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Journal Articles

A c- MPL Splice Variant up-Regulated in Myeloproliferative Neoplasms Modulates Thrombopoietin Signaling and Induces Cycling of Hematopoietic Stem Cells and Inflammatory Progenitors

Linda Resar, Zanshe Thompson, Li Z Luo, Donna Marie Williams, Liping Li, Leslie Cope, Iliana Herrera, Ophelia Rogers, Alison R. Moliterno, Jerry L. Spivak

Blood (2023) 142 (Supplement 1): 3147.

https://doi.org/10.1182/blood-2023-189825

Published: 2023

Journal Articles

HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression

Blood (2022) 139 (18): 2797–2815.

https://doi.org/10.1182/blood.2021013925

Published: 2022

Includes: Supplemental data

Journal Articles

HMGA1 Chromatin Regulators Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce Networks Involved in GATA2 and Proliferation

Liping Li, Jung-Hyun Kim, Wenyan Lu, Leslie Cope, Donna M Williams, Joseph Kim, Raajit Rampal, Richard Koche, Lingling Xian, Li Luo, Marija Vasiljevic, Daniel R Matson, Zhizhuang Joe Zhao, Ophelia Rogers, Matthew C. Stubbs, Karen Reddy, Jerry L. Spivak, Alison R. Moliterno, Linda Resar

Blood (2021) 138 (Supplement 1): 625.

https://doi.org/10.1182/blood-2021-144712

Published: 2021

Journal Articles

The High Mobility Group A1 Chromatin Regulator Is Required for Pathologic Megakaryocyte Development and Progression to Myelofibrosis in JAK2V617F Murine Models

Alison R. Moliterno, MD, Donna Marie Williams, PhD, Liping Li, MD PhD, Lingling Xian, MD PhD, Li Luo, PhD, Amy S. Duffield, MD PhD, Ophelia Rogers, Jerry L. Spivak, MD, Linda Resar, MD

Blood (2019) 134 (Supplement_1): 472.

https://doi.org/10.1182/blood-2019-131432

Published: 2019

Journal Articles

High Mobility Group A1 Chromatin Regulators: Key Epigenetic Switches and Therapeutic Targets Required for Leukemic Transformation in JAK2 Mutant MPN

Liping Li, MD PhD, Wenyan Lu, PhD, Alison R. Moliterno, MD, Lingling Xian, MD PhD, Joseph Kim, BS, Ophelia Rogers, Jerry L. Spivak, MD, Linda Resar, MD

Blood (2019) 134 (Supplement_1): 1680.

https://doi.org/10.1182/blood-2019-130262

Published: 2019

Journal Articles

Development of Liver-Specific Thrombopoietin Targeted Sirnas: Impact on Platelet Count, Megakaryocyte Mass, and Hematopoietic Progenitors in Normal and MPN Murine Models

Dhruv Desai, MSc, Anna Borodovsky, PhD, Wendell P Davis, DVM DACVP, Rohan Degaonkar, Kristina Yucius, Kellie D'Angelo, MLS(ASCP)CM, Paul Gedman, BS, Donna Marie Williams, PhD, Ophelia Rogers, Zhizhuang Joe Zhao, PhD, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2018) 132 (Supplement 1): 4329.

https://doi.org/10.1182/blood-2018-99-117142

Published: 2018

Journal Articles

High Mobility Group A1 Chromatin Remodeling Proteins Amplify Inflammatory Networks to Drive Leukemic Transformation in Chronic Myeloproliferative Neoplasia in Humans and JAK2 V617F Transgenic Mouse Models

Linda Resar, MD, Donna Marie Williams, PhD, Lingling Xian, MD PhD, Wenyan Lu, PhD, Briyana Chisholm, BS, Li Luo, PhD, Zhizhuang Joe Zhao, PhD, Ophelia Rogers, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2018) 132 (Supplement 1): 102.

https://doi.org/10.1182/blood-2018-99-119549

Published: 2018

Journal Articles

Independent Association of Male Sex with Presentation and Clinical Outcomes in Myeloproliferative Neoplasms

Theodoros Karantanos, MDPhD, Shruti Chaturvedi, MBBS,MS, Jerry L. Spivak, MD, Linda Resar, MD, Evan M Braunstein, MDPhD, Styliani Karanika, MD, Donna Marie Williams, PhD, Ophelia Rogers, Alison R. Moliterno, MD

Blood (2018) 132 (Supplement 1): 1768.

https://doi.org/10.1182/blood-2018-99-112683

Published: 2018

Journal Articles

Mechanism of Escape from LNK Negative Regulation: Constitutively Active JAK2V617F Retains Lysine63-Ubiquitin

Jeffrey Patterson-Fortin, MD PhD, Jerry L. Spivak, MD, Amy S. Duffield, MD PhD, Donna Marie Williams, PhD, Ophelia Rogers, Zhizhuang Joe Zhao, PhD, Alison R. Moliterno, MD

Blood (2017) 130 (Supplement 1): 2931.

https://doi.org/10.1182/blood.V130.Suppl_1.2931.2931

Published: 2017

Journal Articles

High Mobility Group A1 Chromatin Remodeling Proteins: Potential Therapeutic Targets Involved in Polycythemia Vera Transformation to Acute Leukemia in Humans and JAK2 V617F Transgenic Mouse Models

Linda Resar, MD, Donna Marie Williams, PhD, Lingling Xian, MD PhD, Zhizhuang Joe Zhao, PhD, Ophelia Rogers, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2017) 130 (Supplement 1): 489.

https://doi.org/10.1182/blood.V130.Suppl_1.489.489

Published: 2017

Journal Articles

High Mobility Group A1/2 Chromatin Remodeling Proteins Associate with Polycythemia Vera Transformation to Acute Leukemia in Humans and a JAK2 V617F Transgenic Mouse Model

Linda Resar, MD, Donna Marie Williams, PhD, Zhizhuang Joe Zhao, PhD, Ophelia Rogers, Lingling Xian, MD PhD, Jerry L. Spivak, MD, Alison R Moliterno, MD

Blood (2016) 128 (22): 1958.

https://doi.org/10.1182/blood.V128.22.1958.1958

Published: 2016

Journal Articles

MPL SV , a Unique MPN MPL Splice Variant, Provokes a Fulminant Myeloid Leukemia in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera

Jerry L. Spivak, MD, Donna Marie Williams, PhD, Zhizhuang Joe Zhao, PhD, Ophelia Rogers, Amy S. Duffield, MD PhD, W. David Hankins, PhD, Alison R Moliterno, MD

Blood (2015) 126 (23): 484.

https://doi.org/10.1182/blood.V126.23.484.484

Published: 2015

Journal Articles

The JAK2 V617F Stem Cell Burden Is Mosaic, Dynamic and Correlates with Clinical Disease Burden in the MPN: An Exploitable Target

Alison R Moliterno, MD, Donna Marie Williams, PhD, Jonathan M. Gerber, MD, Michael A McDevitt, MD PhD, Ophelia Rogers, Jerry L. Spivak, MD

Blood (2015) 126 (23): 4090.

https://doi.org/10.1182/blood.V126.23.4090.4090

Published: 2015

Journal Articles

Essential Thrombocytosis: Redefinition in the Genomic Era

Donna M. Williams, PhD, Michael A McDevitt, MD PhD, Brady L Stein, MDMHS, Ophelia Rogers, Michael B. Streiff, MD, David Neal, Sophie Lanzkron, MD MHS, Linda M. S. Resar, MD, Christine O'Keefe, PhD, Jaroslaw P. Maciejewski, MD PhD, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2014) 124 (21): 3205.

https://doi.org/10.1182/blood.V124.21.3205.3205

Published: 2014

Journal Articles

Single Cell Analysis Of JAK2 V617F Positive MPN Stem/Progenitor Cells In Chronic Phase and Leukemic Transformation

Jonathan M. Gerber, MD, Donna M. Williams, PhD, Ophelia Rogers, Sarah Morse, Hao Zhang, Michael A McDevitt, MD, PhD, Richard J. Jones, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2013) 122 (21): 1609.

https://doi.org/10.1182/blood.V122.21.1609.1609

Published: 2013

Journal Articles

A Functional Thrombopoietin Receptor Is Required for Full Expression of Phenotype in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera

Jerry L. Spivak, MD, Akil Merchant, MD, Donna M. Williams, PhD, Ophelia Rogers, Wanming Zhao, Alison R. Moliterno, MD, Zhizhuang Joe Zhao, PhD

Blood (2012) 120 (21): 427.

https://doi.org/10.1182/blood.V120.21.427.427

Published: 2012

Journal Articles

A Molecular Basis for Risk Stratification in Polycythrmia Vera

Jerry L. Spivak, MD, Donna M. Williams, PhD, Ophelia Rogers, Michael Considine, M.S., Michael Ochs, Ph.D., Alison R. Moliterno, MD

Blood (2012) 120 (21): 429.

https://doi.org/10.1182/blood.V120.21.429.429

Published: 2012

Journal Articles

Polycythemia Vera: Redefinition in the Genomic Era

Alison R. Moliterno, MD, Donna M. Williams, PhD, Michael A McDevitt, MD, PhD, Brady L Stein, MD, Jonathan M. Gerber, MD, Ophelia Rogers, Michael B. Streiff, MD, Sophie Lanzkron, M.D., Linda Resar, M.D., Christine O'Keefe, PhD, Jaroslaw P. Maciejewski, MD, PhD, Jerry L. Spivak, MD

Blood (2012) 120 (21): 1754.

https://doi.org/10.1182/blood.V120.21.1754.1754

Published: 2012

Journal Articles

Buccal Mucosa Cells Are Unsuitable As a Control Tissue to Distinguish Somatic Hematopoietic Mutations From Germline Mutations: Nail DNA Is a Suitable Surrogate

Donna M. Williams, PhD, Ophelia Rogers, D. Treva Rowley, Josef T. Prchal, MD, Jerry L. Spivak, MD, Alison R. Moliterno, MD

Blood (2011) 118 (21): 5156.

https://doi.org/10.1182/blood.V118.21.5156.5156

Published: 2011

Journal Articles

The Leukemic Stem Cell in Polycythemia Vera and Primary Myelofibrosis Is Distinct From the Initiating JAK2 V617F-Positive Hematopoiertic Stem Cell

Jonathan M. Gerber, MD, Brownhilda Ngwang, Hao Zhang, Donna M. Williams, PhD, Ophelia Rogers, Richard J. Jones, Alison R. Moliterno, MD, Jerry L. Spivak, MD

Blood (2011) 118 (21): 613.

https://doi.org/10.1182/blood.V118.21.613.613

Published: 2011

NARROW

A c- MPL Splice Variant up-Regulated in Myeloproliferative Neoplasms Modulates Thrombopoietin Signaling and Induces Cycling of Hematopoietic Stem Cells and Inflammatory Progenitors

HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression

HMGA1 Chromatin Regulators Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce Networks Involved in GATA2 and Proliferation

The High Mobility Group A1 Chromatin Regulator Is Required for Pathologic Megakaryocyte Development and Progression to Myelofibrosis in JAK2V617F Murine Models

High Mobility Group A1 Chromatin Regulators: Key Epigenetic Switches and Therapeutic Targets Required for Leukemic Transformation in JAK2 Mutant MPN

Development of Liver-Specific Thrombopoietin Targeted Sirnas: Impact on Platelet Count, Megakaryocyte Mass, and Hematopoietic Progenitors in Normal and MPN Murine Models

High Mobility Group A1 Chromatin Remodeling Proteins Amplify Inflammatory Networks to Drive Leukemic Transformation in Chronic Myeloproliferative Neoplasia in Humans and JAK2 V617F Transgenic Mouse Models

Independent Association of Male Sex with Presentation and Clinical Outcomes in Myeloproliferative Neoplasms

Mechanism of Escape from LNK Negative Regulation: Constitutively Active JAK2V617F Retains Lysine63-Ubiquitin

High Mobility Group A1 Chromatin Remodeling Proteins: Potential Therapeutic Targets Involved in Polycythemia Vera Transformation to Acute Leukemia in Humans and JAK2 V617F Transgenic Mouse Models

High Mobility Group A1/2 Chromatin Remodeling Proteins Associate with Polycythemia Vera Transformation to Acute Leukemia in Humans and a JAK2 V617F Transgenic Mouse Model

MPL SV , a Unique MPN MPL Splice Variant, Provokes a Fulminant Myeloid Leukemia in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera

The JAK2 V617F Stem Cell Burden Is Mosaic, Dynamic and Correlates with Clinical Disease Burden in the MPN: An Exploitable Target

Essential Thrombocytosis: Redefinition in the Genomic Era

Single Cell Analysis Of JAK2 V617F Positive MPN Stem/Progenitor Cells In Chronic Phase and Leukemic Transformation

A Functional Thrombopoietin Receptor Is Required for Full Expression of Phenotype in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera

A Molecular Basis for Risk Stratification in Polycythrmia Vera

Polycythemia Vera: Redefinition in the Genomic Era

Buccal Mucosa Cells Are Unsuitable As a Control Tissue to Distinguish Somatic Hematopoietic Mutations From Germline Mutations: Nail DNA Is a Suitable Surrogate

The Leukemic Stem Cell in Polycythemia Vera and Primary Myelofibrosis Is Distinct From the Initiating JAK2 V617F-Positive Hematopoiertic Stem Cell

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American Society of Hematology

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ASH Publications

American Society of Hematology

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