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Journal Articles

Single Cell Genotype-Phenotype Analysis Demonstrates That Post-MPN AML Is Driven By Clonal Evolution and Loss of Transcriptional Heterogeneity within Stem Cell Compartments

Jasmin Straube, Julian Grabek, Leanne Cooper, Rohit Haldar, Caroline McNamara, David M Ross, Andrew Perkins, Megan Bywater, Steven W Lane
Journal: Blood
Blood (2024) 144 (Supplement 1): 1346.
https://doi.org/10.1182/blood-2024-199841
Published: 2024
Journal Articles

Results from the Randomized, Multicenter, Global Phase 3 BOREAS Study: Navtemadlin Versus Best Available Therapy in JAK Inhibitor Relapsed / Refractory Myelofibrosis

John O. Mascarenhas, Viola Maria Popov, Sanjay Mohan, Zübeyde Nur Özkurt, Jean-Jacques Kiladjian, Haifa Kathrin Al-Ali, Andrew Perkins, Zhuying Huang, Hope Qamoos, Jesse McGreivy, Wayne Rothbaum, Srdan Verstovsek, Maciej Kaźmierczak
Journal: Blood
Blood (2024) 144 (Supplement 1): 1000.
https://doi.org/10.1182/blood-2024-201642
Published: 2024
Journal Articles

Disease-Modifying Activity of Navtemadlin Correlates with Clinical Responses in a Randomized, Multicenter, Global Phase 3 Study (BOREAS) in JAK-Inhibitor Relapsed/Refractory Myelofibrosis

John O. Mascarenhas, Prithviraj Bose, Hsin-An Hou, Wojciech Homenda, David Ross, Sanjay R Mohan, Jean-Jacques Kiladjian, Haifa Kathrin Al-Ali, Andrew Perkins, Yulia Khalina, Tracy Clevenger, Zhuying Huang, Jesse McGreivy, Wayne Rothbaum, Srdan Verstovsek, Alessandro M. Vannucchi
Journal: Blood
Blood (2024) 144 (Supplement 1): 483.
https://doi.org/10.1182/blood-2024-205937
Published: 2024
Journal Articles

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Catherine L. Carmichael, Jueqiong Wang, Thao Nguyen, Oluseyi Kolawole, Aissa Benyoucef, Charlotte De Mazière, Anna R. Milne, Sona Samuel, Kevin Gillinder, Soroor Hediyeh-zadeh, Anh N. Q. Vo, Yizhou Huang, Kathy Knezevic, William R. L. McInnes, Benjamin J. Shields, Helen Mitchell, Matthew E. Ritchie, Tim Lammens, Beatrice Lintermans, Pieter Van Vlierberghe, Nicholas C. Wong, Katharina Haigh, Julie A. I. Thoms, Emma Toulmin, David J. Curtis, Ethan P. Oxley, Ross A. Dickins, Dominik Beck, Andrew Perkins, Matthew P. McCormack, Melissa J. Davis, Geert Berx, Johannes Zuber, John E. Pimanda, Benjamin T. Kile, Steven Goossens, Jody J. Haigh
Journal: Blood
Blood (2020) 136 (8): 957–973.
https://doi.org/10.1182/blood.2019002548
Published: 2020
Includes: Supplemental data
Journal Articles

Vascular E-Selectin Acts As a Gatekeeper Inducing Commitment and Loss of Self-Renewal in HSC Transmigrating through the Marrow Vasculature

Ingrid G Winkler, PhD, Valerie Barbier, Masters, Jessica Lowe, BSc(Hons), Joshua Tay, PhD, John L Magnani, PhD, Paula Marlton, Anthony K Mills, FRACP, FRCPA, MBBS, Andrew Perkins, MBBS, PhD FRCPA, FRACP, Corrine E Fiveash, BSc(Hons), Johanna M Erbani, PhDstudent, Jean-Pierre Levesque, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4552.
https://doi.org/10.1182/blood-2018-99-120376
Published: 2018
Journal Articles

KLF1 Acts As a Pioneer Transcription Factor to Open Chromatin and Facilitate Recruitment of GATA1

Kevin R. Gillinder, PhD, Graham Magor, BSc, Charles Bell, BSc, Melissa D. Ilsley, BSc PhD, Stephen Huang, BSc, Andrew Perkins, MBBS, PhD, FRCPA, FRACP
Journal: Blood
Blood (2018) 132 (Supplement 1): 501.
https://doi.org/10.1182/blood-2018-99-119608
Published: 2018
Journal Articles

Relationship of JAK2 V617F Allelic Burden (AB) to Demographics, Disease Characteristics, and Response to Therapy in Persist-1, a Randomized Phase III Study of Pacritinib (PAC) Versus Best Available Therapy (BAT) in Patients (pts) with Primary and Secondary Myelofibrosis (MF)

Alessandro M. Vannucchi, Adam Mead, Miklos Egyed, Anita Szoke, Aleksandr Suvorov, Andrew Perkins, Jiri Mayer, Peter Ganly, Harry C. Schouten, Patrizia Tosi, Charles Michael Farber, Pierre Zachee, Jean-Jacques Kiladjian, Jyoti Nangalia, James P. Dean, Huafeng Zhou, Jack W. Singer, Ruben A. Mesa, Claire N. Harrison
Journal: Blood
Blood (2016) 128 (22): 3131.
https://doi.org/10.1182/blood.V128.22.3131.3131
Published: 2016
Journal Articles

Identifying Novel Modifiers of Embryonic Globin Expression By Combining Chipseq, Rnaseq and eQTL Mapping in the Adult Nan Mouse Model

Danitza Nebor, PhD, Kevin R. Gillinder, PhD, Raymond F. Robledo, PhD, Joel H. Graber, PhD, Vivek Philip, PhD, Melissa Ilsley, BSc, James J. Bieker, PhD, Andrew Perkins, PhD, Luanne L. Peters, PhD
Journal: Blood
Blood (2016) 128 (22): 398.
https://doi.org/10.1182/blood.V128.22.398.398
Published: 2016
Journal Articles

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

Andrew Perkins, Xiangmin Xu, Douglas R. Higgs, George P. Patrinos, Lionel Arnaud, James J. Bieker, Sjaak Philipsen, the KLF1 Consensus Workgroup
Journal: Blood
Blood (2016) 127 (15): 1856–1862.
https://doi.org/10.1182/blood-2016-01-694331
Published: 2016
Includes: Supplemental data
Journal Articles

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

Xunde Wang, Laurel Mendelsohn, Heather Rogers, Susan Leitman, Nalini Raghavachari, Yanqin Yang, Yu Ying Yau, Michael Tallack, Andrew Perkins, James G. Taylor, VI, Constance Tom Noguchi, Gregory J. Kato
Journal: Blood
Blood (2014) 124 (6): 946–954.
https://doi.org/10.1182/blood-2013-11-539718
Published: 2014
Journal Articles

Placenta Growth Factor Is Regulated By Heme-Bound Iron Via Erythroid Krüppel-Like Factor In Erythroid Cells and Is Linked To Iron Status In Vivo In Sickle Cell Disease and Hereditary Hemochromatosis

Xunde Wang, PH.D., Laurel G. Mendelsohn, B.S., Heather Marie Rogers, MS, Susan F. Leitman, MD, Andrew Perkins, PhD, Michael Tallack, PhD, James G Taylor, MD, Constance Tom Noguchi, PhD, Gregory J. Kato, M.D.
Journal: Blood
Blood (2013) 122 (21): 432.
https://doi.org/10.1182/blood.V122.21.432.432
Published: 2013
Journal Articles

A global role for EKLF in definitive and primitive erythropoiesis

Denise Hodge, Elise Coghill, Janelle Keys, Tina Maguire, Belinda Hartmann, Alasdair McDowall, Mitchell Weiss, Sean Grimmond, Andrew Perkins
Journal: Blood
Blood (2006) 107 (8): 3359–3370.
https://doi.org/10.1182/blood-2005-07-2888
Published: 2006
Journal Articles

Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice

Elise Coghill, Sarah Eccleston, Vanessa Fox, Loretta Cerruti, Clark Brown, John Cunningham, Stephen Jane, Andrew Perkins
Journal: Blood
Blood (2001) 97 (6): 1861–1868.
https://doi.org/10.1182/blood.V97.6.1861
Published: 2001