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Pasquale L. Fedele
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Journal Articles

Phase 1b Study of Menin-KMT2A Inhibitor Bleximenib in Combination with Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia with KMT2Ar or NPM1 Alterations

Christian Recher, Jenny O'Nions, Ibrahim Aldoss, Ana Alfonso Pierola, Alicia Allred, Juan Manuel Alonso-Dominguez, Laura Barreyro, Pierre Bories, Martin Curtis, Nikki Daskalakis, Matteo Giovanni Della Porta, Hartmut Döhner, Amber D'Souza, James P. Dugan, Jordi Esteve Reyner, Matthew Exum, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Stan Gaj, Sylvain Garciaz, Ana Garrido, Sara Garrido Paniagua, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Elias Jabbour, Madlen Jentzsch, Hagop M. Kantarjian, Marina Konopleva, Jan Krönke, Min Chul Kwon, Christina Loefgren, Oliver Lomas, Valentina Mancini, Ioannis Mantzaris, Giovanni Martinelli, Daniel Morillo Giles, Joseph Murphy, Kathryn Packman, Cristina Papayannidis, Ulrike Philippar, Uwe Platzbecker, Sravanti Rangaraju, Christoph Röllig, Olga Salamero, Madhu Sanga, Tim Sauer, Emma Searle, Natalia Tovar, Trevor Tucker, Nicolas Vallet, Lachlin Vaughan, Gala Vega, Paresh Vyas, Andrew Wei
Journal: Blood
Blood (2024) 144 (Supplement 1): 215.
https://doi.org/10.1182/blood-2024-207072
Published: 2024
Journal Articles

Bleximenib Dose Optimization and Determination of RP2D from a Phase 1 Study in Relapsed/Refractory Acute Leukemia Patients with KMT2A and NPM1 Alterations

Emma Searle, Christian Recher, Maher Abdul-Hay, Sameem Abedin, Ibrahim Aldoss, Ana Alfonso Pierola, Juan M. Alonso-Dominguez, Patrice Chevallier, Carrye Cost, Nikki Daskalakis, Richard Dillon, Neil Dunavin, Jordi Esteve, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Stan Gaj, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Elias Jabbour, Hagop M. Kantarjian, Min Chul Kwon, Anita J Kumar, Teng Fong Ng, Kathryn Packman, Ulrike Philippar, Arnaud Pigneux, Olga Salamero, Madhu Sanga, Prathap Nagaraja Shastri, Richard M. Stone, Peter Tan, Trevor Tucker, Paresh Vyas, Sylvain Garciaz
Journal: Blood
Blood (2024) 144 (Supplement 1): 212.
https://doi.org/10.1182/blood-2024-207106
Published: 2024
Journal Articles

A First-in-Human Phase 1 Study of the Menin-KMT2A (MLL1) Inhibitor JNJ-75276617 in Adult Patients with Relapsed/Refractory Acute Leukemia Harboring KMT2A or NPM1 Alterations

Elias Jabbour, Emma Searle, Maher Abdul-Hay, Sameem Abedin, Ibrahim Aldoss, Ana Alfonso Piérola, Juan Manuel Alonso-Dominguez, Patrice Chevallier, Carrye Cost, Nikki Daskalakis, Richard Dillon, Neil Dunavin, Jordi Esteve, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Sylvain Garciaz, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Min Chul Kwon, Jonathan Miller, Teng Fong Ng, Kathryn Packman, Ulrike Philippar, Arnaud Pigneux, Christian Recher, Olga Salamero, Madhu Sanga, Richard M Stone, Peter Tan, Jan Willem Thuring, Trevor Tucker, Paresh Vyas
Journal: Blood
Blood (2023) 142 (Supplement 1): 57.
https://doi.org/10.1182/blood-2023-172422
Published: 2023
Journal Articles

Survival Outcomes for Plasmablastic Lymphoma: An International, Multicentre Study By the Australasian Lymphoma Alliance

Pietro R Di Ciaccio, BA/LLB MBBS FRACP FRCPA, Mark N. Polizzotto, MBBS, PhD, Kate Cwynarski, MD PhD, Cathy Burton, MBBChir, MA, MD FRCPath, Awachana Jiamsakul, Mark Bower, MD, John Kuruvilla, MD, Silvia Montoto, MD, Pam McKay, MD, Wendy Osborne, MD, Sam Milliken, MBBS, FRACP, FRCPA, Kim Linton, MBChB, MRCP, PhD, Kate Manos, MBBS, Shireen Kassam, MBBS, FRCPath, PhD, Nicole Wong Doo, MBBS,MDFRACP,FRCPA, Anne-Marie Watson, FRACP, FRCPA, MBBS, Pasquale L Fedele, MBBS PhDFRACP FRCPA, Costas K. Yannakou, MBBS (Hons), FRACP, FRCPA, Stewart Hunt, MBBS, Hanna Renshaw, MD BA, Nisha Thakrar, Alexandra Smith, PhD, Daniel Painter, Alice Maxwell, Qin Liu, MBBS, Rageshri Dhairyawan, Graeme Ferguson, Keir Pickard, Nada Hamad, MBBS,BSc,MSc,FRACP FRCPA
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-134972
Published: 2020
Journal Articles

Loss of IRF4 Results in Multiple Myeloma Cell Apoptosis through the Transcriptional up-Regulation of the BH3-Only Proteins Bmf and BIM

Pasquale L. Fedele, MBBS PhDFRACP FRCPA, Yang Liao, PhD, Jianan Gong, PhD, Mark van Delft, PhD, Michael S.Y. Low, MBBS PhDFRACP FRCPA, Lin Tai, PhD, Marco J Herold, PhD, Julie Tellier, PhD, George Grigoriadis, MBBS PhDFRACP FRCPA, David C.S. Huang, MBBS MRCP PhD, Wei Shi, PhD, Stephen Nutt, PhD, Simon Willis, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3103.
https://doi.org/10.1182/blood-2019-126417
Published: 2019
Journal Articles

IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos

Pasquale L. Fedele, Simon N. Willis, Yang Liao, Michael S. Low, Jai Rautela, David H. Segal, Jia-Nan Gong, Nicholas D. Huntington, Wei Shi, David C. S. Huang, George Grigoriadis, Julie Tellier, Stephen L. Nutt
Journal: Blood
Blood (2018) 132 (20): 2166–2178.
https://doi.org/10.1182/blood-2018-05-850727
Published: 2018
Includes: Supplemental data
Journal Articles

Hypercalcaemia at Diagnosis Is an Independent Predictor of Poor Survival in Diffuse Large B-Cell Lymphoma

Michael P Gilbertson, MBBS,FRACP,FRCPA, Maciej Tatarczuch, BMBS, FRACP, FRCPA, Ashish Kumar Panigrahi, MBBS, Samuel Robinson, David Wong, PhD, Pasquale L. Fedele, FRACP, FRCPA, Gareth Gregory, MBBS,PhDFRACP,FRCPA, George Grigoriadis, MBBS PhDFRACP FRCPA, Michael S. Low, MBBS, Sushrut S. Patil, FRACP, FRCPA, Sumita Ratnasingham, FRACP, FRCPA, Jake Shortt, MBBS PhDFRACP FRCPA, Fathima Shahla Vilcassim, MBBS, FRACP, FRCPA, Jonathan Wong, MBBS, Sophie Lee, FRACP, FRCPA, PhD, Duncan P. Carradice, MBBS, FRCPA, FRACP, William E. P. Renwick, MBBS, FRACP, FRCPA, Stephen Opat, FRACP, FRCPA
Journal: Blood
Blood (2017) 130 (Supplement 1): 1568.
https://doi.org/10.1182/blood.V130.Suppl_1.1568.1568
Published: 2017
Journal Articles

The Immunomodulatory Drugs, through Loss of Ikaros and Aiolos, Derepress CD38 and Functionally Synergise with Daratumumab

Pasquale L. Fedele, FRACP, FRCPA, Simon Willis, PhD, Michael S. Low, MBBS, Jai Rautela, PhD, David H. Segal, PhD, Jianan Gong, PhD, Yang Liao, PhD, Nicholas Huntington, PhD, Wei Shi, PhD, David Huang, MBBS PhD, George Grigoriadis, MBBS PhDFRACP FRCPA, Julie Tellier, PhD, Stephen Nutt, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1801.
https://doi.org/10.1182/blood.V130.Suppl_1.1801.1801
Published: 2017