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Journal Articles

Checkpoint inhibitors improve progression free survival after autologous transplant despite poorer pre-transplant response

Free
Jack Taylor-Stuart, Mark Ethell, Mike Potter, Sandra Easdale, Chloe Anthias, Caroline Furness, David Cunningham, Ian Chau, Dima El-Sharkawi, Sunil Iyengar, Emma Nicholson
Journal: Blood
Blood (2025) 146 (Supplement 1): 7134.
https://doi.org/10.1182/blood-2025-7134
Published: 2025
Journal Articles

Multiparametric integration improves diagnostic categorisation of mature, non-CLL B-cell leukemias including atypical CLL - results from the prospective enable-NGS study

Free
Li Yuan Chan, Matthew Cross, Grzegorz Pietka, Kyoko Yamaguchi, Sarah Dunne, Leonora Conneely, Elise Nash, Michael Hubank, Mikel Valganon-Petrizan, Farheen Mir, Michelle Furtado, Gwynn Matthias, Pawel Kaczmarek, Sarah Lawless, Siamak Arami, Sangeeta Atwal, Elisabeth Grey-Davies, Sofia Galli, Betty Cheung, Sudhakaran Makkuni, Andrew Wotherspoon, Ayoma Attygalle, Simon O'Connor, David Taussig, Dima El-Sharkawi, Claire Dearden, Kabir Mohammed, Alan Dunlop, Ricardo Morilla, Karol Pal, Nikos Darzentas, Christopher Oakes, David Gonzalez, Dorte Wren, Sunil Iyengar
Journal: Blood
Blood (2025) 146 (Supplement 1): 1753.
https://doi.org/10.1182/blood-2025-1753
Published: 2025
Journal Articles

Encouraging long-term efficacy and safety from first-in-human phase 1 study of time-limited NVG-111 in relapsed/refractory CLL and MCL

Free
William Townsend, Sarah Leong, Mittal Shah, Toby Batten, David Tucker, Bryson Pottinger, Shankara Paneesha, Dima El-Sharkawi, David Granger, Kieran O'Donovan, Amit Nathwani, Parag Jasani
Journal: Blood
Blood (2025) 146 (Supplement 1): 2125.
https://doi.org/10.1182/blood-2025-2125
Published: 2025
Journal Articles

Extreme thrombocytosis in patients with underlying malignancy; Management, complications and outcomes.

Free
Laura McDonald, Heba Hasan, Lorelyn Donato, Lillie Anne Wylde, Rifa Cardoso, Kevin Boyd, Rita Peralta, Sunil Iyengar, Dima El-Sharkawi
Journal: Blood
Blood (2025) 146 (Supplement 1): 6591.
https://doi.org/10.1182/blood-2025-6591
Published: 2025
Journal Articles

Bexobrutideg (NX-5948), a novel Bruton's tyrosine kinase (BTK) degrader, shows high clinical activity and tolerable safety in patients with Waldenström macroglobulinemia: Updated results from an ongoing Phase 1a/b study

Free
Nirav Shah, Scott Huntington, David Lewis, Talha Munir, Graham Collins, Alvaro Alencar, Kim Linton, Zulfa Omer, Dima El-Sharkawi, Mary Gleeson, Pamela McKay, Jeanette Doorduijn, Jeffery Smith, Daniel Morillo, Pau Abrisqueta, Sarah Injac, Astrid Pulles
Journal: Blood
Blood (2025) 146 (Supplement 1): 5359.
https://doi.org/10.1182/blood-2025-5359
Published: 2025
Journal Articles

Fixed treatment duration mosunetuzumab continues to demonstrate clinically meaningful outcomes in patients with relapsed/refractory (R/R) follicular lymphoma (FL) after ≥2 prior therapies: 5-year follow-up of a pivotal Phase II study

Free
Elizabeth Budde, Laurie Sehn, Matthew Matasar, Stephen Schuster, Sarit Assouline, John Kuruvilla, Won-Seog Kim, Chan Cheah, Mazyar Shadman, Sascha Dietrich, Matthew Ku, Dima El-Sharkawi, Norma Gutiérrez, Michael C. Wei, Shen Yin, Jason Sit, Samuel Tracy, Fidelis Sabalvaro, Elicia Peneul, Nancy Bartlett
Journal: Blood
Blood (2025) 146 (Supplement 1): 5352.
https://doi.org/10.1182/blood-2025-5352
Published: 2025
Journal Articles

Bexobrutideg (NX-5948), a novel Bruton's tyrosine kinase (BTK) degrader, demonstrates rapid and durable clinical responses in Relapsed/Refractory chronic lymphocytic leukemia (CLL): New and updated findings from an ongoing Phase 1a/b trial

Free
Zulfa Omer, Alexey Danilov, Francesco Forconi, Talha Munir, Mary Gleeson, Nirav Shah, Graham Collins, Alvaro Alencar, Jane Robertson, Jonathon Cohen, Karan Dixit, Danielle Brander, John Byrd, Allison Winter, Jeffery Smith, Dima El-Sharkawi, Michal Kwiatek, Iwona Hus, Prioty Islam, Sebastian Grosicki, Michael Tees, Thorsten Zenz, Joanna Romejko-Jarosinska, Sarah Injac, Wojciech Jurczak
Journal: Blood
Blood (2025) 146 (Supplement 1): 86.
https://doi.org/10.1182/blood-2025-86
Published: 2025
Journal Articles

Patient Experience with Venetoclax+Rituximab and BTK Inhibitors in Relapsed or Refractory Chronic Lymphocytic Leukaemia (CLL): A Qualitative Interview Study in the UK (ELECTRIC)

Free
Dima el-Sharkawi, Deborah Rahman, Lisa Lowry, Jo Kelly, Hanna Kew, Nimish Shah, Daniel Martins, Toby Kent, Louise Powell, Beenish Manzoor, Nicolas Martinez-Calle
Journal: Blood
Blood (2024) 144 (Supplement 1): 3731.
https://doi.org/10.1182/blood-2024-209883
Published: 2024
Journal Articles

Prognostication and Treatment-Related Outcomes in Secondary Central Nervous System Involvement of Large B-Cell Lymphoma (SCNSL): Evidence from a Large International Cohort

Free
Juan Pablo Alderuccio, Jahanzaib Khwaja, Sunwoo Han, Paola Ghione, Imran A. Nizamuddin, Aditi Saha, Ning Dong, Yucai Wang, Hua-Jay J Cherng, Seda S. Tolu, Nina Wagner-Johnston, Adam J. Olszewski, Natalie Grover, Jean L. Koff, Amrita Desai, Praveen Ramakrishnan Geethakumari, Tamara K Moyo, Jose Sandoval-Sus, Narendranath Epperla, Danielle S Wallace, Manali Kamdar, Alexey Danilov, Han W. Tun, Javier Munoz, Mayur S. Narkhede, Joanna M. Rhodes, Anca Prica, Andrea Kuhnl, Adrian Maraj, Jessica Okosun, Jeffery Smith, Wendy Osborne, Victoria Calvert, Dima el-Sharkawi, Ammar Hilali, Graham P. Collins, Kim Linton, Nagah Elmusharaf, Anna Santarsieri, Farheen Karim, Thomas Ollila, Sarah Monick, Iris Margalit Trutzer, Nilanjan Ghosh, Jones Can, Amy Ayers, Jacopo Calabrese De Feo, John Sharp, Rachel Treitman, Avyakta Kallam, Izel Okcu, Vismay Deshani, Firas Baidoun, Chathuri Abeyakoon, William Hann, Aisling Barrett, Brad Kahl, Julio C. Chavez, Kate Cwynarski
Journal: Blood
Blood (2024) 144 (Supplement 1): 571.
https://doi.org/10.1182/blood-2024-199781
Published: 2024
Journal Articles

Glofitamab and Epcoritamab in the Real World: A UK Multicentre Retrospective Analysis of Efficacy, Tolerability and Practical Implications

Free
Euan Haynes, Kushani Ediriwickrema, Sarah Lawless, Kevin Joyce, Matthew Wells, Jeffrey Smith, Kim Linton, Anna Santarsieri, George Follows, John Willan, Robert Osborn, Matthew R Wilson, Pamela McKay, Mahina Baloch, Rory McCulloch, Mary Gleeson, David Wrench, David Foldes, Edward Kanfer, Kyaw Zin Maw, Andrea Kuhnl, Matthew Ahearne, Mary Owen, Jane Norman, Ravindu De Silva, Nimish Shah, Harriet Ambrose, Christopher P. Fox, Janine Qasim, Graham P. Collins, Martha Vickers, David Tucker, Li Yuan Chan, Sunil Iyengar, Dima el-Sharkawi, Rebecca Auer, Catherine Cox, Hwai Jing Hiew, Andrew J. Davies, Philippa Kelsey, David John Lewis, Abigail Martin, Gavin Preston, Dominic J. Culligan, Angus Broom, William Wilson, Wendy Osborne, William Townsend
Journal: Blood
Blood (2024) 144 (Supplement 1): 3100.
https://doi.org/10.1182/blood-2024-203781
Published: 2024
Journal Articles

Efficacy and Safety of the Bruton's Tyrosine Kinase (BTK) Degrader NX-5948 in Patients with Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL): Updated Results from an Ongoing Phase 1a/b Study

Free
Nirav N. Shah, Zulfa Omer, Graham P. Collins, Francesco Forconi, Alexey Danilov, John C. Byrd, Dima El-Sharkawi, Emma Searle, Alvaro J Alencar, Shuo Ma, Sarah Injac, Talha Munir
Journal: Blood
Blood (2024) 144 (Supplement 1): 884.
https://doi.org/10.1182/blood-2024-194839
Published: 2024
Journal Articles

Tolerability and Clinical Activity of Novel First-in-Class Oral Agent, Inobrodib (CCS1477), in Combination with Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma

Free
Emma Searle, Victoria Campbell, Charlotte Pawlyn, Ceri Bygrave, Sarah Gooding, James Cavet, Matthew W. Jenner, Vivek Radhakrishnan, Steve Knapper, Dima el-Sharkawi, Jenny O'Nions, Tomasz Knurowski, Karen Clegg, Will Henry West, Debbie Haynes, Kris Frese, Tim Somervaille
Journal: Blood
Blood (2024) 144 (Supplement 1): 1023.
https://doi.org/10.1182/blood-2024-199779
Published: 2024
Journal Articles

Role of Bruton Tyrosine Kinase Inhibitors (BTKi) in Relapsed Refractory (r/r) Hairy Cell Leukaemia Patients: A Single-Centre Real-World Data Set from the Royal Marsden Hospital

Free
Francesca Emily Sillito, Lucy Pickard, Ravindi Miriam, Paras Shah, Sunil Iyengar, Dima El-Sharkawi
Journal: Blood
Blood (2024) 144 (Supplement 1): 6311.
https://doi.org/10.1182/blood-2024-206992
Published: 2024
Journal Articles

Excellent Outcomes with Brentuximab-Nivolumab for Relapsed/ Refractory Primary Mediastinal B-Cell Lymphoma in the Real-World Setting

Free
Lucy Pickard, Li Yuan Chan, Su Li, Michael Potter, Emma Nicholson, Ian Chau, David Cunningham, Juanah Addada, Emily Chernucha, Sunil Iyengar, Dima El-Sharkawi
Journal: Blood
Blood (2024) 144 (Supplement 1): 3085.
https://doi.org/10.1182/blood-2024-204653
Published: 2024
Journal Articles

Initial Findings from a First-in-Human Phase 1a/b Trial of NX-5948, a Selective Bruton's Tyrosine Kinase (BTK) Degrader, in Patients with Relapsed/Refractory B Cell Malignancies

Free
Emma Searle, Francesco Forconi, Kim Linton, Alexey Danilov, Pam McKay, David Lewis, Dima El-Sharkawi, Mary Gleeson, John Riches, Sarah G. Injac, Ted Shih, Srinand Nandakumar, May Tan, Ganesh Cherala, Erin Meredith, Graham P. Collins
Journal: Blood
Blood (2023) 142 (Supplement 1): 4473.
https://doi.org/10.1182/blood-2023-179508
Published: 2023
Journal Articles

Time Limited Exposure to a ROR1 Targeting Bispecific T Cell Engager (NVG-111) Leads to Durable Responses in Subjects with Relapsed Refractory Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL)

Free
William Townsend, Sarah Leong, Mittal Shah, Toby Batten, David Tucker, Bryson Pottinger, Shankaranarayana Paneesha, Dima El-Sharkawi, Toby A. Eyre, Ho Pui Jeff Lam, Jiexin Zheng, Sarah Cook, David Granger, David Ahern, Kieran O'Donovan, Amit C. Nathwani, Parag Jasani
Journal: Blood
Blood (2023) 142 (Supplement 1): 329.
https://doi.org/10.1182/blood-2023-188607
Published: 2023
Journal Articles

Mosunetuzumab Monotherapy Demonstrates Activity and a Manageable Safety Profile in Patients with Relapsed or Refractory Richter's Transformation

Free
Chan Y. Cheah, Sarit Assouline, Ross Baker, Nancy L. Bartlett, Dima El-Sharkawi, Pratyush Giri, Matthew Ku, Stephen J. Schuster, Matthew Matasar, John Radford, Michael C. Wei, Shen Yin, Iris To, Jiangeng Huang, Antonia Kwan, L. Elizabeth Budde
Journal: Blood
Blood (2023) 142 (Supplement 1): 614.
https://doi.org/10.1182/blood-2023-173796
Published: 2023
Journal Articles

A First-in-Human Phase 1 Trial of NX-1607, a First-in-Class Oral CBL-B Inhibitor, in Patients with Advanced Malignancies Including DLBCL

Free
Graham P. Collins, William Townsend, Ahmed Abdulgawad, Swathi Namburi, Anja Williams, Ana Filipa Palma DosReis, Matthew G. Krebs, Jeff Evans, Sarah P. Blagden, Ruth Plummer, Daniel Hochhauser, Adam Sharp, George Cole, Seema Rogers, Daniel Chan, Sarah Whelan, Dima El-Sharkawi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3093.
https://doi.org/10.1182/blood-2023-172875
Published: 2023
Journal Articles

Tolerability and Clinical Activity of Novel First in Class Oral Agent, Inobrodib (CCS1477), in Combination with Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma

Free
Emma Searle, James Cavet, Victoria Campbell, Steve Knapper, Ceri Bygrave, Dima El-Sharkawi, Charlotte Pawlyn, Maria Creignou, Harriet Walter, David Valcárcel, Marta Hidalgo Soto, Jenny O'Nions, Amrutha Sridhar, Tomasz Knurowski, Karen Clegg, Neil Pegg, Will Henry West, Debbie Haynes, Kris Frese, Tim Somervaille
Journal: Blood
Blood (2023) 142 (Supplement 1): 2005.
https://doi.org/10.1182/blood-2023-174652
Published: 2023
Journal Articles

Autologous Transplantation in First Remission in the Rituximab Era in Patients with Mantle Cell Lymphoma: Experience from the Royal Marsden Hospital

Free
Farheen Mir, Anna Robinson, Mark Edward Ethell, Michael Potter, Emma Nicholson, Chloe Anthias, Sandra Easdale, Carlos Gonzalez-Arias, Amit Sud, Claire E. Dearden, Ian Chau, David Cunningham, Dima El-Sharkawi, Bhupinder Sharma, Sunil Iyengar
Journal: Blood
Blood (2022) 140 (Supplement 1): 9366–9367.
https://doi.org/10.1182/blood-2022-166198
Published: 2022