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Piers EM Patten
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Journal Articles

Ibrutinib Plus Venetoclax with MRD-Directed Duration of Treatment Is Superior to FCR and Is a New Standard of Care for Previously Untreated CLL: Report of the Phase III UK NCRI FLAIR Study

Peter Hillmen, David Allan Cairns, Adrian John Clifton Bloor, David Allsup, Kate Cwynarski, Andrew Pettitt, Shankaranarayana Paneesha, Christopher P. Fox, Toby A. Eyre, Francesco Forconi, Nagah Elmusharaf, Ben Kennedy, John G. Gribben, Nicholas Pemberton, Oonagh Sheehy, Gavin Preston, Anna Schuh, Dena Howard, Anna Hockaday, Sharon Jackson, Natasha Greatorex, Sean Girvan, Sue Bell, Julia Brown, Nichola Webster, Surita Dalal, Ruth M de Tute, Andrew Rawstron, Piers EM Patten, Talha Munir
Journal: Blood
Blood (2023) 142 (Supplement 1): 631.
https://doi.org/10.1182/blood-2023-178298
Published: 2023
Journal Articles

Imaging Mass Cytometry Reveals a Highly Heterogenous Cell Makeup of the Follicular Lymphoma Tumour Microenvironment

Paul Buckley, Julie Chan, Laura Jouvin, Cynthia Bishop, Timothy Woo, Katrina Todd, Elizabeth Phillips, Alessia Bottos, Piers EM Patten
Journal: Blood
Blood (2023) 142 (Supplement 1): 4381.
https://doi.org/10.1182/blood-2023-182037
Published: 2023
Journal Articles

Phase 1/2 Study of Acalabrutinib Monotherapy in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia: Final Results with >4 Years of Follow-up

Richard R. Furman, William G. Wierda, Anna Schuh, Piers EM Patten, Jorge M. Chaves, Jennifer R. Brown, Talha Munir, Peter Martin, Farrukh T. Awan, Deborah M. Stephens, Paolo Ghia, Jacqueline C. Barrientos, Krish Patel, Jennifer A. Woyach, Anna Butturini, Marianne de Borja, Min Hui Wang, Susan O'Brien, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 9873–9875.
https://doi.org/10.1182/blood-2022-162394
Published: 2022
Journal Articles

Final Results of the Phase 1/2 Study of Acalabrutinib Monotherapy in Treatment-Naive Chronic Lymphocytic Leukemia with >6 Years of Follow-up

John C. Byrd, Jennifer A. Woyach, Richard R. Furman, Peter Martin, Susan O'Brien, Jennifer R. Brown, Deborah M. Stephens, Jacqueline C. Barrientos, Piers EM Patten, Talha Munir, Krish Patel, Anna Butturini, Marianne de Borja, Min Hui Wang, Nitin Jain, William G. Wierda
Journal: Blood
Blood (2022) 140 (Supplement 1): 9865–9867.
https://doi.org/10.1182/blood-2022-159542
Published: 2022
Journal Articles

Sudden or Cardiac Deaths on Ibrutinib-Based Therapy Were Associated with a Prior History of Hypertension or Cardiac Disease and the Use of ACE-Inhibitors at Study Entry: Analysis from the Phase III NCRI FLAIR Trial

Talha Munir, Alexandra Pitchford, Adrian Bloor, Angus Broom, Moya Young, Ben Kennedy, Renata Walewska, Michelle Furtado, Gavin Preston, Jeffrey R. Neilson, Nicholas Pemberton, Gamal Sidra, Nicholas Morley, Kate Cwynarski, Anna Schuh, Francesco Forconi, Simona Gatto, Shankara Paneesha, Christopher P. Fox, Dena Howard, Anna Hockaday, David Cairns, Sharon Jackson, Natasha Greatorex, Piers EM Patten, David Allsup, Peter Hillmen
Journal: Blood
Blood (2021) 138 (Supplement 1): 2636.
https://doi.org/10.1182/blood-2021-152167
Published: 2021
Journal Articles

Efficacy Comparison of Tisagenlecleucel Versus Standard of Care in Patients with Relapsed or Refractory Follicular Lymphoma

Gilles Salles, Stephen J. Schuster, Martin H. Dreyling, Luca Fischer, John Kuruvilla, Piers EM Patten, Bastian Von Tresckow, Sonali M. Smith, Ana Isabel Jiminez Ubieto, Keith L. Davis, Carla Anjos, Jufen Chu, Jie Zhang, C Lobetti Bodoni, Catherine Thieblemont, Nathan H. Fowler, Michael Dickinson, Joaquin Martinez-Lopez, Yucai Wang, Brian K. Link
Journal: Blood
Blood (2021) 138 (Supplement 1): 3528.
https://doi.org/10.1182/blood-2021-149327
Published: 2021
Journal Articles

Identification of a Novel Proliferating Cell Fraction in Chronic Lymphocytic Leukaemia with High Expression of IgM and Chemokine Receptors

Daniel Friedman, Antony Long, Piers EM Patten, Robbert Hoogeboom
Journal: Blood
Blood (2021) 138 (Supplement 1): 3711.
https://doi.org/10.1182/blood-2021-153415
Published: 2021
Journal Articles

Immunogenicity of Covid-19 Vaccination in Subjects with Myelodysplastic Syndromes

Jennifer Vidler, Thanussuyah Alaguthurai, Sultan Abdul-Jawad, Sivalekha Viramuthu, Richard Beatson, Rosalind Graham, Sheeba Irshad, Austin G. Kulasekararaj, Piers EM Patten
Journal: Blood
Blood (2021) 138 (Supplement 1): 3696.
https://doi.org/10.1182/blood-2021-152401
Published: 2021
Journal Articles

Ibrutinib Plus Rituximab Is Superior to FCR in Previously Untreated CLL: Results of the Phase III NCRI FLAIR Trial

Peter Hillmen, Alexandra Pitchford, Adrian Bloor, Angus Broom, Moya Young, Ben Kennedy, Renata Walewska, Michelle Furtado, Gavin Preston, Jeffrey R. Neilson, Nicholas Pemberton, Gamal Sidra, Nicholas Morley, Kate Cwynarski, Anna Schuh, Francesco Forconi, Nagah Elmusharaf, Shankara Paneesha, Christopher P. Fox, Dena Howard, Anna Hockaday, David Cairns, Sharon Jackson, Natasha Greatorex, Piers EM Patten, David Allsup, Talha Munir
Journal: Blood
Blood (2021) 138 (Supplement 1): 642.
https://doi.org/10.1182/blood-2021-152319
Published: 2021
Journal Articles

A Retrospective Cohort Study of Treatment Outcomes of Adult Patients with Relapsed or Refractory Low-Grade Follicular Lymphoma (ReCORD-FL)

Gilles Salles, Stephen J. Schuster, Luca Fischer, John Kuruvilla, Piers EM Patten, Bastian von Tresckow, Sonali M. Smith, Ana Isabel Jiminez Ubieto, Keith L. Davis, Saurabh P Nagar, Jie Zhang, Vamsi Bollu, Etienne Jousseaume, Roberto Ramos, Yucai Wang, Brian K. Link
Journal: Blood
Blood (2021) 138 (Supplement 1): 1349.
https://doi.org/10.1182/blood-2021-145870
Published: 2021
Journal Articles

Efficacy of Tisagenlecleucel in Adult Patients (Pts) with High-Risk Relapsed/Refractory Follicular Lymphoma (r/r FL): Subgroup Analysis of the Phase II Elara Study

Catherine Thieblemont, Michael Dickinson, Joaquin Martinez-Lopez, Arne Kolstad, Jason P Butler, Monalisa Ghosh, Leslie L. Popplewell, Julio C. Chavez, Emmanuel Bachy, Koji Kato, Hideo Harigae, Marie Jose Kersten, Charalambos Andreadis, Peter A. Riedell, P. Joy Ho, Jose Pérez-Simón, Andy Chen, Loretta Nastoupil, Bastian Von Tresckow, Andres JM Ferreri, Takanori Teshima, Piers EM Patten, Joseph P. McGuirk, Andreas Petzer, Fritz Offner, Andreas Viardot, Pier Luigi Zinzani, Ram Malladi, Aiesha Zia, C Lobetti Bodoni, Aisha Masood, Stephen J. Schuster, Nathan H. Fowler, Martin H. Dreyling
Journal: Blood
Blood (2021) 138 (Supplement 1): 131.
https://doi.org/10.1182/blood-2021-145025
Published: 2021
Journal Articles

Multiparameter Microscopy Analysis of the Follicular Lymphoma Microenvironment and Normal Germinal Centers: In Vivo evidence That Follicular Helper T Cells Form Synapses with Neoplastic B Cells and Are Associated with Proliferation and Expression of Activation Induced Cytidine Deaminase

William M Townsend, MRCP, Robert Marcus, MB, FRCP, FRCPath, Jon Salisbury, Deborah Yallop, MB, BS, BSc.(hons), MRCP, FRCPath, Piers EM Patten, BSc, MRCP, FRCPath, PhD, Andrea GS Buggins, PhD, Stephen Devereux, MD PhD FRCPath
Journal: Blood
Blood (2014) 124 (21): 144.
https://doi.org/10.1182/blood.V124.21.144.144
Published: 2014
Journal Articles

Engraftment of CLL-Derived T Cells in NSG Mice Is Feasible, Can Support CLL Cell Proliferation, and Eliminates the Need for Third Party Antigen Presenting Cells

Piers EM Patten, BSc, MBBCh, PhD, Shih-Shih Chen, Ph.D., Davide Bagnara, Ph.D., Rita Simone, PhD, Sonia Marsilio, PhD, Timothy Tong, Jaqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, M.D., Kanti R Rai, MD, Nicholas Chiorazzi, M.D.
Journal: Blood
Blood (2011) 118 (21): 975.
https://doi.org/10.1182/blood.V118.21.975.975
Published: 2011
Journal Articles

Anti-Inflammatory Curcumin Inhibits Activation-Induced Cytosine Deaminase (AID) within Cycling Normal and CLL B Lymphocytes.

Shabirul Haque, PhD, Bukhtawar Waqas, Hyunjoo Lee, Piers EM Patten, BSc, MRCP, FRCPath, PhD, Jonathan E Kolitz, MD, Steven L Allen, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD, Patricia KA Mongini, PhD
Journal: Blood
Blood (2010) 116 (21): 4606.
https://doi.org/10.1182/blood.V116.21.4606.4606
Published: 2010
Journal Articles

Chronic Lymphocytic Leukemia B Cells Variably Express Functional Activation-Induced Cytosine Deaminase Protein

Piers EM Patten, BSc, MBBCh, PhD, Charles C Chu, PhD, Rajendra N Damle, PhD, Steven L. Allen, MD, Jonathan E Kolitz, MD, Kanti R Rai, MD, Patricia K Mongini, PhD, Nicholas Chiorazzi, MD
Journal: Blood
Blood (2010) 116 (21): 378.
https://doi.org/10.1182/blood.V116.21.378.378
Published: 2010
Journal Articles

Detection of Activation-Induced Cytidine Deaminase RNA In CLL Cells Correlates with Shorter Patient Survival and High Numbers of CD38 + Cells

Charles C Chu, PhD, Piers EM Patten, BSc, MBBCh, PhD, Emilia Albesiano, PhD, Linda P Johnson, BS, William J Kennedy, RN, MS, Lu Zhang, MS, Amanda R Magli, BSE, Rajendra N Damle, PhD, Xiao-Jie Yan, MD, PhD, Shabirul Haque, PhD, Patricia K Mongini, PhD, Jonathan E Kolitz, MD, Steven L Allen, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD
Journal: Blood
Blood (2010) 116 (21): 2415.
https://doi.org/10.1182/blood.V116.21.2415.2415
Published: 2010
Journal Articles

Two Distinct Co-Culture Systems, Designed to Mimic the Tumor Microenvironment, Induce Remarkably Similar Phenotypic Changes in Primary CLL Cells.

Andrea Gail Sherman Buggins, Ph.D., Laurence Pearce, B.Sc, Piers EM Patten, BSc, MRCP, MRCPath, Liam Morgan, Paul Brennan, Chris Fegan, Stephen Devereux, FRCP, FRCPath, Chris J Pepper
Journal: Blood
Blood (2009) 114 (22): 2362.
https://doi.org/10.1182/blood.V114.22.2362.2362
Published: 2009
Journal Articles

Evidence for A Macromolecular Complex in Poor Prognostic CLL That Contains CD38, CD49d, CD44, MMP-9 and ZAP-70.

Andrea Gail Sherman Buggins, Ph.D., Ana Levi, B.Sc., Satyen Gohil, MBBS, B.Sc., Keith Fishlock, MSc, Piers EM Patten, BSc, MRCP, MRCPath, Deborah Yallop, BSc, FRCPath, MB, BS, MRCP, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath, Stephen Devereux, FRCP, FRCPath
Journal: Blood
Blood (2009) 114 (22): 2334.
https://doi.org/10.1182/blood.V114.22.2334.2334
Published: 2009
Journal Articles

Vascular Endothelial Cells Promote the Viability of CLL Cells Via the up-Regulation of Bcl-2 and Bcl-XL

Andrea G S. Buggins, Ph.D., Piers EM Patten, BSc, MRCP, MRCPath, Satyen H Gohil, MBBS, B.Sc., Ghulam J Mufti, FRCP, FRCPath, M.D., Nicholas Shaun B. Thomas, PhD, Stephen Devereux, FRCP, FRCPath, Ph.D.
Journal: Blood
Blood (2008) 112 (11): 357.
https://doi.org/10.1182/blood.V112.11.357.357
Published: 2008