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Reyka G. Jayasinghe
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Journal Articles

Itacitinib for Prevention of Graft-Versus-Host Disease and Cytokine Release Syndrome in Haploidentical Transplantation

Clinical Trials & Observations
Ramzi Abboud, Mark A. Schroeder, Michael P Rettig, Reyka G Jayasinghe, Feng Gao, Jeremy Eisele, Leah Gehrs, Julie K. Ritchey, Jaebok Choi, Camille N Abboud, Iskra Pusic, Meagan A Jacoby, Peter Westervelt, Matthew Christopher, Amanda F. Cashen, Armin Ghobadi, Keith Stockerl-Goldstein, Geoffrey L Uy, John F. DiPersio
Journal: Blood
Blood blood.2024026497.
https://doi.org/10.1182/blood.2024026497
Published: 2024
Includes: Supplemental data
Journal Articles

Immunomodulatory Effects of MEK Inhibition in Multiple Myeloma

Chaitanya Acharya, Reyka G. Jayasinghe, Mark Hamilton, Sacha Gnjatic, Seunghee Kim-Schulze, Hearn Jay Cho, Shaji Kumar, George Mulligan
Journal: Blood
Blood (2024) 144 (Supplement 1): 6863.
https://doi.org/10.1182/blood-2024-210989
Published: 2024
Journal Articles

Elucidation of Human Invariant NKT Cell Immunophenotypes to Provide Insights for Future Universal Donor Derived Cellular Therapeutics

Emily Landy, Melissa Mavers, Reyka G. Jayasinghe, Nathan Schedler, Robert S. Negrin
Journal: Blood
Blood (2024) 144 (Supplement 1): 1159.
https://doi.org/10.1182/blood-2024-194022
Published: 2024
Journal Articles

Motixafortide (CXCR4 Inhibition) Alone and in Combination with Natalizumab (VLA-4 Inhibition) As a Novel Regimen to Mobilize Hematopoietic Stem Cells for Gene Therapies in Sickle Cell Disease: A First-in-Human, Proof-of-Principle Safety and Feasibility Study

Zachary D. Crees, Michael P. Rettig, Reyka G. Jayasinghe, Stephanie Christ, Feng Gao, Hailey Sappington, Sana Saif Ur Rehman, Suzanne R. Thibodeaux, Ella Sorani, Allison A. King, John F. DiPersio
Journal: Blood
Blood (2024) 144 (Supplement 1): 145.
https://doi.org/10.1182/blood-2024-193210
Published: 2024
Journal Articles

Identifying Surface Protein Markers for AML Immunotherapy

Omar M. Ibrahim, Michael P. Rettig, Ezhilarasi Chendamarai, Reyka G. Jayasinghe, Li Ding, John DiPersio
Journal: Blood
Blood (2023) 142 (Supplement 1): 6809.
https://doi.org/10.1182/blood-2023-187831
Published: 2023
Journal Articles

Heterogeneity of Human Invariant Natural Killer T Cells, Including Novel Naïve-like CD8 + and Temra-like CD4 - CD8 - Populations, Revealed through Single Cell RNA-Sequencing

Melissa Mavers, Derek Hollingsworth, Reyka G. Jayasinghe, Chaiyaporn Boonchalermvichian, Biki Gupta, Hao Yan, Jeanette Baker, Beruh Dejene, Kenneth I. Weinberg, Robert S. Negrin
Journal: Blood
Blood (2023) 142 (Supplement 1): 152.
https://doi.org/10.1182/blood-2023-182442
Published: 2023
Journal Articles

Long Non-Coding RNA LINC00XPRR Is Upregulated in Newly Diagnosed Multiple Myeloma Promoting Poor Response to High-Dose Melphalan with Autologous Stem Cell Transplantation and Three-Drug Regimen

Richa Mishra, Katelyn Bagwill, Savannah Gonzales, Vanessa Brizuela, Prasanth Thunuguntla, Yoon Jae Chang, Reyka G. Jayasinghe, Julie Fortier, Mark A. Schroeder, Li Ding, Ravi Vij, John DiPersio, Jessica Silva-Fisher
Journal: Blood
Blood (2023) 142 (Supplement 1): 4668.
https://doi.org/10.1182/blood-2023-180011
Published: 2023
Journal Articles

A Phase I Safety and Feasibility Study to Evaluate Motixafortide (CXCR4/SDF-1 Inhibition) and Natalizumab (VLA-4/VCAM-1 Inhibition) As a Novel Regimen to Mobilize CD34+ Hematopoietic Stem Cells for Gene Therapy in Sickle Cell Disease

Zachary D. Crees, Michael P. Rettig, Reyka G. Jayasinghe, Peter Ruminski, Abi Vainstein, Ella Sorani, Allison A. King, John F. DiPersio
Journal: Blood
Blood (2022) 140 (Supplement 1): 10432–10433.
https://doi.org/10.1182/blood-2022-165454
Published: 2022
Journal Articles

Needle in a Haystack: A Pilot Study Combining Single-Cell Multiomics with Clinical NGS-MRD Sequencing to Search for Circulating Clonotypic Dedifferentiated Myeloma Cells

Scott R. Goldsmith, Reyka G. Jayasinghe, Jonathan Adam Scolnick, Jaren Sia, Mark A Fiala, Michael J Slade, Tianjiao Wang, Li Ding, Ravi Vij
Journal: Blood
Blood (2022) 140 (Supplement 1): 9945–9946.
https://doi.org/10.1182/blood-2022-169604
Published: 2022
Journal Articles

The Dual PI3Kdg Inhibitor Duvelisib Potently Inhibits Cytokine Release Syndrome (CRS) While Maintaining CAR-T Function

Parmeshwar N. Amatya, Reyka G. Jayasinghe, Alun J. Carter, Matthew L. Cooper, Jonathan A. Pachter, John F. DiPersio, Julie K. Ritchey
Journal: Blood
Blood (2022) 140 (Supplement 1): 12686–12687.
https://doi.org/10.1182/blood-2022-167715
Published: 2022
Journal Articles

Myeloma Developing Regimens Using Genomics (MyDRUG): Longitudinal Single-Cell Transcriptional Landscape of the Myeloma and Immune Microenvironment in Relapsed/Refractory Multiple Myeloma Patients Treated with MEK-Inhibitor, Cobimetinib

Reyka G. Jayasinghe, George Mulligan, April Cook, Mark Hamilton, Sacha Gnjatic, Seunghee Kim-Schulze, Hearn J. Cho, Shaji K Kumar
Journal: Blood
Blood (2022) 140 (Supplement 1): 7090–7091.
https://doi.org/10.1182/blood-2022-167462
Published: 2022
Journal Articles

Association between Bone Marrow Immune Microenvironment Following Autologous Stem Cell Transplant and Duration of Response for Multiple Myeloma

Tianjiao Wang, Mark A Fiala, Julie M Fortier, Ruiyang Liu, Reyka G. Jayasinghe, Ravi Vij, Li Ding
Journal: Blood
Blood (2022) 140 (Supplement 1): 7066–7067.
https://doi.org/10.1182/blood-2022-169716
Published: 2022
Journal Articles

Immunophenotypic and Single-Cell Transcriptional Profiling of CD34+ Hematopoietic Stem and Progenitor Cells Mobilized with Motixafortide (BL-8040) and G-CSF Versus Plerixafor and G-CSF Versus Placebo and G-CSF: A Correlative Study of the Genesis Trial

Zachary D. Crees, Michael Retting, Reyka G Jayasinghe, Keith E. Stockerl-Goldstein, Abi Vainstein, Ella Sorani, Debby Ickowicz, Liron Shemesh-Darvish, Shaul Kadosh, John F. DiPersio
Journal: Blood
Blood (2021) 138 (Supplement 1): 3816.
https://doi.org/10.1182/blood-2021-144297
Published: 2021
Journal Articles

Single-Cell RNA-Seq Analysis of CD138-Depleted Bone Marrow Samples Reveals Genetic Alterations and Disease Progression Correlate with Tumor and Bone Marrow Immune Microenvironment in the Mmrf Commpass Study

Lijun Yao, Tianjiao Wang, Sato Kazuhiro, Reyka G Jayasinghe, William Pilcher, Edgar Gonzalez-Kozlova, Yered Pita-Juarez, Taxiarchis Kourelis, Deon Doxie, Beena E Thomas, Brian Lee, Swati S Bhasin, Bhaskar Upadhyaya, Mark A Fiala, Julie Fortier, Travis Dawson, John Leech, Shaji Kumar, Hearn Jay Cho, Seunghee Kim-Schulze, Bee Raj, Stephen T. Oh, John F. DiPersio, Ravi Vij, Adeeb H Rahman, Ioannis Vlachos, Shaadi Mehr, Mark Hamilton, Daniel Auclair, Surendra Dasari, David Avigan, Madhav V Dhodapkar, Sacha Gnjatic, Manoj Bhasin, Li Ding
Journal: Blood
Blood (2021) 138 (Supplement 1): 2691.
https://doi.org/10.1182/blood-2021-154081
Published: 2021
Journal Articles

Interim Analysis of Mmrf Curecloud Research Initiative Identifies High Prevalence and Patterns of Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations in a Real World Myeloma Cohort

Reyka G Jayasinghe, Annette S. Kim, Teni Dowdell, Carrie Cibulskis, Jennifer Yesil, Debanjana Chatterjee, Michele Likens, Shaadi Mehr, Cartik Saravanamuthu, Jean-Baptiste Alberge, Emily Lapinskas, Steven E Labkoff, Keith L Ligon, Hearn Jay Cho, Irene M. Ghobrial, Daniel Auclair
Journal: Blood
Blood (2021) 138 (Supplement 1): 2197.
https://doi.org/10.1182/blood-2021-148782
Published: 2021
Journal Articles

Characterization of T-Cell Exhaustion in Rapid Progressing Multiple Myeloma Using Cross Center Scrna-Seq Study

William Pilcher, Beena E Thomas, Swati S Bhasin, Reyka G Jayasinghe, Adeeb H Rahman, Seunghee Kim-Schulze, Edgar Gonzalez-Kozlova, Taxiarchis Kourelis, Madhav V Dhodapkar, Ravi Vij, Shaji Kumar, Shaadi Mehr, Mark Hamilton, Hearn Jay Cho, Daniel Auclair, David Avigan, Sacha Gnjatic, Li Ding, Manoj Bhasin
Journal: Blood
Blood (2021) 138 (Supplement 1): 401.
https://doi.org/10.1182/blood-2021-153863
Published: 2021
Journal Articles

Architecture of Sample Preparation and Data Governance of Immuno-Genomic Data Collected from Bone Marrow and Peripheral Blood Samples Obtained from Multiple Myeloma Patients

Shaadi Mehr, PhD, Daniel Auclair, Mark Hamilton, PhD, Leon Rozenblit, Hearn Jay Cho, MD PhD, Lijun Yao, MS, Reyka G Jayasinghe, PhD, Manoj Bhasin, PhD, Steven E. Labkoff, MD, Taxiarchis Kourelis, MD, Madhav V. Dhodapkar, MD, Deon Doxie, Sacha Gnjatic, Cassandra Dewitt, Sergey Miron
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-142882
Published: 2020
Journal Articles

Characterization of Plasma and Immune Cells Molecular Landscape That Play a Role in Rapid Progression of Multiple Myeloma Using Cross Center Scrna-Seq Study

Manoj Bhasin, PhD, Beena E Thomas, Reyka G Jayasinghe, PhD, Nicolas Fernandez, PhD, Swati S Bhasin, PhD, Taxiarchis Kourelis, MD, Madhav V. Dhodapkar, MD, Ravi Vij, Shaji K. Kumar, MD, Shaadi Mehr, PhD, Mark Hamilton, PhD, Hearn Jay Cho, MD PhD, Daniel Auclair, Sacha Gnjatic, Li Ding, PhD, David E. Avigan, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–8.
https://doi.org/10.1182/blood-2020-143350
Published: 2020
Journal Articles

Myeloma Cell Associated Therapeutic Protein Discovery Using Single Cell RNA-Seq Data

Lijun Yao, MS, Reyka G Jayasinghe, PhD, Tianjiao Wang, BA, Julie O'Neal, PhD, Ruiyang Liu, BS, Michael P. Rettig, PhD, Chia-Feng Tsai, PhD, Steven M. Foltz, BS, MS, Danny Kohnen, MBA, Smrithi Mani, BS, Fernanda Martins Rodrigues, MSc, Michael C. Wendl, D SC, MS, PHS, Matthew A. Wyczalkowski, PhD, Scott R. Goldsmith, MD, Ying Zhu, PhD, Mark A Fiala, MSW, Liu Tao, BS, PhD, Ravi Vij, MD MBA, Li Ding, PhD, John F. DiPersio, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-142205
Published: 2020
Journal Articles

Integrated Cytof, Scrna-Seq and Cite-Seq Analysis of Bone Marrow Immune Microenvironment in the Mmrf Commpass Study

Lijun Yao, MS, Reyka G Jayasinghe, PhD, Beena E Thomas, Swati S Bhasin, PhD, Nicolas Fernandez, PhD, Taxiarchis Kourelis, MD, Deon Doxie, David E. Avigan, MD, Madhav V. Dhodapkar, MD, Shaji K. Kumar, MD, Ravi Vij, MBBS, Shaadi Mehr, PhD, Mark Hamilton, PhD, Hearn Jay Cho, MD PhD, Daniel Auclair, Sacha Gnjatic, PhD, Manoj Bhasin, PhD, Li Ding, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-142534
Published: 2020