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Journal Articles

Single Agent and Synergistic Combinatorial Efficacy of First-in-Class Small Molecule Imipridone ONC201 in Hematological Malignancies In Vitro and In Vivo through Apoptosis Via the Integrated Stress Response Pathway

Varun Vijay Prabhu, BPharm, MS, PhD, Mala Kiran Talekar, MD, Amriti R Lulla, MS, C. Leah B Kline, Lanlan Zhou, Junior Hall, A. Pieter J Van den Heuvel, David T Dicker, Stephan A Grupp, MD PhD, Mathew Garnett, Ultan McDermott, Cyril H Benes, Jeffrey J Pu, David F Claxton, MD, Wolfgang Oster, MD, Joshua E. Allen, PhD, Wafik S. El-Deiry

Blood (2017) 130 (Supplement 1): 3842.

https://doi.org/10.1182/blood.V130.Suppl_1.3842.3842

Published: 2017

Journal Articles

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia

Shannon L. Maude, Sibasish Dolai, Cristina Delgado-Martin, Tiffaney Vincent, Alissa Robbins, Arthavan Selvanathan, Theresa Ryan, Junior Hall, Andrew C. Wood, Sarah K. Tasian, Stephen P. Hunger, Mignon L. Loh, Charles G. Mullighan, Brent L. Wood, Michelle L. Hermiston, Stephan A. Grupp, Richard B. Lock, David T. Teachey

Blood (2015) 125 (11): 1759–1767.

https://doi.org/10.1182/blood-2014-06-580480

Published: 2015

Includes: Supplemental data

Journal Articles

mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia

David T. Teachey, Cecilia Sheen, Junior Hall, Theresa Ryan, Valerie I. Brown, Jonathan Fish, Gregor S. D. Reid, Alix E. Seif, Robin Norris, Yueh J. Chang, Martin Carroll, Stephan A. Grupp

Blood (2008) 112 (5): 2020–2023.

https://doi.org/10.1182/blood-2008-02-137141

Published: 2008

Includes: Supplemental data

Journal Articles

Targeting Notch signaling in autoimmune and lymphoproliferative disease

David T. Teachey, Alix E. Seif, Valerie I. Brown, Marlo Bruno, Ralph M. Bunte, Yueh J. Chang, John K. Choi, Jonathan D. Fish, Junior Hall, Gregor S. Reid, Theresa Ryan, Cecilia Sheen, Patrick Zweidler-McKay, Stephan A. Grupp

Blood (2008) 111 (2): 705–714.

https://doi.org/10.1182/blood-2007-05-087353

Published: 2008

Journal Articles

CpG Oligonucleotides Induce Anti-Leukemia Activity in a Syngeneic Murine Model of Acute Lymphoblastic Leukemia.

Alix E. Seif, MD, MPH, Marlo D. Bruno, Junior Hall, Valerie I. Brown, MD, PhD, Stephan A. Grupp, MD, PhD, Gregor S.D. Reid, PhD

Blood (2007) 110 (11): 2830.

https://doi.org/10.1182/blood.V110.11.2830.2830

Published: 2007

Journal Articles

In Vivo Control of Acute Lymphoblastic Leukemia by Immunostimulatory CpG Oligonucleotides.

Gregor S.D. Reid, PhD, Hisaki Fujii, MD, Jacqueline Trudeau, PhD, Junior Hall, Jonathan D. Fish, MD, David T. Teachey, MD, Valerie I. Brown, MD, PhD, Kirk R. Schultz, MD, Stephan A. Grupp, MD, PhD

Blood (2006) 108 (11): 1868.

https://doi.org/10.1182/blood.V108.11.1868.1868

Published: 2006

Journal Articles

Targeting Notch Signaling as a Safe and Effective Treatment for Autoimmune and Lymphoproliferative Diseases.

David T. Teachey, MD, Alix Seif, MD, Junior Hall, Theresa Ryan, Gregor Reid, PhD, Yueh Chang, Valerie Brown, MD, PhD, Stephan A. Grupp, MD, PhD

Blood (2006) 108 (11): 647.

https://doi.org/10.1182/blood.V108.11.647.647

Published: 2006

Journal Articles

Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

David T. Teachey, Dana A. Obzut, Kelly Axsom, John K. Choi, Kelly C. Goldsmith, Junior Hall, Jessica Hulitt, Catherine S. Manno, John M. Maris, Nicholas Rhodin, Kathleen E. Sullivan, Valerie I. Brown, Stephan A. Grupp

Blood (2006) 108 (6): 1965–1971.

https://doi.org/10.1182/blood-2006-01-010124

Published: 2006

Includes: Supplemental data

Journal Articles

mTOR Inhibitors Induce Apoptosis and Inhibit Growth of Primary Adult Human ALL in Xenograft and Tissue Culture Models.

David T. Teachey, MD, Valerie I. Brown, MD, PhD, Junior Hall, Jonathan Cooperman, Dana Obzut, MD, Martin Carroll, MD, John K. Choi, MD, Stephan A. Grupp, MD, PhD

Blood (2004) 104 (11): 2748.

https://doi.org/10.1182/blood.V104.11.2748.2748

Published: 2004

NARROW

Single Agent and Synergistic Combinatorial Efficacy of First-in-Class Small Molecule Imipridone ONC201 in Hematological Malignancies In Vitro and In Vivo through Apoptosis Via the Integrated Stress Response Pathway

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia

mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia

Targeting Notch signaling in autoimmune and lymphoproliferative disease

CpG Oligonucleotides Induce Anti-Leukemia Activity in a Syngeneic Murine Model of Acute Lymphoblastic Leukemia.

In Vivo Control of Acute Lymphoblastic Leukemia by Immunostimulatory CpG Oligonucleotides.

Targeting Notch Signaling as a Safe and Effective Treatment for Autoimmune and Lymphoproliferative Diseases.

Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

mTOR Inhibitors Induce Apoptosis and Inhibit Growth of Primary Adult Human ALL in Xenograft and Tissue Culture Models.

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American Society of Hematology

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American Society of Hematology

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