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Journal Articles

Targeting the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Novel Therapeutic Opportunities

Andrea Papait, PhD, Tiziana Vaisitti, PhD, Sara Serra, PhD, Valentina Audrito, PhD, Francesco Tito, Giulia Guerra, Dimitar G Efremov, MDPhD, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 240.
https://doi.org/10.1182/blood-2018-99-118057
Published: 2018
Journal Articles

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

Tiziana Vaisitti, PhD, Sara Serra, PhD, Cinzia Bologna, PhD, Nicoletta Vitale, PhD, Stefania Gobessi, PhD BS, Dimitar G Efremov, MD PhD, Silvia Deaglio, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1721.
https://doi.org/10.1182/blood.V130.Suppl_1.1721.1721
Published: 2017
Journal Articles

Mutations in NOTCH1 PEST Domain Orchestrate CCL19-Driven Homing of Chronic Lymphocytic Leukemia (CLL) Cells By Modulating the Tumor Suppressor Gene DUSP22

Francesca Arruga, PhD, Branimir Gizdic, Cinzia Bologna, Simona Cignetto, Roberta Buonincontri, PhD, Sara Serra, PhD, Tiziana Vaisitti, PhD, Nicoletta Vitale, Giulia Garaffo, Elisabetta Mereu, Fary Diop, Francesco Neri, Marta Coscia, MD PhD, John N. Allan, MD, Roberto Piva, Salvatore Oliviero, Richard R. Furman, MD, Davide Rossi, Gianluca Gaidano, MD PhD, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2016) 128 (22): 969.
https://doi.org/10.1182/blood.V128.22.969.969
Published: 2016
Journal Articles

Targeting Cellular Metabolism and Survival in Chronic Lymphocytic Leukemia and Richter Syndrome Cells By a Novel NF-Kb Inhibitor

Tiziana Vaisitti, PhD, Federica Gaudino, Samedy Ouk, Sara Serra, PhD, Johannes L. Zakrzewski, MD, Erica B. Bhavsar, John N. Allan, MD, Hsiou-Chi Liou, PhD, Richard R. Furman, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2016) 128 (22): 304.
https://doi.org/10.1182/blood.V128.22.304.304
Published: 2016
Journal Articles

Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts

Irene Scarfò, Elisa Pellegrino, Elisabetta Mereu, Ivo Kwee, Luca Agnelli, Elisa Bergaggio, Giulia Garaffo, Nicoletta Vitale, Manuel Caputo, Rodolfo Machiorlatti, Paola Circosta, Francesco Abate, Antonella Barreca, Domenico Novero, Susan Mathew, Andrea Rinaldi, Enrico Tiacci, Sara Serra, Silvia Deaglio, Antonino Neri, Brunangelo Falini, Raul Rabadan, Francesco Bertoni, Giorgio Inghirami, Roberto Piva, the European T-Cell Lymphoma Study Group
Journal: Blood
Blood (2016) 127 (2): 221–232.
https://doi.org/10.1182/blood-2014-12-614503
Published: 2016
Includes: Supplemental data
Journal Articles

Adenosine Signaling Mediates Hypoxic Responses in the Chronic Lymphocytic Leukemia Microenvironment

Sara Serra, PhD, Davide Brusa, PhD, Tiziana Vaisitti, PhD, Roberta Buonincontri, PhD, Valentina Audrito, PhD, Marta Coscia, MD PhD, Davide Rossi, MD PhD, Erica B. Bhavsar, Richard R. Furman, MD, Gianluca Gaidano, MD PhD, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4145.
https://doi.org/10.1182/blood.V126.23.4145.4145
Published: 2015
Journal Articles

SLAMF1/CD150 Activates Autophagy in Chronic Lymphocytic Leukemia Cells, Modulating Chemotaxis and Responses to Therapy

Cinzia Bologna, Roberta Buonincontri, PhD, Sara Serra, PhD, Tiziana Vaisitti, PhD, Valentina Audrito, PhD, Davide Brusa, PhD, Andrea Pagnani, Marta Coscia, Giovanni D'Arena, Erica B. Bhavsar, Richard R. Furman, Davide Rossi, MD PhD, Gianluca Gaidano, Cox Terhorst, Silvia Deaglio
Journal: Blood
Blood (2015) 126 (23): 1728.
https://doi.org/10.1182/blood.V126.23.1728.1728
Published: 2015
Journal Articles

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

Valentina Audrito, Sara Serra, Davide Brusa, Francesca Mazzola, Francesca Arruga, Tiziana Vaisitti, Marta Coscia, Rossana Maffei, Davide Rossi, Tao Wang, Giorgio Inghirami, Menico Rizzi, Gianluca Gaidano, Joe G. N. Garcia, Cynthia Wolberger, Nadia Raffaelli, Silvia Deaglio
Journal: Blood
Blood (2015) 125 (1): 111–123.
https://doi.org/10.1182/blood-2014-07-589069
Published: 2015
Includes: Supplemental data
Journal Articles

Extracellular Nicotinamide Phosphoribosyltransferase (NAMPT) Shapes the CLL Microenvironment Promoting Macrophage M2 Polarization Via a Non-Enzymatic Mechanism

Valentina Audrito, Sara Serra, Davide Brusa, PhD, Francesca Mazzola, PhD, Francesca Arruga, PhD, Tiziana Vaisitti, PhD, Marta Coscia, MD PhD, Rossana Maffei, Davide Rossi, MD, Tao Wang, PhD, Giorgio Inghirami, MD, Menico Rizzi, PhD, Gianluca Gaidano, MD, Cynthia Wolberger, PhD, Nadia Raffaelli, PhD, Silvia Deaglio
Journal: Blood
Blood (2014) 124 (21): 3316.
https://doi.org/10.1182/blood.V124.21.3316.3316
Published: 2014
Journal Articles

Identification of a New Subclass of ALK Negative Anaplastic Large Cell Lymphoma Expressing Aberrant Levels of ERBB4 Transcripts

Irene Scarfò, Elisa Pellegrino, Ivo Kwee, Luca Agnelli, Elisabetta Mereu, Elisa Bergaggio, Francesco Abate, Rodolfo Machiorlatti, Katia Messana, Andrea Rinaldi, Enrico Tiacci, Sara Serra, Silvia Deaglio, Antonino Neri, Brunangelo Falini, Raul Rabadan, Francesco Bertoni, Giorgio Inghirami, MD, Roberto Piva
Journal: Blood
Blood (2014) 124 (21): 1679.
https://doi.org/10.1182/blood.V124.21.1679.1679
Published: 2014
Journal Articles

Regulation Of CLL Growth and Trafficking By The Enzymatic Functions Of CD38: Implications For Therapeutic Targeting

Tiziana Vaisitti, PhD, Valentina Audrito, Sara Serra, Giovanna Sociali, Antonella Zucchetto, Erika Tissino, Andrea Pagnani, Candida Vitale, MD, Marta Coscia, MD, PhD, Valter Gattei, Santina Bruzzone, Silvia Deaglio, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4112.
https://doi.org/10.1182/blood.V122.21.4112.4112
Published: 2013
Journal Articles

Functional Effects Of NOTCH1 Mutations In Chronic Lymphocytic Leukemia Patients

Francesca Arruga, PhD, Branimir Gizdic, Sara Serra, Tiziana Vaisitti, PhD, Davide Rossi, Marta Coscia, MD, PhD, Luca Laurenti, MD, Giovanni D'Arena, Ozren Jaksic, MD, PhD, Giorgio Inghirami, Gianluca Gaidano, Silvia Deaglio, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4117.
https://doi.org/10.1182/blood.V122.21.4117.4117
Published: 2013
Journal Articles

Slamf-1/CD150 Is a Signaling Receptor Expressed by a Subset of Chronic Lymphocytic Leukemia Patients Characterized by a Favorable Prognosis

Cinzia Bologna, Roberta Buonincontri, Sara Serra, Tiziana Vaisitti, PhD, Valentina Audrito, Davide Brusa, Davide Rossi, MD, PhD, Marta Coscia, MD, PhD, Gianluca Gaidano, MD, PhD, Cox Terhorst, PhD, Silvia Deaglio, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1770.
https://doi.org/10.1182/blood.V120.21.1770.1770
Published: 2012
Journal Articles

The PD-1/PD-L1 Axis Contributes to T Cell Dysfunction in Chronic Lymphocytic Leukemia

Davide Brusa, Sara Serra, Marta Coscia, MD, PhD, Davide Rossi, MD, PhD, Gianluca Gaidano, MD, PhD, Giorgio Inghirami, Tiziana Vaisitti, PhD, Silvia Deaglio, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1778.
https://doi.org/10.1182/blood.V120.21.1778.1778
Published: 2012
Journal Articles

CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

Sara Serra, Alberto L. Horenstein, Tiziana Vaisitti, Davide Brusa, Davide Rossi, Luca Laurenti, Giovanni D'Arena, Marta Coscia, Claudio Tripodo, Giorgio Inghirami, Simon C. Robson, Gianluca Gaidano, Fabio Malavasi, Silvia Deaglio
Journal: Blood
Blood (2011) 118 (23): 6141–6152.
https://doi.org/10.1182/blood-2011-08-374728
Published: 2011
Includes: Supplemental data
Journal Articles

CD73-Generated Extracellular Adenosine Creates Microenvironmental Conditions Favoring Growth and Survival of Chronic Lymphocytic Leukemia Cells

Sara Serra, Alberto Horenstein, Tiziana Vaisitti, Davide Brusa, Davide Rossi, Luca Laurenti, Giovanni D'Arena, Marta Coscia, MD, PhD, Claudio Tripodo, Giorgio Inghirami, Simon Robson, Gianluca Gaidano, Fabio Malavasi, Silvia Deaglio
Journal: Blood
Blood (2011) 118 (21): 621.
https://doi.org/10.1182/blood.V118.21.621.621
Published: 2011
Journal Articles

CD38 Regulates Homing and Engraftment of CLL Cells,

Tiziana Vaisitti, Sara Serra, Valentina Audrito, Chris Pepper, Davide Rossi, Giovanni D'Arena, Luca Laurenti, Antonella Zucchetto, Ph.D., Valter Gattei, Gianluca Gaidano, Fabio Malavasi, Silvia Deaglio
Journal: Blood
Blood (2011) 118 (21): 3873.
https://doi.org/10.1182/blood.V118.21.3873.3873
Published: 2011
Journal Articles

Nicotinamide Promotes Apoptosis In Chronic Lymphocytic Leukemia through Activation of the p53/Mir-34a/SIRT1 Tumor Suppressor Network

Valentina Audrito, Tiziana Vaisitti, Sara Serra, Davide Rossi, Daniela Gottardi, Giovanni D’Arena, Gianluca Gaidano, Fabio Malavasi, Silvia Deaglio
Journal: Blood
Blood (2010) 116 (21): 4627.
https://doi.org/10.1182/blood.V116.21.4627.4627
Published: 2010
Journal Articles

CD38 Expression Marks CLL Cells with Invasive Properties

Tiziana Vaisitti, Cinzia Bologna, Sara Serra, Giovanni D'Arena, Davide Rossi, Chris Pepper, Gianluca Gaidano, MD, Fabio Malavasi, Silvia Deaglio
Journal: Blood
Blood (2010) 116 (21): 2422.
https://doi.org/10.1182/blood.V116.21.2422.2422
Published: 2010