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Journal Articles

Single Agent and Synergistic Combinatorial Efficacy of First-in-Class Small Molecule Imipridone ONC201 in Hematological Malignancies In Vitro and In Vivo through Apoptosis Via the Integrated Stress Response Pathway

Varun Vijay Prabhu, BPharm, MS, PhD, Mala Kiran Talekar, MD, Amriti R Lulla, MS, C. Leah B Kline, Lanlan Zhou, Junior Hall, A. Pieter J Van den Heuvel, David T Dicker, Stephan A Grupp, MD PhD, Mathew Garnett, Ultan McDermott, Cyril H Benes, Jeffrey J Pu, David F Claxton, MD, Wolfgang Oster, MD, Joshua E. Allen, PhD, Wafik S. El-Deiry

Blood (2017) 130 (Supplement 1): 3842.

https://doi.org/10.1182/blood.V130.Suppl_1.3842.3842

Published: 2017

Journal Articles

Single Agent and Combinatorial Efficacy of First-in-Class Small Molecule ONC201 in Acute Leukemia and Multiple Myeloma

Varun V Prabhu, PhD, Amriti Lulla, Christina L Kline, PhD, Peter J Van den Heuvel, PhD, Mala K. Talekar, MD, Jessica M Wagner, Rohinton S Tarapore, PhD, David T Dicker, Mathew J Garnett, PhD, Ultan McDermott, MD PhD, Cyril H Benes, PhD, Jeffrey J. Pu, MD PhD, David F. Claxton, MD, Wolfgang Oster, MD PhD, Joshua E Allen, PhD, Wafik S. El-Deiry, MD PhD

Blood (2016) 128 (22): 2759.

https://doi.org/10.1182/blood.V128.22.2759.2759

Published: 2016

Journal Articles

Potent Anti-Leukemic Effects of Small Molecule ONC212, a Member of the Imipridone Class of Anti-Cancer Compounds

Varun V Prabhu, PhD, Rohinton S Tarapore, PhD, Mathew J Garnett, PhD, Ultan McDermott, MD PhD, Cyril H Benes, PhD, Jessica M Wagner, Wafik S. El-Deiry, MD PhD, Martin Stogniew, PhD, Wolfgang Oster, MD PhD, Joshua E Allen, PhD

Blood (2016) 128 (22): 5133.

https://doi.org/10.1182/blood.V128.22.5133.5133

Published: 2016

Journal Articles

ONC201 Possesses a Benign Safety Profile at Highly Efficacious Doses in Normal Human Cells and Animal Toxicology Studies

Joshua E. Allen, PhD, Jo Ishizawa, MD PhD, Wafik S. El-Deiry, MD PhD F.A.C.P, Michael Andreeff, MD PhD

Blood (2014) 124 (21): 4812.

https://doi.org/10.1182/blood.V124.21.4812.4812

Published: 2014

Journal Articles

ONC201 Depletes Cancer Stem Cells in Refractory Cancer Patient Samples

Varun Vijay Prabhu, Jo Ishizawa, MD PhD, Dan Zhao, MD PhD, Joshua E. Allen, PhD, Tracy T. Batchelor, MD, Andrew S. Chi, MD PhD, Michael Andreeff, MD PhD, Wafik S. El-Deiry, MD PhD F.A.C.P

Blood (2014) 124 (21): 5219.

https://doi.org/10.1182/blood.V124.21.5219.5219

Published: 2014

Journal Articles

Caspase-Dependent Anti-Tumor Effects of ONC201/TIC10 on Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM)

Amriti R. Lulla, Christina Leah B Kline, PhD, Liz J. Hernandez-Borrero, Varun Vijay Prabhu, Jessica M Wagner, David T. Dicker, Nathan G. Dolloff, PhD, Brian M Barth, PhD, Jeffrey J Pu, MD PhD, David F. Claxton, MD, Joshua E. Allen, PhD, Wafik S. El-Deiry, MD PhD FACP

Blood (2014) 124 (21): 5224.

https://doi.org/10.1182/blood.V124.21.5224.5224

Published: 2014

Journal Articles

Screen of Small Molecule ONC201/TIC10 Identifies Single Agent Activity and Combinatorial Efficacy with Bortezomib, Rituximab or Dexamethasone in Killing of Acute Lymphoblastic Leukemia Cells

Jessica M Wagner, Varun Vijay Prabhu, Leah L. Kline, PhD, Amriti R. Lulla, Liz J. Hernandez-Borrero, Jeffrey J. Pu, MD PhD, David T. Dicker, Brian M Barth, PhD, David F. Claxton, MD, Joshua E. Allen, PhD, Wafik S. El-Deiry, MD PhD FACP

Blood (2014) 124 (21): 5233.

https://doi.org/10.1182/blood.V124.21.5233.5233

Published: 2014

Journal Articles

ONC201/TIC10 Is Effective As a Monoagent and Synergizes with Chemotherapy to Induce Cell Death in Non-Hodgkin Lymphoma

Mala K. Talekar, MD, Josh Allen, PhD, David T. Dicker, Wafik S. El-Deiry, MD PhD FACP

Blood (2014) 124 (21): 5491.

https://doi.org/10.1182/blood.V124.21.5491.5491

Published: 2014

Journal Articles

Small Molecule ONC201/TIC10 Induces Caspase-Dependent Apoptosis in Acute Lymphoblastic Leukemia Cells Via Modulation of Bcl-2 and IAP Family Proteins

Varun Vijay Prabhu, Amriti R. Lulla, Jessica M Wagner, Liz J. Hernandez-Borrero, Mala K. Talekar, MD, Christina L. Kline, PhD, David T. Dicker, Brian M Barth, PhD, Jeffrey J. Pu, MD PhD, David F. Claxton, MD, Joshua E. Allen, PhD, Wafik S. El-Deiry, MD PhD FACP

Blood (2014) 124 (21): 5237.

https://doi.org/10.1182/blood.V124.21.5237.5237

Published: 2014

Journal Articles

Synergistic Effect of Quinacrine with Chemotherapeutics or TRAIL in Hematopoietic Malignant Cells

Wenge Wang, MD PhD, Amriti R. Lulla, Liz J. Hernandez-Borrero, David T. Dicker, Emmanuel K. Teye, Mala K. Talekar, MD, Nathan G. Dolloff, PhD, Jeffrey J. Pu, MD PhD, Wafik S. El-Deiry, MD PhD

Blood (2014) 124 (21): 5239.

https://doi.org/10.1182/blood.V124.21.5239.5239

Published: 2014

Journal Articles

ONC201(TIC10) Induces TRAIL and Cell Death In Preclinical Models Of Pediatric Lymphoma

Mala Kiran Talekar, MD, Joshua E Allen, PhD, Wafik S. El-Deiry, M.D, Ph.D, F.A.C.P

Blood (2013) 122 (21): 1671.

https://doi.org/10.1182/blood.V122.21.1671.1671

Published: 2013

Journal Articles

ONC201 Exerts p53-Independent Cytotoxicity Through TRAIL and DR5 Induction In Mantle Cell Lymphomas

Jo Ishizawa, MD, PhD, Kensuke Kojima, MD, PhD, Archana Dilip, MS, Vivian R Ruvolo, MA, Bing Z Carter, PhD, Joshua E Allen, PhD, Sattva S. Neelapu, MD, Timothy J. McDonnell, MD, PhD, Mala Kiran Talekar, MD, Wafik S. El-Deiry, MD, Larry W. Kwak, MD, PhD, Michael Andreeff, MD, PhD

Blood (2013) 122 (21): 3822.

https://doi.org/10.1182/blood.V122.21.3822.3822

Published: 2013

NARROW

Single Agent and Synergistic Combinatorial Efficacy of First-in-Class Small Molecule Imipridone ONC201 in Hematological Malignancies In Vitro and In Vivo through Apoptosis Via the Integrated Stress Response Pathway

Single Agent and Combinatorial Efficacy of First-in-Class Small Molecule ONC201 in Acute Leukemia and Multiple Myeloma

Potent Anti-Leukemic Effects of Small Molecule ONC212, a Member of the Imipridone Class of Anti-Cancer Compounds

ONC201 Possesses a Benign Safety Profile at Highly Efficacious Doses in Normal Human Cells and Animal Toxicology Studies

ONC201 Depletes Cancer Stem Cells in Refractory Cancer Patient Samples

Caspase-Dependent Anti-Tumor Effects of ONC201/TIC10 on Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM)

Screen of Small Molecule ONC201/TIC10 Identifies Single Agent Activity and Combinatorial Efficacy with Bortezomib, Rituximab or Dexamethasone in Killing of Acute Lymphoblastic Leukemia Cells

ONC201/TIC10 Is Effective As a Monoagent and Synergizes with Chemotherapy to Induce Cell Death in Non-Hodgkin Lymphoma

Small Molecule ONC201/TIC10 Induces Caspase-Dependent Apoptosis in Acute Lymphoblastic Leukemia Cells Via Modulation of Bcl-2 and IAP Family Proteins

Synergistic Effect of Quinacrine with Chemotherapeutics or TRAIL in Hematopoietic Malignant Cells

ONC201(TIC10) Induces TRAIL and Cell Death In Preclinical Models Of Pediatric Lymphoma

ONC201 Exerts p53-Independent Cytotoxicity Through TRAIL and DR5 Induction In Mantle Cell Lymphomas

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American Society of Hematology

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American Society of Hematology

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