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Journal Articles

Evidence of a Synergistic Cross-Talk between the B Cell Receptor (BCR) and Nicotinamide Phosphoribosyl Transferase (NAMPT) in Richter's Syndrome Patient-Derived Xenograft Models: Therapeutic Implications

Vincenzo Gianluca Messana, Nicoletta Vitale, Matteo Rovere, Lucia Renzullo, Francesca Arruga, Tiziana Vaisitti, Silvia Deaglio

Blood (2021) 138 (Supplement 1): 250.

https://doi.org/10.1182/blood-2021-150238

Published: 2021

Journal Articles

The Tigit/CD226/CD155 Immunomodulatory Axis Is Deregulated in CLL and Contributes to B-Cell Anergy

Francesca Arruga, Andrea Iannello, Nikolaos Ioannou, Alberto Maria Todesco, Marta Coscia, Riccardo Moia, Gianluca Gaidano, John N. Allan, Richard Furman, Tiziana Vaisitti, Alan G. Ramsay, Silvia Deaglio

Blood (2021) 138 (Supplement 1): 3718.

https://doi.org/10.1182/blood-2021-150183

Published: 2021

Journal Articles

Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models

Andrea Iannello, Nicoletta Vitale, Silvia Coma, Francesca Arruga, Amy Chadburn, Arianna Di Napoli, Carlo Laudanna, John N. Allan, Richard R. Furman, Jonathan A. Pachter, Silvia Deaglio, Tiziana Vaisitti

Blood (2021) 137 (24): 3378–3389.

https://doi.org/10.1182/blood.2020010187

Published: 2021

Includes: Supplemental data

Journal Articles

ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient–derived xenograft mouse models

Tiziana Vaisitti, Francesca Arruga, Nicoletta Vitale, Thanh-Trang Lee, Mira Ko, Amy Chadburn, Esteban Braggio, Arianna Di Napoli, Andrea Iannello, John N. Allan, Langdon L. Miller, Brian J. Lannutti, Richard R. Furman, Katti A. Jessen, Silvia Deaglio

Blood (2021) 137 (24): 3365–3377.

https://doi.org/10.1182/blood.2020008404

Published: 2021

Includes: Supplemental data

Journal Articles

Expression of the Tigit/CD226/CD155 Receptors/Ligand System in Chronic Lymphocytic Leukemia

Francesca Arruga, PhD, Giulia Guerra, Denis Baev, PhD, Catherine Hoofd, PhD, Marta Coscia, MD PhD, Giovanni Francesco D'Arena, MD, Gianluca Gaidano, MD PhD, Richard R. Furman, MD, Silvia Deaglio, MD PhD

Blood (2019) 134 (Supplement_1): 5454.

https://doi.org/10.1182/blood-2019-128308

Published: 2019

Journal Articles

Vls-101 Is a Novel Therapeutic Antibody-Drug Conjugate (ADC) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Richter's Syndrome (RS)

Tiziana Vaisitti, PhD, Katti Jessen, PhD, Thanh-Trang Vo, PhD, Mira Ko, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Esteban Braggio, PhD, Arianna Di Napoli, Amy Chadburn, MD, John N. Allan, MD, Richard R. Furman, MD, Langdon L. Miller, Brian J Lanutti, PhD, Silvia Deaglio, MD PhD

Blood (2019) 134 (Supplement_1): 2856.

https://doi.org/10.1182/blood-2019-126827

Published: 2019

Journal Articles

The Dual PI3K-δ/γ Inhibitor Duvelisib in Combination with the Bcl-2 Inhibitor Venetoclax Shows Promising Responses in Richter Syndrome-PDX Models

Andrea Iannello, PhD, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Elisa Marchi, Richard R. Furman, MD, John N. Allan, MD, Silvia Coma, PhD, Jonathan A. Pachter, PhD, Silvia Deaglio, MD PhD, Tiziana Vaisitti, PhD

Blood (2019) 134 (Supplement_1): 2862.

https://doi.org/10.1182/blood-2019-125754

Published: 2019

Journal Articles

CD79b Expression in Richter's Transformation

John N. Allan, MD, Erica B Bhavsar, BS, Tiziana Vaisitti, PhD, Vincent Sarno, Yifang Liu, Francesca Arruga, PhD, Maureen Joyce, Mathias Schulz, MD MBA, Silvia Deaglio, MD PhD, Richard R. Furman, MD, Amy Chadburn, MD

Blood (2019) 134 (Supplement_1): 4279.

https://doi.org/10.1182/blood-2019-128305

Published: 2019

Journal Articles

NOTCH1 Stabilization By PEST Mutations Enhances IgM-Mediated Activity in Chronic Lymphocytic Leukemia

Francesca Arruga, PhD, Valeria Bracciamà, Alison Yeomans, PhD, Annalisa D'Avola, PhD, Marta Coscia, MD, Giovanni Francesco D'Arena, MD, Gianluca Gaidano, MD PhD, John N. Allan, MD, Richard R. Furman, MD, Graham Packham, PhD, Silvia Deaglio, MD PhD, Francesco Forconi, MD DM, PhD FRCPath

Blood (2018) 132 (Supplement 1): 1832.

https://doi.org/10.1182/blood-2018-99-118064

Published: 2018

Journal Articles

Genetic and Molecular Characterization of Novel Richter Syndrome Patient-Derived Xenograft Models

Tiziana Vaisitti, PhD, John N. Allan, MD, Esteban Braggio, PhD, Francesca Arruga, PhD, Amy Chadburn, MD, Richard R. Furman, MD, Silvia Deaglio, MD

Blood (2017) 130 (Supplement 1): 4297.

https://doi.org/10.1182/blood.V130.Suppl_1.4297.4297

Published: 2017

Journal Articles

Mutations in NOTCH1 PEST Domain Orchestrate CCL19-Driven Homing of Chronic Lymphocytic Leukemia (CLL) Cells By Modulating the Tumor Suppressor Gene DUSP22

Blood (2016) 128 (22): 969.

https://doi.org/10.1182/blood.V128.22.969.969

Published: 2016

Journal Articles

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

Valentina Audrito, Sara Serra, Davide Brusa, Francesca Mazzola, Francesca Arruga, Tiziana Vaisitti, Marta Coscia, Rossana Maffei, Davide Rossi, Tao Wang, Giorgio Inghirami, Menico Rizzi, Gianluca Gaidano, Joe G. N. Garcia, Cynthia Wolberger, Nadia Raffaelli, Silvia Deaglio

Blood (2015) 125 (1): 111–123.

https://doi.org/10.1182/blood-2014-07-589069

Published: 2015

Includes: Supplemental data

Journal Articles

NOTCH1 Mutated IGHV Unmutated Chronic Lymphocytic Leukemia Cells Are Characterized By a Constitutive Overexpression of Nucleophosmin-1 and Ribosome-Associated Components

Blood (2014) 124 (21): 3308.

https://doi.org/10.1182/blood.V124.21.3308.3308

Published: 2014

Journal Articles

Extracellular Nicotinamide Phosphoribosyltransferase (NAMPT) Shapes the CLL Microenvironment Promoting Macrophage M2 Polarization Via a Non-Enzymatic Mechanism

Valentina Audrito, Sara Serra, Davide Brusa, PhD, Francesca Mazzola, PhD, Francesca Arruga, PhD, Tiziana Vaisitti, PhD, Marta Coscia, MD PhD, Rossana Maffei, Davide Rossi, MD, Tao Wang, PhD, Giorgio Inghirami, MD, Menico Rizzi, PhD, Gianluca Gaidano, MD, Cynthia Wolberger, PhD, Nadia Raffaelli, PhD, Silvia Deaglio

Blood (2014) 124 (21): 3316.

https://doi.org/10.1182/blood.V124.21.3316.3316

Published: 2014

Journal Articles

NOTCH1 Mutations Are Associated with Low CD20 Expression in Chronic Lymphocytic Leukemia: Evidences for a NOTCH1 -Mediated Epigenetic Regulatory Mechanism

Blood (2014) 124 (21): 296.

https://doi.org/10.1182/blood.V124.21.296.296

Published: 2014

Journal Articles

Functional Effects Of NOTCH1 Mutations In Chronic Lymphocytic Leukemia Patients

Francesca Arruga, PhD, Branimir Gizdic, Sara Serra, Tiziana Vaisitti, PhD, Davide Rossi, Marta Coscia, MD, PhD, Luca Laurenti, MD, Giovanni D'Arena, Ozren Jaksic, MD, PhD, Giorgio Inghirami, Gianluca Gaidano, Silvia Deaglio, MD, PhD

Blood (2013) 122 (21): 4117.

https://doi.org/10.1182/blood.V122.21.4117.4117

Published: 2013

Journal Articles

Extreme Variability of FIP1L1-PDGFRalpha Transcripts In CEL: Analysis of 32 Patients Enrolled In HES0203 Italian Clinical Trial and Correlation with Clinical and Molecular Response After 5 Years Follow-up

Michela Rondoni, MD, Daniela Cilloni, Francesca Arruga, Cristina Papayannidis, Emanuela Ottaviani, Serena Merante, MD, Francesco Buccisano, MD, Sabrina Colarossi, Ilaria Iacobucci, Stefania Paolini, Fabrizio Pane, Giuseppe Saglio, MD, PhD, Francesco Lauria, Michele Baccarani, MD, Giovanni Martinelli

Blood (2010) 116 (21): 1986.

https://doi.org/10.1182/blood.V116.21.1986.1986

Published: 2010

Journal Articles

Harmonized Testing for BCR-ABL Kinase Domain Mutations In CML: Results of a Survey and First Control Round within 28 National Reference Laboratories In Europe

Blood (2010) 116 (21): 894.

https://doi.org/10.1182/blood.V116.21.894.894

Published: 2010

Journal Articles

RASGRP1/APTX Ratio Is a Strong Biomarker of Clinical Response and Survival In AML Patients Treated with Tipifarnib: A Phase I-II Preliminary Results

Giovanni Martinelli, Emanuela Ottaviani, Stefania Paolini, Cristina Papayannidis, Antonio Curti, Sarah Parisi, Ilaria Iacobucci, Daniela Cilloni, Francesca Arruga, Giuseppe Saglio, MD, PhD, Domenico Russo, Giuseppe Visani, Alfonso Zaccaria, Michela Rondoni, MD, Monica Bocchia, Anna Candoni, Renato Fanin, Filippo Gherlinzoni, MD, Michele Baccarani

Blood (2010) 116 (21): 4359.

https://doi.org/10.1182/blood.V116.21.4359.4359

Published: 2010

Journal Articles

Foxo Transcription Factor Activity Is Retained in Quiescent Chronic Myeloid Leukaemia Stem Cells and Activated by Tyrosine Kinase Inhibitors to Mediate “induced-quiescence” in More Mature progenitors.

Daniela Cilloni, MD, PhD, Francesca Pellicano, PhD, Vignir G Helgason, PhD, Cristina Panuzzo, PhD, Francesca Messa, PhD, Brian J Huntly, MD, Elaine Allan, PhD, Francesca Arruga, PhD, Enrico Bracco, PhD, Giuseppe Saglio, MD, Tessa L Holyoake, MD

Blood (2009) 114 (22): 187.

https://doi.org/10.1182/blood.V114.22.187.187

Published: 2009

NARROW

Evidence of a Synergistic Cross-Talk between the B Cell Receptor (BCR) and Nicotinamide Phosphoribosyl Transferase (NAMPT) in Richter's Syndrome Patient-Derived Xenograft Models: Therapeutic Implications

The Tigit/CD226/CD155 Immunomodulatory Axis Is Deregulated in CLL and Contributes to B-Cell Anergy

Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models

ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient–derived xenograft mouse models

Expression of the Tigit/CD226/CD155 Receptors/Ligand System in Chronic Lymphocytic Leukemia

Vls-101 Is a Novel Therapeutic Antibody-Drug Conjugate (ADC) Targeting Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Richter's Syndrome (RS)

The Dual PI3K-δ/γ Inhibitor Duvelisib in Combination with the Bcl-2 Inhibitor Venetoclax Shows Promising Responses in Richter Syndrome-PDX Models

CD79b Expression in Richter's Transformation

NOTCH1 Stabilization By PEST Mutations Enhances IgM-Mediated Activity in Chronic Lymphocytic Leukemia

Genetic and Molecular Characterization of Novel Richter Syndrome Patient-Derived Xenograft Models

Mutations in NOTCH1 PEST Domain Orchestrate CCL19-Driven Homing of Chronic Lymphocytic Leukemia (CLL) Cells By Modulating the Tumor Suppressor Gene DUSP22

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

NOTCH1 Mutated IGHV Unmutated Chronic Lymphocytic Leukemia Cells Are Characterized By a Constitutive Overexpression of Nucleophosmin-1 and Ribosome-Associated Components

Extracellular Nicotinamide Phosphoribosyltransferase (NAMPT) Shapes the CLL Microenvironment Promoting Macrophage M2 Polarization Via a Non-Enzymatic Mechanism

NOTCH1 Mutations Are Associated with Low CD20 Expression in Chronic Lymphocytic Leukemia: Evidences for a NOTCH1 -Mediated Epigenetic Regulatory Mechanism

Functional Effects Of NOTCH1 Mutations In Chronic Lymphocytic Leukemia Patients

Extreme Variability of FIP1L1-PDGFRalpha Transcripts In CEL: Analysis of 32 Patients Enrolled In HES0203 Italian Clinical Trial and Correlation with Clinical and Molecular Response After 5 Years Follow-up

Harmonized Testing for BCR-ABL Kinase Domain Mutations In CML: Results of a Survey and First Control Round within 28 National Reference Laboratories In Europe

RASGRP1/APTX Ratio Is a Strong Biomarker of Clinical Response and Survival In AML Patients Treated with Tipifarnib: A Phase I-II Preliminary Results

Foxo Transcription Factor Activity Is Retained in Quiescent Chronic Myeloid Leukaemia Stem Cells and Activated by Tyrosine Kinase Inhibitors to Mediate “induced-quiescence” in More Mature progenitors.

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American Society of Hematology

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American Society of Hematology

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