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Helga Simon-Molas
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Journal Articles

Reprogramming CLL T-Cell Mitochondrial Fitness Using PI3K Inhibition for Enhancing CAR T-Cell Therapy

Free
Wael Gamal, Nienke B. Goedhart, Helga Simon-Molas, Melanie Mediavilla Varela, Angimar Uriepero Palma, Fleur S. Peters, Eva Sahakian, Arnon P. Kater, Javier Pinilla-Ibarz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4803.
https://doi.org/10.1182/blood-2024-210992
Published: 2024
Journal Articles

Evaluation of the T-Cell Metabolic State of Starting Material and Manufactured CAR T Cell Products and Clinical Outcome of CAR T-Cell Therapy for Large B Cell Lymphoma

Free
Chaja F. Jacobs, Helga Simon-Molas, Gaspard Cretenet, Miriam Gutschow, Amy Chattin, Garrett Collett, Lucrezia Colonna, Fleur S. Peters, Arnon P. Kater
Journal: Blood
Blood (2023) 142 (Supplement 1): 3456.
https://doi.org/10.1182/blood-2023-188577
Published: 2023
Journal Articles

Important Role for Glutamine in Human and Mouse TME Models of CLL ; Towards Development of a PET Tracer As a Novel Diagnostic Tool

Free
Helga Simon-Molas, Chiara Montironi, Gaspard Cretenet, Sjoerd P.P. van Eeden, Rosita Del Prete, Zhenghao Chen, Ingrid A.M. Derks, Mariska Verlaan, Arnon P. Kater, Wissam Beaino, Anna Kabanova, Josée M. Zijlstra, Albert D. Windhorst, Eric Eldering
Journal: Blood
Blood (2023) 142 (Supplement 1): 4622.
https://doi.org/10.1182/blood-2023-174853
Published: 2023
Journal Articles

Multifactorial Basis of T Cell Dysfunction in CLL: Disrupted Mitochondrial Metabolism Induces T Cell Senescence

Free
Nienke B. Goedhart, Helga Simon-Molas, Chiara Montironi, Chaja F. Jacobs, Elena Camerini, Jaco A.C. Van Bruggen, Gaspard Cretenet, Eric Eldering, Fleur S. Peters, Arnon P. Kater
Journal: Blood
Blood (2023) 142 (Supplement 1): 4629.
https://doi.org/10.1182/blood-2023-181624
Published: 2023
Journal Articles

Impaired T-Cell Proliferation in Chronic Lymphocytic Leukemia Patients Is Linked to Disturbed Lipid Metabolism and Homeostasis

Free
Chaja F. Jacobs, Fleur S. Peters, Gaspard Cretenet, Noam Zelcer, Helga Simon-Molas, Arnon P. Kater
Journal: Blood
Blood (2023) 142 (Supplement 1): 4624.
https://doi.org/10.1182/blood-2023-188520
Published: 2023
Journal Articles

Dysfunction of T Cells from Chronic Lymphocytic Leukemia (CLL) Patients Is Linked to Disturbed Lipid and Fatty Acid Homeostasis

Free
Chaja Feige Jacobs, Fleur Peters, Gaspard Cretenet, Eric Eldering, Noam Zelcer, Arnon P. Kater, Helga Simon-Molas
Journal: Blood
Blood (2022) 140 (Supplement 1): 6998–6999.
https://doi.org/10.1182/blood-2022-167217
Published: 2022
Journal Articles

Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment

Free
Zhenghao Chen, Helga Simon-Molas, Gaspard Cretenet, Beatriz Valle-Argos, Lindsay D. Smith, Francesco Forconi, Bauke V. Schomakers, Michel van Weeghel, Dean J. Bryant, Jaco A. C. van Bruggen, Fleur S. Peters, Jeffrey C. Rathmell, Gerritje J. W. van der Windt, Arnon P. Kater, Graham Packham, Eric Eldering
Journal: Blood
Blood (2022) 140 (6): 630–643.
https://doi.org/10.1182/blood.2021013990
Published: 2022
Includes: Supplemental data
Journal Articles

Targeting Metabolic Alterations in CLL Microenvironment; Inhibition of Glutamine Import Attenuates Venetoclax Resistance

Free
Zhenghao Chen, Helga Simon-Molas, Gaspard Cretenet, Beatriz Valle-Argos, Francesco Forconi, Bauke V Schomakers, Michel van Weeghel, Dean Bryant, Jaco A. C. Van Bruggen, Fleur Peters, Gerritje J. W. van der Windt, Arnon P. Kater, Graham Packham, Eric Eldering
Journal: Blood
Blood (2021) 138 (Supplement 1): 3717.
https://doi.org/10.1182/blood-2021-150236
Published: 2021