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Journal Articles

Adult B-Cell Precursor Acute Lymphoblastic Leukemia (BC-ALL) Negative For Recurrent Fusion Genes Are Characterized By a High Complex Genetic Heterogeneity Influencing Prognosis

Free
Ilaria Iacobucci, Anna Ferrari, Margherita Perricone, Valentina Robustelli, Cristina Papayannidis, MD, Roberta Zuntini, Maria Chiara Abbenante, Claudia Venturi, Carmen Baldazzi, Emanuela Ottaviani, Barbara Giannini, Andrea Ghelli Luserna Di Rorà, Annalisa Lonetti, Antonella Vitale, Loredana Elia, Viviana Guadagnuolo, Nicoletta Testoni, BS, Simona Soverini, Stefania Paolini, Sarah Parisi, Chiara Sartor, Federica Cattina, Domenico Russo, Robin Foà, Sabina Chiaretti, Alexander Kohlmann, PhD, Giovanni Martinelli
Journal: Blood
Blood (2013) 122 (21): 2622.
https://doi.org/10.1182/blood.V122.21.2622.2622
Published: 2013
Journal Articles

In Vitro and in Vivo Single-Agent Efficacy of Checkpoint Kinase 1 (Chk1) and 2 (Chk2) Inhibitor PF-0477736 (Pfizer) in B- and T-Acute Lymphoblastic Leukemia (ALL)

Free
Ilaria Iacobucci, Andrea Ghelli Luserna Di Rorà, Maria Vittoria Verga Falzacappa, Enrico Derenzini, MD, Anna Ferrari, Cristina Papayannidis, Claudia Venturi, Annalisa Lonetti, Viviana Guadagnuolo, Federica Cattina, Emanuela Ottaviani, Maria Chiara Abbenante, Domenico Russo, Michele Baccarani, MD, Pier Giuseppe Pelicci, Giovanni Martinelli, MD
Journal: Blood
Blood (2012) 120 (21): 1496.
https://doi.org/10.1182/blood.V120.21.1496.1496
Published: 2012
Journal Articles

Down-Regulation of BMI-1 Is a New Marker of Sensitivity to Mdm2 Inhibition in B-Acute Lymphoblastic Leukemia.

Free
Ilaria Iacobucci, Daniela Erriquez, Anna Ferrari, Cristina Papayannidis, Claudia Venturi, Stefania Trino, Viviana Guadagnuolo, Annalisa Lonetti, Federica Cattina, Emanuela Ottaviani, Maria Chiara Abbenante, Sarah Parisi, Simona Soverini, Domenico Russo, Fabrizio Pane, Michele Baccarani, MD, Giovanni Perini, Giovanni Martinelli
Journal: Blood
Blood (2012) 120 (21): 2522.
https://doi.org/10.1182/blood.V120.21.2522.2522
Published: 2012
Journal Articles

The Novel Small Molecule Chk1/Chk2 Inhibitor PF-0477736 (Pfizer) Is Highly Active As Single Agent in Philadelphia-Positive Acute Lymphoblastic Leukemia (Ph+ ALL)

Free
Ilaria Iacobucci, PhD, Federica Cattina, MD, Silvia Pomella, Annalisa Lonetti, Enrico Derenzini, MD, Elisa Brighenti, Anna Ferrari, Cristina Papayannidis, Maria Vittoria Verga Falzacappa, Viviana Guadagnuolo, Michela Aluigi, PhD, Emanuela Ottaviani, Serena Formica, Maria Chiara Abbenante, Simona Soverini, Domenico Russo, Fabrizio Pane, Pier Guiseppe Pellicci, Michele Baccarani, MD, Giovanni Martinelli
Journal: Blood
Blood (2011) 118 (21): 76.
https://doi.org/10.1182/blood.V118.21.76.76
Published: 2011
Journal Articles

BCR-ABL1 -Positive Acute Lymphoblastic Leukemia Patients Treated with Only TKI Vs Conventional Chemo Plus TKI Therapy Show Similar DNA Alterations At Relapse Targeting Key Regulators of Tumor Suppression, Cell Cycle Control, and Lymphoid/B-Cell Development,

Free
Ilaria Iacobucci, PhD, Heike Pfifer, Annalisa Lonetti, Cristina Papayannidis, Anna Ferrari, Stefania Trino, Maria Chiara Abbenante, Sarah Parisi, Simona Soverini, Antonella Vitale, Stefania Paolini, Emanuela Ottaviani, Carmen Baldazzi, Fabrizio Pane, Michele Baccarani, MD, Oliver G. Ottmann, MD, PhD, Giovanni Martinelli, MD
Journal: Blood
Blood (2011) 118 (21): 3580.
https://doi.org/10.1182/blood.V118.21.3580.3580
Published: 2011
Journal Articles

Ultra-Deep Amplicon Sequencing Using Roche 454 Technology Allows High Sensitivity Bcr-Abl Kinase Domain Mutation Screening and Anticipates Emerging Mutations Leading to Resistance to Tyrosine Kinase Inhibitors in Philadelphia-Positive Leukemia Patients,

Free
Simona Soverini, Caterina De Benedittis, Alessandra Gnani, Ilaria Iacobucci, PhD, Domenico Russo, Federica Cattina, MD, Fausto Castagnetti, Gabriele Gugliotta, Cristina Papayannidis, Antonella Vitale, Loredana Elia, Robin Foà, Francesca Palandri, Annalisa Lonetti, Maria Teresa Bochicchio, Sandra Durante, Gianantonio Rosti, MD, Michele Baccarani, MD, Giovanni Martinelli
Journal: Blood
Blood (2011) 118 (21): 3775.
https://doi.org/10.1182/blood.V118.21.3775.3775
Published: 2011
Journal Articles

Validation of the New European LeukemiaNet (ELN) Recommendations for Bcr-Abl Kinase Domain Mutation Analysis In Chronic Myeloid Leukemia: An Analysis of the GIMEMA CML Working Party Studies

Free
Simona Soverini, Alessandra Gnani, Caterina De Benedittis, Fausto Castagnetti, Gabriele Gugliotta, Maria Teresa Bochicchio, Francesca Palandri, Mario Arpinati, Francesca Bonifazi, Elisabetta Abruzzese, Federica Sorà, Giuliana Alimena, Patrizia Pregno, MD, Giorgina Specchia, Domenico Russo, Fabrizio Pane, Giuseppe Saglio, MD, Marzia Salvucci, Alfonso Zaccaria, Giovanni Poletti, Barbara Giannini, Ilaria Iacobucci, PhD, Annalisa Lonetti, Sandra Durante, Gianantonio Rosti, MD, Michele Baccarani, MD, Giovanni Martinelli, MD
Journal: Blood
Blood (2011) 118 (21): 112.
https://doi.org/10.1182/blood.V118.21.112.112
Published: 2011
Journal Articles

Nelarabine Is Safe and Effective In Adult Relapsed or Refractory T Cell Acute Lymphoblastic Leukemia (T-ALL) and Lymphoblastic Lymphoma (T-LBL): The Bologna Experience

Free
Cristina Papayannidis, Ilaria Iacobucci, PhD, Mariachiara Abbenante, Annalisa Lonetti, Viviana Guadagnuolo, Anna Ferrari, Emanuela Ottaviani, Nicoletta Testoni, Carmen Baldazzi, Antonio Curti, MD, Sarah Parisi, Cristina Clissa, MD, Michele Baccarani, MD, Giovanni Martinelli
Journal: Blood
Blood (2011) 118 (21): 4250.
https://doi.org/10.1182/blood.V118.21.4250.4250
Published: 2011
Journal Articles

ARF Loss, a Negative Prognostic Factor in Philadelphia-Positive Acute Lymphoblastic Leukemia, May Be Efficiently Overcome by the Small Molecule MDM2 Antagonist RG7112

Free
Ilaria Iacobucci, PhD, Federica Cattina, MD, Silvia Pomella, Annalisa Lonetti, Anna Ferrari, Cristina Papayannidis, Stefania Trino, Daniela Erriquez, Viviana Guadagnuolo, Emanuela Ottaviani, Serena Formica, Simona Soverini, Francesca Paoloni, Marco Vignetti, Domenico Russo, Giovanni Perini, Michele Baccarani, MD, Giovanni Martinelli, MD
Journal: Blood
Blood (2011) 118 (21): 2574.
https://doi.org/10.1182/blood.V118.21.2574.2574
Published: 2011
Journal Articles

TP53 Alterations Including Missense Mutations, Aberrant Exon-Junctions and Internal Intron Retentions Are Frequent and May Contribute to MDM2 Antagonist-Resistance in B-Acute Lymphoblastic leukemia

Free
Ilaria Iacobucci, PhD, Anna Ferrari, Stefania Trino, Annalisa Lonetti, Cristina Papayannidis, Alberto Ferrarini, Luca Venturini, Maria Chiara Abbenante, Sarah Parisi, Federica Cattina, MD, Simona Soverini, Stefania Paolini, Domenico Russo, Marco Vignetti, Fabrizio Pane, Pellegrino Musto, Massimo Delledonne, Michele Baccarani, MD, Giovanni Martinelli, MD
Journal: Blood
Blood (2011) 118 (21): 1484.
https://doi.org/10.1182/blood.V118.21.1484.1484
Published: 2011
Journal Articles

Drug Resistance and Bcr-Abl Kinase Domain Mutations In Philadelphia-Positive Acute Lymphoblastic Leukemia From the Imatinib to the 2 nd -Generation Tyrosine Kinase Inhibitor Era: The Main Changes Are In the Type of Mutations, but Not In the Frequency of Mutation Involvement

Free
Simona Soverini, Alessandra Gnani, Caterina De Benedittis, Ilaria Iacobucci, PhD, Annalisa Lonetti, Cristina Papayannidis, Leonardo Potenza, Mario Luppi, Serena Merante, Michele Malagola, Domenico Russo, Mario Tiribelli, Marzia Salvucci, Alfonso Zaccaria, Barbara Giannini, Giovanni Poletti, Antonella Vitale, Loredana Elia, Marco Vignetti, Robin Foà, Michele Baccarani, MD, Giovanni Martinelli
Journal: Blood
Blood (2011) 118 (21): 575.
https://doi.org/10.1182/blood.V118.21.575.575
Published: 2011
Journal Articles

Susceptibility to Philadelphia-Positive acute Lymphoblastic Leukemia (ALL) Is Associated with a Germline Polymorphism In the ANRIL ( CDKN2BAS ) Locus.

Free
Ilaria Iacobucci, Marco Sazzini, Anna Ferrari, Annalisa Lonetti, Alessio Boattini, Cristina Papayannidis, Paolo Garagnani, Mariachiara Abbenante, Vilma Mantovani, Elena Marasco, Emanuela Ottaviani, Stefania Paolini, Domenico Girelli, Marco Vignetti, Fabrizio Pane, MD, Simona Soverini, Michele Baccarani, Giovanni Martinelli
Journal: Blood
Blood (2010) 116 (21): 1670.
https://doi.org/10.1182/blood.V116.21.1670.1670
Published: 2010
Journal Articles

Use of a High Sensitive Nanofluidic Array for the Detection of Rare Copies of BCR-ABL1 Transcript In Patients with Philadelphia-Positive Acute Lymphoblastic Leukemia (ALL).

Free
Ilaria Iacobucci, Annalisa Lonetti, Anna Ferrari, Cristina Papayannidis, Simona Soverini, Stefania Paolini, Mariachiara Abbenante, Viviana Guadagnuolo, Sarah Parisi, Leonardo Potenza, Mario Luppi, Federica Cattina, Domenico Russo, Fabrizio Pane, MD, Michele Baccarani, Giovanni Martinelli
Journal: Blood
Blood (2010) 116 (21): 1677.
https://doi.org/10.1182/blood.V116.21.1677.1677
Published: 2010
Journal Articles

Whole Transcriptome Resequencing of Paired Diagnosis-Relapse BCR-ABL1 -Positive Acute Lymphoblastic Leukemia (ALL) Samples Reveals the Loss of Cell Cycle Regulation as the Main Mechanism Responsible for Leukemia Progression.

Free
Ilaria Iacobucci, Annalisa Lonetti, Alberto Ferrarini, Marco Sazzini, Anna Ferrari, Cristina Papayannidis, Simona Soverini, Enrico Giacomelli, Luciano Xumerle, Viviana Guadagnuolo, Antonella Vitale, Fabrizio Pane, MD, Michele Baccarani, Massimo Delledonne, Giovanni Martinelli
Journal: Blood
Blood (2010) 116 (21): 1024.
https://doi.org/10.1182/blood.V116.21.1024.1024
Published: 2010
Journal Articles

Evaluation of the GeneXpert Assay for the Monitoring of BCR-ABL Transcript Levels In Chronic Myeloid Leukemia (CML) Patients: Preliminary Results of a Comparison with the Manual and Traditional Manual TaqMan RQ-PCR Assay

Free
Marco Suriano, Giovanni Martinelli, Angela Poerio, Marilina Amabile, Gianantonio Rosti, Fausto Castagnetti, Ilaria Iacobucci, Simona Soverini, Annalisa Lonetti, Cristina Papayannidis, Mariachiara Abbenante, Sarah Parisi, Francesca Palandri, Michele Baccarani, MD
Journal: Blood
Blood (2010) 116 (21): 4831.
https://doi.org/10.1182/blood.V116.21.4831.4831
Published: 2010
Journal Articles

Identification of A Pharmacogenomic Profile Associated with High Sensitivity and Low Toxicity to a Combination of Gemtuzumab Ozogamicin Plus Fludarabine, Cytarabine, Idarubicin Regimen In CD33-Positive Acute Myeloid Leukemia (AML) Patients

Free
Ilaria Iacobucci, Annalisa Lonetti, Anna Candoni, Marco Sazzini, Serena Formica, Emanuela Ottaviani, Anna Ferrari, Cristina Papayannidis, Angela Michelutti, Eleonora Toffoletti, Annalisa Astolfi, Stefania Paolini, Mariachiara Abbenante, Sarah Parisi, Domenico Russo, Daniela Damiani, Filippo Gherlinzoni, MD, Michele Gottardi, Michele Baccarani, MD, Renato Fanin, Giovanni Martinelli
Journal: Blood
Blood (2010) 116 (21): 967.
https://doi.org/10.1182/blood.V116.21.967.967
Published: 2010
Journal Articles

Efficacy and Feasibility of Nelarabine Savage Therapy In Adult Relapsed or Refractory T Cell Acute Lymphoblastic Leukemia (T-ALL) and Lymphoblastic Lymphoma (T-LBL) Strongly Indicates the Introduction of a Nelarabine-Based First Line Regimen

Free
Cristina Papayannidis, Ilaria Iacobucci, Mariachiara Abbenante, Stefania Paolini, Sarah Parisi, Annalisa Lonetti, Viviana Guadagnuolo, Anna Ferrari, Emanuela Ottaviani, Nicoletta Testoni, Antonio Curti, Cristina Clissa, MD, Michele Baccarani, Giovanni Martinelli, MD
Journal: Blood
Blood (2010) 116 (21): 4335.
https://doi.org/10.1182/blood.V116.21.4335.4335
Published: 2010
Journal Articles

First Line Treatment with Nilotinib 800 Mg Daily Results In Unprecedentedly High Rate of Rapid, “Deep” and Stable Molecular Responses as Assessed by a High Sensitive Nanofluidic Array for the Detection of Rare Copies of BCR-ABL1 Transcript: Results of a Phase 2 Trial of the GIMEMA CML Working Party

Free
Giovanni Martinelli, Angela Poerio, Marilina Amabile, Ilaria Iacobucci, Simona Soverini, Fausto Castagnetti, Francesca Palandri, Gabriele Gugliotta, Adele Capucci, Mario Tiribelli, Fabio Stagno, MD, Alfonso Zaccaria, Tamara Intermesoli, Bruno Martino, Monica Bocchia, Michele Cedrone, Nicoletta Testoni, Massimo Breccia, MD, Giuliana Alimena, MD, Luciano Levato, Cristina Papayannidis, Annalisa Lonetti, Carolina Terragna, Domenico Russo, Fabrizio Pane, MD, Giuseppe Saglio, MD, PhD, Gianantonio Rosti, Michele Baccarani, MD
Journal: Blood
Blood (2010) 116 (21): 2720.
https://doi.org/10.1182/blood.V116.21.2720.2720
Published: 2010
Journal Articles

The Inactivation of the Tumor Suppressor Genes CDKN2A/ARF by Genomic Deletions Frequently Occurs and Worsens Prognosis In Adult BCR-ABL1 Positive Acute Lymphoblastic Leukemia (ALL) Patients

Free
Ilaria Iacobucci, Anna Ferrari, Annalisa Lonetti, Cristina Papayannidis, Viviana Guadagnuolo, Emanuela Ottaviani, Mariachiara Abbenante, Federica Cattina, Antonella Vitale, Stefania Paolini, Simona Soverini, Sarah Parisi, Francesca Paoloni, BS, Fausto Castagnetti, Marco Vignetti, Robin Foà, Michele Baccarani, Giovanni Martinelli
Journal: Blood
Blood (2010) 116 (21): 3136.
https://doi.org/10.1182/blood.V116.21.3136.3136
Published: 2010
Journal Articles

Genome-Wide Analysis by High-Resolution SNP Array Identifies Novel Genomic Alterations in Acute Promyelocytic Leukemia (APL).

Free
Ilaria Iacobucci, PhD, Emanuela Ottaviani, Federica Salmi, Viviana Guadagnuolo, Nicoletta Testoni, Annalisa Lonetti, Cristina Papayannidis, Stefania Paolini, Daniela Cilloni, MD, Michele Malagola, Carmen Baldazzi, Francesca Messa, Anna Candoni, Francesca Arruga, Giuseppe Visani, Giuseppe Saglio, MD, Michela Rondoni, Fabrizio Pane, MD, Hasan Syed Khizer, Michele Baccarani, Giovanni Martinelli, MD, Francesco Lo Coco
Journal: Blood
Blood (2009) 114 (22): 167.
https://doi.org/10.1182/blood.V114.22.167.167
Published: 2009