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Ashwin Unnikrishnan
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Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy

Brief Report
Annatina S. Schnegg-Kaufmann, Julie A. I. Thoms, Golam Sarower Bhuyan, Henry R. Hampton, Lachlin Vaughan, Kayleigh Rutherford, Purvi M. Kakadia, Hui Mei Lee, Emma M. V. Johansson, Timothy W. Failes, Greg M. Arndt, Jason Koval, Robert Lindeman, Pauline Warburton, Alba Rodriguez-Meira, Adam J. Mead, Ashwin Unnikrishnan, Sarah Davidson, Mark N. Polizzotto, Mark Hertzberg, Elli Papaemmanuil, Stefan K. Bohlander, Omid R. Faridani, Christopher J. Jolly, Fabio Zanini, John E. Pimanda
Journal: Blood
Blood (2023) 141 (11): 1316–1321.
https://doi.org/10.1182/blood.2022018602
Published: 2023
Includes: Supplemental data
Journal Articles

Clinical Response to Azacytidine (AZA) Is Associated with Increased Contribution from Mutated Blood Progenitors: Insights from Single Cell Genotyping of Matched Stem/Progenitor and Mature Blood Cells from MDS/CMML Patients Pre- and Post-AZA Treatment

Julie A.I. Thoms, Annatina Schnegg-Kaufmann, Golam Sarower Bhuyan, Henry R. Hampton, Lachlin Vaughan, Kayleigh Rutherford, Purvi M. Kakadia, Hui Mei Lee, Emma Johansson, Tim W. Failes, Greg M. Arndt, Jason Koval, Sarah Davidson, Robert Lindeman, Pauline Warburton, Alba Rodriguez-Meira, Adam J Mead, Ashwin Unnikrishnan, Mark Hertzberg, Mark N. Polizzotto, Elli Papaemmanuil, Stefan K. Bohlander, Omid Faridani, Christopher J. Jolly, Fabio Zanini, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 9751–9752.
https://doi.org/10.1182/blood-2022-163158
Published: 2022
Journal Articles

In Vivo Drug Incorporation and Intracellular Dynamics of Injectable Versus Oral Azacytidine: A Phase II Open Label Multicentre Trial

John E. Pimanda, Julie A.I. Thoms, Henry R. Hampton, Sarah Davidson, Swapna Joshi, Chowdhury H. Sarowar, Xin Ying Lim, Andrea C. Nunez, Purvi M. Kakadia, Russell Pickford, Mark Raftery, Sally Hough, Griselda Buckland, Michelle Bailey, Yuvaraj Ghodke, Noorul Absar, Lachlin Vaughan, Leonardo Pasalic, Chun Yew Fong, Melita Kenealy, Devendra Hiwase, Rohanna Stoddart, Soma Mohammed, Linda Lee, Freda H. Passam, Kevin Spring, Kristy K. Skarratt, Patricia Rebeiro, Stephen R Larsen, Peter Presgrave, William S Stevenson, Silvia Ling, Campbell Tiley, Stephen Fuller, Fernando Roncolato, Anoop Kumar Enjeti, Dirk Hoenemann, Charlotte Lemech, Stefan K. Bohlander, Jake Olivier, Mark Hertzberg, Ashwin Unnikrishnan, Mark N. Polizzotto
Journal: Blood
Blood (2022) 140 (Supplement 1): 6927–6929.
https://doi.org/10.1182/blood-2022-157634
Published: 2022
Journal Articles

Identification of Recurrent Alternative RNA Splicing in Adverse-Risk Acute Myeloid Leukemia

Govardhan Anande, Ashwin Unnikrishnan, PhD, Nandan Deshpande, PhD, Sylvain Mareschal, Aarif M. N. Batcha, Tobias Herold, MD, Sören Lehmann, MD PhD, Marc Wilkins, PhD, Jason Wong, PhD, John Pimanda, MBBS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 457.
https://doi.org/10.1182/blood-2019-129537
Published: 2019
Journal Articles

In Vivo Assessment of Intracellular Dynamics Comparing Injection Versus Oral Azacitidine in a Phase IIb Investigator Initiated Clinical Trial

Ashwin Unnikrishnan, PhD, Xin Ying Lim, PhD, Swapna Joshi, Andrea C. Nunez, PhD, Lachlin Vaughan, MBBS, BSc, FRACP, FRCPA, Russell Pickford, PhD, Sally Hough, Sarah Davidson, Chun Fong, Melita Kenealy, MD, Devendra K Hiwase, MBBS, MD FRACP, FRCPA, PhD, Leonardo Pasalic, MBBS, PhD, Soma Mohammed, Linda Lee, PhD, Freda H. Passam, MD PhD, Kevin Spring, PhD, Patricia Rebeiro, MD, Silvia Ling, MBBS, PhD, Stephen Fuller, MBBS, PhD, Peter Presgrave, MBBS, Fernando Roncolato, BMed, FRACP, FRCPA, Stephen Larsen, MBBS, PhD FRACP, FRCPA, Anoop K Enjeti, MBBS,FRCPA, FRACP,PhDMD,MRCP, William S. Stevenson, MBBS, PhD, Campbell Tiley, MBBS, FRACP, Peter J Campbell, Charlotte Lemech, MD FRACP, Jake Olivier, PhD, Mark Hertzberg, MD MBBS, PhD, Mark N. Polizzotto, MBBS, FRACP, FRCPA, John Pimanda, MBBS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4247.
https://doi.org/10.1182/blood-2019-123921
Published: 2019
Journal Articles

Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms

Stefan Sonderegger, PhD MSc, Loretta Cerruti, BSc, Cedric Tremblay, PhD, Emma Toulmin, PhD, Jesslyn Saw, BSc, Tom Nebl, PhD, Katherine M Hannan, PhD, Steven W. Lane, MD PhD, Hendrik Falk, PhD, Ashwin Unnikrishnan, PhD, Paul Stupple, PhD, Ian Street, PhD, Stephen Jane, MDPhD, Rachel Altura, PhD, Benjamin Nicholson, PhD, David J. Curtis, MBBS,PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 53.
https://doi.org/10.1182/blood-2018-99-118406
Published: 2018
Journal Articles

Srsf2 P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells

Monique F. Smeets, Shuh Ying Tan, Jane Jialu Xu, Govardhan Anande, Ashwin Unnikrishnan, Alistair M. Chalk, Scott R. Taylor, John E. Pimanda, Meaghan Wall, Louise E. Purton, Carl R. Walkley
Journal: Blood
Blood (2018) 132 (6): 608–621.
https://doi.org/10.1182/blood-2018-04-845602
Published: 2018
Includes: Supplemental data
Journal Articles

Granulomonocytic Progenitors (GMPs) Are Key Target Cells of Azacitidine in MDS and AML

Ashfaq Ali, PhD, Justine Penneroux, Reinaldo Dal Bello Jr, Aline Massé, Samuel Quentin, Ashwin Unnikrishnan, PhD, Lucie Hernandez, Emmanuel Raffoux, MD, Raouf Benabelali, Aline Renneville, MDPhD, Claude Preudhomme, PharmD, PhD, John Pimanda, PhDFRACP,FRCPA,MBBS, Herve Dombret, MD, Jean Soulier, MDPhD, Pierre Fenaux, MD PhD, Emmanuelle Clappier, PharmD,PhD, Lionel Ades, MD PhD, Raphael Itzykson, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 587.
https://doi.org/10.1182/blood.V130.Suppl_1.587.587
Published: 2017
Journal Articles

Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

Rabab Nasrallah, Eva M. Fast, Parham Solaimani, Kathy Knezevic, Alexia Eliades, Rahima Patel, Roshana Thambyrajah, Ashwin Unnikrishnan, Julie Thoms, Dominik Beck, Chris S. Vink, Aileen Smith, Jason Wong, Mairi Shepherd, David Kent, Rahul Roychoudhuri, Fabian Paul, Julia Klippert, Annette Hammes, Thomas Willnow, Bertie Göttgens, Elaine Dzierzak, Leonard I. Zon, George Lacaud, Valerie Kouskoff, John E. Pimanda
Journal: Blood
Blood (2016) 128 (15): 1928–1939.
https://doi.org/10.1182/blood-2016-02-697870
Published: 2016
Includes: Supplemental data
Journal Articles

An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML

Ashwin Unnikrishnan, PhD, Elli Papaemmanuil, PhD, Dominik Beck, PhD, Arjun Verma, B.Sc., Ashu Kumari, PhD, Laura A. Richards, Kathy Knezevic, Vashe Chandrakanthan, PhD, Julie A.I. Thoms, PhD, Melinda L. Tursky, PhD, Yizhou Huang, Sally Galbraith, PhD, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Magnus Tobiasson, MD, Petter S. Woll, PhD, Andrea Pellagatti, PhD, Susan R. Wilson, PhD, Robert Lindeman, MD, Jacqueline Boultwood, PhD, Kevin Lynch, MBBS, Sten Eirik Jacobsen, Ghulam J Mufti, FRCP, FRCPath, Eva Hellstrom-Lindberg, MD PhD, Karen Lee Mackenzie, PhD, Jason W.H. Wong, PhD, Peter J Campbell, MD PhD, John E. Pimanda, MDPhD
Journal: Blood
Blood (2015) 126 (23): 710.
https://doi.org/10.1182/blood.V126.23.710.710
Published: 2015
Journal Articles

Identification of a Prognostic Gene Expression Signature for AZA Response in MDS and CMML Patients

Ashwin Unnikrishnan, PhD, Dominik Beck, PhD, Arjun Verma, Laura A Richards, Julie A I Thoms, PhD, Ashu Kumari, PhD, Sally Galbraith, PhD, Austin Kulasekararaj, Magnus Tobiasson, MD, Petter S Woll, PhD, Andrea Pellagatti, PhD, Elli Papaemmanuil, PhD, Susan R Wilson, PhD, Robert Lindeman, MD, Peter J Campbell, PhD, Jacqueline Boultwood, PhD, Kevin Lynch, MBBS, Sten Eirik W Jacobsen, MD PhD, Ghulam J. Mufti, DM, FRCP, FRCPath, Eva Hellstrom-Lindberg, MD PhD, Karen L MacKenzie, PhD, Jason WH Wong, PhD, John E Pimanda, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4601.
https://doi.org/10.1182/blood.V124.21.4601.4601
Published: 2014
Journal Articles

Mutations in Histone Modulators and HOXA5 Methylation Levels Affects Survival in Azacitidine Treated MDS Patients

Magnus Tobiasson, MD, Mohsen Karimi, Marios Dimitriou, Ying Qu, MDM.Sc, Andreas Lennartsson, PhD, Hani Abdulkadir Ali, Ashwin Unnikrishnan, PhD, Martin Jadersten, MDPhD, Monika Jansson, Asmaa Ben Azenkoud, John E Pimanda, MD PhD, Karl Ekwall, Prof, Johanna Ungerstedt, MD PhD, Soren Lehmann, MD PhD, Eva Hellstrom-Lindberg, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4613.
https://doi.org/10.1182/blood.V124.21.4613.4613
Published: 2014
Journal Articles

Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes

e-blood
Dominik Beck, Julie A. I. Thoms, Dilmi Perera, Judith Schütte, Ashwin Unnikrishnan, Kathy Knezevic, Sarah J. Kinston, Nicola K. Wilson, Tracey A. O’Brien, Berthold Göttgens, Jason W. H. Wong, John E. Pimanda
Journal: Blood
Blood (2013) 122 (14): e12–e22.
https://doi.org/10.1182/blood-2013-03-490425
Published: 2013
Includes: Supplemental data