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Kira A Young
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Journal Articles

Variation in mesenchymal KITL/SCF and IGF1 expression in middle age underlies steady-state hematopoietic stem cell aging

Kira A. Young, Maria A. Telpoukhovskaia, Johanna Hofmann, Jayna J. Mistry, Konstantinos D. Kokkaliaris, Jennifer J. Trowbridge
Journal: Blood
Blood (2024) 144 (4): 378–391.
https://doi.org/10.1182/blood.2024024275
Published: 2024
Includes: Supplemental data
Journal Articles

Bone Marrow Microenvironment and Hematopoietic Cell Types Are Differentially Affected By Transcriptomic Quality Control Filtering Metrics in Single Cell Data

Maria A. Telpoukhovskaia, Kira A. Young, Jayna J. Mistry, Jennifer J. Trowbridge
Journal: Blood
Blood (2023) 142 (Supplement 1): 5621.
https://doi.org/10.1182/blood-2023-181867
Published: 2023
Journal Articles

Reduction in Lymphoid-Supporting Factors By Mesenchymal Stromal Cells Drives Myeloid-Biased Hematopoiesis at Middle Age

Kira A. Young, Maria A. Telpoukhovskaia, Johanna Hofmann, Konstantinos D. Kokkaliaris, Jayna J. Mistry, Jennifer J. Trowbridge
Journal: Blood
Blood (2023) 142 (Supplement 1): 2701.
https://doi.org/10.1182/blood-2023-181924
Published: 2023
Journal Articles

Dnmt3a -Mutant Haematopoietic Stem and Progenitor Cells Induce Mesenchymal Stromal Cell Senescence through the Production of Alarmins S100A8/A9

Jayna J. Mistry, Kira A. Young, Patricia Colom Diaz, Ines Fernandez Maestre, Ross L Levine, Jennifer J. Trowbridge
Journal: Blood
Blood (2023) 142 (Supplement 1): 1331.
https://doi.org/10.1182/blood-2023-181888
Published: 2023
Journal Articles

Elevated Functional Hematopoietic Stem and Progenitor Cells in the Peripheral Blood of G-CSF-Mobilized Dnmt3a -Mutant Mice

Kira A. Young, Griffin J. Nye, Jennifer J. Trowbridge
Journal: Blood
Blood (2023) 142 (Supplement 1): 6783.
https://doi.org/10.1182/blood-2023-181913
Published: 2023
Journal Articles

Oncostatin M (OSM) Regulates an Inflammatory Cytokine Network in Dnmt3a -Mutant Hematopoietic Stem Cells

Logan Sari Schwartz, Kira A. Young, Tim Stearns, Nathan Boyer, Kristina Mujica, Jennifer J. Trowbridge
Journal: Blood
Blood (2023) 142 (Supplement 1): 5603.
https://doi.org/10.1182/blood-2023-182334
Published: 2023
Journal Articles

Bone Marrow Stromal Cell Senescence Induced By Dnmt3a -Mutant Hematopoietic Stem and Progenitor Cells Accelerates Clonal Hematopoiesis and Progression to Leukemia

Jayna J Mistry, Kira A Young, Jennifer J Trowbridge
Journal: Blood
Blood (2022) 140 (Supplement 1): 1265.
https://doi.org/10.1182/blood-2022-169485
Published: 2022
Journal Articles

Robust Mitochondrial Metabolism Provides a Fitness Advantage to Dnmt3a -Mutant Hematopoietic Stem Cells in the Context of Aging

Kira A Young, Jayna J Mistry, James Chavez, Eric Pietras, Jennifer J Trowbridge
Journal: Blood
Blood (2022) 140 (Supplement 1): 2866–2867.
https://doi.org/10.1182/blood-2022-163707
Published: 2022