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Julie A.I. Thoms
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Journal Articles

Clinical Response to Azacitidine in Myelodysplastic Neoplasms Is Associated with Distinct DNA Methylation Changes in Haematopoietic Stem and Progenitor Cells In Vivo

Julie A.I. Thoms, Feng Yan, Henry R. Hampton, Sarah Davidson, Swapna Joshi, Jesslyn Saw, Chowdhury H. Sarowar, Xin Ying Lim, Andrea C Nunez, Purvi M. Kakadia, Golam Sarower Bhuyan, Xiaoheng Zou, Mary Nguyen, Elaheh S Ghodousi, Forrest C Koch, Fatemeh Vafaee, I. Richard Thompson, Mohammad M. Karimi, Russell Pickford, Mark J Raftery, Sally Hough, Griselda Buckland, Michelle Bailey, Yuvaraj Ghodke, Noorul Absar, Lachlin Vaughan, Leonardo Pasalic, Chun Yew Fong, Melita Kenealy, Devendra Hiwase, Rohanna Stoddart, Soma Mohammed, Linda Lee, Freda H Passam, Stephen Robert Larsen, Kevin J Spring, Kristen K Skarratt, Patricia Rebeiro, Peter Presgrave, William S Stevenson, Silvia Ling, Campbell Tiley, Stephen Fuller, Fernando Roncolato, Anoop K Enjeti, Dirk Hoenemann, Charlotte Lemech, Christopher J Jolly, Stefan K. Bohlander, David J. Curtis, Jason Wong, Ashwin Unnikrishnan, Mark S. Hertzberg, Jake Olivier, Mark N Polizzotto, John E Pimanda
Journal: Blood
Blood (2024) 144 (Supplement 1): 3223.
https://doi.org/10.1182/blood-2024-201216
Published: 2024
Journal Articles

Clinical Response to Azacytidine (AZA) Is Associated with Increased Contribution from Mutated Blood Progenitors: Insights from Single Cell Genotyping of Matched Stem/Progenitor and Mature Blood Cells from MDS/CMML Patients Pre- and Post-AZA Treatment

Julie A.I. Thoms, Annatina Schnegg-Kaufmann, Golam Sarower Bhuyan, Henry R. Hampton, Lachlin Vaughan, Kayleigh Rutherford, Purvi M. Kakadia, Hui Mei Lee, Emma Johansson, Tim W. Failes, Greg M. Arndt, Jason Koval, Sarah Davidson, Robert Lindeman, Pauline Warburton, Alba Rodriguez-Meira, Adam J Mead, Ashwin Unnikrishnan, Mark Hertzberg, Mark N. Polizzotto, Elli Papaemmanuil, Stefan K. Bohlander, Omid Faridani, Christopher J. Jolly, Fabio Zanini, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 9751–9752.
https://doi.org/10.1182/blood-2022-163158
Published: 2022
Journal Articles

Comparative Analysis of Genome-Scale Gene Regulatory Networks in Human Hematopoietic Stem and Myeloid Progenitor Fractions

Shruthi Subramanian, Julie A.I. Thoms, Yizhou Huang, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S Woll, Diego Chacon Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O' Brien, Annette Trickett, Jason Powell, Stuart M Pitson, Maher K. Gandhi, Paola Cornejo, Emily Wong, Steven W Lane, Bertie Gottgens, Hamid Alinejad Rokny, Jason W.H Wong, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 2846–2848.
https://doi.org/10.1182/blood-2022-165620
Published: 2022
Journal Articles

In Vivo Drug Incorporation and Intracellular Dynamics of Injectable Versus Oral Azacytidine: A Phase II Open Label Multicentre Trial

John E. Pimanda, Julie A.I. Thoms, Henry R. Hampton, Sarah Davidson, Swapna Joshi, Chowdhury H. Sarowar, Xin Ying Lim, Andrea C. Nunez, Purvi M. Kakadia, Russell Pickford, Mark Raftery, Sally Hough, Griselda Buckland, Michelle Bailey, Yuvaraj Ghodke, Noorul Absar, Lachlin Vaughan, Leonardo Pasalic, Chun Yew Fong, Melita Kenealy, Devendra Hiwase, Rohanna Stoddart, Soma Mohammed, Linda Lee, Freda H. Passam, Kevin Spring, Kristy K. Skarratt, Patricia Rebeiro, Stephen R Larsen, Peter Presgrave, William S Stevenson, Silvia Ling, Campbell Tiley, Stephen Fuller, Fernando Roncolato, Anoop Kumar Enjeti, Dirk Hoenemann, Charlotte Lemech, Stefan K. Bohlander, Jake Olivier, Mark Hertzberg, Ashwin Unnikrishnan, Mark N. Polizzotto
Journal: Blood
Blood (2022) 140 (Supplement 1): 6927–6929.
https://doi.org/10.1182/blood-2022-157634
Published: 2022
Journal Articles

Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia

Peter Truong, Sylvie Shen, Swapna Joshi, Ali Afrasiabi, Ling Zhong, Mark J. Raftery, Jonas Larsson, Richard B. Lock, Carl R. Walkley, Hamid Alinejad Rokny, Julie A.I. Thoms, Christopher J. Jolly, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 220–221.
https://doi.org/10.1182/blood-2022-165713
Published: 2022
Journal Articles

A Tissue-Specific Transcriptional Element for C/ebpa Is Required for HSC Maintenance and Neutrophil Development

Roberto Avellino, Marije Havermans, Claudia Erpelinck, Mathijs Sanders, Stefan Groeschel, Harmen Vandewerken, Remco M. Hoogenboezem, M.Sc., Elwin Rombouts, Kirsten Van Lom, Paulette Van Strien, Hans De Looper, Claudia Christine Gebhard, Michael Rehli, Dominik Beck, PhD, Julie A.I. Thoms, PhD, Stefan Erkeland, Ivo Touw, John E. Pimanda, MDPhD, Eric JM Bindels, Ruud Delwel
Journal: Blood
Blood (2015) 126 (23): 301.
https://doi.org/10.1182/blood.V126.23.301.301
Published: 2015
Journal Articles

An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML

Ashwin Unnikrishnan, PhD, Elli Papaemmanuil, PhD, Dominik Beck, PhD, Arjun Verma, B.Sc., Ashu Kumari, PhD, Laura A. Richards, Kathy Knezevic, Vashe Chandrakanthan, PhD, Julie A.I. Thoms, PhD, Melinda L. Tursky, PhD, Yizhou Huang, Sally Galbraith, PhD, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Magnus Tobiasson, MD, Petter S. Woll, PhD, Andrea Pellagatti, PhD, Susan R. Wilson, PhD, Robert Lindeman, MD, Jacqueline Boultwood, PhD, Kevin Lynch, MBBS, Sten Eirik Jacobsen, Ghulam J Mufti, FRCP, FRCPath, Eva Hellstrom-Lindberg, MD PhD, Karen Lee Mackenzie, PhD, Jason W.H. Wong, PhD, Peter J Campbell, MD PhD, John E. Pimanda, MDPhD
Journal: Blood
Blood (2015) 126 (23): 710.
https://doi.org/10.1182/blood.V126.23.710.710
Published: 2015