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Melanie Mediavilla-Varela
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Journal Articles

Enhancing CAR-T Therapy in CLL By Modulating the Immunosuppressive Tumor Microenvironment: A Novel Approach with Significant Therapeutic Potential

Angimar Uriepero Palma, Melanie Mediavilla Varela, Maria Elena Marquez, Wael Gamal, Mohammad Ammad-ud-din, Pablo Oppezzo, Eva Sahakian, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4607.
https://doi.org/10.1182/blood-2024-204892
Published: 2024
Journal Articles

Identifying the Role of Endoplasmic Reticulum Stress in CLL T-Cell Dysfunction

Wael Gamal, Melanie Mediavilla Varela, Angimar Uriepero Palma, Mohammad Ammad Ud Din, Julio C. Chavez, Eva Sahakian, Paulo C. Rodriguez, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 1848.
https://doi.org/10.1182/blood-2024-210608
Published: 2024
Journal Articles

Reprogramming CLL T-Cell Mitochondrial Fitness Using PI3K Inhibition for Enhancing CAR T-Cell Therapy

Wael Gamal, Nienke B. Goedhart, Helga Simon-Molas, Melanie Mediavilla Varela, Angimar Uriepero Palma, Fleur S. Peters, Eva Sahakian, Arnon P. Kater, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4803.
https://doi.org/10.1182/blood-2024-210992
Published: 2024
Journal Articles

A Phase I Study of Duvelisib in Combination with Oral Azacitidine (BMS-986345) in Mature T Cell Lymphoma

Hayder Saeed, Melanie Mediavilla Varela, Eva Sahakian, Mahrukh Naqvi, Qiangxing Mo, Ling Zhang, Rikesh Makanji, Yumeng Zhang, Ning Dong, Leidy Lismeris Isenalumhe, Sameh Gaballa, Julio C. Chavez, Bijal D Shah, Celeste M. Bello, Lubomir Sokol, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 3065.
https://doi.org/10.1182/blood-2024-205173
Published: 2024
Journal Articles

Efficacy of Combinatorial Treatment Approaches in CTCL

Melanie Mediavilla-Varela, Eva Sahakian, Carly Harro, John J. Powers, Jose Conejo-Garcia, Lubomir Sokol, Javier Pinilla Ibarz
Journal: Blood
Blood (2022) 140 (Supplement 1): 11880–11881.
https://doi.org/10.1182/blood-2022-169915
Published: 2022
Journal Articles

Metabolic Abnormalities Associated with T-Cell Exhaustion in CLL Eµ-TCL1 Murine Model

Wael Gamal, Melanie Mediavilla-Varela, Kamira Maharaj, Angimar Uriepero, Vishaal Kunta, Eva Sahakian, Javier Pinilla Ibarz
Journal: Blood
Blood (2022) 140 (Supplement 1): 6994–6995.
https://doi.org/10.1182/blood-2022-166704
Published: 2022
Journal Articles

Targeting Inflammatory Pathways to Reverse Immunosuppressive Tumor Microenvironment in Chronic Lymphocytic Leukemia

Angimar Uriepero, Melanie Mediavilla-Varela, Kamira Maharaj, Wael Gamal, Maria Elena Marquez, John J. Powers, Vishaal Kunta, Eva Sahakian, Pablo Oppezzo, Javier Pinilla Ibarz
Journal: Blood
Blood (2022) 140 (Supplement 1): 6988–6989.
https://doi.org/10.1182/blood-2022-167331
Published: 2022
Journal Articles

Second Treatment Free Remission after Combination Therapy with Ruxolitinib Plus Tyrosine Kinase Inhibitors in Chronic Phase Chronic Myeloid Leukemia (CML)

Kendra Sweet, Ehab L. Atallah, Jerry P. Radich, Mei-Jie Zhang, Eva Sahakian, Melanie Mediavilla-Varela, Alexis Vistocky, Michael C. Heinrich, James E. Thompson, Michael J. Mauro, Kathryn E Flynn, Arielle Baim, Javier Pinilla Ibarz
Journal: Blood
Blood (2021) 138 (Supplement 1): 2555.
https://doi.org/10.1182/blood-2021-147954
Published: 2021
Journal Articles

Efficacy of Vecabrutinib Treatment in a Murine Model of Sclerodermatous Graft-Versus-Host-Disease

Kamira Maharaj, Melanie Mediavilla-Varela, Angimar Uriepero, Judith A. Fox, Pietro Taverna, Wael Gamal, Eva Sahakian, Javier Pinilla Ibarz
Journal: Blood
Blood (2021) 138 (Supplement 1): 1685.
https://doi.org/10.1182/blood-2021-150598
Published: 2021