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Journal Articles

Spatial Transcriptomics Identifies Aberrant Communication between Dendritic Cells and Leukemia Stem Cells As a Therapeutically Targetable Axis in Juvenile Myelomonocytic Leukemia

Eleni Louka, Kristian Gurashi, Sean Wen, Mariolina Salio, Christina Simoglou Karali, Roman Doll, Sally-Ann Clark, Anastasia Kosmidou, Rosalin Cooper, Daniel Royston, Deena Iskander, Nawshad Hayder, Renuka Teague, Cristina Tormo Garcia, Maria Greco, Paola Vargas Gutierrez, Joshua Bull, Anupama Rao, Irene Roberts, Adam J Mead
Journal: Blood
Blood (2024) 144 (Supplement 1): 822.
https://doi.org/10.1182/blood-2024-208902
Published: 2024
Journal Articles

KLF5 Is a Key Regulator of IMiD-Induced Neutropenia

Christina Simoglou Karali, Simone G Riva, Sally-Ann Clark, E. Ravza Gür, Nicholas Denny, Roman Doll, Anastasia Kosmidou, Assunta Adamo, Shady Adnan Awad, Srinivasa Adusumalli, Jiangpeikun Song, Sean Wen, Nikolaos Sousos, Eleni Louka, Nawshad Hayder, Kim Sharp, William E. Pierceall, Anjan Thakurta, Anita K. Gandhi, Patrick R. Hagner, James Oliver Davies, Kilian Huber, Jim Hughes, Adam J Mead
Journal: Blood
Blood (2024) 144 (Supplement 1): 2527.
https://doi.org/10.1182/blood-2024-207135
Published: 2024
Journal Articles

Constructing a Computational Workflow for the Identification of Novel Cellular and Molecular Drivers of Human Granulopoiesis

Simone G Riva, Christina Simoglou Karali, E. Ravza Gür, Martin Sergeant, Edward Sanders, Sally-Ann Clark, Nicholas Denny, Roman Doll, Anastasia Kosmidou, Assunta Adamo, Shady Adnan Awad, Srinivasa Adusumalli, Jiangpeikun Song, Sean Wen, Nikolaos Sousos, Eleni Louka, Nawshad Hayder, Kim Sharp, William E. Pierceall, Anjan Thakurta, Anita K. Gandhi, Patrick R. Hagner, James Oliver Davies, Kilian Huber, Adam J Mead, Jim Hughes
Journal: Blood
Blood (2024) 144 (Supplement 1): 2525.
https://doi.org/10.1182/blood-2024-207224
Published: 2024
Journal Articles

Causes and Consequences of Clonal Hematopoiesis with Unknown Drivers in 409,553 Whole-Genome Sequenced UK Biobank Participants

Sean Wen, Marcin Karpinski, Dimitrios Vitsios, Sebastian Wasilewski, Slavé Petrovski, Andrew R. Harper, Margarete A. Fabre, George S Vassiliou, Jonathan Mitchell
Journal: Blood
Blood (2024) 144 (Supplement 1): 945.
https://doi.org/10.1182/blood-2024-205118
Published: 2024
Journal Articles

Platelet-Restricted Clonal Hematopoiesis

Nikolaos Sousos, Lauren Murphy, Sean Wen, Angela Hamblin, Sally-Ann Clark, Christina Simoglou Karali, Jessica Whittle, Zemin Ren, Haseeb Rahman, Nawshad Hayder, Akriti Rastogi, Michael Jacobs, Susan Shapiro, Bethan Psaila, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 814.
https://doi.org/10.1182/blood-2023-188000
Published: 2023
Journal Articles

Ancestry-Specific Genetic Determinants of Clonal Haematopoiesis: A Comparative Analysis of 136,401 Admixed Americans and 419,228 Europeans

Sean Wen, Fengyuan Hu, Abhishek Nag, Ioanna Tachmazidou, Sri Vishnu Vardhan Deevi, Haeyam Taiy, Katherine Smith, Keren Carss, Sebastian Wasilewski, Jesus Alegre-Díaz, Pablo Kuri-Morales, Jaime Berumen, Roberto Tapia-Conyer, Jonathan Emberson, Jason M. Torres, Rory Collins, Quanli Wang, Slavé Petrovski, Margarete Fabre, Andrew Harper, George Vassiliou, Jonathan Mitchell
Journal: Blood
Blood (2023) 142 (Supplement 1): 816.
https://doi.org/10.1182/blood-2023-173484
Published: 2023
Journal Articles

Chromothripsis Orchestrates Leukemic Transformation in Blast Phase MPN through Targetable Amplification of DYRK1A

Charlotte K Brierley, Bon Ham Yip, Giulia Orlando, Harsh Goyal, Sean Wen, Jeremy Wen, Max F. Levine, Alba Rodriguez-Meira, Assunta Adamo, Matthew Bashton, Angela Hamblin, Sally-Ann Clark, Jennifer O Sullivan, Lauren Murphy, Aude-Anais Olijnik, Anitria Cotton, Shilpa Narina, Shondra Pruett-Miller, Amir Enshaei, Claire N Harrison, Mark W. Drummond, Steve Knapper, Ayalew Tefferi, Ileana antony-Debre, Supat Thongjuea, Stefan N Constantinescu, Elli Papaemmanuil, Bethan Psaila, John D. Crispino, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 993.
https://doi.org/10.1182/blood-2023-178556
Published: 2023
Journal Articles

Cooperation between SF3B1 and JAK2 V617F Mutations Accelerates Fibrotic Progression in Myeloproliferative Neoplasms By Enhancing STAT1 Signaling

Jennifer O Sullivan, Sean Wen, Affaf Aliouat, Alba Rodriguez-Meira, Sally-Ann Clark, Neil Ashley, Amy Wood, Ramy Slama, Guanlin Wang, Angela Hamblin, Lauren Murphy, Christina Simoglou Karali, Charlotte K Brierley, Adam P Cribbs, Aimee Paterson, Claire N Harrison, Bethan Psaila, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 861.
https://doi.org/10.1182/blood-2023-185118
Published: 2023
Journal Articles

A Multiomic Single-Cell Atlas of Human Myelopoiesis Reveals Cellular and Molecular Drivers of Immunomodulatory Drug-Induced Neutropenia

Christina Simoglou Karali, Simone Riva, Sally-Ann Clark, Sean Wen, Nikolaos Sousos, Eleni Louka, E. Ravza Gür, Nawshad Hayder, William E. Pierceall, Anjan Thakurta, Anita K. Gandhi, Patrick R Hagner, Jim Hughes, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 935.
https://doi.org/10.1182/blood-2023-182041
Published: 2023
Journal Articles

The SF3B1 K666 Hotspot Mutation Confers Unfavourable Disease Risk across Major Myeloid Neoplasm Subgroups

Jennifer O Sullivan, Amy Wood, Sean Wen, Angela Hamblin, Sonia Fox, Christina Yap, Mary Frances McMullin, Nicholas C. P. Cross, Claire N Harrison, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 4552.
https://doi.org/10.1182/blood-2023-185043
Published: 2023
Journal Articles

Single-Cell Mutation Profiling and Alternative Splicing Analysis Reveals Distinct Aberrant Splicing of U2AF1 S34 and U2AF1 Q157 in Myeloid Malignancies

Sean Wen, Jennifer O Sullivan, Joanna Baxter, Nikolaos Sousos, Adam J Mead, Alba Rodriguez-Meira
Journal: Blood
Blood (2023) 142 (Supplement 1): 4133.
https://doi.org/10.1182/blood-2023-185999
Published: 2023