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Journal Articles

Targeting Aurora Kinase with a Superior T-Cell Receptor Gene-Transfer Vector

Nicholas Casey, PhD, Hiroshi Fujiwara, MD PhD, Kazushi Tanimoto, MDPhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD PhD, Hiroshi Shiku, MD PhD, Masaki Yasukawa, MD PhD

Blood (2015) 126 (23): 4291.

https://doi.org/10.1182/blood.V126.23.4291.4291

Published: 2015

Journal Articles

Generation of BCR-ABL Reactive CD4+ T Helper Cells By Reprograming and Redifferentiation

Norihiro Ueda, MD, Yasusi Uemura, PhD, Rhong Zhang, MD PhD, Shuichi Kitayama, Yutaka Yasui, Minako Tatsumi, Tian-Yi Liu, MD PhD, Kiyotaka Kuzushima, MD PhD, Hitoshi Kiyoi, MD PhD, Tomoki Naoe, MD PhD, Shin Kaneko, MD PhD

Blood (2015) 126 (23): 3424.

https://doi.org/10.1182/blood.V126.23.3424.3424

Published: 2015

Journal Articles

Comprehensive T-Cell Receptor Repertoire Analysis Using Deep Sequencing and Single Cell Cloning Reveals Extreme Oligoclonality of Ex Vivo Expanded Cytomegalovirus-Reactive Cytotoxic T-Cells

Takahiko Miyama, MD, Takakazu Kawase, MD PhD, Kazutaka Kitaura, DVM, PhD, Ren Chishaki, Masashi Shibata, Kumi Oshima, MD PhD, Hiroshi Hamana, PhD, Hiroyuki Kishi, PhD, Kiyotaka Kuzushima, MD PhD, Hiroh Saji, BS, Ryuji Suzuki, DVM, PhD, Tatsuo Ichinohe, MD

Blood (2015) 126 (23): 1891.

https://doi.org/10.1182/blood.V126.23.1891.1891

Published: 2015

Journal Articles

Concomitant Administration of Gene-Modified T Cells Expressing a Chimeric CD16-CD3ζ Receptor with Mogamulizmab Synergistically Suppresses Adult T Cell Leukemia Cells in Vivo

Kazushi Tanimoto, MD PhD, Hiroshi Fujiwara, MD PhD, Hiroki Tanaka, MD, Fumihiro Ochi, MD, Hiroaki Asai, MDPhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD PhD, Hiroshi Shiku, MD PhD, John Barrett, MD, Masaki Yasukawa, MD PhD

Blood (2014) 124 (21): 307.

https://doi.org/10.1182/blood.V124.21.307.307

Published: 2014

Journal Articles

Construction and Molecular Characterization Of a T-Cell Receptor-Like Antibody and CAR-T Cells Specific For Minor Histocompatibility Antigen HA-1H

Yoko Inaguma, MD, Yasushi Akahori, PhD, Yoshiki Akatsuka, MD, PhD, Yuko Murayama, Keiko Shiraishi, Sachiko Tsuzuki-Iba, Akemi Endoh, Juri Tsujikawa, Ayako Demachi-Okamura, PhD, Kaho Hiramatsu, Hiroh Saji, PhD, Yukiya Yamamoto, MD, PhD, Naoki Yamamoto, PhD, Nishimura Yasuharu, MD, PhD, Toshitada Takahashi, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Nobuhiko Emi, MD, PhD

Blood (2013) 122 (21): 4490.

https://doi.org/10.1182/blood.V122.21.4490.4490

Published: 2013

Journal Articles

Co-Administration Of Gene-Modified CD4 + T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia

Hiroshi Fujiwara, MD, PhD, Fumihiro Ochi, MD, Toshiki Ochi, MD, PhD, Hiroaki Asai, MD, PhD, Yukihiro Miyazaki, MD, PhD, Taichi Azuma, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Miwako Narita, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2013) 122 (21): 144.

https://doi.org/10.1182/blood.V122.21.144.144

Published: 2013

Journal Articles

Development of a novel redirected T-cell–based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia

Yukihiro Miyazaki, Hiroshi Fujiwara, Hiroaki Asai, Fumihiro Ochi, Toshiki Ochi, Taichi Azuma, Takashi Ishida, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa

Blood (2013) 121 (24): 4894–4901.

https://doi.org/10.1182/blood-2012-11-465971

Published: 2013

Includes: Supplemental data

Journal Articles

Redirected CD4 + T Cells towards HLA Class I-Restricted WT1 Epitope Successfully Display Multifactorial Helper Function for the Enhancement of Antileukemia Efficacy Mediated by Redirected T-Cell Based Immunocelltherapy.

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Sachiko Okamoto, PhD, Hiroaki Asai, MD, Junichi Mineno, PhD, Miwako Narita, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 3153.

https://doi.org/10.1182/blood.V120.21.3153.3153

Published: 2012

Journal Articles

Human Telomerase Reverse Transcriptase–specific T-Cell Receptor Gene Transfer Redirects T Cells to Display an Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Hiroshi Fujiwara, MD, PhD, Fumihiro Ochi, Yukihiro Miyazaki, MD, Hiroaki Asai, MD, Takashi Ishida, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 1902.

https://doi.org/10.1182/blood.V120.21.1902.1902

Published: 2012

Journal Articles

Therapeutically Infused Redirected T Cells Targeting WT1 Successfully Inhibited Leukemia Stem Cells in Vivo

Hiroaki Asai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Yukihiro Miyazaki, MD, Fumihiro Ochi, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 4221.

https://doi.org/10.1182/blood.V120.21.4221.4221

Published: 2012

Journal Articles

Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity

Kozo Nagai, Toshiki Ochi, Hiroshi Fujiwara, Jun An, Toshiaki Shirakata, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, J. Joseph Melenhorst, Emma Gostick, David A. Price, Eiichi Ishii, Masaki Yasukawa

Blood (2012) 119 (2): 368–376.

https://doi.org/10.1182/blood-2011-06-360354

Published: 2012

Includes: Supplemental data

Journal Articles

Redirected CD4 + T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8 + T Cells Using the Identical Gene Transfer

Toshiki Ochi, MD, PhD, Hiroshi Fujiwara, MD, PhD, Sachiko Okamoto, PhD, Hiroaki Asai, MD, Yukihiro Miyazaki, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 645.

https://doi.org/10.1182/blood.V118.21.645.645

Published: 2011

Journal Articles

Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Hiroaki Asai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Jun An, MD, PhD, Toshiaki Shirakata, MD, PhD, Kozo Nagai, MD, Yukihiro Miyazaki, MD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 2059.

https://doi.org/10.1182/blood.V118.21.2059.2059

Published: 2011

Journal Articles

Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia,

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Hiroaki Asai, MD, Kozo Nagai, MD, Takashi Ishida, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 4169.

https://doi.org/10.1182/blood.V118.21.4169.4169

Published: 2011

Journal Articles

Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety

Toshiki Ochi, Hiroshi Fujiwara, Sachiko Okamoto, Jun An, Kozo Nagai, Toshiaki Shirakata, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa

Blood (2011) 118 (6): 1495–1503.

https://doi.org/10.1182/blood-2011-02-337089

Published: 2011

Includes: Supplemental data

Journal Articles

A novel animal model of Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis in humanized mice

Kei Sato, Naoko Misawa, Chuanyi Nie, Yorifumi Satou, Dai Iwakiri, Masao Matsuoka, Rei Takahashi, Kiyotaka Kuzushima, Mamoru Ito, Kenzo Takada, Yoshio Koyanagi

Blood (2011) 117 (21): 5663–5673.

https://doi.org/10.1182/blood-2010-09-305979

Published: 2011

Includes: Supplemental data

Journal Articles

Engineering of Human T-Cells with a Novel Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer Confers Anti-Leukemia Reactivity

Kozo Nagai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Jun An, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, Hiroshi Shiku, MD, PhD, J. Joseph Melenhorst, PhD, Emma Gostic, David A Price, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 4290.

https://doi.org/10.1182/blood.V116.21.4290.4290

Published: 2010

Journal Articles

Dual Engineering of Human CD8 + T-Cells with WT1-Specific TCR Gene and Chemokine Receptor Gene Transfer Confers Functionally Strengthened Anti-Cancer Reactivity

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, An Jun, MD, Toshiaki Shirakata, Kozo Nagai, MD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 4295.

https://doi.org/10.1182/blood.V116.21.4295.4295

Published: 2010

Journal Articles

Augmented Expression of WT1-Specific TCR and Inhibition of Mispaired-TCR Formation In TCR-Gene Modified T-Cells Can Concomitantly Be Achieved Using a Novel Retroviral Vector with Silencers for Endogenous TCRs

Toshiki Ochi, MD, PhD, Hiroshi Fujiwara, MD, PhD, Sachiko Okamoto, PhD, Jun An, Kozo Nagai, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 1020.

https://doi.org/10.1182/blood.V116.21.1020.1020

Published: 2010

Journal Articles

CD8 Coreceptor-Independent T Cell Stimulation Induces High Avidity CTL In the Presence of IL-21

Osamu Imataki, Sascha Ansén, Makito Tanaka, Marcus O. Butler, Alla Berezovskaya, Kiyotaka Kuzushima, Lee M. Nadler, Naoto Hirano

Blood (2010) 116 (21): 2086.

https://doi.org/10.1182/blood.V116.21.2086.2086

Published: 2010

NARROW

Targeting Aurora Kinase with a Superior T-Cell Receptor Gene-Transfer Vector

Generation of BCR-ABL Reactive CD4+ T Helper Cells By Reprograming and Redifferentiation

Comprehensive T-Cell Receptor Repertoire Analysis Using Deep Sequencing and Single Cell Cloning Reveals Extreme Oligoclonality of Ex Vivo Expanded Cytomegalovirus-Reactive Cytotoxic T-Cells

Concomitant Administration of Gene-Modified T Cells Expressing a Chimeric CD16-CD3ζ Receptor with Mogamulizmab Synergistically Suppresses Adult T Cell Leukemia Cells in Vivo

Construction and Molecular Characterization Of a T-Cell Receptor-Like Antibody and CAR-T Cells Specific For Minor Histocompatibility Antigen HA-1H

Co-Administration Of Gene-Modified CD4 + T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia

Development of a novel redirected T-cell–based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia

Redirected CD4 + T Cells towards HLA Class I-Restricted WT1 Epitope Successfully Display Multifactorial Helper Function for the Enhancement of Antileukemia Efficacy Mediated by Redirected T-Cell Based Immunocelltherapy.

Human Telomerase Reverse Transcriptase–specific T-Cell Receptor Gene Transfer Redirects T Cells to Display an Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Therapeutically Infused Redirected T Cells Targeting WT1 Successfully Inhibited Leukemia Stem Cells in Vivo

Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity

Redirected CD4 + T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8 + T Cells Using the Identical Gene Transfer

Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia,

Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety

A novel animal model of Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis in humanized mice

Engineering of Human T-Cells with a Novel Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer Confers Anti-Leukemia Reactivity

Dual Engineering of Human CD8 + T-Cells with WT1-Specific TCR Gene and Chemokine Receptor Gene Transfer Confers Functionally Strengthened Anti-Cancer Reactivity

Augmented Expression of WT1-Specific TCR and Inhibition of Mispaired-TCR Formation In TCR-Gene Modified T-Cells Can Concomitantly Be Achieved Using a Novel Retroviral Vector with Silencers for Endogenous TCRs

CD8 Coreceptor-Independent T Cell Stimulation Induces High Avidity CTL In the Presence of IL-21

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American Society of Hematology

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American Society of Hematology

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