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Journal Articles

Single-Cell Transcriptomic Analysis of Bone Marrow from Humanized Sickle Cell Mice Reveals a Subpopulation of Highly-Expressing S100A8/A9 Mesenchymal Stem Cells

Jacopo Ceolan, Petros Kolovos, Enrica Federti, Panagiotis Liakopoulos, Veronica Riccardi, Immacolata Andolfo, Alessandro Mattè, Roberta Russo, Achille Iolascon, Helene Gleitz, Sjaak Philipsen, Lucia De Franceschi

Blood (2024) 144 (Supplement 1): 3867.

https://doi.org/10.1182/blood-2024-209911

Published: 2024

Journal Articles

Lu/BCAM Expression Defines Functionally Distinct Red Blood Cells

Blood (2024) 144 (Supplement 1): 2454.

https://doi.org/10.1182/blood-2024-209794

Published: 2024

Journal Articles

A ubiquitin ligase toggles red cell differentiation

Thijs C. J. Verheul, Sjaak Philipsen

Blood (2021) 137 (2): 143–144.

https://doi.org/10.1182/blood.2020009697

Published: 2021

Journal Articles

Genetic Heterogeneity of KLF1, a Master Regulator of Erythropoiesis, Revealed an Autosomal Recessive Ψβ-Thalassemia and a Very Strong Promoter In Vivo

Laura Grech, PhD MSc, B.Sc, Joseph Borg, PhDMSc,BSc, Ruth Galdies, M.Sc BPharm, Carmen Attard, Christian A. Scerri, MD PhD, Sjaak Philipsen, PhD, Alexander E. Felice

Blood (2020) 136 (Supplement 1): 7.

https://doi.org/10.1182/blood-2020-143018

Published: 2020

Journal Articles

An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells

Masato Miyata, Nynke Gillemans, Dorit Hockman, Jeroen A. A. Demmers, Jan-Fang Cheng, Jun Hou, Matti Salminen, Christopher A. Fisher, Stephen Taylor, Richard J. Gibbons, Jared J. Ganis, Leonard I. Zon, Frank Grosveld, Eskeatnaf Mulugeta, Tatjana Sauka-Spengler, Douglas R. Higgs, Sjaak Philipsen

Blood (2020) 136 (3): 269–278.

https://doi.org/10.1182/blood.2020004826

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

Andrew Perkins, Xiangmin Xu, Douglas R. Higgs, George P. Patrinos, Lionel Arnaud, James J. Bieker, Sjaak Philipsen, the KLF1 Consensus Workgroup

Blood (2016) 127 (15): 1856–1862.

https://doi.org/10.1182/blood-2016-01-694331

Published: 2016

Includes: Supplemental data

Journal Articles

ASH1L: A Novel Beta-Globin Gene Regulator in Humans?

Amandine Breton, PhD, Laura Sonzogni, PhD, Andria Theodorou, PhD, Suleyman Aktuna, PhD, Stephan Menzel, PhD, Frank Grosveld, PhD, Sjaak Philipsen, PhD, Swee Lay Thein, MD DSc

Blood (2015) 126 (23): 641.

https://doi.org/10.1182/blood.V126.23.641.641

Published: 2015

Journal Articles

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function

Marjolein Meinders, Divine I. Kulu, Harmen J. G. van de Werken, Mark Hoogenboezem, Hans Janssen, Rutger W. W. Brouwer, Wilfred F. J. van Ijcken, Erik-Jan Rijkers, Jeroen A. A. Demmers, Imme Krüger, Timo K. van den Berg, Guntram Suske, Laura Gutiérrez, Sjaak Philipsen

Blood (2015) 125 (12): 1957–1967.

https://doi.org/10.1182/blood-2014-08-593343

Published: 2015

Includes: Multimedia, Supplemental data

Journal Articles

TAF10 Interacts with GATA1 Transcription Factor and Controls Mouse Erythropoiesis

Petros Papadopoulos, PhD, Laura Gutierrez, PhD, Jeroen Demmers, PhD, Dimitris Papageorgiou, PhD, Elena Karkoulia, PhD, John Strouboulis, PhD, Reinier van der Linden, Elisabeth Scheer, Farzin Pourfarzad, PhD, Dick Dekkers, Peter Vandenberghe, MD PhD, Sjaak Philipsen, PhD, Frank Grosveld, PhD, László Tora, PhD

Blood (2014) 124 (21): 2912.

https://doi.org/10.1182/blood.V124.21.2912.2912

Published: 2014

Journal Articles

Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression

Vip Viprakasit, Supachai Ekwattanakit, Suchada Riolueang, Nipon Chalaow, Chris Fisher, Karen Lower, Hitoshi Kanno, Kalaya Tachavanich, Sasithorn Bejrachandra, Jariya Saipin, Monthana Juntharaniyom, Kleebsabai Sanpakit, Voravarn S. Tanphaichitr, Duantida Songdej, Christian Babbs, Richard J. Gibbons, Sjaak Philipsen, Douglas R. Higgs

Blood (2014) 123 (10): 1586–1595.

https://doi.org/10.1182/blood-2013-09-526087

Published: 2014

Includes: Supplemental data

Journal Articles

A new twist to the GATA switch

Sjaak Philipsen

Blood (2013) 122 (20): 3391–3392.

https://doi.org/10.1182/blood-2013-09-527606

Published: 2013

Journal Articles

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice

Fatemehsadat Esteghamat, Nynke Gillemans, Ivan Bilic, Emile van den Akker, Ileana Cantù, Teus van Gent, Ursula Klingmüller, Kirsten van Lom, Marieke von Lindern, Frank Grosveld, Thamar Bryn van Dijk, Meinrad Busslinger, Sjaak Philipsen

Blood (2013) 121 (13): 2553–2562.

https://doi.org/10.1182/blood-2012-06-434530

Published: 2013

Includes: Supplemental data

Journal Articles

Erythropoiesis and Globin Switching in Compound Klf1::Bcl11a mutant mice

Fatemehsadat Esteghamat, Nynke Gillemans, Ivan Bilic, Emile van den Akker, Ileana Cantu', Teus van Gent, Ursula Klingmuller, PhD, Kirsten van Lom, Marieke von Lindern, Frank Grosveld, Thamar van Dijk, Meinrad Busslinger, Sjaak Philipsen, PhD

Blood (2012) 120 (21): 1019.

https://doi.org/10.1182/blood.V120.21.1019.1019

Published: 2012

Journal Articles

Does Quantitative Heterogeneity of Human Fetal Hemoglobin (Hb F) Reveal Friends or Foes of KLF1 in Globin Gene Switching ?

Alexander E. Felice, MD, PhD, Ruth Galdies, BPharm MSc, Joseph Borg, BSc MSc PhD, Godfrey Grech, BSc MPhil PhD, Wilma Cassar, BPharm, Christian A Scerri, MD PhD, George P Patrinos, PhD, Sjaak Philipsen, PhD

Blood (2011) 118 (21): 1092.

https://doi.org/10.1182/blood.V118.21.1092.1092

Published: 2011

Journal Articles

Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis

Sten F. Libregts, Laura Gutiérrez, Alexander M. de Bruin, Felix M. Wensveen, Petros Papadopoulos, Wilfred van Ijcken, Zeliha Özgür, Sjaak Philipsen, Martijn A. Nolte

Blood (2011) 118 (9): 2578–2588.

https://doi.org/10.1182/blood-2010-10-315218

Published: 2011

Includes: Supplemental data

Journal Articles

Chronic IFNγ Production Induces Anemia by Reducing Erythrocyte Lifespan and Inhibiting Erythropoiesis through An IRF-1/PU.1-Axis

Sten F. W. M. Libregts, Laura Gutierrez, PhD, Alexander M. de Bruin, PhD, Felix M. Wensveen, Petros Papadopoulos, PhD, Wilfred van Ijcken, PhD, Zeliha Ozgur, Sjaak Philipsen, PhD, Martijn A. Nolte, PhD

Blood (2010) 116 (21): 4234.

https://doi.org/10.1182/blood.V116.21.4234.4234

Published: 2010

Journal Articles

Fetal globin expression is regulated by Friend of Prmt1

Thamar Bryn van Dijk, Nynke Gillemans, Farzin Pourfarzad, Kirsten van Lom, Marieke von Lindern, Frank Grosveld, Sjaak Philipsen

Blood (2010) 116 (20): 4349–4352.

https://doi.org/10.1182/blood-2010-03-274399

Published: 2010

Includes: Supplemental data

Journal Articles

Vegf regulates embryonic erythroid development through Gata1 modulation

Benjamin Drogat, Joanna Kalucka, Laura Gutiérrez, Hamida Hammad, Steven Goossens, Morvarid Farhang Ghahremani, Sonia Bartunkova, Katharina Haigh, Kim Deswarte, Omar Nyabi, Michael Naessens, Napoleone Ferrara, Ursula Klingmüller, Bart N. Lambrecht, Andras Nagy, Sjaak Philipsen, Jody J. Haigh

Blood (2010) 116 (12): 2141–2151.

https://doi.org/10.1182/blood-2010-01-264143

Published: 2010

Includes: Supplemental data

Journal Articles

Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis

Laura Gutiérrez, Saho Tsukamoto, Mikiko Suzuki, Harumi Yamamoto-Mukai, Masayuki Yamamoto, Sjaak Philipsen, Kinuko Ohneda

Blood (2008) 111 (8): 4375–4385.

https://doi.org/10.1182/blood-2007-09-115121

Published: 2008

Journal Articles

Gata1 regulates dendritic-cell development and survival

Laura Gutiérrez, Tatjana Nikolic, Thamar B. van Dijk, Hamida Hammad, Nanda Vos, Monique Willart, Frank Grosveld, Sjaak Philipsen, Bart N. Lambrecht

Blood (2007) 110 (6): 1933–1941.

https://doi.org/10.1182/blood-2006-09-048322

Published: 2007

Includes: Supplemental data

NARROW

Single-Cell Transcriptomic Analysis of Bone Marrow from Humanized Sickle Cell Mice Reveals a Subpopulation of Highly-Expressing S100A8/A9 Mesenchymal Stem Cells

Lu/BCAM Expression Defines Functionally Distinct Red Blood Cells

A ubiquitin ligase toggles red cell differentiation

Genetic Heterogeneity of KLF1, a Master Regulator of Erythropoiesis, Revealed an Autosomal Recessive Ψβ-Thalassemia and a Very Strong Promoter In Vivo

An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

ASH1L: A Novel Beta-Globin Gene Regulator in Humans?

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function

TAF10 Interacts with GATA1 Transcription Factor and Controls Mouse Erythropoiesis

Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression

A new twist to the GATA switch

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice

Erythropoiesis and Globin Switching in Compound Klf1::Bcl11a mutant mice

Does Quantitative Heterogeneity of Human Fetal Hemoglobin (Hb F) Reveal Friends or Foes of KLF1 in Globin Gene Switching ?

Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis

Chronic IFNγ Production Induces Anemia by Reducing Erythrocyte Lifespan and Inhibiting Erythropoiesis through An IRF-1/PU.1-Axis

Fetal globin expression is regulated by Friend of Prmt1

Vegf regulates embryonic erythroid development through Gata1 modulation

Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis

Gata1 regulates dendritic-cell development and survival

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American Society of Hematology

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American Society of Hematology

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