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Loretta Cerruti
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Journal Articles

PRMT5 Inhibition Selectively Targets Acute Myeloid Leukemia Stem Cells Though a p53-Dependent Mechanism

Emma Toulmin, PhD, Stefan Sonderegger, PhD MSc, Loretta Cerruti, BSc, Andrej Terzic, BSc, Feng Yan, BSc, Nicholas Wong, PhD, Ian Street, PhD, Paul Stupple, PhD, Stephen Jane, MD PhD, Andrew H Wei, MBBS, PhD, Rachel Altura, PhD, Benjamin Nicholson, PhD, David J. Curtis, MBBS,PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4061.
https://doi.org/10.1182/blood-2018-99-117835
Published: 2018
Journal Articles

Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms

Stefan Sonderegger, PhD MSc, Loretta Cerruti, BSc, Cedric Tremblay, PhD, Emma Toulmin, PhD, Jesslyn Saw, BSc, Tom Nebl, PhD, Katherine M Hannan, PhD, Steven W. Lane, MD PhD, Hendrik Falk, PhD, Ashwin Unnikrishnan, PhD, Paul Stupple, PhD, Ian Street, PhD, Stephen Jane, MDPhD, Rachel Altura, PhD, Benjamin Nicholson, PhD, David J. Curtis, MBBS,PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 53.
https://doi.org/10.1182/blood-2018-99-118406
Published: 2018
Journal Articles

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

Fiona C. Brown, Ashlee J. Conway, Loretta Cerruti, Janelle E. Collinge, Catriona McLean, James S. Wiley, Ben T. Kile, Stephen M. Jane, David J. Curtis
Journal: Blood
Blood (2015) 126 (26): 2863–2870.
https://doi.org/10.1182/blood-2014-10-609362
Published: 2015
Includes: Supplemental data
Journal Articles

Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression

Gerhard Rank, Loretta Cerruti, Richard J. Simpson, Robert L. Moritz, Stephen M. Jane, Quan Zhao
Journal: Blood
Blood (2010) 116 (9): 1585–1592.
https://doi.org/10.1182/blood-2009-10-251116
Published: 2010
Includes: Supplemental data
Journal Articles

The Protein Methyltransferase Prmt5 Links Histone H4 Methylation to Dnmt3a-Dependent DNA Methylation and Transcriptional Silencing of the Fetal Globin Genes.

Stephen Jane, MD, PhD, Quan Zhao, PhD, Gerhard Rank, PhD, Loretta Cerruti, BSc, David J. Curtis, MD, PhD, John M. Cunningham, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 361.
https://doi.org/10.1182/blood.V108.11.361.361
Published: 2006
Journal Articles

Repression of human γ-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter

Quan Zhao, Wenlai Zhou, Gerhard Rank, Rosemary Sutton, Xi Wang, Helen Cumming, Loretta Cerruti, John M. Cunningham, Stephen M. Jane
Journal: Blood
Blood (2006) 107 (5): 2138–2145.
https://doi.org/10.1182/blood-2005-06-2497
Published: 2006
Journal Articles

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

Nicole M. Haynes, Joseph A. Trapani, Michèle W. L. Teng, Jacob T. Jackson, Loretta Cerruti, Stephen M. Jane, Michael H. Kershaw, Mark J. Smyth, Phillip K. Darcy
Journal: Blood
Blood (2002) 100 (9): 3155–3163.
https://doi.org/10.1182/blood-2002-04-1041
Published: 2002
Journal Articles

Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice

Elise Coghill, Sarah Eccleston, Vanessa Fox, Loretta Cerruti, Clark Brown, John Cunningham, Stephen Jane, Andrew Perkins
Journal: Blood
Blood (2001) 97 (6): 1861–1868.
https://doi.org/10.1182/blood.V97.6.1861
Published: 2001