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Kate Cwynarski
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Journal Articles

IGHV Unmutated Status, Low Tumor Lysis Risk Disease and BRAF Mutated Status Are Predictors for Early MRD Responders Treated with MRD Defined Ibrutinib with Venetoclax: Report of the UK NCRI FLAIR Study

Talha Munir, Abraham Mullasseril Varghese, Adrian Bloor, David Allsup, Kate Cwynarski, Andrew Pettitt, Shankara Paneesha, Christopher P Fox, Toby A. Eyre, Francesco Forconi, Nagah Elmusharaf, Ben Kennedy, Prof. John G. Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Anna Schuh, Anna Hockaday, David A. Cairns, Sharon Jackson, Natasha Greatorex, Sean Girvan, Sue Bell, David Stones, Nichola McWhirter, Surita Dalal, Andrew Rawstron, Piers Patten, Peter Hillmen
Journal: Blood
Blood (2024) 144 (Supplement 1): 585.
https://doi.org/10.1182/blood-2024-211449
Published: 2024
Journal Articles

Delays to Diagnosis of Peripheral T-Cell Lymphoma and Clinical Utility of Molecular Profiling: A UK Multicentre Real-World Study

Jesca Boot, Elizabeth Nelmes, Findlay Bewicke-Copley, Krushika Paleja, Emily Davenport, Ross Henderson, William Hann, Xiao-Yin Zhang, Hannah Bielby, Harshita Goradia, Naim Rahimi, Amjad Hmaid, Rumman Fatima Nizam, Imogen Welding, Vivek Radhakrishnan, Callum Harris, Danielle Monteil, Andrew Clear, Maria Calaminici, Paul Greaves, Andrew J. Davies, Graham P. Collins, Matthew R Wilson, Jeffery Smith, Christopher P Fox, Wendy Osborne, Lucy Cook, Matthew Ahearne, Kate Cwynarski, John G. Gribben, Jessica Okosun
Journal: Blood
Blood (2024) 144 (Supplement 1): 4445.
https://doi.org/10.1182/blood-2024-205820
Published: 2024
Journal Articles

Multi-Centre Real-World Outcomes of Large B-Cell Lymphoma Patients Treated with 2L Axicabtagene Ciloleucel in the UK

Andrea Kuhnl, Amy A Kirkwood, Claire Roddie, Caroline Besley, Jane Norman, Ben Uttenthal, Frances Seymour, Andrew J. Davies, Wendy Osborne, William Townsend, Emil Arjun Kumar, Amrith Mathew, Carlos Gonzalez Arias, Ceri Jones, Aikaterini Panopoulou, Ahmed Abdulgawad, Edward Bataillard, Pierre McCarthy, Nicolas Martinez-Calle, Vaishali Dulobdas, Rajesh Alajangi, Ram Malladi, Muddeha Waraich, Olateni Awofisayo, Hwai Jing Hiew, Callum Harris, Michael Northend, Adrian Maraj, Shankaranarayana Paneesha, Kasys Meira-Gervatauskas, Kate Cwynarski, Graham P. Collins, Roderick J. Johnson, Robin Sanderson, Maeve O'Reilly, Tobias Menne, Sridhar Chaganti
Journal: Blood
Blood (2024) 144 (Supplement 1): 2342.
https://doi.org/10.1182/blood-2024-200738
Published: 2024
Journal Articles

Prognostication and Treatment-Related Outcomes in Secondary Central Nervous System Involvement of Large B-Cell Lymphoma (SCNSL): Evidence from a Large International Cohort

Juan Pablo Alderuccio, Jahanzaib Khwaja, Sunwoo Han, Paola Ghione, Imran A. Nizamuddin, Aditi Saha, Ning Dong, Yucai Wang, Hua-Jay J Cherng, Seda S. Tolu, Nina Wagner-Johnston, Adam J. Olszewski, Natalie Grover, Jean L. Koff, Amrita Desai, Praveen Ramakrishnan Geethakumari, Tamara K Moyo, Jose Sandoval-Sus, Narendranath Epperla, Danielle S Wallace, Manali Kamdar, Alexey Danilov, Han W. Tun, Javier Munoz, Mayur S. Narkhede, Joanna M. Rhodes, Anca Prica, Andrea Kuhnl, Adrian Maraj, Jessica Okosun, Jeffery Smith, Wendy Osborne, Victoria Calvert, Dima el-Sharkawi, Ammar Hilali, Graham P. Collins, Kim Linton, Nagah Elmusharaf, Anna Santarsieri, Farheen Karim, Thomas Ollila, Sarah Monick, Iris Margalit Trutzer, Nilanjan Ghosh, Jones Can, Amy Ayers, Jacopo Calabrese De Feo, John Sharp, Rachel Treitman, Avyakta Kallam, Izel Okcu, Vismay Deshani, Firas Baidoun, Chathuri Abeyakoon, William Hann, Aisling Barrett, Brad Kahl, Julio C. Chavez, Kate Cwynarski
Journal: Blood
Blood (2024) 144 (Supplement 1): 571.
https://doi.org/10.1182/blood-2024-199781
Published: 2024
Journal Articles

A Multicenter, Open-Label, Phase 3, Randomized Controlled Trial of Duvelisib Versus Investigator's Choice of Gemcitabine or Bendamustine in Patients with Relapsed/Refractory Nodal T Cell Lymphoma with T Follicular Helper Phenotype

Kate Cwynarski, Eva Domingo Domenech, David Sidransky, Ohad S Bentur, Pier Luigi Zinzani
Journal: Blood
Blood (2024) 144 (Supplement 1): 3074.1.
https://doi.org/10.1182/blood-2024-203290
Published: 2024
Journal Articles

Ibrutinib as part of risk-stratified treatment for posttransplant lymphoproliferative disorder: the phase 2 TIDaL trial

Clinical Trials & Observations
Sridhar Chaganti, Shanna Maycock, Graham McIlroy, Aimee Jackson, Rebecca Bishop, Sarah Johnson, Edward Kanfer, Shireen Kassam, Kate Cwynarski, David Wrench, Arvind Arumainathan, Christopher P. Fox, Rod Johnson, Pam McKay, Shankara Paneesha, Clare Rowntree, Constantine Balotis, Graham P. Collins, Andrew Davies, Josh Wright, Sarah Burns, Arian Laurence, Keith Wheatley, Tobias Menne
Journal: Blood
Blood (2024) 144 (4): 392–401.
https://doi.org/10.1182/blood.2024023847
Published: 2024
Includes: Supplemental data
Journal Articles

The influence of immunodeficiency, disease features, and patient characteristics on survival in plasmablastic lymphoma

Clinical Trials & Observations
Pietro R. Di Ciaccio, Mark N. Polizzotto, Kate Cwynarski, Alina S. Gerrie, Catherine Burton, Mark Bower, John Kuruvilla, Silvia Montoto, Pam McKay, Christopher P. Fox, Samuel Milliken, Awachana Jiamsakul, Wendy Osborne, Graham P. Collins, Kate Manos, Kim M. Linton, Sunil Iyengar, Shireen Kassam, Michelle Poon Limei, David Kliman, Nicole Wong Doo, Anne-Marie Watson, Pasquale Fedele, Costas K. Yannakou, Stewart Hunt, Matthew Ku, Laurie H. Sehn, Alexandra Smith, Hanna Renshaw, Alice Maxwell, Qin Liu, Rageshri Dhairyawan, Graeme Ferguson, Keir Pickard, Daniel Painter, Nisha Thakrar, Kevin W. Song, Nada Hamad
Journal: Blood
Blood (2024) 143 (2): 152–165.
https://doi.org/10.1182/blood.2023021348
Published: 2024
Includes: Supplemental data
Journal Articles

How I treat secondary CNS involvement by aggressive lymphomas

Juan Pablo Alderuccio, Lakshmi Nayak, Kate Cwynarski
Journal: Blood
Blood (2023) 142 (21): 1771–1783.
https://doi.org/10.1182/blood.2023020168
Published: 2023
Journal Articles

Efficacy and Safety of Valemetostat Monotherapy in Patients with Relapsed or Refractory Peripheral T-Cell Lymphomas: Primary Results of the Phase 2 VALENTINE-PTCL01 Study

Steven M. Horwitz, Koji Izutsu, Neha Mehta-Shah, Raul Cordoba, Stefan K. Barta, Emmanuel Bachy, Giuseppe Gritti, Eric Jacobsen, Shigeru Kusumoto, Yann Guillermin, Anca Prica, Dok Hyun Yoon, Eva Domingo Domenech, Jie Wang, Jin Seok Kim, Kate Cwynarski, Marjolein van der Poel, Ai Inoue, Jin Jin, Sutan Wu, Keiko Nakajima, Pier Luigi Zinzani
Journal: Blood
Blood (2023) 142 (Supplement 1): 302.
https://doi.org/10.1182/blood-2023-179304
Published: 2023
Journal Articles

Survival Patterns of Non-Randomized Patients in the IELSG37 Study: Deauville Score 4 Is Not Necessarily Associated with Poor Outcome in Primary Mediastinal Lymphoma

Emanuele Zucca, Luca Ceriani, Andrew S. Davies, Giovannino Ciccone, Umberto Ricardi, Alice Di Rocco, Iryna Kryachok, Barbara Botto, Monica Balzarotti, Alessandra Tucci, Vittorio Ruggero Zilioli, Sara Usai, Luca Arcaini, Elsa Pennese, Anna Dabrowska-Iwanicka, Andrés José María Ferreri, Franceso Merli, Wei Li Zhao, David Hodgson, Codruta Ionescu, Luigi Rigacci, Claudia Cellini, Caterina Stelitano, Stefano Volpetti, Carla Minoia, Michele Spina, Alexander Fossa, George Mikhaeel, Kate Cwynarski, Andrea Janikova, Yana Stepanishyna, Mats Jerkeman, Andreas Huettmann, Maria Gomes da Silva, Don A. Stevens, Sally F Barrington, Bogdan Małkowski, Ur Metser, Annibale Versari, Stephane Chauvie, Oreste Bagni, Kelly Cozens, Sonia Perticone, Nicoletta Ielmini, Letizia Deantonio, Jan Walewski, Marek Trneny, Mary Gospodarowicz, Franco Cavalli, Peter Johnson, Maurizio Martelli
Journal: Blood
Blood (2023) 142 (Supplement 1): 1718.
https://doi.org/10.1182/blood-2023-174093
Published: 2023
Journal Articles

Ibrutinib Plus Venetoclax with MRD-Directed Duration of Treatment Is Superior to FCR and Is a New Standard of Care for Previously Untreated CLL: Report of the Phase III UK NCRI FLAIR Study

Peter Hillmen, David Allan Cairns, Adrian John Clifton Bloor, David Allsup, Kate Cwynarski, Andrew Pettitt, Shankaranarayana Paneesha, Christopher P. Fox, Toby A. Eyre, Francesco Forconi, Nagah Elmusharaf, Ben Kennedy, John G. Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Anna Schuh, Dena Howard, Anna Hockaday, Sharon Jackson, Natasha Greatorex, Sean Girvan, Sue Bell, Julia Brown, Nichola Webster, Surita Dalal, Ruth M de Tute, Andrew Rawstron, Piers EM Patten, Talha Munir
Journal: Blood
Blood (2023) 142 (Supplement 1): 631.
https://doi.org/10.1182/blood-2023-178298
Published: 2023
Journal Articles

Patient-reported outcomes in ZUMA-7, a phase 3 study of axicabtagene ciloleucel in second-line large B-cell lymphoma

Clinical Trials & Observations
Mahmoud Elsawy, Julio C. Chavez, Irit Avivi, Jean-François Larouche, Luciano Wannesson, Kate Cwynarski, Keren Osman, Kelly Davison, Jakob D. Rudzki, Saurabh Dahiya, Kathleen Dorritie, Samantha Jaglowski, John Radford, Franck Morschhauser, David Cunningham, Alejandro Martin Garcia-Sancho, Dimitrios Tzachanis, Matthew L. Ulrickson, Reem Karmali, Natasha Kekre, Catherine Thieblemont, Gunilla Enblad, Peter Dreger, Ram Malladi, Namita Joshi, Wei-Jhih Wang, Caitlyn T. Solem, Julia Thornton Snider, Paul Cheng, Christina To, Marie José Kersten
Journal: Blood
Blood (2022) 140 (21): 2248–2260.
https://doi.org/10.1182/blood.2022015478
Published: 2022
Includes: Supplemental data
Journal Articles

Combination of Ibrutinib Plus Venetoclax with MRD-Driven Duration of Treatment Results in a Higher Rate of MRD Negativity in IGHV Unmutated Than Mutated CLL: Updated Interim Analysis of FLAIR Study

Talha Munir, Alexandra Pitchford, Adrian Bloor, Andrew Pettitt, Piers E.M. Patten, Francesco Forconi, Anna Schuh, Christopher P Fox, Simona Gatto, Ben Kennedy, John Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Dena Howard, Anna Hockaday, David Cairns, Sharon Jackson, Natasha Greatorex, Nichola McWhirter, Jane Shingles, Kate Cwynarski, Shankara Paneesha, David Allsup, Andrew Rawstron, Peter Hillmen
Journal: Blood
Blood (2022) 140 (Supplement 1): 231–233.
https://doi.org/10.1182/blood-2022-170463
Published: 2022
Journal Articles

First in Human Study of AUTO4, a TRBC1-Targeting CAR T-Cell Therapy in Relapsed/Refractory TRBC1-Positive Peripheral T-Cell Lymphoma

Kate Cwynarski, Gloria Iacoboni, Eleni Tholouli, Tobias F. Menne, David A. Irvine, Nivetha Balasubramaniam, Leigh Wood, Justin Shang, Yiyun Zhang, Silvia Basilico, Birgit Huber, Mary Vinson, Koki Lilova, Wolfram Brugger, Martin Pule
Journal: Blood
Blood (2022) 140 (Supplement 1): 10316–10317.
https://doi.org/10.1182/blood-2022-165971
Published: 2022
Journal Articles

Replacing Procarbazine with Dacarbazine in Escalated Beacopp Dramatically Reduces the Post Treatment Haematopoietic Stem and Progenitor Cell Mutational Burden in Hodgkin Lymphoma Patients with No Apparent Loss of Clinical Efficacy

Anna Santarsieri, Emily Mitchell, Katherine Sturgess, Pauline Brice, Tobias F. Menne, Wendy Osborne, Thomas Creasey, Kirit M. Ardeshna, Sarah Behan, Kaljit Bhuller, Stephen Booth, Nikesh D. Chavda, Graham P. Collins, Dominic J. Culligan, Kate Cwynarski, Andrew Davies, Abigail Downing, David Dutton, Michelle Furtado, Eve Gallop-Evans, Andrew Hodson, David Hopkins, Hannah Hsu, Sunil Iyengar, Stephen G. Jones, Kim M. Linton, Oliver C. Lomas, Nicolas Martinez-Calle, Abhinav Mathur, Pamela McKay, Sateesh K. Nagumantry, Deirdre O'Mahony, Elizabeth H. Phillips, Neil Phillips, John F. Rudge, Nimish K. Shah, Gwyneth Stafford, Alex Sternberg, Rachel Trickey, Benjamin J. Uttenthal, Natasha Wetherall, Andrew K. McMillan, Michael Stratton, Elisa Laurenti, Peter J. Campbell, George A. Follows
Journal: Blood
Blood (2022) 140 (Supplement 1): 1761–1764.
https://doi.org/10.1182/blood-2022-166543
Published: 2022
Journal Articles

Impact on Tumour Treatment and Outcome of Sars-Cov-2 Infection in 91 Patients with Primary CNS Lymphoma: A Real-Life Study of the International PCNSL Collaborative Group

Teresa Calimeri, Sara Steffanoni, Alice Laurenge, Christopher P. Fox, Carole Soussain, Christian Grommes, Maria Chiara Tisi, Jesca Boot, Nicola Crosbie, Carlo Visco, Luca Arcaini, Sridhar Chaganti, Alvaro J. Alencar, Daniele Armiento, Ilaria Romano, Marianna C. Sassone, Jorg Dietrich, Gilad Itchaki, Riccardo Bruna, Nicola S Fracchiolla, Laura Arletti, Adriano Venditti, Stephen Booth, Pellegrino Musto, Khe Hoang-Xuan, Tracy Batchelor, Kate Cwynarski, Andrés J.M. Ferreri
Journal: Blood
Blood (2022) 140 (Supplement 1): 3785–3787.
https://doi.org/10.1182/blood-2022-167915
Published: 2022
Journal Articles

Impact of Double Expression of MYC and BCL-2 on Outcomes in Primary CNS Lymphoma: A UK Multicentre Analysis

Edward Poynton, Emily Chernucha, James Day, Catherine Prodger, David Hopkins, Pallav Rakesh, Tess O'Neill, Nisha Thakrar, Ayse Akarca, Sabine Pomplun, Teresa Marafioti, Maria Calaminici, Sridhar Chaganti, Pam McKay, Jeffery Smith, Toby A. Eyre, Nicolas Martinez-Calle, Kate Cwynarski, Christopher P. Fox, Jessica Okosun
Journal: Blood
Blood (2022) 140 (Supplement 1): 372–374.
https://doi.org/10.1182/blood-2022-157699
Published: 2022
Journal Articles

Timing of high-dose methotrexate CNS prophylaxis in DLBCL: a multicenter international analysis of 1384 patients

Matthew R. Wilson, Toby A. Eyre, Amy A. Kirkwood, Nicole Wong Doo, Carole Soussain, Sylvain Choquet, Nicolás Martinez-Calle, Gavin Preston, Matthew Ahearne, Elisabeth Schorb, Marie-Pierre Moles-Moreau, Matthew Ku, Chiara Rusconi, Jahanzaib Khwaja, Mayur Narkhede, Katharine L. Lewis, Teresa Calimeri, Eric Durot, Loïc Renaud, Andreas Kiesbye Øvlisen, Graham McIlroy, Timothy J. Ebsworth, Johnathan Elliot, Anna Santarsieri, Laure Ricard, Nimish Shah, Qin Liu, Adam S. Zayac, Francesco Vassallo, Laure Lebras, Louise Roulin, Naelle Lombion, Kate Manos, Ruben Fernandez, Nada Hamad, Alberto Lopez-Garcia, Deirdre O'Mahony, Praveen Gounder, Nathalie Forgeard, Charlotte Lees, Kossi Agbetiafa, Tim Strüßmann, Thura Win Htut, Aline Clavert, Hamish Scott, Anna Guidetti, Brett R. Barlow, Emmanuelle Tchernonog, Jeffery Smith, Fiona Miall, Christopher P. Fox, Chan Y. Cheah, Tarec Christoffer El Galaly, Andrés J.M. Ferreri, Kate Cwynarski, Pamela McKay
Journal: Blood
Blood (2022) 139 (16): 2499–2511.
https://doi.org/10.1182/blood.2021014506
Published: 2022
Includes: Supplemental data
Journal Articles

Real World Escalated Beacopdac Delivers Similar Outcomes to Escalated Beacopp and Superior Outcomes to Response-Adapted (RATHL) ABVD, While Potentially Reducing Toxicity Compared with Escalated Beacopp

Anna Santarsieri, Katherine Sturgess, Pauline Brice, Tobias F Menne, Wendy Osborne, Thomas Creasey, Kirit M. Ardeshna, Sarah Behan, Kaljit Bhuller, Stephen Booth, Graham P. Collins, Kate Cwynarski, Andrew Davies, Michelle Furtado, Eve Gallop-Evans, Andrew Hodson, Sunil Iyengar, Stephen G Jones, Kim Linton, Nicolas Martinez-Calle, Pamela McKay, Sateesh K Nagumantry, Deirdre O'Mahony, Beth Phillips, Neil Phillips, John F Rudge, Nimish Shah, Gwyneth Stafford, Alex Sternberg, Rachel Trickey, Benjamin J Uttenthal, Nathasha Wetherall, Andrew K McMillan, George A Follows
Journal: Blood
Blood (2021) 138 (Supplement 1): 877.
https://doi.org/10.1182/blood-2021-146242
Published: 2021
Journal Articles

Sudden or Cardiac Deaths on Ibrutinib-Based Therapy Were Associated with a Prior History of Hypertension or Cardiac Disease and the Use of ACE-Inhibitors at Study Entry: Analysis from the Phase III NCRI FLAIR Trial

Talha Munir, Alexandra Pitchford, Adrian Bloor, Angus Broom, Moya Young, Ben Kennedy, Renata Walewska, Michelle Furtado, Gavin Preston, Jeffrey R. Neilson, Nicholas Pemberton, Gamal Sidra, Nicholas Morley, Kate Cwynarski, Anna Schuh, Francesco Forconi, Simona Gatto, Shankara Paneesha, Christopher P. Fox, Dena Howard, Anna Hockaday, David Cairns, Sharon Jackson, Natasha Greatorex, Piers EM Patten, David Allsup, Peter Hillmen
Journal: Blood
Blood (2021) 138 (Supplement 1): 2636.
https://doi.org/10.1182/blood-2021-152167
Published: 2021