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Agnieszka Sroka-Porada
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Journal Articles

River-52: A Multicenter, Open-Label Clinical Trial of RVU120 in Patients with Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia

Cristina Papayannidis, Krzysztof Mądry, Piotr Centkowski, Witold Prejzner, Aleksandra Butrym, Dominik Chraniuk, Chadi Saba, Noemi Angelosanto, Ruth Curley, Hendrik Nogai, Renata Dudziak, Oleksandr Moybenko, Tomasz Rzymski, Milena Mazan, Agnieszka Sroka-Porada, Gary Wilkinson, Eytan M. Stein
Journal: Blood
Blood (2024) 144 (Supplement 1): 6005.
https://doi.org/10.1182/blood-2024-206906
Published: 2024
Journal Articles

River-81: A Multicenter, Open-Label, Dose-Finding Clinical Trial to Assess Safety, PK, PD, Clinical Efficacy of RVU120 in Combination with Venetoclax in Patients with AML Failing Prior Venetoclax Plus Hypomethylating Agent Therapy

Maria Benedetta Giannini, Adolfo De la Fuente Burguera, Adriano Venditti, Witold Prejzner, Sara García, Noemi Angelosanto, Hendrik Nogai, Renata Dudziak, Vakul Mohanty, Natalia Baran, Marta Obacz, Urszula Pakulska, Jerzy Woźnicki, Katarzyna Wiklik, Marta Micek, Tomasz Rzymski, Milena Mazan, Agnieszka Sroka-Porada, Gary Wilkinson, Aleksandra Butrym, Erika Borlenghi, Krzysztof Mądry, Jan Kulis, Diego Coelho, Daniel Grzywczak
Journal: Blood
Blood (2024) 144 (Supplement 1): 5999.
https://doi.org/10.1182/blood-2024-200055
Published: 2024
Journal Articles

Preclinical and Clinical Evidence for Erythroid-Stimulating Activity of RVU120 CDK8/19 Inhibitor in AML and MDS

Noemi Angelosanto, Ewa Lech Marańda, Jan Maciej Zaucha, Camille N. Abboud, Agnieszka Sroka-Porada, Wiktoria Ogrodzińska, Magdalena Kozakowska, Urszula Głowniak-Kwitek, Karolina Bukowska-Strakova, Tomasz Rzymski, Milena Mazan, Urszula Pakulska, Kristina Göller, Ewa Zarzycka, Hendrik Nogai
Journal: Blood
Blood (2023) 142 (Supplement 1): 2800.
https://doi.org/10.1182/blood-2023-189064
Published: 2023
Journal Articles

Targeting CDK8/CDK19 to Disrupt Leukemic Stem Cell-like Population in Acute Myeloid Leukemia: Exploring RVU120 As a Promising Frontline Therapy

Milena Mazan, Urszula Pakulska, Adrianna Moszyńska, Agnieszka Sroka-Porada, Krzysztof Tomasz Szade, Michał Mikula, Magdalena Kozakowska, Przemysław Juszczyński, Katarzyna Wiklik, Kristina Göller, Marta Obacz, Camille N. Abboud, Jan Maciej Zaucha, Ewa Lech Marańda, Noemi Angelosanto, Hendrik Nogai, Tomasz Rzymski
Journal: Blood
Blood (2023) 142 (Supplement 1): 4175.
https://doi.org/10.1182/blood-2023-188866
Published: 2023
Journal Articles

Safety and Efficacy Results from CLI120-001 a Phase 1 Study in RR-AML and HR-MDS: Update from Higher Dose Levels

Ewa Lech Marańda, Elżbieta Patkowska, Natalia Jakacka, Camille N. Abboud, Howard A. Burris, Scott R. Solomon, Noemi Angelosanto, Tomasz Rzymski, Peter Littlewood, Kamil Kuś, Agnieszka Sroka-Porada, Renata Dudziak, Hendrik Nogai, Axel Glasmacher, Terrence Bradley, Gautam Borthakur, Elie Mouhayar, Paweł Steckiewicz, Sylwia Kościółek- Zgódka, Agata Szymańska, Jan Maciej Zaucha
Journal: Blood
Blood (2023) 142 (Supplement 1): 2913.
https://doi.org/10.1182/blood-2023-186620
Published: 2023
Journal Articles

Multiomics Analysis Confirms Effective Target Engagement for RVU120 - a First-in-Class CDK8/19 Kinase Inhibitor in AML and MR-MDS Patients and Reveals the Mechanism of Action

Tomasz Rzymski, Agnieszka Sroka-Porada, Magdalena Kozakowska, Urszula Głowniak-Kwitek, Karolina Bukowska-Strakova, Marta Obacz, Peter Littlewood, Kamil Kuś, Kristina Goller, Kinga Kęska, Urszula Pakulska, Kamila Kozłowska-Tomczyk, Monika Madej, Milena Mazan, Przemyslaw Juszczynski, Jan M. Zaucha, Agnieszka Zarzycka, Noemi Angelosanto, Hendrik Nogai, Krzysztof Brzózka
Journal: Blood
Blood (2022) 140 (Supplement 1): 5939–5940.
https://doi.org/10.1182/blood-2022-168906
Published: 2022