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Sara El Ashkar
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Journal Articles

Discovery of JNJ-89853413, a First-in-Class CD33xVδ2 T-Cell Engager for the Treatment of Acute Myeloid Leukemia

Sara El Ashkar, Lorena Kallal, Kavita Raman, Ranjeet Prasad Dash, Nirav Shah, Lore Delbroek, Lénárd Kertész, Heleen Van Acker, Steffie Junius, Ivo Cornelissen, Surendar Arumugam, Lauren Gerloff, Kathryn Bradford, E. Christine Pietsch, Leopoldo Luistro, Bethany Mattson, Christina Guttke, Karim Safer, Janine Arts, Sonal Patel, Ulrike Philippar
Journal: Blood
Blood (2024) 144 (Supplement 1): 2054.
https://doi.org/10.1182/blood-2024-203248
Published: 2024
Journal Articles

Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A - and NPM1 -altered leukemias

Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, Vineet Pande, Ann Marien, Dries Goffin, Daniela V. Wenge, Hong Yue, Jevon A. Cutler, Cyrus Jin, Florian Perner, Shanna M. Hogeling, Paul L. Shaffer, Frank Jacobs, Petra Vinken, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Balpreet Bhogal, Karin Verstraeten, Sara El Ashkar, Jennifer A. Perry, Prathiba Jayaguru, Laura Barreyro, Anna Kuchnio, Nicolas Darville, Daniel Krosky, Gregor Urbanietz, Bie Verbist, James P. Edwards, Glenn S. Cowley, Robert Kirkpatrick, Ruth Steele, Lucille Ferrante, Christina Guttke, Nikki Daskalakis, E. Christine Pietsch, David M. Wilson, Ricardo Attar, Yusri Elsayed, Eric S. Fischer, Jan Jacob Schuringa, Scott A. Armstrong, Kathryn Packman, Ulrike Philippar
Journal: Blood
Blood (2024) 144 (11): 1206–1220.
https://doi.org/10.1182/blood.2023022480
Published: 2024
Includes: Supplemental data
Journal Articles

Pharmacological Characterization of JNJ-75276617, a Menin-KMT2A Inhibitor, As Targeted Treatment for KMT2A-Altered and NPM1-Mutant Acute Leukemia

Min Chul Kwon, Olivier Querolle, Xuedong Dai, Jan Willem Thuring, Tinne Verhulst, Ann Marien, Dries Goffin, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Karin Verstraeten, Sara El Ashkar, Shanna M Hogeling, Frank Jacob, Petra Vinken, Nicolas Darville, Vineet Pande, Daniel Krosky, Gregor Urbanietz, Bie Verbist, Lucille A. Ferrante, Christina Diane Drenberg, David Wilson, Ricardo M. Attar, Jan Jacob Schuringa, Nikki Daskalakis, Kathryn Packman, Christine Pietsch, Yusri Elsayed, Ulrike Philippar
Journal: Blood
Blood (2022) 140 (Supplement 1): 5928–5929.
https://doi.org/10.1182/blood-2022-168921
Published: 2022
Journal Articles

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Sara El Ashkar, Juerg Schwaller, Tim Pieters, Steven Goossens, Jonas Demeulemeester, Frauke Christ, Siska Van Belle, Sabine Juge, Nancy Boeckx, Alan Engelman, Pieter Van Vlierberghe, Zeger Debyser, Jan De Rijck
Journal: Blood
Blood (2018) 131 (1): 95–107.
https://doi.org/10.1182/blood-2017-05-786962
Published: 2018
Includes: Supplemental data
Journal Articles

New Insights to the MLL Recombinome Including 8 Novel Partner Genes ACTN4, C2CD3, DCP1A, FLNA, LAMC3, LOC100128568, NRIP3, and TNRC18.

Claus Meyer, PhD, Eric Kowarz, PhD, Julia Hofmann, Thomas Fischer, Sara El Ashkar, Andrea Teigler-Schlegel, PhD, Brian Balgobind, MD, Thomas Burmeister, PhD, Etienne De Braekeleer, Eric Delabesse, PhD, Aline Renneville, MD, Theo Dingermann, PhD, Thomas Klingebiel, MD, Rolf Marschalek, PhD
Journal: Blood
Blood (2008) 112 (11): 2047.
https://doi.org/10.1182/blood.V112.11.2047.2047
Published: 2008