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Journal Articles

Durable Clinical Impacts and Mechanisms of Action and Resistance in EZH1/2-Targeting Epigenetic Therapy

Blood (2022) 140 (Supplement 1): 756–757.

https://doi.org/10.1182/blood-2022-159275

Published: 2022

Journal Articles

EZH1/2, SWI/SNF, and MLL2 Dependent Heterochromatin Formation and Abnormal Transcriptome in Hematological Malignancies

Makoto Yamagishi, PhD, Dai Fujikawa, PhD, Makoto Hori, Daisuke Honma, PhD, Nobuaki Adachi, PhD, Seiichiro Kobayashi, MD, PhD, Masako Iwanaga, MD PhD MPH, Atae Utsunomiya, MD, Seiji Okada, MD, PhD, Kunihiro Tsukasaki, MD PhD, Kensei Tobinai, MD PhD, Kazushi Araki, D.V.M., PhD, Toshiki Watanabe, MD, PhD, Kaoru Uchimaru, MD, PhD

Blood (2017) 130 (Supplement 1): 1200.

https://doi.org/10.1182/blood.V130.Suppl_1.1200.1200

Published: 2017

Journal Articles

Proof of Merit in New Diet Therapy Against Adult T-Cell Leukemia/Lymphoma: Applying Specific Amino Acid Dependency of Leukemia/Lymphoma Cells

Tomohiro Ishigaki, MD PhD, Yuki Taya, MD PhD, Satoshi Yamazaki, PhD, Seiichiro Kobayashi, MD PhD, Nobuhiro Ohno, MD, Kaoru Uchimaru, MD PhD, Arinobu Tojo, MD PhD, Hiromitsu Nakauchi, MD PhD

Blood (2016) 128 (22): 1765.

https://doi.org/10.1182/blood.V128.22.1765.1765

Published: 2016

Journal Articles

Development and Molecular Analysis of Synthetic Lethality By Targeting EZH1 and EZH2 in Non-Hodgkin Lymphomas

Makoto Yamagishi, PhD, Makoto Hori, Dai Fujikawa, PhD, Daisuke Honma, PhD, Nobuaki Adachi, PhD, Takeo Ohsugi, D.V.M., PhD, Kazumi Nakano, PhD, Makoto Nakashima, Seiichiro Kobayashi, MD, PhD, Masako Iwanaga, MD, PhD, Atae Utsunomiya, MD, PhD, Seiji Okada, MD, PhD, Kunihiro Tsukasaki, MD, Kensei Tobinai, MD, PhD, Kazushi Araki, D.V.M., PhD, Toshiki Watanabe, MD, PhD, Kaoru Uchimaru, MD PhD

Blood (2016) 128 (22): 462.

https://doi.org/10.1182/blood.V128.22.462.462

Published: 2016

Journal Articles

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

Dai Fujikawa, Shota Nakagawa, Makoto Hori, Naoya Kurokawa, Ai Soejima, Kazumi Nakano, Tadanori Yamochi, Makoto Nakashima, Seiichiro Kobayashi, Yuetsu Tanaka, Masako Iwanaga, Atae Utsunomiya, Kaoru Uchimaru, Makoto Yamagishi, Toshiki Watanabe

Blood (2016) 127 (14): 1790–1802.

https://doi.org/10.1182/blood-2015-08-662593

Published: 2016

Includes: Supplemental data

Journal Articles

Polycomb-Dependent Epigenetic Landscape in Adult T Cell Leukemia (ATL); Providing Proof of Concept for Targeting EZH1/2 to Selectively Eliminate the HTLV-1 Infected Population

Makoto Yamagishi, PhD, Dai Fujikawa, Daisuke Honma, PhD, Nobuaki Adachi, PhD, Shota Nakagawa, Makoto Hori, Naoya Kurokawa, Ai Soejima, Kazumi Nakano, PhD, Tadanori Yamochi, PhD, Makoto Nakashima, Seiichiro Kobayashi, MD, PhD, Yuetsu Tanaka, MD, PhD, Masako Iwanaga, MD, PhD, Atae Utsunomiya, MD, PhD, Kaoru Uchimaru, MD, PhD, Kunihiro Tsukasaki, MD, PhD, Kazushi Araki, D.V.M., PhD, Toshiki Watanabe, MD, PhD

Blood (2015) 126 (23): 572.

https://doi.org/10.1182/blood.V126.23.572.572

Published: 2015

Journal Articles

Comprehensive Analysis of Surface Antigens on Adult T-Cell Leukemia/Lymphoma (ATL) Cells and Search for ATL-Initiating Cell Markers

Tomohiro Ishigaki, MD, Seiichiro Kobayashi, MD PhD, Nobuhiro Ohno, MD PhD, Nobuaki Nakano, MD, Atae Utsunomiya, MD PhD, Satoshi Yamazaki, PhD, Nobukazu Watanabe, MD PhD, Kaoru Uchimaru, MD PhD, Arinobu Tojo, MD PhD, Hiromitsu Nakauchi, MD PhD

Blood (2014) 124 (21): 1674.

https://doi.org/10.1182/blood.V124.21.1674.1674

Published: 2014

Journal Articles

Unique Role of mTOR Inhibitor, Everolimus in Inducible Regulatory T Cells

Tokiko Nagamura-Inoue, MD, PhD., Yuki Yamamoto, MT., Seiichiro Kobayashi, MD, PhD, Kazuo Ogami, Kiyoko Izawa, PhD, Miki Yuzawa, MT., Hajime Tsunoda, MD, PhD., Arinobu Tojo, MD, PhD.

Blood (2012) 120 (21): 4349.

https://doi.org/10.1182/blood.V120.21.4349.4349

Published: 2012

Journal Articles

The in Vitro and In Vivo Oncogenic Activity of Homodimeric Mutant of Interleukin-7 Receptor a Chain (IL7Rα) Highlights the Significance of the IL7Rα/Jak1 Pathway in T-Cell Acute Lymphoblastic Leukemia

Kazuaki Yokoyama, MD, Nozomi Yokoyama, Kiyoko Izawa, PhD, Ai Kotani, MD, PhD, Ratanakanit Harnprasopwat, PhD, Akira Harashima, MD, PhD, Seiichiro Kobayashi, MD, PhD, Arinobu Tojo, MD, PhD

Blood (2011) 118 (21): 73.

https://doi.org/10.1182/blood.V118.21.73.73

Published: 2011

Journal Articles

Bcr-Abl Impairs T Cell Development From Murine Induced Pluripotent Stem Cells and Hematopoietic Stem Cells; A Partial Explanation for the Concept That Ph+ Clone Never Involves T Cell Lineage in CML,

Bidisha Chanda, MBBS, Kiyoko Izawa, PhD, Ratanakanit Harnprasopwat, PhD, Keisuke Takahashi, Seiichiro Kobayashi, MD, PhD, Yumi Kanegae, PhD, Izumu Saito, PhD, Arinobu Tojo, MD, PhD

Blood (2011) 118 (21): 3748.

https://doi.org/10.1182/blood.V118.21.3748.3748

Published: 2011

Journal Articles

The Significance of mTOR Inhibitor, Everolimus in TGF-β-Induced Regulatory T cells from Cord Blood

Tokiko Nagamura-Inoue, Seiichiro Kobayashi, MD, PhD, Kazuo Ogami, Yuki Yamamoto, Kiyoko Izawa, PhD, Arinobu Tojo, MD, PhD

Blood (2011) 118 (21): 2180.

https://doi.org/10.1182/blood.V118.21.2180.2180

Published: 2011

Journal Articles

Hormone-Conditional Activation of Bcr-Abl Kinase Highlights Stat5 Anti-Apoptotic Pathway Prior to Promoting Cell Growth.

Ratanakanit Harnprasopwat, Naoyuki Takahashi, MD, PhD, Seiichiro Kobayashi, MD, PhD, Kazuaki Yokoyama, MD, Kiyoko Izawa, PhD, Ai Kotani, MD, PhD, Toshio Kitamura, MD, PhD, Arinobu Tojo, MD, PhD

Blood (2010) 116 (21): 3380.

https://doi.org/10.1182/blood.V116.21.3380.3380

Published: 2010

Journal Articles

Leukemic T Cells Are Specifically Enriched In a Unique CD3 dim CD7 low Subpopulation of CD4 + T Cells In Acute-Type Adult T Cell Leukemia

Yamin Tian, MD, Seiichiro Kobayashi, MD, PhD, Nobuhiro Ohno, MD, Masamichi Isobe, MD, Mayuko Tsuda, MD, Yuji Zaike, Nobukazu Watanabe, MD, PhD, Kenzaburo Tani, MD, PhD, Arinobu Tojo, MD, PhD, Kaoru Uchimaru, MD, PhD

Blood (2010) 116 (21): 4144.

https://doi.org/10.1182/blood.V116.21.4144.4144

Published: 2010

Journal Articles

Leukemogenic Fusion Gene (p190 BCR-ABL) Transduction Into Hematopoietic Stem/Progenitor Cells In the Common Marmoset

Yamin Tian, MD, Yan Dong, MD, PhD, Seiichiro Kobayashi, MD, PhD, Manabu Ozawa, PhD, Kiyoko Izawa, PhD, Yuansong Bai, MD, PhD, Yasushi Soda, MD, PhD, Erika Sasaki, PhD, Toshio Itoh, PhD, Naoki Oyaizu, MD, PhD, Satoshi Takahashi, Arinobu Tojo, MD, PhD, Chieko Kai, PhD, Kenzaburo Tani, MD, PhD

Blood (2010) 116 (21): 4323.

https://doi.org/10.1182/blood.V116.21.4323.4323

Published: 2010

Journal Articles

CD26 Is Down-Regulated In Inducible Regulatory T Cells

Tokiko Nagamura-Inoue, Kazuo Ogami, Seiichiro Kobayashi, MD, PhD, Naoyuki Takahashi, Kazuaki Yokoyama, MD, Arinobu Tojo, MD, PhD

Blood (2010) 116 (21): 4706.

https://doi.org/10.1182/blood.V116.21.4706.4706

Published: 2010

Journal Articles

Conditional Activation of Bcr-Abl Kinase Delineates Time-Dependent Transforming Events in Hematopoietic Cells.

Ratanakanit Harnprasopwat, Kiyoko Izawa, Seiichiro Kobayashi, Ai Kotani, Naoyuki Takahashi, Arinobu Tojo, MD, PhD

Blood (2009) 114 (22): 2162.

https://doi.org/10.1182/blood.V114.22.2162.2162

Published: 2009

Journal Articles

Tumor Necrosis Factor-α Contributes to Microenvironmental up- Regulation of NF-κB Activity in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Implication for a Novel Therapeutic Target.

Hui-Jen Tsai, MD, Seiichiro Kobayashi, MD, PhD, Kiyoko Itoh, PhD, Takaomi Ishida, PhD, Kazuo Umezawa, PhD, Arinobu Tojo, MD, PhD

Blood (2008) 112 (11): 1912.

https://doi.org/10.1182/blood.V112.11.1912.1912

Published: 2008

Journal Articles

Large Scale Selective Ex Vivo Expansion of CD4 + CD25 + FOXP3 + Regulatory T Cells from Peripheral Blood.

Tokiko Nagamura-Inoue, MD, PhD, Kazuo Ogami, Kazuaki Yokoyama, Kiyoko Izawa, Seiichiro Kobayashi, Shin Nakayama, Ikuo Ishige, Yusuke Inoue, Jun Ooi, Kaoru Uchimaru, Satoshi Takahashi, Arinobu Tojo

Blood (2008) 112 (11): 2344.

https://doi.org/10.1182/blood.V112.11.2344.2344

Published: 2008

Journal Articles

RNAi-Mediated Silencing of p190Bcr-Abl Inactivates Stat5 and Cooperates with Imatinib Mesylate and 17-Allylamino-17-Demetoxygeldanamycin in Selective Killing of p190Bcr-Abl-Expressing Leukemia Cells.

Muneyoshi Futami, MD, Toshiyuki Hatano, Yasushi Soda, M.D., Ph.D., Seiichiro Kobayashi, M.D., Ph.D., Makoto Miyagishi, Ph.D., Arinobu Tojo, M.D., Ph.D.

Blood (2007) 110 (11): 2783.

https://doi.org/10.1182/blood.V110.11.2783.2783

Published: 2007

Journal Articles

Microenvironmental Up-Regulation of NF-kB Activity Via P65-Dependent and Independent Pathways in a Bioimaging Model of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.

Hui-Jen Tsai, MD, Seiichiro Kobayashi, M.D., Ph.D., Kiyoko Itoh, Ph.D., Takaomi Ishida, Ph.D., Kazuo Umezawa, Ph.D., Arinobu Tojo, M.D., Ph.D.

Blood (2007) 110 (11): 723.

https://doi.org/10.1182/blood.V110.11.723.723

Published: 2007

NARROW

Durable Clinical Impacts and Mechanisms of Action and Resistance in EZH1/2-Targeting Epigenetic Therapy

EZH1/2, SWI/SNF, and MLL2 Dependent Heterochromatin Formation and Abnormal Transcriptome in Hematological Malignancies

Proof of Merit in New Diet Therapy Against Adult T-Cell Leukemia/Lymphoma: Applying Specific Amino Acid Dependency of Leukemia/Lymphoma Cells

Development and Molecular Analysis of Synthetic Lethality By Targeting EZH1 and EZH2 in Non-Hodgkin Lymphomas

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

Polycomb-Dependent Epigenetic Landscape in Adult T Cell Leukemia (ATL); Providing Proof of Concept for Targeting EZH1/2 to Selectively Eliminate the HTLV-1 Infected Population

Comprehensive Analysis of Surface Antigens on Adult T-Cell Leukemia/Lymphoma (ATL) Cells and Search for ATL-Initiating Cell Markers

Unique Role of mTOR Inhibitor, Everolimus in Inducible Regulatory T Cells

The in Vitro and In Vivo Oncogenic Activity of Homodimeric Mutant of Interleukin-7 Receptor a Chain (IL7Rα) Highlights the Significance of the IL7Rα/Jak1 Pathway in T-Cell Acute Lymphoblastic Leukemia

Bcr-Abl Impairs T Cell Development From Murine Induced Pluripotent Stem Cells and Hematopoietic Stem Cells; A Partial Explanation for the Concept That Ph+ Clone Never Involves T Cell Lineage in CML,

The Significance of mTOR Inhibitor, Everolimus in TGF-β-Induced Regulatory T cells from Cord Blood

Hormone-Conditional Activation of Bcr-Abl Kinase Highlights Stat5 Anti-Apoptotic Pathway Prior to Promoting Cell Growth.

Leukemic T Cells Are Specifically Enriched In a Unique CD3 dim CD7 low Subpopulation of CD4 + T Cells In Acute-Type Adult T Cell Leukemia

Leukemogenic Fusion Gene (p190 BCR-ABL) Transduction Into Hematopoietic Stem/Progenitor Cells In the Common Marmoset

CD26 Is Down-Regulated In Inducible Regulatory T Cells

Conditional Activation of Bcr-Abl Kinase Delineates Time-Dependent Transforming Events in Hematopoietic Cells.

Tumor Necrosis Factor-α Contributes to Microenvironmental up- Regulation of NF-κB Activity in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Implication for a Novel Therapeutic Target.

Large Scale Selective Ex Vivo Expansion of CD4 + CD25 + FOXP3 + Regulatory T Cells from Peripheral Blood.

RNAi-Mediated Silencing of p190Bcr-Abl Inactivates Stat5 and Cooperates with Imatinib Mesylate and 17-Allylamino-17-Demetoxygeldanamycin in Selective Killing of p190Bcr-Abl-Expressing Leukemia Cells.

Microenvironmental Up-Regulation of NF-kB Activity Via P65-Dependent and Independent Pathways in a Bioimaging Model of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.

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American Society of Hematology

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American Society of Hematology

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