Page 1 | Search Results | Blood | American Society of Hematology

1-20 of 34

Sort by

Sort Order Select

Journal Articles

Decitabine Activity Against TP53 -Mutated Myeloid Neoplasms Is Enhanced By Combination with a Non-Cytotoxic p53/BAX-Independent Inhibitor of Pyrimidine Synthesis

Sudipta Biswas, Zeinab Albadry M. Zahran, Xiaorong Gu, Lisa Cardone, Akriti G. Jain, Kateryna Fedorov, Ben K. Tomlinson, Mendel Goldfinger, Amit Verma, Yogenthiran Saunthararajah

Blood (2024) 144 (Supplement 1): 1382.

https://doi.org/10.1182/blood-2024-210609

Published: 2024

Journal Articles

Developing a Therapeutic Strategy for Targeting Metabolic Vulnerability of TET2 Mutant Leukemia

Xiaorong Gu, Yahan Zhang, Songa Bae, Dongxu Jiang, Nakisha D Williams, Daniel Vail, Simon Schlanger, Jill Durkin, Yvonne Parker, Daniel Lindner, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 2918.

https://doi.org/10.1182/blood-2024-207470

Published: 2024

Journal Articles

TET2 Regulates Stability of Mismatch Repair Protein MSH6 and Helps Maintain Genomic Stability Independent of Its Dioxygenase Function

Dongxu Jiang, Yahan Zhang, Xiaorong Gu, Daniel J Vail, Jill Durkin, Simon Schlanger, J. Joseph Melenhorst, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 40.

https://doi.org/10.1182/blood-2024-211171

Published: 2024

Journal Articles

Metabolic Reprogramming By IDH1 Neomorph Epigenetically Guides CAR T Cell Differentiation

Kunho Chung, Dongxu Jiang, Xiaorong Gu, Jie Xu, Céline Grégoire, Beatriz Coutinho De Oliveira, Babal Kant Jha, J. Joseph Melenhorst

Blood (2024) 144 (Supplement 1): 1035.

https://doi.org/10.1182/blood-2024-205836

Published: 2024

Journal Articles

FLT3-ITD Signaling Continuously Degrades p53 By the Ubiquitin-Proteosome Pathway Explaining Chemo-Resistance

Xiaorong Gu, Zeinab Albadry M. Zahran, Ramesh Balusu, Jaroslaw Maciejewski, Babal K. Jha, Yogenthiran Saunthararajah

Blood (2024) 144 (Supplement 1): 2714.

https://doi.org/10.1182/blood-2024-205887

Published: 2024

Journal Articles

Loss of TET2 Increases MHC Class I Expression in Acute Myeloid Leukemia

Xiaorong Gu, Songa Bae, Yahan Zhang, Nakisha D Williams, Dongxu Jiang, Simon Schlanger, Valeria Visconte, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 4159.

https://doi.org/10.1182/blood-2024-208348

Published: 2024

Journal Articles

Loss of TET2 Creates a Distinct Immunopeptidome in Acute Myeloid Leukemia

Xiaorong Gu, Yahan Zhang, Songa Bae, Dongxu Jiang, Daniel Vail, Simon Schlanger, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 4154.

https://doi.org/10.1182/blood-2024-208025

Published: 2024

Journal Articles

Low Regimen Therapeutic Strategies to Mitigate TET2 Mutant Clonal Hematopoiesis

Dongxu Jiang, Daniel J Vail, Yahan Zhang, Raziullah Khan, Anand Tiwari, Simon Schlanger, Kunho Chung, Cassandra Gilmour, Xiaorong Gu, Yvonne Parker, J. Joseph Melenhorst, Daniel Lindner, Jaroslaw Maciejewski, Babal K. Jha

Blood (2024) 144 (Supplement 1): 2664.

https://doi.org/10.1182/blood-2024-211363

Published: 2024

Journal Articles

Metabolic Signatures and Pathway Rewiring in TET2-Mutated Myeloid Neoplasia

Xiaorong Gu, Dongxu Jiang, Simon Schlanger, Nakisha D Williams, Divya Jyoti Singh, Daniel Vail, Jill Durkin, Yahan Zhang, Valeria Visconte, Jaroslaw P. Maciejewski, Babal Kant Jha

Blood (2023) 142 (Supplement 1): 2747.

https://doi.org/10.1182/blood-2023-189228

Published: 2023

Journal Articles

Fatty Acid Binding Protein FABP5 Inhibition Activates Retinoic Acid Signaling and Induces Differentiation in Acute Myeloid Leukemia

Divya Jyoti Singh, Metis Hasipek, Dongxu Jiang, Daniel Vail, Yahan Zhang, Jill Durkin, Naomi Kawashima, Simon Schlanger, Xiaorong Gu, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah, Hetty E. Carraway, Babal Kant Jha

Blood (2023) 142 (Supplement 1): 1422.

https://doi.org/10.1182/blood-2023-189274

Published: 2023

Journal Articles

Loss of Function MBD4 Mutation Impairs DNA Repair in Association with TET2 in Acute Myeloid Leukemia

Naomi Kawashima, Dongxu Jiang, Daniel Vail, Divya Jyoti Singh, Xiaorong Gu, Simon Schlanger, Carmelo Gurnari, Yasuo Kubota, Brittany L Stewart, Valeria Visconte, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2023) 142 (Supplement 1): 1371.

https://doi.org/10.1182/blood-2023-182142

Published: 2023

Journal Articles

BCR-ABL1 Dislocates NPM1, PU.1 and KLF1 into Cytoplasm to Thereby Skew Granulo-Monocytic and Impede Erythroid Differentiation

Zeinab Albadry M. Zahran, Xiaorong Gu, Babal K. Jha, Yogenthiran Saunthararajah

Blood (2023) 142 (Supplement 1): 1375.

https://doi.org/10.1182/blood-2023-187016

Published: 2023

Journal Articles

Methyl-CpG Binding Domain Protein MBD2 Is a Targetable Vulnerability in TET2 Mutant Myeloid Neoplasia

Dongxu Jiang, Yihong Guan, Shinjini Ganguly, Aysegul Balyimez, Andrew Muskara, Divya Jyoti Singh, Simona Pagliuca, Daniel Vail, Yahan Zhang, Jill Durkin, Naomi Kawashima, Xiaorong Gu, Carmelo Gurnari, Jaroslaw P. Maciejewski, Omar Mian, Babal K. Jha

Blood (2023) 142 (Supplement 1): 2766.

https://doi.org/10.1182/blood-2023-186924

Published: 2023

Journal Articles

Demonstration That Loss of TET2 Impairs DNA Mismatch Repair Resulting in Clonally Restricted Genomic Instability

Dongxu Jiang, Feng Pan, Yihong Guan, Xiaorong Gu, Naomi Kawashima, Divya Jyoti Singh, Danai Dima, Guangbo Qu, Edward F Greenberg, Valeria Visconte, Omar Mian, Mingjiang Xu, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2022) 140 (Supplement 1): 1989–1990.

https://doi.org/10.1182/blood-2022-169467

Published: 2022

Journal Articles

FLT3-ITD Degrades CEBPA Via the Ubiquitin-Proteosome Pathway

Xiaorong Gu, Zeinab Albadry M. Zahran, Nneha Sakre, Caroline Schuerger, Yogenthiran Saunthararajah

Blood (2022) 140 (Supplement 1): 2993–2994.

https://doi.org/10.1182/blood-2022-166612

Published: 2022

Journal Articles

A Novel Approach to Induce ATRA Mediated Differentiation in NPM1 Mutant Acute Myeloid Leukemia

Metis Hasipek, Yihong Guan, Dale Grabowski, Xiaorong Gu, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah, Hetty E. Carraway, Babal K. Jha

Blood (2021) 138 (Supplement 1): 786.

https://doi.org/10.1182/blood-2021-151394

Published: 2021

Journal Articles

Epigenetic Enzyme Mutations in Myeloid Malignancies Are Selected By Chromatin-Remodeling Requirements That Vary By Lineage- and Maturation-Stage

Sunisa Kongkiatkamon, Xiaorong Gu, Kwok Peng Ng, Simona Pagliuca, Vera Adema, Wencke Walter, Yasunobu Nagata, Cassandra M Kerr, Cassandra M Kerr, Manja Meggendorfer, Hassan Awada, Stephan Hutter, Carmelo Gurnari, Claudia Haferlach, Babal K. Jha, Valeria Visconte, Torsten Haferlach, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah

Blood (2021) 138 (Supplement 1): 1148.

https://doi.org/10.1182/blood-2021-153618

Published: 2021

Journal Articles

Role of Oligoadenylate Synthetases in Myeloid Neoplasia

Metis Hasipek, PhD, Yihong Guan, PhD, Dale Grabowski, BS, Xiaorong Gu, PhD, Yogenthiran Saunthararajah, MD, Robert Silverman, PhD, George R Stark, PhD, Jaroslaw Maciejewski, PhD, Babal K. Jha, PhD

Blood (2020) 136 (Supplement 1): 29–30.

https://doi.org/10.1182/blood-2020-142457

Published: 2020

Journal Articles

Venetoclax Inhibition of Pyrimidine Synthesis Guides Methods for Integration with Decitabine or 5-Azacytidine That Are Non-Myelosuppressive

Xiaorong Gu, PhD, Rita Tohme, PhD, Mendel Goldfinger, MD, Benjamin K. Tomlinson, MD, Nneha Sakre, PhD, Shannon Hanmer, Babal K. Jha, PhD, Jaroslaw P. Maciejewski, MD PhD, Amit Verma, MBBS, Yogenthiran Saunthararajah, MD

Blood (2020) 136 (Supplement 1): 26–27.

https://doi.org/10.1182/blood-2020-143200

Published: 2020

Journal Articles

A Novel Therapeutic Strategy for Preferential Elimination of Multiple Myeloma Cells By Targeting Protein Disulfide Isomerase

Metis Hasipek, PhD, Dale Grabowski, BS, Yihong Guan, PhD, Anand D. Tiwari, PhD, Xiaorong Gu, PhD, Jason Valent, MD, Jaroslaw Maciejewski, PhD, Frederic Joel Reu, James G Phillips, PhD, Babal K. Jha, PhD

Blood (2020) 136 (Supplement 1): 32–33.

https://doi.org/10.1182/blood-2020-142847

Published: 2020

NARROW

Decitabine Activity Against TP53 -Mutated Myeloid Neoplasms Is Enhanced By Combination with a Non-Cytotoxic p53/BAX-Independent Inhibitor of Pyrimidine Synthesis

Developing a Therapeutic Strategy for Targeting Metabolic Vulnerability of TET2 Mutant Leukemia

TET2 Regulates Stability of Mismatch Repair Protein MSH6 and Helps Maintain Genomic Stability Independent of Its Dioxygenase Function

Metabolic Reprogramming By IDH1 Neomorph Epigenetically Guides CAR T Cell Differentiation

FLT3-ITD Signaling Continuously Degrades p53 By the Ubiquitin-Proteosome Pathway Explaining Chemo-Resistance

Loss of TET2 Increases MHC Class I Expression in Acute Myeloid Leukemia

Loss of TET2 Creates a Distinct Immunopeptidome in Acute Myeloid Leukemia

Low Regimen Therapeutic Strategies to Mitigate TET2 Mutant Clonal Hematopoiesis

Metabolic Signatures and Pathway Rewiring in TET2-Mutated Myeloid Neoplasia

Fatty Acid Binding Protein FABP5 Inhibition Activates Retinoic Acid Signaling and Induces Differentiation in Acute Myeloid Leukemia

Loss of Function MBD4 Mutation Impairs DNA Repair in Association with TET2 in Acute Myeloid Leukemia

BCR-ABL1 Dislocates NPM1, PU.1 and KLF1 into Cytoplasm to Thereby Skew Granulo-Monocytic and Impede Erythroid Differentiation

Methyl-CpG Binding Domain Protein MBD2 Is a Targetable Vulnerability in TET2 Mutant Myeloid Neoplasia

Demonstration That Loss of TET2 Impairs DNA Mismatch Repair Resulting in Clonally Restricted Genomic Instability

FLT3-ITD Degrades CEBPA Via the Ubiquitin-Proteosome Pathway

A Novel Approach to Induce ATRA Mediated Differentiation in NPM1 Mutant Acute Myeloid Leukemia

Epigenetic Enzyme Mutations in Myeloid Malignancies Are Selected By Chromatin-Remodeling Requirements That Vary By Lineage- and Maturation-Stage

Role of Oligoadenylate Synthetases in Myeloid Neoplasia

Venetoclax Inhibition of Pyrimidine Synthesis Guides Methods for Integration with Decitabine or 5-Azacytidine That Are Non-Myelosuppressive

A Novel Therapeutic Strategy for Preferential Elimination of Multiple Myeloma Cells By Targeting Protein Disulfide Isomerase

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only