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Deena Iskander
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Journal Articles

The Fetal Specific Gene LIN28B Is Essential for Human Fetal B-Lymphopoiesis and Initiation of KMT2A-AFF1+ Infant Acute Lymphoblastic Leukemia

Rebecca E Ling, Thomas Jackson, Natalina Elliott, Joe W Cross, Lucy Hamer, Arundhati S Wuppalapati, Alastair L Smith, Catherine M Chahrour, Okan Sevim, Deena Iskander, Guanlin Wang, Sorcha I O'Byrne, Siobhan Rice, Joe R Harman, Bethan Psaila, Rhys G Morgan, Irene Roberts, Thomas A Milne, Anindita Roy
Journal: Blood
Blood (2024) 144 (Supplement 1): 199.
https://doi.org/10.1182/blood-2024-198819
Published: 2024
Journal Articles

Spatial Transcriptomics Identifies Aberrant Communication between Dendritic Cells and Leukemia Stem Cells As a Therapeutically Targetable Axis in Juvenile Myelomonocytic Leukemia

Eleni Louka, Kristian Gurashi, Sean Wen, Mariolina Salio, Christina Simoglou Karali, Roman Doll, Sally-Ann Clark, Anastasia Kosmidou, Rosalin Cooper, Daniel Royston, Deena Iskander, Nawshad Hayder, Renuka Teague, Cristina Tormo Garcia, Maria Greco, Paola Vargas Gutierrez, Joshua Bull, Anupama Rao, Irene Roberts, Adam J Mead
Journal: Blood
Blood (2024) 144 (Supplement 1): 822.
https://doi.org/10.1182/blood-2024-208902
Published: 2024
Journal Articles

Multimodal Single Cell Analysis Reveals Hematopoietic Changes across the Human Lifespan

Tomoya Isobe, Mariana Quiroga Londoño, Nicole Mende, Emily Stephenson, Deena Iskander, Simone Webb, Issac Goh, Vijay Shanmugiah, Rebecca Hannah, Anindita Roy, Irene Roberts, Elisa Laurenti, Muzlifah Haniffa, Nicola K. Wilson, Berthold Gottgens
Journal: Blood
Blood (2024) 144 (Supplement 1): 2659.
https://doi.org/10.1182/blood-2024-204131
Published: 2024
Journal Articles

Two’s company but three’s a blast!

Deena Iskander
Journal: Blood
Blood (2022) 140 (14): 1578–1580.
https://doi.org/10.1182/blood.2022017644
Published: 2022
Journal Articles

Turning up the HEAT(R3) in Diamond-Blackfan anemia

Deena Iskander, Alan J. Warren
Journal: Blood
Blood (2022) 139 (21): 3101–3102.
https://doi.org/10.1182/blood.2022015881
Published: 2022
Journal Articles

Single-Cell Transcriptional Landscapes of Human Bone Marrow Reveal Distinct Erythroid Phenotypes Underpinned By Genotype in Diamond-Blackfan Anemia

Deena Iskander, MD, Guanlin Wang, PhD, Elisabeth F Heuston, PhD, Chrysi Christodoulidou, Bethan Psaila, MD PhD, Mark E Robinson, PhD, Aristeidis Chaidos, MD PhD, Pritesh Trivedi, MSc, Nikolaos Trasanidis, PhD, Alexia Katsarou, MD, Richard Szydlo, PhD, NISC Comparative SequencingProgram, Qais Al-Oqaily, MD PhD, Valentina S Caputo, PhD, Kanagaraju Ponnusamy, PhD, Anindita Roy, MD PhD, Leena Karnik, FRCPath, MRCP, Kikkeri Naresh, MD, Adam J. Mead, MD PhD, Supat Thongjuea, PhD, Marjorie Brand, PhD, Josu de la Fuente, David M. Bodine, PhD, Irene Roberts, MD PhD, Anastasios Karadimitris, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-141535
Published: 2020
Journal Articles

Novel ZBP1-IRF3 Dependency in Multiple Myeloma Mediated By IRF3-Driven Regulation of Cell Cycle Genes

Kanagaraju Ponnusamy, Maria-Myrsini Tzioni, MS, Murshida Begum, MS, Mark E Robinson, Valentina S Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, MD, Irene Roberts, Pritesh Trivedi, MSc, Holger W Auner, MD PhD, Kikkeri Naresh, MD, Aristeidis Chaidos, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 2521.
https://doi.org/10.1182/blood-2019-125768
Published: 2019
Journal Articles

Myeloma Cell Addiction to the Transcription Factor TCF11

Valentina Caputo, PhD, Katerina Goudevenou, PhD, Nikolaos Trasanidis, BSc, MSc, Kyriaki Petevi, MD, Xiaolin Xiao, PhD, Kanagaraju Ponnusamy, PhD, Deena Iskander, MD, David Pitcher, PhD, Antonia Rotolo, MD, Holger W. Auner, MD PhD, Aristeidis Chaidos, MD PhD, Anastasios Karadimitris, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1194.
https://doi.org/10.1182/blood.V130.Suppl_1.1194.1194
Published: 2017
Journal Articles

Molecular and Functional Characterization of Disease-Propagating Stem Cells in Juvenile Myelomonocytic Leukemia

Eleni Louka, MD, Benjamin Povinelli, PhD, Alba Rodriguez-Meira, Gemma Buck, BSc, Angela Hamblin, MD PhD, Christopher Booth, Anindita Roy, MD PhD, Natalina Elliott, PhD, Deena Iskander, MD, Josu de la Fuente, FRCP, PhD FRCPath, Nicholas James Fordham, MBBS, BSc, Sorcha Isabella Obyrne, Sarah Inglott, Anupama Gopala Rao, MB, MRCP, MRCPath, Irene Roberts, MD, Adam J Mead, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 379.
https://doi.org/10.1182/blood.V130.Suppl_1.379.379
Published: 2017
Journal Articles

Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs

Brief Report
Deena Iskander, Bethan Psaila, Gareth Gerrard, Aristeidis Chaidos, Hui En Foong, Yvonne Harrington, Leena C. Karnik, Irene Roberts, Josu de la Fuente, Anastasios Karadimitris
Journal: Blood
Blood (2015) 125 (16): 2553–2557.
https://doi.org/10.1182/blood-2014-10-608042
Published: 2015
Includes: Supplemental data
Journal Articles

Developmental Stage Specific B-Progenitor Expansion in Normal Fetal Bone Marrow Is Absent in Down Syndrome: Implications for Infant ALL

Anindita Roy, MDPhD, Georg Bohn, Katerina Goudevenou, Gillian Cowan, Neha Bhatnagar, David O'Connor, Oliver Tunstall, Jerry Chan, Phillip Bennett, Sailesh Kumar, Deena Iskander, Sarah Inglott, Binbin Liu, Philip Ancliff, Anastasios Karadimitris, Irene Roberts, MDFRCP FRCPCH FRCPath
Journal: Blood
Blood (2014) 124 (21): 4331.
https://doi.org/10.1182/blood.V124.21.4331.4331
Published: 2014
Journal Articles

Transcriptional and epigenetic basis for restoration of G6PD enzymatic activity in human G6PD-deficient cells

Kalliopi Makarona, Valentina S. Caputo, Joana R. Costa, Binbin Liu, David O’Connor, Deena Iskander, David Roper, Lynn Robertson, Neha Bhatnagar, Evangelos Terpos, Elisabeth Georgiou, Maria Papaioannou, D. Mark Layton, Lucio Luzzatto, Irene Roberts, Anastasios Karadimitris
Journal: Blood
Blood (2014) 124 (1): 134–141.
https://doi.org/10.1182/blood-2014-02-553792
Published: 2014
Includes: Supplemental data
Journal Articles

Target Enrichment and High-Throughput Sequencing of 80 Ribosomal Protein Genes to Identify Mutations Associated with Diamond-Blackfan Anaemia.

Gareth Gerrard, PhD, Mikel Valgañón, PhD, Hui En Foong, MSc, Dalia Kasperaviciute, PhD, Michael Müller, PhD, Laurence Game, PhD, Deena Iskander, MRCP, Irene Roberts, Letizia Foroni, MD, PhD, FRCPath, Josu de la Fuente, PhD, FRCP, MRCPCH, FRCPath, Anastasios Karadimitris, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2369.
https://doi.org/10.1182/blood.V120.21.2369.2369
Published: 2012
Journal Articles

Patients with Diamond Blackfan Anaemia Have Abnormalities of Cellular and Humoral Immunity

Deena Iskander, MRCP, Yvonne Harrington, RCN, Irene Roberts, Anastasios Karadimitris, MD, PhD, Josu de la Fuente, PhD, FRCP, MRCPCH, FRCPath
Journal: Blood
Blood (2012) 120 (21): 3484.
https://doi.org/10.1182/blood.V120.21.3484.3484
Published: 2012