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Journal Articles

Safety, Tolerability, and Pharmacokinetic Profile of Single and Multiple Ascending Doses of GB5121, a CNS-Penetrant BTK Inhibitor, in Healthy Subjects

Brian J Kirby, Richard Aranda, Renee Ward, Marcos W Steinberg, Maria Hernandez, Judith Sosa, Matt Cravets, Mark J Rose, Robin Osterhout, Zhaoqing Ding, Isharat Yusuf, Judith Fox, Anita Mathias

Blood (2022) 140 (Supplement 1): 11570–11571.

https://doi.org/10.1182/blood-2022-160388

Published: 2022

Journal Articles

Trial in Progress: A Phase 1b/2 Study of GB5121, a Brain-Penetrant, Potent, Highly Selective, and Irreversible BTK Inhibitor for Relapsed/Refractory Primary/Secondary CNS Lymphoma and Primary Vitreoretinal Lymphoma

Carole Soussain, Samar Issa, Katharine L Lewis, Christian Grommes, Judith Fox, Renee Ward, Caryn Peterson, Matt Cravets, Anita Mathias, Judith Sosa, Brian J Kirby, Zhaoqing Ding, Isharat Yusuf, Mark J Rose, Marcos W Steinberg, Han W. Tun

Blood (2022) 140 (Supplement 1): 12068–12069.

https://doi.org/10.1182/blood-2022-158599

Published: 2022

Journal Articles

Phase 1b/2 Pharmacokinetic/Pharmacodynamic (PK/PD) Study of Combination Voreloxin and Cytarabine in Relapsed or Refractory Acute Myeloid Leukemia Patients.

Jeffrey E Lancet, MD, Gail J. Roboz, MD, Larry D. Cripe, Michael Maris, MD, Alan F List, MD, Judith Fox, Glenn C Michelson, MD, Judith Karp

Blood (2009) 114 (22): 635.

https://doi.org/10.1182/blood.V114.22.635.635

Published: 2009

Journal Articles

A Phase 2 Dose Regimen Optimization Study of Three Schedules of Voreloxin as Single Agent Therapy for Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia.

Farhad Ravandi, MD, Hagop M. Kantarjian, MD, Larry D. Cripe, Michael Maris, MD, Maureen Cooper, MD, Shaker R. Dakhil, MD, Richard M Stone, MD, Francesco Turturro, MD, Tianling Chen, MD, MSc, Kristi Mahadocon, Judith Fox, Craig Berman, Glenn C Michelson, MD, Robert K Stuart

Blood (2009) 114 (22): 1037.

https://doi.org/10.1182/blood.V114.22.1037.1037

Published: 2009

Journal Articles

A Phase 1 Trial of SNS-032, a Potent and Specific CDK 2, 7 and 9 Inhibitor, in Chronic Lymphocytic Leukemia and Multiple Myeloma

William G. Wierda, MD, R. Chen, MD, William Plunkett, MD, Steven Coutre, MD, Ashraf Z. Badros, MD, Leslie Popplewell, MD, David Siegel, MD, Rajni Sinha, MD, Donald Harvey, Pharm.D., Judith Fox, PhD, Kristi Mahadocon, Peggy Kegley, Mary G. Bolton, MD, PhD

Blood (2008) 112 (11): 3178.

https://doi.org/10.1182/blood.V112.11.3178.3178

Published: 2008

Journal Articles

Voreloxin (formerly known as SNS-595) in Combination with Cytarabine Demonstrates Preliminary Clinical Responses in a Phase 1 Study in Relapsed/Refractory Acute Myeloid Leukemia.

Jeffrey Lancet, MD, Judith E. Karp, MD, Larry D. Cripe, MD, Gail J. Roboz, MD, Matt Suster, Nguyen Tan, Rachael Hawtin, Judith Fox, Craig Berman, Glenn Michelson

Blood (2008) 112 (11): 1955.

https://doi.org/10.1182/blood.V112.11.1955.1955

Published: 2008

Journal Articles

A Phase 1 Dose Escalation Study of a Fully Human, Antagonist Anti-CD40 Antibody, HCD122 (Formerly CHIR-12.12) in Patients with Relapsed and Refractory Multiple Myeloma.

William Bensinger, MD, Sundar Jagannath, MD, Pamela S. Becker, MD, PhD, Kenneth C. Anderson, MD, Edward A. Stadtmauer, MD, Lea Aukerman, PhD, Judith Fox, PhD, Sandhya Girish, PhD, Sanela Bilic, PharmD, Serge Guzy, PhD, Alan Solinger, MD, Sherri Dort, BS, Yongyu Wang, MD, Deborah Hurst, MD

Blood (2006) 108 (11): 3575.

https://doi.org/10.1182/blood.V108.11.3575.3575

Published: 2006

Journal Articles

Pharmacokinetics and Pharmacodynamics from a First-in-Human Phase 1 Dose Escalation Study with Antagonist Anti-CD40 Antibody, HCD122 (Formerly CHIR-12.12), in Patients with Relapsed and Refractory Chronic Lymphocytic Leukemia.

John C. Byrd, MD, Ian W. Flinn, MD, Khuda D. Khan, MD, Thomas J. Kipps, MD, Lea Aukerman, PhD, Judith Fox, PhD, Sandhya Girish, PhD, Serge Guzy, PhD, Sanela Bilic, PharmD, Alan Solinger, MD, Sherri Dort, BS, Yongyu Wang, MD, Deborah Hurst, MD, Susan O’Brien, MD

Blood (2006) 108 (11): 2837.

https://doi.org/10.1182/blood.V108.11.2837.2837

Published: 2006

NARROW

Safety, Tolerability, and Pharmacokinetic Profile of Single and Multiple Ascending Doses of GB5121, a CNS-Penetrant BTK Inhibitor, in Healthy Subjects

Trial in Progress: A Phase 1b/2 Study of GB5121, a Brain-Penetrant, Potent, Highly Selective, and Irreversible BTK Inhibitor for Relapsed/Refractory Primary/Secondary CNS Lymphoma and Primary Vitreoretinal Lymphoma

Phase 1b/2 Pharmacokinetic/Pharmacodynamic (PK/PD) Study of Combination Voreloxin and Cytarabine in Relapsed or Refractory Acute Myeloid Leukemia Patients.

A Phase 2 Dose Regimen Optimization Study of Three Schedules of Voreloxin as Single Agent Therapy for Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia.

A Phase 1 Trial of SNS-032, a Potent and Specific CDK 2, 7 and 9 Inhibitor, in Chronic Lymphocytic Leukemia and Multiple Myeloma

Voreloxin (formerly known as SNS-595) in Combination with Cytarabine Demonstrates Preliminary Clinical Responses in a Phase 1 Study in Relapsed/Refractory Acute Myeloid Leukemia.

A Phase 1 Dose Escalation Study of a Fully Human, Antagonist Anti-CD40 Antibody, HCD122 (Formerly CHIR-12.12) in Patients with Relapsed and Refractory Multiple Myeloma.

Pharmacokinetics and Pharmacodynamics from a First-in-Human Phase 1 Dose Escalation Study with Antagonist Anti-CD40 Antibody, HCD122 (Formerly CHIR-12.12), in Patients with Relapsed and Refractory Chronic Lymphocytic Leukemia.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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