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Journal Articles

Mutations in AMBRA1 aggravate β-thalassemia by impairing autophagy-mediated clearance of free α-globin

Yong Long, Qianqian Zhang, Ling Ling, Yuan Zhuang, Xiaolei Wei, Haoyang Huang, Zhanping Lu, Yushan Huang, Xianming Chen, Yuhua Ye, Xiaoqin Feng, Haokun hao Zhang, Binbin Huang, Yueyan Huang, Yidan Liang, Mingyan Fang, Yukio Nakamura, Bin Lin, Xinhua Zhang, Daru Lu, Xin Jin, Xiangmin Xu
Journal: Blood
Blood blood.2023022688.
https://doi.org/10.1182/blood.2023022688
Published: 2024
Includes: Supplemental data
Journal Articles

Social Stress Impacts Multicellular Molecular Mechanisms in the Brain Affecting Nociception and Neuroimmune Activity in Sickle Cell Disease

Donovan A Argueta, Carolina Mireles, Kendall O'Daniel, Mya Arellano, Stacy B Kiven, Mingyu Du, Zhiqun Tan, Kevin G Johnston, Xiangmin Xu, Kalpna Gupta
Journal: Blood
Blood (2024) 144 (Supplement 1): 622.
https://doi.org/10.1182/blood-2024-201862
Published: 2024
Journal Articles

Prime Editing of the α-Thalassemia Hb Constant Spring Mutation

Congwen Shao, Qing Liu, Jinchao Xu, Ye Xin, Jianxiang Zhang, Yuhua Ye, Hualei Luo, Xinhua Zhang, Xiangmin Xu, Peng Xu
Journal: Blood
Blood (2023) 142 (Supplement 1): 5001.
https://doi.org/10.1182/blood-2023-185425
Published: 2023
Journal Articles

Safety and Efficacy of RM-001 (Autologous HBG1/2 Promoter-modified CD34+ Hematopoietic Stem and Progenitor Cells) in Patients with Transfusion-Dependent β-Thalassemia

Rongrong Liu, Li Wang, Hui Xu, Xiaolin Yin, Junbin Liang, Wenqiang Xie, Gaohui Yang, Yaoyun Li, Yali Zhou, Lei Shi, Bin Xiao, Lingling Shi, Zeyan Shi, Xuemei Zhou, Xiangmin Xu, Jianpei Fang, Yongrong Lai, Junjiu Huang, Xinhua Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4994.
https://doi.org/10.1182/blood-2023-181453
Published: 2023
Journal Articles

A natural DNMT1 mutation elevates the fetal hemoglobin level via epigenetic derepression of the γ-globin gene in β-thalassemia

Brief Report
Yi Gong, Xinhua Zhang, Qianqian Zhang, Yanxia Zhang, Yuhua Ye, Wenxia Yu, Congwen Shao, Tizhen Yan, Jin Huang, Jianmei Zhong, Li Wang, Yaoyun Li, Liren Wang, Xiangmin Xu
Journal: Blood
Blood (2021) 137 (12): 1652–1657.
https://doi.org/10.1182/blood.2020006425
Published: 2021
Includes: Supplemental data
Journal Articles

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

Andrew Perkins, Xiangmin Xu, Douglas R. Higgs, George P. Patrinos, Lionel Arnaud, James J. Bieker, Sjaak Philipsen, the KLF1 Consensus Workgroup
Journal: Blood
Blood (2016) 127 (15): 1856–1862.
https://doi.org/10.1182/blood-2016-01-694331
Published: 2016
Includes: Supplemental data
Journal Articles

Human STEAP3 mutations with no phenotypic red cell changes

Dun Liu, Sheng Yi, Xinhua Zhang, Ping Fang, Chenguang Zheng, Li Lin, Ren Cai, Yuhua Ye, Yuqiu Zhou, Yunhao Liang, Feng Cheng, Xuelian Zhang, Wanjun Zhou, Narla Mohandas, Xiuli An, Xiangmin Xu
Journal: Blood
Blood (2016) 127 (8): 1067–1071.
https://doi.org/10.1182/blood-2015-09-670174
Published: 2016
Includes: Supplemental data
Journal Articles

KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia

Dun Liu, Xinhua Zhang, Lihua Yu, Ren Cai, Xiaoxia Ma, Chengguang Zheng, Yuqiu Zhou, Qiji Liu, Xiaofeng Wei, Li Lin, Tizhen Yan, Jiwei Huang, Narla Mohandas, Xiuli An, Xiangmin Xu
Journal: Blood
Blood (2014) 124 (5): 803–811.
https://doi.org/10.1182/blood-2014-03-561779
Published: 2014
Includes: Supplemental data