK1/2 Inhibitor Ruxolitinib for Systemic Chronic Active Epstein-Barr Virus Disease: An Investigator-Initiated Trial

Yu Uemura, Masahide Yamamoto, Masataka Ishimura, Hirokazu Kanegane, Akihisa Sawada, Akihiro Hirakawa, Ken-Ichi Imadome, Mayumi Yoshimori, Masashi Nagata, Norio Shimizu, Ryuji Koike, Ayako Arai
Journal: Blood
Blood (2022) 140 (Supplement 1): 6571–6572.
https://doi.org/10.1182/blood-2022-168565
Published: 2022
Journal Articles

The Plasma Level of IL-1β As a Biomarker of Angiopathy in Systemic Chronic Active EBV Infection

Ayaka Ohashi, Yu Uemura, Mayumi Yoshimori, Naomi Wada, Ken-Ichi Imadome, Kazuo Yudo, Takatoshi Koyama, Miwako Nishio, Ayako Arai
Journal: Blood
Blood (2021) 138 (Supplement 1): 4495.
https://doi.org/10.1182/blood-2021-149843
Published: 2021
Journal Articles

What Plasma Level of Interferon-γ Indicates in Systemic Chronic Active Epstein-Barr Virus Infection

Yu Uemura, Mayumi Yoshimori, Ayaka Ohashi, Tsuneaki Hirakawa, Naomi Wada, Ken-Ichi Imadome, Ayako Arai
Journal: Blood
Blood (2021) 138 (Supplement 1): 4529.
https://doi.org/10.1182/blood-2021-152285
Published: 2021
Journal Articles

A Nationwide Survey on Chronic Active Epstein-Barr Virus Infection in Japan Based on New Diagnostic Criteria: Clinical Features and Treatment Strategies

Ayako Arai, MD PhD, Ichiro Yonese, Chizuko Sakashita, MD PhD, Ken-Ichi Imadome, PhD, Tohru Kobayashi, MD PhD, Akihisa Sawada, MD PhD, Yoshinori Ito, MD PhD, Shouichi Ohga, MD PhD, Hiroshi Kimura, MD, Ph. D., Shigeyoshi Fujiwara, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1631.
https://doi.org/10.1182/blood-2018-99-117854
Published: 2018
Journal Articles

Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma

Hiroshi Higuchi, Natsuko Yamakawa, Ken-Ichi Imadome, Takashi Yahata, Ryutaro Kotaki, Jun Ogata, Masatoshi Kakizaki, Koji Fujita, Jun Lu, Kazuaki Yokoyama, Kazuki Okuyama, Ai Sato, Masako Takamatsu, Natsumi Kurosaki, Syakira Mohamad Alba, Azran Azhim, Ryouichi Horie, Toshiki Watanabe, Toshio Kitamura, Kiyoshi Ando, Takao Kashiwagi, Toshimitsu Matsui, Akinao Okamoto, Hiroshi Handa, Masahiko Kuroda, Naoya Nakamura, Ai Kotani
Journal: Blood
Blood (2018) 131 (23): 2552–2567.
https://doi.org/10.1182/blood-2017-07-794529
Published: 2018
Includes: Supplemental data
Journal Articles

Tumor Cells from EBV-Positive T- or NK-Cell Neoplasms Induce Differentiation and Activation of Macrophages By Secreting Humoral Factors

Akiho Tsuzura, Mayumi Yoshimori, Kanoko Konno, Ken-Ichi Imadome, PhD, Erika Onozawa, Ryunosuke Ohkawa, PhD, Minoru Tozuka, PhD, Osamu Miura, MD, PhD, Ayako Arai, MD, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4026.
https://doi.org/10.1182/blood.V130.Suppl_1.4026.4026
Published: 2017
Journal Articles

STAT3 Is Activated By EBV in T or NK Cells Leading to Development of EBV-T/NK-Lymphoproliferative Disorders

Honami Komatsu, Ken-Ichi Imadome, PhD, Haruna Shibayama, Tomotaka Yada, Momoko Yamada, Kouhei Yamamoto, MDPhD, Takatoshi Koyama, MD PhD, Shigeyoshi Fujiwara, MD PhD, Osamu Miura, MD PhD, Ayako Arai, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3026.
https://doi.org/10.1182/blood.V124.21.3026.3026
Published: 2014
Journal Articles

Epstein–Barr Virus Induces Activation-Induced Cytidine Deaminase Expression in T or NK Cells Leading to Mutagenesis and Development of Lymphoma

Ayako Arai, MD, PhD, Masato Horino, Ken-Ichi Imadome, PhD, Kohsuke Imai, MD, PhD, Honami Komatsu, Ludan Wang, MD, Go Matsuda, Kasumi Hamazaki, Morito Kurata, MD, PhD, Tetsuya Kurosu, MD, PhD, Shigeyoshi Fujiwara, MD, PhD, Osamu Miura, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1765.
https://doi.org/10.1182/blood.V122.21.1765.1765
Published: 2013
Journal Articles

L-Asparaginase Monotherapy for T- and NK-Cell Type of Chronic Active Epstein-Barr Virus Infection in Adults: A Pilot Study

Ayako Arai, MD, PhD, Minako Jinta, MD, Ken-Ichi Imadome, PhD, Mayumi Yoshimori, Shigeyoshi Fujiwara, MD, PhD, Osamu Miura, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 4953.
https://doi.org/10.1182/blood.V118.21.4953.4953
Published: 2011
Journal Articles

NF-κB Is Constitutively Activated in EBV-Infected T or NK Cells and Can Be a Molecular Target for EBV-Positive T/NK-Cell Lymphoproliferative Disease Treatment

Ayako Arai, MD, PhD, Mayumi Takahashi, Ken-Ichi Imadome, PhD, Takatoshi Koyama, MD, PhD, Yasunori Saitoh, MD, PhD, Shoji Yamaoka, MD, PhD, Shigeyoshi Fujiwara, MD, PhD, Osamu Miura, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1998.
https://doi.org/10.1182/blood.V116.21.1998.1998
Published: 2010
Journal Articles

CD137 Expression Is Enhanced in EBV-Infected T or NK Cells by Viral Protein LMP1 and Mediates Anti-Apoptotic Intracellular Signaling through NF-ĸB Activation.

Ayako Arai, MD, PhD, Ken-ichi Imadome, PhD, Mayumi Takahashi, Koichi Naka, Tetsuya Fukuda, MD, PhD, Shigeyoshi Fujiwara, MD, PhD, Osamu Miura, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 1929.
https://doi.org/10.1182/blood.V114.22.1929.1929
Published: 2009