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Journal Articles

Unveiling FLT3 in B-ALL: Molecular drivers and targeted treatment opportunities

Free
Anna Ferrari, Federico Lo Schiavo, Chiara Salvesi, Lorenzo Ledda, Matteo Paganelli, Asia Spedaluzzi, Cristina Papayannidis, Giovanni Marconi, Michela Rondoni, Anna Maria Mianulli, Barbara Giannini, Crescenza Pasciolla, Fabio Giglio, Sara Galimberti, Monica Fumagalli, Prassede Salutari, Valentina Gaidano, Eugenio Fonzi, Maria Benedetta Giannini, Andrea Ghelli Luserna di Rorà, Giovanni Martinelli, Giorgia Simonetti
Journal: Blood
Blood (2025) 146 (Supplement 1): 5148.
https://doi.org/10.1182/blood-2025-5148
Published: 2025
Journal Articles

Efficacy and safety of pivekimab sunirine in blastic plasmacytoid dendritic cell neoplasm in patients with prior or concomitant hematologic malignancy: Results from the cadenza study

Free
Naveen Pemmaraju, Luca Mazzarella, Giovanni Marconi, David Sallman, Matthew Ulrickson, Roland Walter, Valerio Maisano, Breanne Fishman, Yining Du, Jalaja Potluri, Hagop Kantarjian, Naval Daver
Journal: Blood
Blood (2025) 146 (Supplement 1): 5195.
https://doi.org/10.1182/blood-2025-5195
Published: 2025
Journal Articles

The use of danicopan as an add-on therapy in a ravulizumab-treated adult patient with paroxysmal nocturnal hemoglobinuria (PNH) and concomitant stage IV renal failure has induced a marked improvement of anemia and of clinically significant extravascular hemolysis in absence of deterioration of renal function

Free
Francesco Lanza, Barbara Castagnari, Claudia Cellini, Evita Massari, Martina Cantelli, Giovanni Marconi
Journal: Blood
Blood (2025) 146 (Supplement 1): 6446.
https://doi.org/10.1182/blood-2025-6446
Published: 2025
Journal Articles

Preliminary results from RIVER-81, a phase 2 study of romaciclib (RVU120) + venetoclax in patients with acute myeloid leukemia failing first-line venetoclax + hypomethylating agent (HMA)

Free
Pau Montesinos, Adolfo De La Fuente Burguera, Sara Garcia Avila, Thomas Cluzeau, Sylvain Garciaz, Krzysztof Madry, Witold Prejzner, Milena Mazan, Urszula Pakulska, Urszula Glowniak, Jan Kulis, Diego Coelho, Marta Obacz, Agnieszka Sroka-Porada, Gary Wilkinson, Renata Windak, Renata Dudziak, Chadi Saba, Tomasz Rzymski, Hendrik Nogai, Cristina Papayannidis, Giovanni Marconi, Jaroslaw Dybko, Juan Miguel Bergua Burgues, Maria Benedetta Giannini, Ernesta Audisio
Journal: Blood
Blood (2025) 146 (Supplement 1): 3424.
https://doi.org/10.1182/blood-2025-3424
Published: 2025
Journal Articles

NPM1 and IDH1/2 mutations show limited prognostic impact in relapsed AML: Evidence from the avalon cohort

Free
Calogero Vetro, Irene Azzali, Elisabetta Petracci, Cristina Papayannidis, Eleonora Eleuteri, Fanny Erika Palumbo, Vincenzo Federico, Nicola Stefano Fracchiolla, Patrizia Zappasodi, Maria Paola Martelli, Maria Benedetta Giannini, Lorenzo Brunetti, Raffaele Palmieri, jacopo nanni, Giorgia Simonetti, Fabio Guolo, Paola Minetto, Luca Maurillo, Federica Gigli, Atto Billio, Elisabetta Todisco, Giovanni Martinelli, Giovanni Marconi
Journal: Blood
Blood (2025) 146 (Supplement 1): 6967.
https://doi.org/10.1182/blood-2025-6967
Published: 2025
Journal Articles

Prognostic risk integration for survival modeling (PRISM) in newly diagnosed acute myeloid leukemia treated with venetoclax:  a multinational retrospective cohort study

Free
Curtis Lachowiez, Andy Kaempf, Jad Othman, Seongseok Yun, Mael Heiblig, Michael Heuser, Rabia Shahswar, Anand Patel, Rafael Madero-Marroquin, Joseph Cannova, Irene Zacheo, Federica Monaco, Dimitrios Drekolias, Fatima Tuz Zahra, Amine Belhabri, Urbain Tauveron-Jalenques, Emmanuelle Tavernier, Martin Carre, Gaspar Aspas Requena, Nicola Long, Rachel Cook, Elie Traer, Ronan Swords, Jennifer Saultz, Jenny O'Nions, Faisal Basheer, John Laurie, Shivani Handa, Eytan Stein, Maria Baer, Wendy Stock, Rebecca Olin, William Blum, Gary Schiller, Tara Lin, Emily Curran, Ying Huang, Rina Welkie, Ashley Yocum, Giovanni Marconi, Ellen Madarang, Justin Watts, Yazan Madanat, Richard Dillon, Sanam Loghavi, Joshua Zeidner, Daniel Pollyea, Elsa Bernard
Journal: Blood
Blood (2025) 146 (Supplement 1): 453.
https://doi.org/10.1182/blood-2025-453
Published: 2025
Journal Articles

Prognostic relevance of mutational profile in secondary Acute Myeloid Leukemia patients treated with CPX-351.

Free
Carola Riva, Paola Minetto, Giovanni Marconi, Giada Zecchetti, Stefano Nicoletta, Michela Rondoni, Roberta Romei, Ylenia Azzanelli, Nicoletta Colombo, Sara Rosellini, Alessia Parodi, Elisabetta Tedone, Enrico Carminati, Francesco Puglisi, Clara Nurra, Giuseppina Fugazza, Paolo Nozza, Michele Cea, Francesco Lanza, Roberto Lemoli, Fabio Guolo
Journal: Blood
Blood (2025) 146 (Supplement 1): 1623.
https://doi.org/10.1182/blood-2025-1623
Published: 2025
Journal Articles

Efficacy and safety of a retreatment with inotuzumab ozogamicin in adult patients with relapsed/refractory acute lymphoblastic leukemia: A Campus ALL study

Free
Gianluca Cavallaro, Ferdinando Porretto, Patrizia Chiusolo, Cristina Papayannidis, Mario Delia, Nicola Stefano Fracchiolla, Francesco Grimaldi, Matteo Leoncin, Antonino Mule', Mario Annunziata, Immacolata Attolico, Claudia Maria Basilico, Ilaria Capolsini, Daniele G. Mattei, Giovanni Marconi, Matteo Piccini, Chiara Pavoni, Antonio Curti, Robin Foà, Federico Lussana
Journal: Blood
Blood (2025) 146 (Supplement 1): 5127.
https://doi.org/10.1182/blood-2025-5127
Published: 2025
Journal Articles

Centralized MRD Assessment in Gimema AML1718 Trial, a Phase 2 Open-Label Study of Venetoclax Combined with Intensified FLAI Chemotherapy (V-FLAI) As Induction Therapy of Non Low-Risk AML

Free
Paola Minetto, Fabio Guolo, Sara Rosellini, Alfonso Piciocchi, Giovanni Marconi, Ernesta Audisio, Giorgio Priolo, Cristina Papayannidis, Maurizio Martelli, Giovanni Marsili, Monica Bocchia, Francesco Lanza, Albana Lico, Fabio Ciceri, Matteo Giovanni Della Porta, Marco Frigeni, Luisa Giaccone, Germana Beltrami, Erika Borlenghi, Maria Chiara Di Chio, Carmine Selleri, Enrico Crea, Irene Urbino, Chiara Sartor, Clara Minotti, Valentina Arena, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Giuseppe Saglio, Adriano Venditti, Marco Vignetti, Paola Fazi, Elisabetta Tedone, Giovanni Martinelli, Roberto Massimo Lemoli
Journal: Blood
Blood (2024) 144 (Supplement 1): 1574.
https://doi.org/10.1182/blood-2024-198139
Published: 2024
Journal Articles

Venetoclax and Azacitidine for Relapse Prevention in NPM1 -Mutated Acute Myeloid Leukemia in Molecular Failure: Results from the Ongoing Gimema AML2521 Phase 2 Trial

Free
Chiara Sartor, Anna Candoni, Alfonso Piciocchi, Giovanni Marsili, Paola Fazi, Cristina Papayannidis, Stefania Paolini, Gianluca Cristiano, Luca Maurillo, Mario Tiribelli, Antonino Mulè, Melissa Campanelli, Giovanni Marconi, Paola Minetto, Emanuela Ottaviani, Maria Teresa Voso, Francesca Bonifazi, Attilio Olivieri, Pellegrino Musto, Francesco Di Raimondo, Roberto Massimo Lemoli, Maria Paola Martelli, Brunangelo Falini, Michele Cavo, Adriano Venditti, Francesco Buccisano, Antonio Curti
Journal: Blood
Blood (2024) 144 (Supplement 1): 2893.
https://doi.org/10.1182/blood-2024-210315
Published: 2024
Journal Articles

Survival Analysis of Gimema AML1718, a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Free
Giovanni Marconi, Alfonso Piciocchi, Ernesta Audisio, Cristina Papayannidis, Fabio Guolo, Marco Cerrano, Valentina Arena, Saveria Capria, Michela Rondoni, Matteo Giovanni Della Porta, Germana Beltrami, Monica Bocchia, Albana Lico, Luisa Giaccone, Marianna Rossi, Catello Califano, Matteo Giovanni Carrabba, Chiara Cattaneo, Marco Frigeni, Maria Chiara Di Chio, Bianca Serio, Roberto Freilone, Antonio Curti, Paola Minetto, Giovanni Marsili, Clara Minotti, Beatrice Anna Zannetti, Francesca Cotugno, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Sara Rosellini, Elisabetta Tedone, Adriano Venditti, Roberto Massimo Lemoli, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2024) 144 (Supplement 1): 2891.
https://doi.org/10.1182/blood-2024-207842
Published: 2024
Journal Articles

Impact-AML: A European Project for Optimizing Treatment and Assessing Quality of Life in Relapsed/Refractory Acute Myeloid Leukemia Patients

Free
Antonio Maturo, Elisa Castellaccio, Veronica Moretti, Samantha Nier, Giovanni Martinelli, Giovanni Marconi, Gerardo Musuraca, Simone Adelsbach, Martina Vittoria Minguzzi, Maria Belles Esteller
Journal: Blood
Blood (2024) 144 (Supplement 1): 7651.
https://doi.org/10.1182/blood-2024-206970
Published: 2024
Journal Articles

T/NK Cell-Associated Transcriptomic Profile Informs Response to FLT3 Inhibitors in Acute Myeloid Leukemia

Free
Jacopo Nanni, Jayakumar Vadakekolathu, Lorenza Bandini, Marilena Ciciarello, Karyna Volkava, Samantha Bruno, Valentina Robustelli, Letizia Zannoni, Chiara Sartor, Gianluca Cristiano, Federico Zingarelli, Andrea Davide Romagnoli, Caterina Azzimondi, Federica Ardizzoia, Raffaele Ciruolo, Giovanni Marconi, Claudia Venturi, Ajsi Kanapari, Gaia Mazzocchetti, Giorgia Simonetti, Martina Ghetti, Nicoletta Testoni, Sarah Parisi, Stefania Paolini, Simona Soverini, Emanuela Ottaviani, Cristina Papayannidis, Michele Cavo, Sergio Rutella, Antonio Curti
Journal: Blood
Blood (2024) 144 (Supplement 1): 2916.
https://doi.org/10.1182/blood-2024-205994
Published: 2024
Journal Articles

Disease Course and Treatment Patterns of Acute Myeloid Leukemia with FLT3 Mutations and Myeloid Sarcoma Reveal High Efficacy of Gilteritinib: A Multicentric Retrospective Study

Free
Francesco Angotzi, Erika Borlenghi, Chiara Sartor, Maria Benedetta Giannini, Giovanni Marconi, Edoardo Tamellini, Mauro Turrini, Federica Loscocco, Ernesta Audisio, Vincenzo Federico, Calogero Vetro, Andrea Visentin, Carmela Gurrieri, Livio Trentin, Felicetto Ferrara, Federica Lessi
Journal: Blood
Blood (2024) 144 (Supplement 1): 1523.
https://doi.org/10.1182/blood-2024-209605
Published: 2024
Journal Articles

Safety and Tolerability of AZD0466 As Monotherapy for Patients with Advanced Hematologic Malignancies. Results from a Phase I/II Trial

Free
Shukaib Arslan, Giovanni Marconi, Giovanni Martinelli, Shaun Fleming, Antonio Curti, Shira N. Dinner, James S Blachly, Matteo Giovanni Della Porta, Ashish Bajel, Tim Sauer, Martina Crysandt, Arnaud Pigneux, Lars Fransecky, Claudia D Baldus, Marina Y. Konopleva, Yotvat Marmor, Shringi Sharma, Nairouz Elgeioushi, Patricia Cheung, Emily Rowe, Ekaterina Jahn, Ting Yu, Jamal Saeh, Raoul Tibes, Fathima Zumla Cader, Nitin Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 5907.
https://doi.org/10.1182/blood-2023-179168
Published: 2023
Journal Articles

Novel Mechanisms of Venetoclax Resistance in Acute Myeloid Leukemia Based on Genomic Rearrangements

Free
Irene Zacheo, Anna Ferrari, Eugenio Fonzi, Maria Teresa Bochicchio, Giorgia Capirossi, Jacopo Nanni, Matteo Paganelli, Chiara Servilli, Lorenzo Ledda, Martina Ghetti, Mouna Jandoubi, Matteo Marchesini, Agnese Mattei, Giovanni Martinelli, Giovanni Marconi, Giorgia Simonetti
Journal: Blood
Blood (2023) 142 (Supplement 1): 4165.
https://doi.org/10.1182/blood-2023-189435
Published: 2023
Journal Articles

A Phase II Study of Single Agent Aspacytarabine (BST-236) in Adults Unfit for Intensive Chemotherapy with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML) or Higher Risk Myelodysplastic Syndromes (R/R HR MDS)

Free
Marie Anne Hospital, Thomas Cluzeau, Alice Garnier, Giovanni Marconi, Emmanuelle Tavernier, Sylvain Thepot, Aspasia Stamatoullas, Cristina Papayannidis, Sophie Park, Noemie Bigot, Lamya AIT SI Selmi, Fatiha Chermat, Sylvie Chevret, Pierre Fenaux
Journal: Blood
Blood (2023) 142 (Supplement 1): 2923.
https://doi.org/10.1182/blood-2023-185609
Published: 2023
Journal Articles

Pre-Existing Myeloid Subclones May Account for a Subset of Acute Myeloid Leukemias and Myelodysplastic Neoplasms in Patients with Pre-Existing or Contemporary Lymphoid Disorders

Free
Agnese Mattei, Giovanni Marconi, Sonia Ronconi, Delia Cangini, Michela Ceccolini, Claudio Cerchione, Irene Zacheo, Maria Benedetta Giannini, Marianna Norata, Giovanni Martinelli, Anna Ferrari, Maria Teresa Bochicchio, Martina Ghetti, Matteo Marchesini, Giorgia Simonetti, Gerardo Musuraca, Davide Nappi
Journal: Blood
Blood (2023) 142 (Supplement 1): 1475.
https://doi.org/10.1182/blood-2023-186760
Published: 2023
Journal Articles

Final Analysis for the Primary End-Point of Gimema AML1718, a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Free
Giovanni Marconi, Alfonso Piciocchi, Ernesta Audisio, Cristina Papayannidis, Fabio Guolo, Marco Cerrano, Valentina Arena, Capria Saveria, Michela Rondoni, Matteo Giovanni Della Porta, Geramana Beltrami, Monica Bocchia, Albana Lico, Luisa Giaccone, Marianna Rossi, Catello Califano, Matteo Giovanni Carrabba, Chiara Cattaneo, Marco Frigeni, Maria Chiara Di Chio, Bianca Serio, Roberto Freilone, Antonio Curti, Paola Minetto, Giovanni Marsili, Clara Minotti, Beatrice Zannetti, Francesca Cotugno, Jacopo Nanni, Giorgia Simonetti, Maria Teresa Bochicchio, Sara Rosellini, Elisabetta Tedone, Adriano Venditti, Roberto Massimo Lemoli, Marco Vignetti, Paola Fazi, Giovanni Martinelli
Journal: Blood
Blood (2023) 142 (Supplement 1): 1536.
https://doi.org/10.1182/blood-2023-184678
Published: 2023
Journal Articles

Impact-AML: A European Master Framework for Cohort Studies and Pragmatic Clinical Trials in Relapse or Refractory Acute Myeloid Leukemia

Free
Giovanni Marconi, Petros Kountouris, Jiri Mayer, Lars Bullinger, Dirk Reinhardt, Pau Montesinos, Pietro Merli, Marco Vignetti, Jos Dumortier, Jesús María Hernández-Rivas, Michael Heuser, Rolandas Gerbutavicius, Antonio Francesco Maturo, Gianni D'Errico, Samantha Nier, Chiara Zingaretti, Irene Azzali, Federica Campacci, Maria Del Mar Mañú-Pereira, Franco Locatelli, Rüdiger Hehlmann, Dietger W. Niederwieser, Giovanni Martinelli
Journal: Blood
Blood (2023) 142 (Supplement 1): 1533.
https://doi.org/10.1182/blood-2023-184745
Published: 2023