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Journal Articles

Hematopoietic Stem Cell Aging Promotes Expansion of Tet2 Mutant Clones By Cell Intrinsic Mechanisms

Marco De Dominici, Lamis Naddaf, Vadym Zaberezhnyy, Andrew Goodspeed, Sheng Li, James Degregori

Blood (2024) 144 (Supplement 1): 191.

https://doi.org/10.1182/blood-2024-206384

Published: 2024

Journal Articles

Title: In Vivo Clonal Tracing of Hematopoietic Stem and Progenitor Cells Reveals Increased Clonal Heterogeneity during Aging, Alongside Critical Changes in Selection Patterns

Lamis Naddaf, Marco De Dominici, Xiaowen Chen, Parveen Kumar, James S Chavez, Travis Roeder, Shilpita Karmakar, Eric M. Pietras, Hideyuki Oguro, James DeGregori, Sheng Li

Blood (2024) 144 (Supplement 1): 2671.

https://doi.org/10.1182/blood-2024-202289

Published: 2024

Journal Articles

Exploring Aging Dependent Adaptations of Splicing Factor Mutations in Clonal Hematopoiesis

Bridget Hoag, Marco De Dominici, Michael O. Alberti, James DeGregori

Blood (2023) 142 (Supplement 1): 5597.

https://doi.org/10.1182/blood-2023-191086

Published: 2023

Journal Articles

Translational Control of FLT3-Mutated AML Cell Survival

Daniela R Ortiz Chavez, Hae J Park, Mark A Gregory, James DeGregori

Blood (2023) 142 (Supplement 1): 5959.

https://doi.org/10.1182/blood-2023-190567

Published: 2023

Journal Articles

Aging, inflammation, and HSC

James DeGregori

Blood (2020) 136 (2): 153–154.

https://doi.org/10.1182/blood.2020006070

Published: 2020

Journal Articles

PU.1 Enforces Hematopoietic Stem Cell Quiescence during Chronic Inflammation

James Chavez, BS, Jennifer L Rabe, BS, BA, Kelly Higa, MS, Dirk Loeffler, Ahmed Nouraiz, PhD, Taylor Mills, BA, Beau M Idler, Brett M. Stevens, PhD, Courtney Fleenor, PhD, Claus Nerlov, PhD, Hideaki Nakajima, MD, James Hagman, Timm Schroeder, PhD, Hyun Min Kim, PhD, Craig T Jordan, PhD, James DeGregori, Eric Pietras, PhD

Blood (2019) 134 (Supplement_1): 822.

https://doi.org/10.1182/blood-2019-129300

Published: 2019

Journal Articles

TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

Blood (2019) 134 (9): 727–740.

https://doi.org/10.1182/blood.2019000200

Published: 2019

Includes: Multimedia, Supplemental data

Journal Articles

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Rachel Culp-Hill, Julie A. Reisz, Shanshan Pei, Annika Gustafson, Nabilah Khan, James DeGregori, Daniel A. Pollyea, Craig T. Jordan

Blood (2019) 134 (4): 389–394.

https://doi.org/10.1182/blood.2019898114

Published: 2019

Includes: Supplemental data

Journal Articles

Cysteine and Cystine Depletion Targets Leukemia Stem Cells

Courtney L Jones, PhD, Brett M Stevens, PhD, Angelo D'Alessandro, Rachel Culp-Hill, BS, Julie Reisz, PhD, Haobin Ye, PhD, Nabilah Khan, Mohd Minhajuddin, PhD, James DeGregori, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD

Blood (2018) 132 (Supplement 1): 431.

https://doi.org/10.1182/blood-2018-99-113181

Published: 2018

Journal Articles

TNF-α Driven Inflammation and Mitochondrial Dysfunction Characterize the Platelet Hyperreactivity of Aging and Myeloproliferative Neoplasms (MPN)

Pavel Davizon-Castillo, MD, Brandon McMahon, MD, Sonia Aguila, PhD, Kenneth L. Jones, PhD, George D Trahan, MS, Katrina J. Ashworth, MS, David Bark, PhD, Robert A. Campbell, PhD, Kelly Higa, MS, Lauren Christine Shih, BA, Natalie Saunders, MD, James DeGregori, Matthew T. Rondina, MD, Jorge Di Paola, MD

Blood (2018) 132 (Supplement 1): 1134.

https://doi.org/10.1182/blood-2018-99-119620

Published: 2018

Journal Articles

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

Courtney L Jones, PhD, Brett M Stevens, PhD, Angelo D'Alessandro, PhD, Julia Reisz, PhD, Rachel Culp-Hill, BS, Travis Nemkov, Shanshan Pei, PhD, Nabilah Khan, Biniam Adane, PhD, Haobin Ye, PhD, Dominik Reinhold, Clayton Smith, MD, James DeGregori, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD

Blood (2018) 132 (Supplement 1): 1521.

https://doi.org/10.1182/blood-2018-99-111965

Published: 2018

Journal Articles

Aging-Associated Inflammation Due to Elevated Levels of TNF-α Increases Activation of the Integrin αIIbβ3 and the Procoagulant Potential of Platelets

Pavel Davizon-Castillo, MD, Ken L. Jones, PhD, Sonia Aguila, PhD, David Bark, PhD, Katrina J. Ashworth, MS, Kelly Higa, MS, Eric Martin Pietras, PhD, Robert A. Campbell, PhD, Lauren Christine Shih, BA, Natalie Saunders, MD, James DeGregori, Matthew T. Rondina, MD, Jorge Di Paola, MD

Blood (2017) 130 (Supplement 1): 292.

https://doi.org/10.1182/blood.V130.Suppl_1.292.292

Published: 2017

Journal Articles

Pro-Inflammatory Cytokines Drive the Development of a Prothrombotic Platelet Phenotype in Inflammation and Aging

Pavel Davizon-Castillo, Katrina Ashworth, MS, Kelly Higa, MS, Giovanny Hernandez, Sumitra Acharya, Robert A. Campbell, PhD, Matthew Rondina, MD, Colm B. Collins, PhD, Anthony Donato, MD, Lisa Lesniewski, James DeGregori, Michael Holer, Nirmal Banda, Jorge Di Paola, MD, Eric Martin Pietras, PhD

Blood (2016) 128 (22): 3747.

https://doi.org/10.1182/blood.V128.22.3747.3747

Published: 2016

Journal Articles

Genome-Wide shRNA Screen Identifies WEE1 As a Critical Mediator of Cell Fate and Novel Therapeutic Target in AML,

Christopher C. Porter, MD, Jihye Kim, Ph.D., Susan Fosmire, Christy M. Gearheart, Ph.D., Annemie van Linden, Ph.D., Vadym Zaberezhnyy, Dexiang Gao, Ph.D., Aik Choon Tan, Ph.D., James DeGregori, Ph.D.

Blood (2011) 118 (21): 3503.

https://doi.org/10.1182/blood.V118.21.3503.3503

Published: 2011

Journal Articles

The Addition of Cyclosporine to Dasatinib Therapy of Murine Bcr-Abl + Leukemia Improves Disease Control Independent of Altered Pharmacokinetics

Christopher C. Porter, MD, Mark A. Gregory, Ph.D., Vadym Zaberezhnyy, Jelena Klawitter, Ph.D., Uwe Christians, Ph.D., James DeGregori, Ph.D.

Blood (2010) 116 (21): 600.

https://doi.org/10.1182/blood.V116.21.600.600

Published: 2010

Journal Articles

Knockdown of HPRT Enables Selection of Genetically Modified Human Hematopoietic Progenitor Cells.

Rashmi Choudhary, Ph.D., Brian Freed, Ph.D., James DeGregori, Christopher C. Porter, MD

Blood (2010) 116 (21): 3772.

https://doi.org/10.1182/blood.V116.21.3772.3772

Published: 2010

Journal Articles

Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection

Christopher C. Porter, James DeGregori

Blood (2008) 112 (12): 4466–4474.

https://doi.org/10.1182/blood-2008-03-146571

Published: 2008

Includes: Supplemental data

Journal Articles

In Vitro and In Vivo Selection of Genetically Modified Cells Using shRNA Against HPRT and Treatment with 6-thioguanine.

Christopher C. Porter, MD, James DeGregori

Blood (2007) 110 (11): 2590.

https://doi.org/10.1182/blood.V110.11.2590.2590

Published: 2007

NARROW

Hematopoietic Stem Cell Aging Promotes Expansion of Tet2 Mutant Clones By Cell Intrinsic Mechanisms

Title: In Vivo Clonal Tracing of Hematopoietic Stem and Progenitor Cells Reveals Increased Clonal Heterogeneity during Aging, Alongside Critical Changes in Selection Patterns

Exploring Aging Dependent Adaptations of Splicing Factor Mutations in Clonal Hematopoiesis

Translational Control of FLT3-Mutated AML Cell Survival

Aging, inflammation, and HSC

PU.1 Enforces Hematopoietic Stem Cell Quiescence during Chronic Inflammation

TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

Cysteine and Cystine Depletion Targets Leukemia Stem Cells

TNF-α Driven Inflammation and Mitochondrial Dysfunction Characterize the Platelet Hyperreactivity of Aging and Myeloproliferative Neoplasms (MPN)

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

Aging-Associated Inflammation Due to Elevated Levels of TNF-α Increases Activation of the Integrin αIIbβ3 and the Procoagulant Potential of Platelets

Pro-Inflammatory Cytokines Drive the Development of a Prothrombotic Platelet Phenotype in Inflammation and Aging

Genome-Wide shRNA Screen Identifies WEE1 As a Critical Mediator of Cell Fate and Novel Therapeutic Target in AML,

The Addition of Cyclosporine to Dasatinib Therapy of Murine Bcr-Abl + Leukemia Improves Disease Control Independent of Altered Pharmacokinetics

Knockdown of HPRT Enables Selection of Genetically Modified Human Hematopoietic Progenitor Cells.

Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection

In Vitro and In Vivo Selection of Genetically Modified Cells Using shRNA Against HPRT and Treatment with 6-thioguanine.

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American Society of Hematology

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American Society of Hematology

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