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Journal Articles

A Multi-Modal Analysis of Acquired Resistance to Acalabrutinib and Pirtobrutinib Provides Potential Strategies to Augment Treatment Outcome with BTKi Drugs

Xiaoyun Wu, Shariful Islam, Derek B Oien, Collin Tokheim, Alex Beacom, Neeraj Aryal, Michelle Hsueh, Muskan Floren, Douglas Ross-Thriepland, Daniel Barrell, Ultan McDermott, Veerendra Munugalavadla, Daniel Auclair, Simon Rule, Arthur Shaffer, Jude Fitzgibbon, Lisa Drew

Blood (2023) 142 (Supplement 1): 1452.

https://doi.org/10.1182/blood-2023-189924

Published: 2023

Journal Articles

Elongator Complex Regulates MCL1 Dependency Via IRE1-XBP1 Axis of the ER Stress Response Pathway in Multiple Myeloma

Neeraj K Aryal, Anjana Sundarrajan, Scott Boiko, David Jenkins, Huayang Liu, Miika Ahdesmaki, Aurelie Bornot, Andrew Jarnuczak, Eric Miele, Ultan McDermott, Stephen Fawell, Lisa Drew, Larry H. Boise, Justin Cidado

Blood (2021) 138 (Supplement 1): 2275.

https://doi.org/10.1182/blood-2021-151194

Published: 2021

Journal Articles

Single Agent and Synergistic Combinatorial Efficacy of First-in-Class Small Molecule Imipridone ONC201 in Hematological Malignancies In Vitro and In Vivo through Apoptosis Via the Integrated Stress Response Pathway

Varun Vijay Prabhu, BPharm, MS, PhD, Mala Kiran Talekar, MD, Amriti R Lulla, MS, C. Leah B Kline, Lanlan Zhou, Junior Hall, A. Pieter J Van den Heuvel, David T Dicker, Stephan A Grupp, MD PhD, Mathew Garnett, Ultan McDermott, Cyril H Benes, Jeffrey J Pu, David F Claxton, MD, Wolfgang Oster, MD, Joshua E. Allen, PhD, Wafik S. El-Deiry

Blood (2017) 130 (Supplement 1): 3842.

https://doi.org/10.1182/blood.V130.Suppl_1.3842.3842

Published: 2017

Journal Articles

The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199

Takenobu Nii, PhD, Jo Ishizawa, MD PhD, Varun Vijay Prabhu, BPharm, MS, PhD, Vivian Ruvolo, PhD, Neel Madhukar, Ran Zhao, Hong Mu, MD PhD, Lauren Heese, Kensuke Kojima, MD PhD, Mathew Garnett, Ultan McDermott, Cyril H Benes, Neil Charter, Sean Deacon, Olivier Elemento, PhD, Joshua E. Allen, PhD, Wolfgang Oster, MD, Martin Stogniew, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 2616.

https://doi.org/10.1182/blood.V130.Suppl_1.2616.2616

Published: 2017

Journal Articles

Single Agent and Combinatorial Efficacy of First-in-Class Small Molecule ONC201 in Acute Leukemia and Multiple Myeloma

Varun V Prabhu, PhD, Amriti Lulla, Christina L Kline, PhD, Peter J Van den Heuvel, PhD, Mala K. Talekar, MD, Jessica M Wagner, Rohinton S Tarapore, PhD, David T Dicker, Mathew J Garnett, PhD, Ultan McDermott, MD PhD, Cyril H Benes, PhD, Jeffrey J. Pu, MD PhD, David F. Claxton, MD, Wolfgang Oster, MD PhD, Joshua E Allen, PhD, Wafik S. El-Deiry, MD PhD

Blood (2016) 128 (22): 2759.

https://doi.org/10.1182/blood.V128.22.2759.2759

Published: 2016

Journal Articles

Potent Anti-Leukemic Effects of Small Molecule ONC212, a Member of the Imipridone Class of Anti-Cancer Compounds

Varun V Prabhu, PhD, Rohinton S Tarapore, PhD, Mathew J Garnett, PhD, Ultan McDermott, MD PhD, Cyril H Benes, PhD, Jessica M Wagner, Wafik S. El-Deiry, MD PhD, Martin Stogniew, PhD, Wolfgang Oster, MD PhD, Joshua E Allen, PhD

Blood (2016) 128 (22): 5133.

https://doi.org/10.1182/blood.V128.22.5133.5133

Published: 2016

Journal Articles

Personally Tailored Risk Prediction of AML Based on Comprehensive Genomic and Clinical Data

Moritz Gerstung, PhD, Elli Papaemmanuil, PhD, Inigo Martincorena, PhD, Lars Bullinger, MD, Verena I. Gaidzik, MD, Peter Paschka, MD, Michael Heuser, MD, Felicitas Thol, MD, Niccolo Bolli, MD PhD, Peter Ganly, BMBCh, PhD, Arnold Ganser, MD, Ultan McDermott, MD PhD, Michael R Stratton, MD PhD, Konstanze Döhner, MD, Hartmut Döhner, Prof. Dr., Richard F. Schlenk, MD, Peter J Campbell, MD PhD

Blood (2015) 126 (23): 85.

https://doi.org/10.1182/blood.V126.23.85.85

Published: 2015

Journal Articles

A Crispr/Cas9 Drop-out Screen Identifies Genome-Wide Genetic Valnerubilities in Acute Myeloid Leukaemia

Blood (2015) 126 (23): 554.

https://doi.org/10.1182/blood.V126.23.554.554

Published: 2015

NARROW

A Multi-Modal Analysis of Acquired Resistance to Acalabrutinib and Pirtobrutinib Provides Potential Strategies to Augment Treatment Outcome with BTKi Drugs

Elongator Complex Regulates MCL1 Dependency Via IRE1-XBP1 Axis of the ER Stress Response Pathway in Multiple Myeloma

Single Agent and Synergistic Combinatorial Efficacy of First-in-Class Small Molecule Imipridone ONC201 in Hematological Malignancies In Vitro and In Vivo through Apoptosis Via the Integrated Stress Response Pathway

The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199

Single Agent and Combinatorial Efficacy of First-in-Class Small Molecule ONC201 in Acute Leukemia and Multiple Myeloma

Potent Anti-Leukemic Effects of Small Molecule ONC212, a Member of the Imipridone Class of Anti-Cancer Compounds

Personally Tailored Risk Prediction of AML Based on Comprehensive Genomic and Clinical Data

A Crispr/Cas9 Drop-out Screen Identifies Genome-Wide Genetic Valnerubilities in Acute Myeloid Leukaemia

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American Society of Hematology

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American Society of Hematology

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