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Journal Articles

Efficacy and Safety of the Bruton's Tyrosine Kinase (BTK) Degrader NX-5948 in Patients with Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL): Updated Results from an Ongoing Phase 1a/b Study

Nirav N. Shah, Zulfa Omer, Graham P. Collins, Francesco Forconi, Alexey Danilov, John C. Byrd, Dima El-Sharkawi, Emma Searle, Alvaro J Alencar, Shuo Ma, Sarah Injac, Talha Munir
Journal: Blood
Blood (2024) 144 (Supplement 1): 884.
https://doi.org/10.1182/blood-2024-194839
Published: 2024
Journal Articles

Role of Bruton Tyrosine Kinase Inhibitors (BTKi) in Relapsed Refractory (r/r) Hairy Cell Leukaemia Patients: A Single-Centre Real-World Data Set from the Royal Marsden Hospital

Francesca Emily Sillito, Lucy Pickard, Ravindi Miriam, Paras Shah, Sunil Iyengar, Dima El-Sharkawi
Journal: Blood
Blood (2024) 144 (Supplement 1): 6311.
https://doi.org/10.1182/blood-2024-206992
Published: 2024
Journal Articles

Prognostication and Treatment-Related Outcomes in Secondary Central Nervous System Involvement of Large B-Cell Lymphoma (SCNSL): Evidence from a Large International Cohort

Juan Pablo Alderuccio, Jahanzaib Khwaja, Sunwoo Han, Paola Ghione, Imran A. Nizamuddin, Aditi Saha, Ning Dong, Yucai Wang, Hua-Jay J Cherng, Seda S. Tolu, Nina Wagner-Johnston, Adam J. Olszewski, Natalie Grover, Jean L. Koff, Amrita Desai, Praveen Ramakrishnan Geethakumari, Tamara K Moyo, Jose Sandoval-Sus, Narendranath Epperla, Danielle S Wallace, Manali Kamdar, Alexey Danilov, Han W. Tun, Javier Munoz, Mayur S. Narkhede, Joanna M. Rhodes, Anca Prica, Andrea Kuhnl, Adrian Maraj, Jessica Okosun, Jeffery Smith, Wendy Osborne, Victoria Calvert, Dima el-Sharkawi, Ammar Hilali, Graham P. Collins, Kim Linton, Nagah Elmusharaf, Anna Santarsieri, Farheen Karim, Thomas Ollila, Sarah Monick, Iris Margalit Trutzer, Nilanjan Ghosh, Jones Can, Amy Ayers, Jacopo Calabrese De Feo, John Sharp, Rachel Treitman, Avyakta Kallam, Izel Okcu, Vismay Deshani, Firas Baidoun, Chathuri Abeyakoon, William Hann, Aisling Barrett, Brad Kahl, Julio C. Chavez, Kate Cwynarski
Journal: Blood
Blood (2024) 144 (Supplement 1): 571.
https://doi.org/10.1182/blood-2024-199781
Published: 2024
Journal Articles

Glofitamab and Epcoritamab in the Real World: A UK Multicentre Retrospective Analysis of Efficacy, Tolerability and Practical Implications

Euan Haynes, Kushani Ediriwickrema, Sarah Lawless, Kevin Joyce, Matthew Wells, Jeffrey Smith, Kim Linton, Anna Santarsieri, George Follows, John Willan, Robert Osborn, Matthew R Wilson, Pamela McKay, Mahina Baloch, Rory McCulloch, Mary Gleeson, David Wrench, David Foldes, Edward Kanfer, Kyaw Zin Maw, Andrea Kuhnl, Matthew Ahearne, Mary Owen, Jane Norman, Ravindu De Silva, Nimish Shah, Harriet Ambrose, Christopher P. Fox, Janine Qasim, Graham P. Collins, Martha Vickers, David Tucker, Li Yuan Chan, Sunil Iyengar, Dima el-Sharkawi, Rebecca Auer, Catherine Cox, Hwai Jing Hiew, Andrew J. Davies, Philippa Kelsey, David John Lewis, Abigail Martin, Gavin Preston, Dominic J. Culligan, Angus Broom, William Wilson, Wendy Osborne, William Townsend
Journal: Blood
Blood (2024) 144 (Supplement 1): 3100.
https://doi.org/10.1182/blood-2024-203781
Published: 2024
Journal Articles

Excellent Outcomes with Brentuximab-Nivolumab for Relapsed/ Refractory Primary Mediastinal B-Cell Lymphoma in the Real-World Setting

Lucy Pickard, Li Yuan Chan, Su Li, Michael Potter, Emma Nicholson, Ian Chau, David Cunningham, Juanah Addada, Emily Chernucha, Sunil Iyengar, Dima El-Sharkawi
Journal: Blood
Blood (2024) 144 (Supplement 1): 3085.
https://doi.org/10.1182/blood-2024-204653
Published: 2024
Journal Articles

Patient Experience with Venetoclax+Rituximab and BTK Inhibitors in Relapsed or Refractory Chronic Lymphocytic Leukaemia (CLL): A Qualitative Interview Study in the UK (ELECTRIC)

Dima el-Sharkawi, Deborah Rahman, Lisa Lowry, Jo Kelly, Hanna Kew, Nimish Shah, Daniel Martins, Toby Kent, Louise Powell, Beenish Manzoor, Nicolas Martinez-Calle
Journal: Blood
Blood (2024) 144 (Supplement 1): 3731.
https://doi.org/10.1182/blood-2024-209883
Published: 2024
Journal Articles

Tolerability and Clinical Activity of Novel First-in-Class Oral Agent, Inobrodib (CCS1477), in Combination with Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma

Emma Searle, Victoria Campbell, Charlotte Pawlyn, Ceri Bygrave, Sarah Gooding, James Cavet, Matthew W. Jenner, Vivek Radhakrishnan, Steve Knapper, Dima el-Sharkawi, Jenny O'Nions, Tomasz Knurowski, Karen Clegg, Will Henry West, Debbie Haynes, Kris Frese, Tim Somervaille
Journal: Blood
Blood (2024) 144 (Supplement 1): 1023.
https://doi.org/10.1182/blood-2024-199779
Published: 2024
Journal Articles

Tolerability and Clinical Activity of Novel First in Class Oral Agent, Inobrodib (CCS1477), in Combination with Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma

Emma Searle, James Cavet, Victoria Campbell, Steve Knapper, Ceri Bygrave, Dima El-Sharkawi, Charlotte Pawlyn, Maria Creignou, Harriet Walter, David Valcárcel, Marta Hidalgo Soto, Jenny O'Nions, Amrutha Sridhar, Tomasz Knurowski, Karen Clegg, Neil Pegg, Will Henry West, Debbie Haynes, Kris Frese, Tim Somervaille
Journal: Blood
Blood (2023) 142 (Supplement 1): 2005.
https://doi.org/10.1182/blood-2023-174652
Published: 2023
Journal Articles

Mosunetuzumab Monotherapy Demonstrates Activity and a Manageable Safety Profile in Patients with Relapsed or Refractory Richter's Transformation

Chan Y. Cheah, Sarit Assouline, Ross Baker, Nancy L. Bartlett, Dima El-Sharkawi, Pratyush Giri, Matthew Ku, Stephen J. Schuster, Matthew Matasar, John Radford, Michael C. Wei, Shen Yin, Iris To, Jiangeng Huang, Antonia Kwan, L. Elizabeth Budde
Journal: Blood
Blood (2023) 142 (Supplement 1): 614.
https://doi.org/10.1182/blood-2023-173796
Published: 2023
Journal Articles

A First-in-Human Phase 1 Trial of NX-1607, a First-in-Class Oral CBL-B Inhibitor, in Patients with Advanced Malignancies Including DLBCL

Graham P. Collins, William Townsend, Ahmed Abdulgawad, Swathi Namburi, Anja Williams, Ana Filipa Palma DosReis, Matthew G. Krebs, Jeff Evans, Sarah P. Blagden, Ruth Plummer, Daniel Hochhauser, Adam Sharp, George Cole, Seema Rogers, Daniel Chan, Sarah Whelan, Dima El-Sharkawi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3093.
https://doi.org/10.1182/blood-2023-172875
Published: 2023
Journal Articles

Initial Findings from a First-in-Human Phase 1a/b Trial of NX-5948, a Selective Bruton's Tyrosine Kinase (BTK) Degrader, in Patients with Relapsed/Refractory B Cell Malignancies

Emma Searle, Francesco Forconi, Kim Linton, Alexey Danilov, Pam McKay, David Lewis, Dima El-Sharkawi, Mary Gleeson, John Riches, Sarah G. Injac, Ted Shih, Srinand Nandakumar, May Tan, Ganesh Cherala, Erin Meredith, Graham P. Collins
Journal: Blood
Blood (2023) 142 (Supplement 1): 4473.
https://doi.org/10.1182/blood-2023-179508
Published: 2023
Journal Articles

Time Limited Exposure to a ROR1 Targeting Bispecific T Cell Engager (NVG-111) Leads to Durable Responses in Subjects with Relapsed Refractory Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL)

William Townsend, Sarah Leong, Mittal Shah, Toby Batten, David Tucker, Bryson Pottinger, Shankaranarayana Paneesha, Dima El-Sharkawi, Toby A. Eyre, Ho Pui Jeff Lam, Jiexin Zheng, Sarah Cook, David Granger, David Ahern, Kieran O'Donovan, Amit C. Nathwani, Parag Jasani
Journal: Blood
Blood (2023) 142 (Supplement 1): 329.
https://doi.org/10.1182/blood-2023-188607
Published: 2023
Journal Articles

Does R-IPI Remain Predictive of Relapse Risk for Patients with DLBCL Achieving a Complete Remission with Frontline Therapy: Landmark Analysis of Two Large Prospective Clinical Trials

Dima El-Sharkawi, Tasneem Elnafie, Sarah Thompson, Louise Stanton, Nicholas Counsell, Amit Sud, Ian Chau, Bhupinder Sharma, Peter Johnson, David C. Linch, Sunil Iyengar, Andrew Davies, David Cunningham
Journal: Blood
Blood (2022) 140 (Supplement 1): 7908–7909.
https://doi.org/10.1182/blood-2022-167852
Published: 2022
Journal Articles

Autologous Transplantation in First Remission in the Rituximab Era in Patients with Mantle Cell Lymphoma: Experience from the Royal Marsden Hospital

Farheen Mir, Anna Robinson, Mark Edward Ethell, Michael Potter, Emma Nicholson, Chloe Anthias, Sandra Easdale, Carlos Gonzalez-Arias, Amit Sud, Claire E. Dearden, Ian Chau, David Cunningham, Dima El-Sharkawi, Bhupinder Sharma, Sunil Iyengar
Journal: Blood
Blood (2022) 140 (Supplement 1): 9366–9367.
https://doi.org/10.1182/blood-2022-166198
Published: 2022
Journal Articles

First-in-Human Phase I Trial of a ROR1 Targeting Bispecific T Cell Engager (NVG-111) in Combination with Ibrutinib or As Monotherapy in Subjects with Relapsed Refractory Chronic Lymphocytic Leukaemia (CLL) and Mantle Cell Lymphoma (MCL)

William Townsend, Sarah Leong, David Tucker, Bryson Pottinger, Shankara Paneesha, Dima El-Sharkawi, Toby A. Eyre, Toby Batten, Mittal Shah, Sarah Cook, David Granger, Kieran O'Donovan, Amit C. Nathwani, Parag Jasani
Journal: Blood
Blood (2022) 140 (Supplement 1): 4162–4163.
https://doi.org/10.1182/blood-2022-169658
Published: 2022
Journal Articles

A Phase 1-2, Open-Label Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Activity of Tolinapant in Combination with Oral Decitabine/Cedazuridine and Oral Decitabine/Cedazuridine Alone in Subjects with Relapsed/Refractory Peripheral T-Cell Lymphoma

Jake Shortt, Brian Poligone, Vincent Ribrag, Pier Luigi Zinzani, Dima El-Sharkawi, Jan Walewski, Anca Prica, Laksmi Wilson, Sonia Souza, Harold N. Keer, Jason A. Taylor, Enrica Marchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 12033–12034.
https://doi.org/10.1182/blood-2022-158650
Published: 2022
Journal Articles

Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Cost Evaluation Study of Management and Surveillance, and Review of the Recent USA and UK Guidelines

Aia S Mehdi, Rachel O'Connell, Michael Potter, Chris Marshall, Liza Van Kerckhoven, Sunil Iyengar, Emma Nicholson, Dima El-Sharkawi, Marios Tasoulis, David Cunningham, Bhupinder Sharma
Journal: Blood
Blood (2021) 138 (Supplement 1): 4014.
https://doi.org/10.1182/blood-2021-153675
Published: 2021
Journal Articles

Ethnic Disparities in Waldenström's Macroglobulinaemia in the United Kingdom - Analysis from the Wmuk Rory Morrison Registry

Aisha S Patel, Jahanzaib Khwaja, Helen McCarthy, Guy Pratt, Jaimal Kothari, Jindriska Lindsay, Roger G Owen, Josephine Crowe, Dima El-Sharkawi, Nilima Parry-Jones, Kirsty Cuthill, Maria Atta, Kim Linton, Agapi Parcharidou, Charalampia Kyriakou, Deborah Turner, Jeffery Smith, Simona Gatto, Nicola Crosbie, Suzanne O Arulogun, Shirley D'Sa
Journal: Blood
Blood (2021) 138 (Supplement 1): 1977.
https://doi.org/10.1182/blood-2021-153590
Published: 2021
Journal Articles

COVID-19 in patients with CLL: improved survival outcomes and update on management strategies

Clinical Trials & Observations
Lindsey E. Roeker, Toby A. Eyre, Meghan C. Thompson, Nicole Lamanna, Alexander R. Coltoff, Matthew S. Davids, Peter O. Baker, Lori Leslie, Kerry A. Rogers, John N. Allan, Raul Cordoba, Alberto Lopez-Garcia, Darko Antic, John M. Pagel, Nicolas Martinez-Calle, José Antonio García-Marco, Jose‐Ángel Hernández‐Rivas, Fatima Miras, Catherine C. Coombs, Anders Österborg, Lotta Hansson, Amanda N. Seddon, Javier López Jiménez, Matthew R. Wilson, Dima El-Sharkawi, Daniel Wojenski, Shuo Ma, Talha Munir, Susana Valenciano, Erlene Seymour, Paul M. Barr, Jeffrey Pu, Piers E. M. Patten, Guilherme F. Perini, Scott F. Huntington, Helen Parry, Suchitra Sundaram, Alan Skarbnik, Manali Kamdar, Ryan Jacobs, Harriet Walter, Renata Walewska, Angus Broom, Sonia Lebowitz, Krista M. Isaac, Craig A. Portell, Inhye E. Ahn, Chaitra S. Ujjani, Mazyar Shadman, Sigrid S. Skånland, Elise A. Chong, Anthony R. Mato
Journal: Blood
Blood (2021) 138 (18): 1768–1773.
https://doi.org/10.1182/blood.2021011841
Published: 2021
Includes: Supplemental data
Journal Articles

Targeted Next Generation Sequencing Improves Diagnosis in Unclassifiable Leukemic Indolent B-Cell Non-Hodgkin Lymphoma and Identifies a Subset with Recurrent MYD88 Mutations in a Prospective Multicentre Study

Matthew J Cross, MBBS, BSc, Grzegorz Pietka, PhD, Sarah Dunne, Leonora Conneely, Michael Hubank, PhD, Corinne De Lord, MD FRCPath, Michelle Furtado, MD FRCPath, PhD, Pawel Kaczmarek, MD PhD, Dima El-Sharkawi, Claire E. Dearden, MD FRCP, FRCPath, Kabir Mohammed, Alan Stewart Dunlop, MSc, BS, Ricardo Morilla, Karol Pal, PhD, Nikos Darzentas, PhD, David Gonzalez, PhD, Dorte Wren, PhDFRCPath, Sunil Iyengar, MD FRCPath, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-141542
Published: 2020