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Silvia Coma
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Journal Articles

PI3Kδ/γ Inhibitor Duvelisib Modulates Inflammatory Profile in Severe COVID-19 Patients: Results from a Randomized Placebo-Controlled Phase 2 Study

Hanwen Zhang, Shuhua Wang, Manali Rupji, Chenxi Wu, Sanjay Chandrasekaran, Christopher R. Funk, Patrick J. King, Saketh Kollipara, Ishani Rao, Esohe Ayanru, Julia Duffy, Roberta Kaplow, Aseala Abousaud, Aneesh Mehta, John D. Roback, Daniel Kalman, G. Marshall Lyon, III, Mark Caridi-Scheible, Gregory Bisson, Yuan Liu, Silvia Coma, Jonathan A. Pachter, Cynthia R. Giver, Edmund K. Waller
Journal: Blood
Blood (2022) 140 (Supplement 1): 11187–11189.
https://doi.org/10.1182/blood-2022-165567
Published: 2022
Journal Articles

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

Christopher Ronald Funk, Shuhua Wang, Kevin Z. Chen, Alexandra Waller, Aditi Sharma, Claudia L. Edgar, Vikas A. Gupta, Shanmuganathan Chandrakasan, Jaquelyn T. Zoine, Andrew Fedanov, Sunil S. Raikar, Jean L. Koff, Christopher R. Flowers, Silvia Coma, Jonathan A. Pachter, Sruthi Ravindranathan, H. Trent Spencer, Mala Shanmugam, Edmund K. Waller
Journal: Blood
Blood (2022) 139 (4): 523–537.
https://doi.org/10.1182/blood.2021011597
Published: 2022
Includes: Supplemental data
Journal Articles

Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models

Andrea Iannello, Nicoletta Vitale, Silvia Coma, Francesca Arruga, Amy Chadburn, Arianna Di Napoli, Carlo Laudanna, John N. Allan, Richard R. Furman, Jonathan A. Pachter, Silvia Deaglio, Tiziana Vaisitti
Journal: Blood
Blood (2021) 137 (24): 3378–3389.
https://doi.org/10.1182/blood.2020010187
Published: 2021
Includes: Supplemental data
Journal Articles

Macrophage Activation By Dual PI3K-δ/γ Inhibition Enhances Anti-CD47-Mediated Phagocytosis and Prolongs Survival in DLBCL

James Godfrey, MD, Wenjun Kang, MS, Lei Huang, PhD, Silvia Coma, PhD, Roy Maute, PhD, Mark P. Chao, MD PhD, Jonathan A Pachter, PhD, Sonali Smith, MD, Justin Kline, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40.
https://doi.org/10.1182/blood-2020-143304
Published: 2020
Journal Articles

The Dual PI3K-δ/γ Inhibitor Duvelisib in Combination with the Bcl-2 Inhibitor Venetoclax Shows Promising Responses in Richter Syndrome-PDX Models

Andrea Iannello, PhD, Francesca Arruga, PhD, Nicoletta Vitale, PhD, Elisa Marchi, Richard R. Furman, MD, John N. Allan, MD, Silvia Coma, PhD, Jonathan A. Pachter, PhD, Silvia Deaglio, MD PhD, Tiziana Vaisitti, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2862.
https://doi.org/10.1182/blood-2019-125754
Published: 2019
Journal Articles

Inhibition of Let- 7 Maturation By Lin28b Controls Timing of Embryonic and Adult Myeloid Progenitor Phenotypes during Development

Robert G Rowe, MD PhD, Leo D. Wang, MDPhD, Silvia Coma, PhD, Samantha Ross, Phi Nguyen, Daniel Pearson, Amy J. Wagers, PhD, George Q. Daley, MD PhD
Journal: Blood
Blood (2014) 124 (21): 763.
https://doi.org/10.1182/blood.V124.21.763.763
Published: 2014