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Journal Articles

Circulating RAS/RAF and DNA-Repair Gene Mutations Associates with High-Risk/Treatment Resistance in Primary Refractory Multiple Myeloma

Sridurga Mithraprabhu, John Reynolds, Rose Turner, Hang Quach, Noemi Horvath, Ian H Kerridge, Flora Yuen, Tiffany Khong, Brian G.M. Durie, Andrew Spencer
Journal: Blood
Blood (2022) 140 (Supplement 1): 9933–9934.
https://doi.org/10.1182/blood-2022-171053
Published: 2022
Journal Articles

Multiple Myeloma-Derived Circulating Extracellular Vesicles Affect Normal Human Stromal Cell Behaviour and Promote Tumor Progression: A Multi-Omic Approach

Antonia Reale, Irena Carmichael, Rong Xu, Haoyun Fang, Jaynish S Shah, Tiffany Khong, Nicholas Bingham, Malarmathy Ramachandran, Maoshan Chen, David W Greening, Andrew Spencer
Journal: Blood
Blood (2022) 140 (Supplement 1): 7080–7081.
https://doi.org/10.1182/blood-2022-168440
Published: 2022
Journal Articles

Targeting Bclxl Mitigates Mcl1 Chemoresistance in Multiple Myeloma

Ioanna Savvidou, Tiffany Khong, Irena Carmichael, Jaynish S Shah, Sridurga Mithraprabhu, Andrew Spencer
Journal: Blood
Blood (2021) 138 (Supplement 1): 2656.
https://doi.org/10.1182/blood-2021-149936
Published: 2021
Journal Articles

Response Adaptive Salvage Treatment with Carfilzomib-Thalidomide-Dexamethasone for Newly Diagnosed Transplant Eligible Multiple Myeloma Patients Failing Front-Line Bortezomib-Based Induction Therapy - Final Analysis from the Australasian Leukemia and Lymphoma Group (ALLG) MM17 Trial

Rose Turner, Hang Quach, Noemi Horvath, Ian H Kerridge, Flora Yuen, Edwin Sze-Hung Lee, Edward S. Morris, Anna Kalff, Krystal Bergin, Shreerang Sridesai, Malgorzata Gorniak, Sridurga Mithraprabhu, Tiffany Khong, John Reynolds, Andrew Spencer
Journal: Blood
Blood (2021) 138 (Supplement 1): 1663.
https://doi.org/10.1182/blood-2021-152034
Published: 2021
Journal Articles

Immune Cell Profiles in Patients Treated with Lenalidomide and Alternate Day Prednisolone Maintenance Post Upfront ASCT for Multiple Myeloma (LEOPARD Trial)

Anna Kalff, MBBS (Hons) FRACP FRCPA, Sam Norton, PhD, Tiffany Khong, BSc, PhD, Malarmathy Ramachandran, Mary H. Young, PhD, William Pierceall, Anjan Thakurta, Udo Oppermann, PhD, Manman Guo, John Reynolds, PhD, Andrew Spencer
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-141746
Published: 2020
Journal Articles

A Longitudinal Evaluation of Euroflow and Combined Quantitative Immunoprecipitation (QIP) and Free Light Chain (FLC) Mass Spectometry (MS) in Functional High Risk Multiple Myeloma

Andrew Spencer, DM, Tiffany Khong, BSc, PhD, Flora Yuen, BBiomedSc, Hannah Victoria Giles, FRCPath, MRCP, Malgorzata Gorniak, BSc, Hang Quach, MBBS, FRACP, FRCPA, MD, Noemi Horvath, MBBS FRACP FRCPA, Ian H. Kerridge, FRACP,FRCPA,MPhil,BA, Edwin Sze-Hung Lee, MD FRACP, FRCP, FRCPA, FRCPath, Krystal Bergin, Shreerang Sridesai, MBBS, FRACP, FRCPA, Anna Kalff, MBBS, John Reynolds, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3090.
https://doi.org/10.1182/blood-2019-129760
Published: 2019
Journal Articles

Identification of Novel Immune Cell Populations in Lenalidomide Refractory Relapsed Multiple Myeloma Patients Treated with Pomalidomide and Low Dose Dexamethasone

Anna Kalff, MBBS, Tiffany Khong, BSc, PhD, Malarmathy Ramachandran, Sam Norton, PhD, Andrew Mitchell, PhD, John Reynolds, PhD, Hang Quach, MBBS, FRACP, FRCPA, MD, P Joy Ho, MBBS(Syd) DPhil(Oxon) FRACP FRCPA FFSc(RCPA), Noemi Horvath, MBBS FRACP FRCPA, Peter Mollee, MBBS, MMSc, FRACP, FRCPA, Nola Kennedy, Roslyn Kemp, Andrew Spencer, DM
Journal: Blood
Blood (2019) 134 (Supplement_1): 3186.
https://doi.org/10.1182/blood-2019-130154
Published: 2019
Journal Articles

Panobinostat (LBH589) in Combination with the β-Catenin Inhibitor Tegavivint (BC2059) Exerts Significant Anti-Myeloma Activity Both in Vitro and In Vivo

Ioanna Savvidou, MD, Tiffany Khong, BSc, PhD, Sophie Whish, Tara Sepehrizadeh, Sridurga Mithraprabhu, PhD MSc, Michael DeVeer, BSc, PhD, Andrew Spencer, DM
Journal: Blood
Blood (2019) 134 (Supplement_1): 5540.
https://doi.org/10.1182/blood-2019-126468
Published: 2019
Journal Articles

MCL-1 Inhibitor-Induced Killing of Multiple Myeloma Is Modulated By the Relative Level of Expression of Pro-Survival Members of the BCL-2 Family and the Proto-Oncogene MYC

Andrew Spencer, DM, Tiffany Khong, BSc, PhD, Maoshan Chenn, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1825.
https://doi.org/10.1182/blood-2019-127843
Published: 2019
Journal Articles

Resistance to Nutrient Deprivation Via Metabolic Re-Programming As Mechanism of 'Metastasis' Promotion in Multiple Myeloma

Ioanna Savvidou, MD, Sahan Chandrasekara, MD, Maoshan Chenn, PhD, Tiffany Khong, BSc, PhD, Andrew Spencer, MBBS, FRACP, FRCPA, DM
Journal: Blood
Blood (2018) 132 (Supplement 1): 3218.
https://doi.org/10.1182/blood-2018-99-112802
Published: 2018
Journal Articles

CRISPR-Cas9 Mediated CD45 Knockout Inactivates Src Family Kinases and Impairs Cell Migration in Multiple Myeloma

Wing Yu Man, BSc, Tiffany Khong, BSc, PhD, Andrew Spencer, MBBS, MD FRACP, FRCPA
Journal: Blood
Blood (2018) 132 (Supplement 1): 1907.
https://doi.org/10.1182/blood-2018-99-117532
Published: 2018
Journal Articles

Preliminary Analysis of the Australasian Leukaemia and Lymphoma Group (ALLG) MM17 Trial: Response Adaptive Salvage Treatment with Carfilzomib-Thalidomide-Dexamethasone (KTd) for Newly Diagnosed Transplant Eligible Multiple Myeloma Patients Failing Front-Line Bortezomib-Based Induction Therapy

Andrew Spencer, MBBS, FRACP, FRCPA, DM, Hang Quach, MD FRACP, FRCPA, MBBS, Noemi Horvath, MBBS FRACP FRCPA, Ian H. Kerridge, FRACP, FRCPA, MPhil, BA, Flora Yuen, BBiomedSc, Edwin Sze-Hung Lee, MD FRACP, FRCP, FRCPA, FRCPath, Edward S. Morris, BMBS, DM, Anna Kalff, MBBS, Krystal Bergin, Shreerang Sirdesai, MBBS, FRACP, FRCPA, Malgorzata Gorniak, BSc, Sridurga Mithraprabhu, PhD MSc, Tiffany Khong, BSc, PhD, John Reynolds, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3279.
https://doi.org/10.1182/blood-2018-99-113982
Published: 2018
Journal Articles

Metabolomic Profiling of Serum from Myeloma and MGUS Patients - a Novel Strategy to Identify Potential Biomarkers of Myeloma Development and Progression

Samar Masoumi Moghaddam, MD PhD, Dovile Anderson, PhD, Darren Creek, PhD, Tiffany Khong, BSc, PhD, Andrew Spencer, MBBS, FRACP, FRCPA, DM
Journal: Blood
Blood (2018) 132 (Supplement 1): 1891.
https://doi.org/10.1182/blood-2018-99-117541
Published: 2018
Journal Articles

TOP2A a New Predictive Marker of Response to Carfilzomib in Multiple Myeloma

Antonia Reale, MD Oncologist in training, Tiffany Khong, BSc, PhD, Sridurga Mithraprabhu, PhD, John Reynolds, Malarmathy Ramachandran, Ioanna Savvidou, MD PhD, Krystal Bergin, Jay Hocking, MD PhDstudent, Andrew Spencer
Journal: Blood
Blood (2016) 128 (22): 4461.
https://doi.org/10.1182/blood.V128.22.4461.4461
Published: 2016
Journal Articles

Mutational Characterisation and Tracking Disease Progression Using Circulating Cell-Free Tumor DNA in Multiple Myeloma Patients

Sridurga Mithraprabhu, PhD, Tiffany Khong, BSc, PhD, Malarmathy Ramachandran, Annie W.S. Chow, Daniela Klarica, RN, Laura Mai, Stephanie Walsh, David Broemeling, Andre Marziali, Matthew Wiggin, Jay Hocking, MD PhDstudent, Anna Kalff, MBBS, FRACP, FRCPA, Brian G.M. Durie, MD, Andrew Spencer
Journal: Blood
Blood (2016) 128 (22): 3280.
https://doi.org/10.1182/blood.V128.22.3280.3280
Published: 2016
Journal Articles

Targeting the Pro-Survival BCL2 Proteins with BH3 Mimetic Compounds for Treating Multiple Myeloma

Jia-Nan Gong, PhD, Tiffany Khong, PhD, David Segal, PhD, Yuan Yao, Mark F van Delft, PhD, Andrew Spencer, Andrew W Roberts, MBBS, PhD, David CS Huang, MBBS, MRCP, PhD
Journal: Blood
Blood (2016) 128 (22): 3293.
https://doi.org/10.1182/blood.V128.22.3293.3293
Published: 2016
Journal Articles

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1

Jia-Nan Gong, Tiffany Khong, David Segal, Yuan Yao, Chris D. Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume Lessene, Andrew Spencer, Marco J. Herold, Andrew W. Roberts, David C. S. Huang
Journal: Blood
Blood (2016) 128 (14): 1834–1844.
https://doi.org/10.1182/blood-2016-03-704908
Published: 2016
Includes: Supplemental data
Journal Articles

A New Generation XIAP Inhibitor Induces Apoptosis of Human Myeloma Cells and Synergises with Conventional and Novel Anti-Myeloma Therapeutics.

Tiffany Khong, PhD, BSc(Hons), Andrew Spencer, MBBS, FRACP, FRCPA, DM
Journal: Blood
Blood (2007) 110 (11): 4787.
https://doi.org/10.1182/blood.V110.11.4787.4787
Published: 2007
Journal Articles

Modulation of the Mitochondrial (Type 2) Apoptotic Pathway Can Enhance Apo2L/TRAIL - Mediated Killing of Human Multiple Myeloma (MM) Cells.

Tiffany Khong, Sung Lin Yeh, Karly Souris, Andrew Spencer
Journal: Blood
Blood (2006) 108 (11): 3447.
https://doi.org/10.1182/blood.V108.11.3447.3447
Published: 2006
Journal Articles

Azacitidine Down-Regulates Both IL-6 Signalling and NFkB Activity in Human Myeloma Cells.

Tiffany Khong, BSc, PhD, Andrew Spencer, MBBS,FRACP,FRCPA,MD.
Journal: Blood
Blood (2006) 108 (11): 3441.
https://doi.org/10.1182/blood.V108.11.3441.3441
Published: 2006