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Journal Articles

The High Mobility Group A1 (HMGA1) Chromatin Regulator Induces Inflammatory Signals and Promotes Atherogenesis in Tet2 Mutant Clonal Hematopoiesis

Zanshe Thompson, Iliana Herrera, Zion Williams, Li Z Luo, Audrey-Ann Supreme, Bailey West, Hyunsung Woo, Marios Arvantis, Charles Lowenstein, Lewis Becker, Linda Resar

Blood (2024) 144 (Supplement 1): 189.

https://doi.org/10.1182/blood-2024-211575

Published: 2024

Journal Articles

HMGA1 Chromatin Regulators Disrupt 3D Genome Architecture and Chromatin Looping to Repress MHC II Genes and Drive Immune Evasion during MPN Progression

Linda Resar, Joseph Kim, Audrey-Ann Supreme, Hyunsung Woo, Bailey West, Mariah C. Antopia, Zanshe Thompson, Karen Reddy, Jung-Hyun Kim, Leslie Cope, Raajit Rampal, Richard Koche, Alison R. Moliterno, Jerry L. Spivak

Blood (2024) 144 (Supplement 1): 756.

https://doi.org/10.1182/blood-2024-211336

Published: 2024

Journal Articles

High Mobility Group A1 (HMGA1) Chromatin Regulators Maintain Quiescent, Regenerative HSC By Repressing IGF1 Networks That Promote Stem Cell Aging

Zanshe Thompson, Li Z Luo, Liping Li, Bowen Wang, Jung-Hyun Kim, Lingling Xian, Bailey West, Leslie Cope, John Lister, Linda Resar

Blood (2024) 144 (Supplement 1): 1277.

https://doi.org/10.1182/blood-2024-211649

Published: 2024

Journal Articles

Targeting HMGA1 Epigenetic Regulators and Downstream ETV5 Pathways with Histone Deacetylase Inhibitors in Combination Therapy for Relapsed, Pediatric B-ALL

Linda Resar, Jung-Hyun Kim, Li Z Luo, Katharina Hayer, Camilo Arenas Merizalde, Leslie Cope, Andrei Thomas-Tikhonenko, Sarah K. Tasian

Blood (2024) 144 (Supplement 1): 1361.

https://doi.org/10.1182/blood-2024-211514

Published: 2024

Journal Articles

A c- MPL Splice Variant up-Regulated in Myeloproliferative Neoplasms Modulates Thrombopoietin Signaling and Induces Cycling of Hematopoietic Stem Cells and Inflammatory Progenitors

Linda Resar, Zanshe Thompson, Li Z Luo, Donna Marie Williams, Liping Li, Leslie Cope, Iliana Herrera, Ophelia Rogers, Alison R. Moliterno, Jerry L. Spivak

Blood (2023) 142 (Supplement 1): 3147.

https://doi.org/10.1182/blood-2023-189825

Published: 2023

Journal Articles

HMGA1 Chromatin Regulators Drive Immune Evasion in MPN Progression through Epigenetic Rewiring to Repress Antigen Presentation

Joseph Kim, Audrey-Ann Supreme, Bailey West, Mariah C. Antopia, Karen Reddy, Leslie Cope, Jung-Hyun Kim, Raajit K. Rampal, Richard Koche, Jerry L. Spivak, Alison R. Moliterno, Linda Resar

Blood (2023) 142 (Supplement 1): 992.

https://doi.org/10.1182/blood-2023-186452

Published: 2023

Journal Articles

High Mobility Group A1 Chromatin Regulators Drive Regenerative Capacity during Stress Hematopoiesis through Modulation of TNF-α and Aging Transcriptional Networks

Zanshe Thompson, Li Z Luo, Bowen Wang, Jung-Hyun Kim, Hyunsung Woo, Leslie Cope, Linda Resar

Blood (2023) 142 (Supplement 1): 4050.

https://doi.org/10.1182/blood-2023-189964

Published: 2023

Journal Articles

Single Cell Transcriptomics Reveal That HMGA1 Chromatin Regulators Drive Transcriptional Networks Involved in Megakaryocyte Expansion, Platelet Activation, and Interferon Signaling in JAK2 V617F Myeloproliferative Neoplasms

Zanshe Thompson, Li Z Luo, Liping Li, Bowen Wang, Jung-Hyun Kim, Hyunsung Woo, Bailey West, Anandi Krishnan, Leslie Cope, Alison R. Moliterno, Jerry L. Spivak, Linda Resar

Blood (2023) 142 (Supplement 1): 3145.

https://doi.org/10.1182/blood-2023-190323

Published: 2023

Journal Articles

HMGA1-ETV5 Axis Is Essential for Relapsed B-Cell Leukemia and Provides Novel Therapeutic Targets

Jung-Hyun Kim, Liping Li, Zixin Zhang, Katharina Hayer, Li Luo, Leslie Cope, Lingling Xian, Andrei Thomas-Tikhonenko, Linda Resar

Blood (2022) 140 (Supplement 1): 3478–3479.

https://doi.org/10.1182/blood-2022-167037

Published: 2022

Journal Articles

A Noncoding Germline Variant Creates a Gain-of-Function De Novo Enhancer That up-Regulates IL5 Transcription to Cause Familial Hypereosinophilia, Revealing a Previously Undescribed Mechanism for Human Disease

Jung-Hyun Kim, Abbie Bowman, Senbagavalli Babu, Jan Cools, Sofie Demeyer, Majid Kazemian, Warren Leonard, Jian-Xin Lin, Michelle Makiya, Mathieu Perez, Colin L. Sweeney, Luis M Franco, Neelam Redekar, Justin Lack, Linda Resar, Amy D Klion

Blood (2022) 140 (Supplement 1): 1399–1400.

https://doi.org/10.1182/blood-2022-169953

Published: 2022

Journal Articles

The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation

Joseph Kim, Jung-Hyun Kim, Leslie Cope, Liping Li, Raajit K Rampal, Richard Koche, Jerry L. Spivak, Alison R. Moliterno, Linda Resar

Blood (2022) 140 (Supplement 1): 801–802.

https://doi.org/10.1182/blood-2022-166969

Published: 2022

Journal Articles

The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation and Immune Attack

Joseph Kim, Jung-Hyun Kim, Leslie Cope, Liping Li, Raajit Rampal, Richard Koche, Donna M Williams, Jerry L. Spivak, Alison R. Moliterno, Linda Resar

Blood (2021) 138 (Supplement 1): 2546.

https://doi.org/10.1182/blood-2021-151139

Published: 2021

Journal Articles

High Mobility Group A1 (HMGA1) Epigenetic Regulators Induce ETV5 Networks in Relapsed B-Cell Leukemia and Provide Novel Therapeutic Targets

Jung-Hyun Kim, Liping Li, Zixin Zhang, Katharina Hayer, Lingling Xian, Li Luo, Leslie Cope, Andrei Thomas-Tikhonenko, Linda Resar

Blood (2021) 138 (Supplement 1): 707.

https://doi.org/10.1182/blood-2021-152950

Published: 2021

Journal Articles

HMGA1 Chromatin Regulators Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce Networks Involved in GATA2 and Proliferation

Liping Li, Jung-Hyun Kim, Wenyan Lu, Leslie Cope, Donna M Williams, Joseph Kim, Raajit Rampal, Richard Koche, Lingling Xian, Li Luo, Marija Vasiljevic, Daniel R Matson, Zhizhuang Joe Zhao, Ophelia Rogers, Matthew C. Stubbs, Karen Reddy, Jerry L. Spivak, Alison R. Moliterno, Linda Resar

Blood (2021) 138 (Supplement 1): 625.

https://doi.org/10.1182/blood-2021-144712

Published: 2021

Journal Articles

The High Mobility Group A1 Chromatin Regulator Is Required for Pathologic Megakaryocyte Development and Progression to Myelofibrosis in JAK2V617F Murine Models

Alison R. Moliterno, MD, Donna Marie Williams, PhD, Liping Li, MD PhD, Lingling Xian, MD PhD, Li Luo, PhD, Amy S. Duffield, MD PhD, Ophelia Rogers, Jerry L. Spivak, MD, Linda Resar, MD

Blood (2019) 134 (Supplement_1): 472.

https://doi.org/10.1182/blood-2019-131432

Published: 2019

Journal Articles

Use of Pegylated Interferon in Six Pediatric Patients with Myeloproliferative Neoplasms

Nicole Kucine, MD, Shayla Bergmann, MD, Spencer Krichevsky, BS, Devin Jones, MS, Michael E. Rytting, MD, Linda Resar, MD, John Mascarenhas, MD, Srdan Verstovsek, MD PhD, Ronald Hoffman, MD

Blood (2019) 134 (Supplement_1): 4194.

https://doi.org/10.1182/blood-2019-124023

Published: 2019

Journal Articles

High Mobility Group A1 Chromatin Regulators Function As Critical Drivers of Leukemogenesis in Preclinical Models of Relapsed, Pediatric B-Cell ALL

Liping Li, MD PhD, Katharina Hayer, Lingling Xian, MD PhD, Li Luo, PhD, Leslie Cope, Andrei Thomas-Tikhonenko, PhD, Linda Resar, MD

Blood (2019) 134 (Supplement_1): 3946.

https://doi.org/10.1182/blood-2019-130261

Published: 2019

Journal Articles

High Mobility Group A1 Chromatin Regulators: Key Epigenetic Switches and Therapeutic Targets Required for Leukemic Transformation in JAK2 Mutant MPN

Liping Li, MD PhD, Wenyan Lu, PhD, Alison R. Moliterno, MD, Lingling Xian, MD PhD, Joseph Kim, BS, Ophelia Rogers, Jerry L. Spivak, MD, Linda Resar, MD

Blood (2019) 134 (Supplement_1): 1680.

https://doi.org/10.1182/blood-2019-130262

Published: 2019

Journal Articles

Worse Outcomes in Males with MPN Are Associated with Qualitative and Quantitative Differences in Non-Driver Mutational Burden

Theodoros Karantanos, MD PhD, Evan M Braunstein, MD PhD, Shruti Chaturvedi, MBBS, MS, Jerry L. Spivak, MD, Linda Resar, MD, Styliani Karanika, MD, Donna Marie Williams, PhD, Christopher D Gocke, MD, Alison R. Moliterno, MD

Blood (2019) 134 (Supplement_1): 837.

https://doi.org/10.1182/blood-2019-125393

Published: 2019

Journal Articles

Independent Association of Male Sex with Presentation and Clinical Outcomes in Myeloproliferative Neoplasms

Theodoros Karantanos, MDPhD, Shruti Chaturvedi, MBBS,MS, Jerry L. Spivak, MD, Linda Resar, MD, Evan M Braunstein, MDPhD, Styliani Karanika, MD, Donna Marie Williams, PhD, Ophelia Rogers, Alison R. Moliterno, MD

Blood (2018) 132 (Supplement 1): 1768.

https://doi.org/10.1182/blood-2018-99-112683

Published: 2018

NARROW

The High Mobility Group A1 (HMGA1) Chromatin Regulator Induces Inflammatory Signals and Promotes Atherogenesis in Tet2 Mutant Clonal Hematopoiesis

HMGA1 Chromatin Regulators Disrupt 3D Genome Architecture and Chromatin Looping to Repress MHC II Genes and Drive Immune Evasion during MPN Progression

High Mobility Group A1 (HMGA1) Chromatin Regulators Maintain Quiescent, Regenerative HSC By Repressing IGF1 Networks That Promote Stem Cell Aging

Targeting HMGA1 Epigenetic Regulators and Downstream ETV5 Pathways with Histone Deacetylase Inhibitors in Combination Therapy for Relapsed, Pediatric B-ALL

A c- MPL Splice Variant up-Regulated in Myeloproliferative Neoplasms Modulates Thrombopoietin Signaling and Induces Cycling of Hematopoietic Stem Cells and Inflammatory Progenitors

HMGA1 Chromatin Regulators Drive Immune Evasion in MPN Progression through Epigenetic Rewiring to Repress Antigen Presentation

High Mobility Group A1 Chromatin Regulators Drive Regenerative Capacity during Stress Hematopoiesis through Modulation of TNF-α and Aging Transcriptional Networks

Single Cell Transcriptomics Reveal That HMGA1 Chromatin Regulators Drive Transcriptional Networks Involved in Megakaryocyte Expansion, Platelet Activation, and Interferon Signaling in JAK2 V617F Myeloproliferative Neoplasms

HMGA1-ETV5 Axis Is Essential for Relapsed B-Cell Leukemia and Provides Novel Therapeutic Targets

A Noncoding Germline Variant Creates a Gain-of-Function De Novo Enhancer That up-Regulates IL5 Transcription to Cause Familial Hypereosinophilia, Revealing a Previously Undescribed Mechanism for Human Disease

The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation

The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation and Immune Attack

High Mobility Group A1 (HMGA1) Epigenetic Regulators Induce ETV5 Networks in Relapsed B-Cell Leukemia and Provide Novel Therapeutic Targets

HMGA1 Chromatin Regulators Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce Networks Involved in GATA2 and Proliferation

The High Mobility Group A1 Chromatin Regulator Is Required for Pathologic Megakaryocyte Development and Progression to Myelofibrosis in JAK2V617F Murine Models

Use of Pegylated Interferon in Six Pediatric Patients with Myeloproliferative Neoplasms

High Mobility Group A1 Chromatin Regulators Function As Critical Drivers of Leukemogenesis in Preclinical Models of Relapsed, Pediatric B-Cell ALL

High Mobility Group A1 Chromatin Regulators: Key Epigenetic Switches and Therapeutic Targets Required for Leukemic Transformation in JAK2 Mutant MPN

Worse Outcomes in Males with MPN Are Associated with Qualitative and Quantitative Differences in Non-Driver Mutational Burden

Independent Association of Male Sex with Presentation and Clinical Outcomes in Myeloproliferative Neoplasms

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American Society of Hematology

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American Society of Hematology

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