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Terence J. Purdon
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CD19-CAR Cytokine Induced Killer Cells Armored with IL-18 Control Tumor Burden, Prolong Mouse Survival and Result in In Vivo Persistence of CAR-CIK Cells in a Model of B-Cell Acute Lymphoblastic Leukemia

Mark Debenedette, Terence J Purdon, James Ryan McCloud, Ana Plachco, Marcus Norris, Alicia Gamble, John F Krisko, Irina Y Tcherepanova, Charles A Nicolette, Renier Brentjens
Journal: Blood
Blood (2023) 142 (Supplement 1): 6826.
https://doi.org/10.1182/blood-2023-178793
Published: 2023
Journal Articles

Phase I First-in-Class Trial of MCARH109, a G Protein Coupled Receptor Class C Group 5 Member D (GPRC5D) Targeted CAR T Cell Therapy in Patients with Relapsed or Refractory Multiple Myeloma

Sham Mailankody, Claudia Diamonte, Lisa Fitzgerald, Peter Kane, Xiuyan Wang, Devanjan S. Sikder, Brigitte Senechal, Vladimir P. Bermudez, Diana Frias, Justina Morgan, Patrick Grant, Terence J Purdon, Kinga Hosszu, Sean M Devlin, Urvi A Shah, Jonathan Landa, Alexander Lesokhin, Neha Korde, Hani Hassoun, Carlyn Tan, Malin Hultcrantz, Gunjan L. Shah, Heather J Landau, David J. Chung, Michael Scordo, Mikhail Roshal, Ola Landgren, Ahmet Dogan, Sergio A Giralt, Jae H Park, Isabelle Rivière, Renier J Brentjens, Eric L Smith
Journal: Blood
Blood (2021) 138 (Supplement 1): 827.
https://doi.org/10.1182/blood-2021-153204
Published: 2021
Journal Articles

Optimal Dual-Targeted CAR Construct Simultaneously Targeting Bcma and GPRC5D Prevents Bcma-Escape Driven Relapse in Multiple Myeloma

Carlos Fernandez de Larrea, MD PhD, Mette Staehr, PhD, Andrea Lopez, Yunxin Chen, MBBS, Terence J Purdon, MS, Khong Y. Ng, PhD, Hans Wendel, MD, Renier J. Brentjens, MD PhD, Eric L Smith, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 136.
https://doi.org/10.1182/blood-2019-126145
Published: 2019
Journal Articles

Clinical Responses and Pharmacokinetics of MCARH171, a Human-Derived Bcma Targeted CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma: Final Results of a Phase I Clinical Trial

Sham Mailankody, MBBS, Arnab Ghosh, MBBS, PhD, Mette Staehr, PhD, Terence J Purdon, MS, Mikhail Roshal, MD PhD, Elizabeth Halton, NP-BC AOCNP, Claudia Diamonte, RN, John Pineda, RN, Pavan Anant, BS, Yvette Bernal, MS, Analisa Wills, Neha Korde, MD, Nikoletta Lendvai, MDPhD, Alexander M. Lesokhin, MD, Hani Hassoun, MD, Malin Hultcrantz, MD PhD, Heather J. Landau, MD, Gunjan L. Shah, MD, Michael Scordo, MD, David J. Chung, MDPhD, Oscar B Lahoud, MD, Pallavi Khattar, MD, Carlos Fernandez de Larrea, MD PhD, Qi Gao, Achim Jungbluth, MDPhD, Jae H. Park, MD, Kevin J. Curran, MD, Craig S. Sauter, MD, Maria Lia Palomba, MD, Brigitte Senechal, PhD, Xiuyan Wang, PhD, Ahmet Dogan, MD PhD, Sergio Giralt, MD, Isabelle Riviere, PhD, Ola Landgren, MD PhD, Renier J. Brentjens, MD PhD, Eric L. Smith, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 959.
https://doi.org/10.1182/blood-2018-99-119717
Published: 2018
Journal Articles

CAR T Cell Therapy Targeting G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D), a Novel Target for the Immunotherapy of Multiple Myeloma

Eric L. Smith, MD PhD, Kimberly Harrington, Mette Staehr, PhD, Reed Masakayan, MS, Jon Jones, BS, Thomas Long, PhD, Majid Ghoddusi, DVM, PhD, Terence J Purdon, MS, Trevor Do, Xiuyan Wang, PhD, Minh Pham, Jessica M Brown, Elizabeth Peguero, Carlos Fernández De Larrea, MD PhD, Pei Wang, PhD, Hong Liu, MD PhD, Yiyang Xu, PhD, Sarah Garrett, Steven Almo, PhD, Isabelle Riviere, PhD, Cheng Liu, PhD, Blythe Duke Sather, PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 589.
https://doi.org/10.1182/blood-2018-99-110471
Published: 2018
Journal Articles

Development of JCARH125: Optimization of a Fully Human Anti-Bcma CAR for Use in the Treatment of Multiple Myeloma

Kim Harrington, BS, Rebecca Wu, BS, Collin Hauskins, BS, Rupesh Amin, PhD, Thomas Long, PhD, Aye Chen, BA, Ayu Rahardjo, BS, Casey Thayer, BS, Garnet Navvaro, BS, Madelyn Myers, MS, Jon Jones, BS, Alex Baturevych, BS, Stan Morkowski, PhD, Ruth Salmon, PhD, Christopher J Bond, PhD, Mette Staehr, PhD, Terence J Purdon, MS, Reed Masakayan, MS, Cheng Liu, PhD, Hong Liu, MD PhD, Yiyang Xu, PhD, Pei Wang, PhD, Margot Pont, PhD, Damian J. Green, MD, Renier J. Brentjens, MD PhD, Eric L Smith, MDPhD, Blythe Duke Sather, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1813.
https://doi.org/10.1182/blood.V130.Suppl_1.1813.1813
Published: 2017
Journal Articles

Development and Evaluation of a Human Single Chain Variable Fragment (scFv) Derived Bcma Targeted CAR T Cell Vector Leads to a High Objective Response Rate in Patients with Advanced MM

Eric L Smith, MDPhD, Sham Mailankody, MBBS, Arnab Ghosh, MBBS, PhD, Reed Masakayan, MS, Mette Staehr, PhD, Terence J Purdon, MS, Elizabeth Halton, NP, Claudia Diamonte, RN, Pavan Anant, Yvette Bernal, MS, Xiuyan Wang, PhD, Yongzeng Wang, PhD, Sarah Garrett, Steven Almo, PhD, Pei Wang, PhD, Hong Liu, MD PhD, Yiyang Xu, PhD, Elena Mead, MD, Jae H. Park, MD, Kevin J. Curran, MD, Craig S. Sauter, MD, Sergio A. Giralt, MD, Ola Landgren, MD PhD, Ahmet Dogan, MD PhD, Mikhail Roshal, MDPhD, Cheng Liu, PhD, Isabelle Riviere, PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 742.
https://doi.org/10.1182/blood.V130.Suppl_1.742.742
Published: 2017
Journal Articles

Enhancing CAR T Cell Anti-Tumor Efficacy through Secreted Single Chain Variable Fragment (scFv) Immune Checkpoint Blockade

Sarwish Rafiq, PhD, Hollie J. Jackson, PhD, Oladapo Yeku, MD PhD, Terence J Purdon, MS, Dayenne G. van Leeuwen, Kevin J. Curran, MD, Ryan N Ahmed, Grace D Cullen, Su Yan, Pei Wang, PhD, Jingyi Xiang, Cheng Liu, PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 842.
https://doi.org/10.1182/blood.V130.Suppl_1.842.842
Published: 2017
Journal Articles

CD33-Directed Chimeric Antigen Receptor (CAR) T Cells for the Treatment of Acute Myeloid Leukemia (AML)

Sarwish Rafiq, PhD, Terence J. Purdon, Liora M. Schultz, MD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2825.
https://doi.org/10.1182/blood.V128.22.2825.2825
Published: 2016
Journal Articles

Implications of Concurrent Ibrutinib Therapy on CAR T-Cell Manufacturing and Phenotype and on Clinical Outcomes Following CD19-Targeted CAR T-Cell Administration in Adults with Relapsed/Refractory CLL

Mark Blaine Geyer, MD, Jae H. Park, MD, Isabelle Riviere, PhD, Brigitte Senechal, PharmD, PhD, Xiuyan Wang, PhD, Terence J. Purdon, Michel W. Sadelain, MD PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2016) 128 (22): 58.
https://doi.org/10.1182/blood.V128.22.58.58
Published: 2016
Journal Articles

IL-18 Secreting CAR T Cells Enhance Cell Persistence, Induce Prolonged B Cell Aplasia and Eradicate CD19+ Tumor Cells without Need for Prior Conditioning

Mauro P. Avanzi, MD PhD, Dayenne G. van Leeuwen, Xinghuo Li, Kenneth Cheung, Hyebin Park, Terence J. Purdon, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2016) 128 (22): 816.
https://doi.org/10.1182/blood.V128.22.816.816
Published: 2016
Journal Articles

Interim Safety Analysis: a Phase I Trial of High Dose Therapy and Autologous Stem Cell Transplantation Followed By Infusion of Chimeric Antigen Receptor Modified T-Cells (19-28z CAR-T) Directed Against CD19+ B-Cells for Relapsed and Refractory Aggressive B Cell Non-Hodgkin Lymphoma (B-NHL)

Craig S. Sauter, MD, Isabelle Riviere, PhD, Yvette J Bernal, MS, Xiuyan Wang, PhD, Terence J. Purdon, Sarah Yoo, Craig H Moskowitz, MD, Sergio Giralt, MD, Matthew J Matasar, MD MS, Kevin J. Curran, MD, Jae H Park, MD, Michel Sadelain, MD PhD, Renier J. Brentjens, MD PhD
Journal: Blood
Blood (2014) 124 (21): 677.
https://doi.org/10.1182/blood.V124.21.677.677
Published: 2014