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James Chavez
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Journal Articles

Human HSPCs CRISPR-engineered to endogenously express oncogenic NRAS generate a transplantable lethal myeloid malignancy targetable with novel RAS therapeutics

Free
Shirley Liu, Cailin Collins, James Chavez, Suyoun Choi, Thomas Koehnke, Ravi Majeti
Journal: Blood
Blood (2025) 146 (Supplement 1): 5004.
https://doi.org/10.1182/blood-2025-5004
Published: 2025
Journal Articles

Inhibition of DOCK1 prevents the clonal expansion of high-risk TP53-mutant clonal hematopoiesis induced by genotoxic stressors.

Free
Yang Feng, Thomas Koehnke, Bolan Patrick, Brooks Benard, Kensuke Kayamori, Emma Heaton, Cailin Collins, James Chavez, Tian Zhang, Andrew Gentles, Ravi Majeti
Journal: Blood
Blood (2025) 146 (Supplement 1): 631.
https://doi.org/10.1182/blood-2025-631
Published: 2025
Journal Articles

Robust Mitochondrial Metabolism Provides a Fitness Advantage to Dnmt3a -Mutant Hematopoietic Stem Cells in the Context of Aging

Free
Kira A Young, Jayna J Mistry, James Chavez, Eric Pietras, Jennifer J Trowbridge
Journal: Blood
Blood (2022) 140 (Supplement 1): 2866–2867.
https://doi.org/10.1182/blood-2022-163707
Published: 2022
Journal Articles

PU.1 Enforces Hematopoietic Stem Cell Quiescence during Chronic Inflammation

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James Chavez, BS, Jennifer L Rabe, BS, BA, Kelly Higa, MS, Dirk Loeffler, Ahmed Nouraiz, PhD, Taylor Mills, BA, Beau M Idler, Brett M. Stevens, PhD, Courtney Fleenor, PhD, Claus Nerlov, PhD, Hideaki Nakajima, MD, James Hagman, Timm Schroeder, PhD, Hyun Min Kim, PhD, Craig T Jordan, PhD, James DeGregori, Eric Pietras, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 822.
https://doi.org/10.1182/blood-2019-129300
Published: 2019
Journal Articles

Rheumatoid Arthritis Causes Hematopoietic Stem Cell Reprogramming to Maintain Functionality

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Taylor Mills, BA, Giovanny Hernandez, BS, Jennifer L Rabe, BS, BA, Susan Kuldanek, MD, James Chavez, BA, Greg Kirkpatrick, PhD, Leila Noetzli, PhD, Widian Jubair, MD, Michelle Zanche, MS, Jason R Myers, MS, Brett M. Stevens, PhD BS, Courtney Fleenor, PhD, Biniam Adane, PhD, John M Ashton, PhD, Craig T Jordan, PhD, James Hagman, Jorge Di Paola, MD, Michael Holers, MD, Kristine Kuhn, Eric Pietras, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2573.
https://doi.org/10.1182/blood-2018-99-120272
Published: 2018