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Journal Articles

In Vivo Analysis of PML-RARA in a Humanized Mouse Model

Hiromichi Matsushita, MD PhD, Takashi Yahata, PhD, Yin Sheng, PhD, Yoshihiko Nakamura, PhD, Yukari Muguruma, PhD, Hideyuki Matsuzawa, Masayuki Tanaka, Hideki Hayashi, Tadayuki Sato, Anar Damdinsuren, MD, Makoto Onizuka, MD PhD, Mamoru Ito, Hayato Miyachi, MD PhD, Pier Paolo Pandolfi, MD PhD, Kiyoshi Ando

Blood (2014) 124 (21): 1020.

https://doi.org/10.1182/blood.V124.21.1020.1020

Published: 2014

Journal Articles

Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome

Blood (2013) 121 (21): 4377–4387.

https://doi.org/10.1182/blood-2012-12-474387

Published: 2013

Includes: Supplemental data

Journal Articles

Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells

Takashi Yahata, Tomomi Takanashi, Yukari Muguruma, Abd Aziz Ibrahim, Hideyuki Matsuzawa, Tomoko Uno, Yin Sheng, Makoto Onizuka, Mamoru Ito, Shunichi Kato, Kiyoshi Ando

Blood (2011) 118 (11): 2941–2950.

https://doi.org/10.1182/blood-2011-01-330050

Published: 2011

Includes: Supplemental data

Journal Articles

A novel animal model of Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis in humanized mice

Kei Sato, Naoko Misawa, Chuanyi Nie, Yorifumi Satou, Dai Iwakiri, Masao Matsuoka, Rei Takahashi, Kiyotaka Kuzushima, Mamoru Ito, Kenzo Takada, Yoshio Koyanagi

Blood (2011) 117 (21): 5663–5673.

https://doi.org/10.1182/blood-2010-09-305979

Published: 2011

Includes: Supplemental data

Journal Articles

Establishment of a Novel CNS Infiltrated Xenograft Model through Engraftment of Patient-Derived Acute Lymphoblastic Leukemic Cells Into NOD/SCID/γc Null Mouse

Itaru Kato, Akira Niwa, Megumu Saito, Hisanori Fujino, Satoshi Saida, Hidefumi Hiramatsu, Koichi Oshima, Mamoru Ito, Souichi Adachi, MD, PhD, Toshio Heike, MD, Tatsutoshi Nakahata, MD

Blood (2010) 116 (21): 3248.

https://doi.org/10.1182/blood.V116.21.3248.3248

Published: 2010

Journal Articles

CXCR4 Blockade as a New Targeted Therapy for Acute Myeloide Leukemia Characterised by High Cell Surface Density of CXCR4.

Yanyan Zhang, Dima Jouni, Monika Wittner, Hakim Bouamar, Herve Dombret, MD, PhD, FRCP, Paul Coppo, Paule Opolon, Nobutaka Fujii, Mamoru Ito, William Vainchenker, MD, PhD, Stephane de Botton, Fawzia Louache

Blood (2009) 114 (22): 4570.

https://doi.org/10.1182/blood.V114.22.4570.4570

Published: 2009

Journal Articles

Blockage of SDF-1-CXCR4 Axis by AMD 3100 Can Be a Novel Therapy for Acute Lymphoblastic Leukemia by Targeting the Extramedullary Sites of Leukemic Cells.

Itaru Kato, M.D., Akira Niwa, M.D., Hisanori Fujino, M.D., PhD., Katsutsugu Umeda, M.D., PhD., Satoshi Saida, M.D., Souichi Adachi, MD, PhD, Mamoru Ito, Toshio Heike, M.D., PhD., Tatsutoshi Nakahata, M.D., Ph.D.

Blood (2009) 114 (22): 981.

https://doi.org/10.1182/blood.V114.22.981.981

Published: 2009

Journal Articles

NOD/SCID/γ c null mice provide a Unique Model to Investigate Childhood Haematopoietic Malignancies

Itaru Kato, M.D., Akira Niwa, M.D., Katsutsugu Umeda, M.D., Ph.D., Mamoru Ito, Ph.D., Toshio Heike, M.D., Ph.D., Tatsutoshi Nakahata, M.D., Ph.D.

Blood (2008) 112 (11): 3963.

https://doi.org/10.1182/blood.V112.11.3963.3963

Published: 2008

Journal Articles

Interferon-α2b–induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes

Akiko Yamane, Takanori Nakamura, Hidenori Suzuki, Mamoru Ito, Yasuyuki Ohnishi, Yasuo Ikeda, Yoshitaka Miyakawa

Blood (2008) 112 (3): 542–550.

https://doi.org/10.1182/blood-2007-12-125906

Published: 2008

Journal Articles

Interferon-α2b-Induced Thrombocytopenia Is Caused by Inhibition of Cytoplasmic Maturation and Platelet Production, but Not Proliferation and Endomitosis in Human Megakaryocytes.

Akiko Yamane, MD, Takanori Nakamura, Mamoru Ito, Yasuyuki Ohnishi, Yasuo Ikeda, MD, PhD, Yoshitaka Miyakawa, MD, PhD

Blood (2007) 110 (11): 2195.

https://doi.org/10.1182/blood.V110.11.2195.2195

Published: 2007

Journal Articles

Prevention of Human Interferon-alpha-Induced Thrombocytopenia by a Non-Peptidyl Human Thrombopoietin Receptor Activator, NIP-004.

Akiko Yamane, Takanori Nakamura, Mamoru Ito, Yasuyuki Ohnishi, Yasuo Ikeda, Yoshitaka Miyakawa

Blood (2006) 108 (11): 1145.

https://doi.org/10.1182/blood.V108.11.1145.1145

Published: 2006

Journal Articles

Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells

Takashi Yahata, Shizu Yumino, Yin Seng, Hiroko Miyatake, Tomoko Uno, Yukari Muguruma, Mamoru Ito, Hiroyuki Miyoshi, Shunichi Kato, Tomomitsu Hotta, Kiyoshi Ando

Blood (2006) 108 (7): 2446–2454.

https://doi.org/10.1182/blood-2006-02-002204

Published: 2006

Includes: Supplemental data

Journal Articles

Hematopoietic stem cell–engrafted NOD/SCID/IL2Rγ null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses

Satoru Watanabe, Kazuo Terashima, Shinrai Ohta, Shigeo Horibata, Misako Yajima, Yoko Shiozawa, M. Zahidunnabi Dewan, Zhong Yu, Mamoru Ito, Tomohiro Morio, Norio Shimizu, Mitsuo Honda, Naoki Yamamoto

Blood (2006) 109 (1): 212–218.

https://doi.org/10.1182/blood-2006-04-017681

Published: 2006

Journal Articles

A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis

Takanori Nakamura, Yoshitaka Miyakawa, Atsushi Miyamura, Akiko Yamane, Hidenori Suzuki, Mamoru Ito, Yasuyuki Ohnishi, Norihisa Ishiwata, Yasuo Ikeda, Nobutomo Tsuruzoe

Blood (2006) 107 (11): 4300–4307.

https://doi.org/10.1182/blood-2005-11-4433

Published: 2006

Journal Articles

Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment

Yukari Muguruma, Takashi Yahata, Hiroko Miyatake, Tadayuki Sato, Tomoko Uno, Jobu Itoh, Shunichi Kato, Mamoru Ito, Tomomitsu Hotta, Kiyoshi Ando

Blood (2006) 107 (5): 1878–1887.

https://doi.org/10.1182/blood-2005-06-2211

Published: 2006

Journal Articles

Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir

M. Zahidunnabi Dewan, Jun-nosuke Uchihara, Kazuo Terashima, Mitsuo Honda, Tetsutaro Sata, Mamoru Ito, Nobutaka Fujii, Kimiharu Uozumi, Kunihiro Tsukasaki, Masao Tomonaga, Yoko Kubuki, Akihiko Okayama, Masakazu Toi, Naoki Mori, Naoki Yamamoto

Blood (2006) 107 (2): 716–724.

https://doi.org/10.1182/blood-2005-02-0735

Published: 2006

Journal Articles

A Novel Non-Peptidyl Human C-Mpl Agonist, NIP-004, Stimulates Human Megakaryopoiesis and Thrombopoiesis.

Takanori Nakamura, Yoshitaka Miyakawa, Atsushi Miyamura, Akiko Yamane, Hidenori Suzuki, Katsuaki Miyaji, Mamoru Ito, Yasuyuki Ohnishi, Norihisa Ishiwata, Yasuo Ikeda, Nobutomo Tsuruzoe

Blood (2005) 106 (11): 3148.

https://doi.org/10.1182/blood.V106.11.3148.3148

Published: 2005

Journal Articles

Activation of C/EBPα in Hematopoietic Stem Cells Leads to Growth Suppression and Impairment of Megakaryocyte Differentiation.

Yumi Fukuchi, PhD, Fumi Shibata, Miyuki Ito, Yuko Goto-Koshino, PhD, Yusuke Sotomaru, PhD, Mamoru Ito, PhD, Toshio Kitamura, MD. PhD, Hideaki Nakajima, MD. PhD

Blood (2005) 106 (11): 2264.

https://doi.org/10.1182/blood.V106.11.2264.2264

Published: 2005

Journal Articles

Direct Evidence of Multilineage Differentiation and Self-Renewal Division of Individual Human Hematopoietic Stem Cell Clones In Vivo.

Takashi Yahata, PhD, Shizu Yumino, RA, Hiroko Miyatake, RA, Uno Tomoko, RA, Yin Sheng, RA, Yukari Muguruma, PhD, Mamoru Ito, PhD, Hiroyuki Miyoshi, PhD, Shunichi Kato, MD, Tomomitsu Hotta, MD, Kiyoshi Ando, MD

Blood (2005) 106 (11): 1725.

https://doi.org/10.1182/blood.V106.11.1725.1725

Published: 2005

Journal Articles

Use of the NOD/SCID/γ c null Mouse Model To Assess the Hepatocyte-Producing Ability of Human Hematopoietic Cells.

Hisanori Fujino, Hidefumi Hiramatsu, Atsunori Tsuchiya, Haruyoshi Noma, Mitsutaka Shiota, Katsutsugu Umeda, Momoko Yoshimoto, Toshio Heike, Mamoru Ito, Tatsutoshi Nakahata

Blood (2005) 106 (11): 1695.

https://doi.org/10.1182/blood.V106.11.1695.1695

Published: 2005

NARROW

In Vivo Analysis of PML-RARA in a Humanized Mouse Model

Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome

Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells

A novel animal model of Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis in humanized mice

Establishment of a Novel CNS Infiltrated Xenograft Model through Engraftment of Patient-Derived Acute Lymphoblastic Leukemic Cells Into NOD/SCID/γc Null Mouse

CXCR4 Blockade as a New Targeted Therapy for Acute Myeloide Leukemia Characterised by High Cell Surface Density of CXCR4.

Blockage of SDF-1-CXCR4 Axis by AMD 3100 Can Be a Novel Therapy for Acute Lymphoblastic Leukemia by Targeting the Extramedullary Sites of Leukemic Cells.

NOD/SCID/γ c null mice provide a Unique Model to Investigate Childhood Haematopoietic Malignancies

Interferon-α2b–induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes

Interferon-α2b-Induced Thrombocytopenia Is Caused by Inhibition of Cytoplasmic Maturation and Platelet Production, but Not Proliferation and Endomitosis in Human Megakaryocytes.

Prevention of Human Interferon-alpha-Induced Thrombocytopenia by a Non-Peptidyl Human Thrombopoietin Receptor Activator, NIP-004.

Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells

Hematopoietic stem cell–engrafted NOD/SCID/IL2Rγ null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses

A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis

Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment

Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir

A Novel Non-Peptidyl Human C-Mpl Agonist, NIP-004, Stimulates Human Megakaryopoiesis and Thrombopoiesis.

Activation of C/EBPα in Hematopoietic Stem Cells Leads to Growth Suppression and Impairment of Megakaryocyte Differentiation.

Direct Evidence of Multilineage Differentiation and Self-Renewal Division of Individual Human Hematopoietic Stem Cell Clones In Vivo.

Use of the NOD/SCID/γ c null Mouse Model To Assess the Hepatocyte-Producing Ability of Human Hematopoietic Cells.

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American Society of Hematology

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American Society of Hematology

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