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Journal Articles

Mutations in AMBRA1 aggravate β-thalassemia by impairing autophagy-mediated clearance of free α-globin

Yong Long, Qianqian Zhang, Ling Ling, Yuan Zhuang, Xiaolei Wei, Haoyang Huang, Zhanping Lu, Yushan Huang, Xianming Chen, Yuhua Ye, Xiaoqin Feng, Haokun hao Zhang, Binbin Huang, Yueyan Huang, Yidan Liang, Mingyan Fang, Yukio Nakamura, Bin Lin, Xinhua Zhang, Daru Lu, Xin Jin, Xiangmin Xu
Journal: Blood
Blood blood.2023022688.
https://doi.org/10.1182/blood.2023022688
Published: 2024
Includes: Supplemental data
Journal Articles

Updated Safety and Efficacy Results of RM-001, Autologous HBG1/2 Promoter-Modified CD34+ Hematopoietic Stem and Progenitor Cells, in Treating Transfusion-Dependent β-Thalassemia

Rongrong Liu, Li Wang, Hui Xu, Jianpei Fang, Sixi Liu, Xiaolin Yin, Junbin Liang, Xinyu Li, Yue Li, Gaohui Yang, Yaoyun Li, Yali Zhou, Lei Shi, Yongrong Lai, Junjiu Huang, Xinhua Zhang
Journal: Blood
Blood (2024) 144 (Supplement 1): 4960.
https://doi.org/10.1182/blood-2024-206549
Published: 2024
Journal Articles

First-in-Human Study of Autologous HBA2-Edited CD34+ Hematopoietic Stem and Progenitor Cells in Alpha-Thalassemia with Constant Spring Mutation

Li Wang, Hui Xu, Junbin Liang, Yaoyun Li, Lin Cheng, Ying Luo, Liancheng Huang, Lei Shi, Lihong Zeng, Rongrong Luo, Bin Xiao, Meiping Liu, Liping Huang, Zhendong Xiao, Xinhua Zhang, Junjiu Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 4959.
https://doi.org/10.1182/blood-2024-206807
Published: 2024
Journal Articles

Prime Editing of the α-Thalassemia Hb Constant Spring Mutation

Congwen Shao, Qing Liu, Jinchao Xu, Ye Xin, Jianxiang Zhang, Yuhua Ye, Hualei Luo, Xinhua Zhang, Xiangmin Xu, Peng Xu
Journal: Blood
Blood (2023) 142 (Supplement 1): 5001.
https://doi.org/10.1182/blood-2023-185425
Published: 2023
Journal Articles

Safety and Efficacy of RM-001 (Autologous HBG1/2 Promoter-modified CD34+ Hematopoietic Stem and Progenitor Cells) in Patients with Transfusion-Dependent β-Thalassemia

Rongrong Liu, Li Wang, Hui Xu, Xiaolin Yin, Junbin Liang, Wenqiang Xie, Gaohui Yang, Yaoyun Li, Yali Zhou, Lei Shi, Bin Xiao, Lingling Shi, Zeyan Shi, Xuemei Zhou, Xiangmin Xu, Jianpei Fang, Yongrong Lai, Junjiu Huang, Xinhua Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4994.
https://doi.org/10.1182/blood-2023-181453
Published: 2023
Journal Articles

Efficacy and Safety of Brl-101, CRISPR-Cas9-Mediated Gene Editing of the BCL11A Enhancer in Transfusion-Dependent β-Thalassemia

Biao Zheng, Rongrong Liu, Xinhua Zhang, Bin Fu, Yajing Xu, Jun Shi, Xiaoqin Feng, Li Wang, Chris Wang, Rongmei Liang, Lingzhi Tan, Fei Wang, Dali Li, Yuxuan Wu, Mingyao Liu, Yongrong Lai
Journal: Blood
Blood (2023) 142 (Supplement 1): 4995.
https://doi.org/10.1182/blood-2023-186031
Published: 2023
Journal Articles

A natural DNMT1 mutation elevates the fetal hemoglobin level via epigenetic derepression of the γ-globin gene in β-thalassemia

Brief Report
Yi Gong, Xinhua Zhang, Qianqian Zhang, Yanxia Zhang, Yuhua Ye, Wenxia Yu, Congwen Shao, Tizhen Yan, Jin Huang, Jianmei Zhong, Li Wang, Yaoyun Li, Liren Wang, Xiangmin Xu
Journal: Blood
Blood (2021) 137 (12): 1652–1657.
https://doi.org/10.1182/blood.2020006425
Published: 2021
Includes: Supplemental data
Journal Articles

Human STEAP3 mutations with no phenotypic red cell changes

Dun Liu, Sheng Yi, Xinhua Zhang, Ping Fang, Chenguang Zheng, Li Lin, Ren Cai, Yuhua Ye, Yuqiu Zhou, Yunhao Liang, Feng Cheng, Xuelian Zhang, Wanjun Zhou, Narla Mohandas, Xiuli An, Xiangmin Xu
Journal: Blood
Blood (2016) 127 (8): 1067–1071.
https://doi.org/10.1182/blood-2015-09-670174
Published: 2016
Includes: Supplemental data
Journal Articles

KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia

Dun Liu, Xinhua Zhang, Lihua Yu, Ren Cai, Xiaoxia Ma, Chengguang Zheng, Yuqiu Zhou, Qiji Liu, Xiaofeng Wei, Li Lin, Tizhen Yan, Jiwei Huang, Narla Mohandas, Xiuli An, Xiangmin Xu
Journal: Blood
Blood (2014) 124 (5): 803–811.
https://doi.org/10.1182/blood-2014-03-561779
Published: 2014
Includes: Supplemental data
Journal Articles

Hybrid AAV6/2-Mediated Human β-Globin Expression in β-Thalassemia Patient Hematopoietic Stem Cells Transplanted Into Irradiated BALB/c Nude Mouse

Mengqun Tan, Zhenqing Liu, Juan Zhang, Zhiyan Li, Liujiang Song, Xiaolin Yin, Xinhua Zhang
Journal: Blood
Blood (2011) 118 (21): 4715.
https://doi.org/10.1182/blood.V118.21.4715.4715
Published: 2011
Journal Articles

Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production

Chongyun Fang, Xinhua Zhang, Takashi Miwa, Wen-Chao Song
Journal: Blood
Blood (2009) 114 (5): 1005–1015.
https://doi.org/10.1182/blood-2009-01-198283
Published: 2009
Journal Articles

Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo

Xinhua Zhang, Yuko Kimura, Chongyun Fang, Lin Zhou, Georgia Sfyroera, John D. Lambris, Rick A. Wetsel, Takashi Miwa, Wen-Chao Song
Journal: Blood
Blood (2007) 110 (1): 228–236.
https://doi.org/10.1182/blood-2006-12-063636
Published: 2007