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Christina Simoglou Karali
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Journal Articles

Spatial Transcriptomics Identifies Aberrant Communication between Dendritic Cells and Leukemia Stem Cells As a Therapeutically Targetable Axis in Juvenile Myelomonocytic Leukemia

Eleni Louka, Kristian Gurashi, Sean Wen, Mariolina Salio, Christina Simoglou Karali, Roman Doll, Sally-Ann Clark, Anastasia Kosmidou, Rosalin Cooper, Daniel Royston, Deena Iskander, Nawshad Hayder, Renuka Teague, Cristina Tormo Garcia, Maria Greco, Paola Vargas Gutierrez, Joshua Bull, Anupama Rao, Irene Roberts, Adam J Mead
Journal: Blood
Blood (2024) 144 (Supplement 1): 822.
https://doi.org/10.1182/blood-2024-208902
Published: 2024
Journal Articles

KLF5 Is a Key Regulator of IMiD-Induced Neutropenia

Christina Simoglou Karali, Simone G Riva, Sally-Ann Clark, E. Ravza Gür, Nicholas Denny, Roman Doll, Anastasia Kosmidou, Assunta Adamo, Shady Adnan Awad, Srinivasa Adusumalli, Jiangpeikun Song, Sean Wen, Nikolaos Sousos, Eleni Louka, Nawshad Hayder, Kim Sharp, William E. Pierceall, Anjan Thakurta, Anita K. Gandhi, Patrick R. Hagner, James Oliver Davies, Kilian Huber, Jim Hughes, Adam J Mead
Journal: Blood
Blood (2024) 144 (Supplement 1): 2527.
https://doi.org/10.1182/blood-2024-207135
Published: 2024
Journal Articles

Constructing a Computational Workflow for the Identification of Novel Cellular and Molecular Drivers of Human Granulopoiesis

Simone G Riva, Christina Simoglou Karali, E. Ravza Gür, Martin Sergeant, Edward Sanders, Sally-Ann Clark, Nicholas Denny, Roman Doll, Anastasia Kosmidou, Assunta Adamo, Shady Adnan Awad, Srinivasa Adusumalli, Jiangpeikun Song, Sean Wen, Nikolaos Sousos, Eleni Louka, Nawshad Hayder, Kim Sharp, William E. Pierceall, Anjan Thakurta, Anita K. Gandhi, Patrick R. Hagner, James Oliver Davies, Kilian Huber, Adam J Mead, Jim Hughes
Journal: Blood
Blood (2024) 144 (Supplement 1): 2525.
https://doi.org/10.1182/blood-2024-207224
Published: 2024
Journal Articles

Platelets Sequester Extracellular DNA, Capturing Tumour-Derived and Free Fetal DNA

Lauren Murphy, Jeanne Inchauspe, Nikolaos Sousos, Natalie Jooss, Hayley L Belnoue-Davis, Pamela Holland, Rong Li, Giampiero Valenzano, Fenella Roseman, Sujata Biswas, Sally-Ann Clark, Jennifer O'Sullivan, Michael Rimmer, Abdullah O Khan, Christina Simoglou Karali, Eric ONeill, Nadia Nasreddin, Ian Hitchcock, Milka Koupenova, Manu Vatish, Paul Rees, Simon Leedham, Adam J Mead, Benjamin Schuster-Boeckler, Christopher Gregory, Bethan Psaila
Journal: Blood
Blood (2023) 142 (Supplement 1): 277.
https://doi.org/10.1182/blood-2023-182697
Published: 2023
Journal Articles

Platelet-Restricted Clonal Hematopoiesis

Nikolaos Sousos, Lauren Murphy, Sean Wen, Angela Hamblin, Sally-Ann Clark, Christina Simoglou Karali, Jessica Whittle, Zemin Ren, Haseeb Rahman, Nawshad Hayder, Akriti Rastogi, Michael Jacobs, Susan Shapiro, Bethan Psaila, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 814.
https://doi.org/10.1182/blood-2023-188000
Published: 2023
Journal Articles

A Multiomic Single-Cell Atlas of Human Myelopoiesis Reveals Cellular and Molecular Drivers of Immunomodulatory Drug-Induced Neutropenia

Christina Simoglou Karali, Simone Riva, Sally-Ann Clark, Sean Wen, Nikolaos Sousos, Eleni Louka, E. Ravza Gür, Nawshad Hayder, William E. Pierceall, Anjan Thakurta, Anita K. Gandhi, Patrick R Hagner, Jim Hughes, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 935.
https://doi.org/10.1182/blood-2023-182041
Published: 2023
Journal Articles

Cooperation between SF3B1 and JAK2 V617F Mutations Accelerates Fibrotic Progression in Myeloproliferative Neoplasms By Enhancing STAT1 Signaling

Jennifer O Sullivan, Sean Wen, Affaf Aliouat, Alba Rodriguez-Meira, Sally-Ann Clark, Neil Ashley, Amy Wood, Ramy Slama, Guanlin Wang, Angela Hamblin, Lauren Murphy, Christina Simoglou Karali, Charlotte K Brierley, Adam P Cribbs, Aimee Paterson, Claire N Harrison, Bethan Psaila, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 861.
https://doi.org/10.1182/blood-2023-185118
Published: 2023
Journal Articles

Cross-Talk between Hematopoietic Cells and Fibroblast Subsets Drives Inflammation and Remodelling of the Bone Marrow Microenvironment in Myeloproliferative Neoplasms

Rong Li, Michela Colombo, Guanlin Wang, Sally-Ann Clark, Antonio Rodriguez-Romera, Yiran Meng, Abdullah Khan, Wei Xiong Wen, Nikolaos Sousos, Lauren Murphy, Christina Simoglou Karali, Korsuk Sirinukunwattana, Jennifer O'Sullivan, Ruggiero Norfo, Qian Cheng, Charlotte Brierley, Joana Carrelha, Zemin Ren, Gabriel A. Rabinovich, Vijay A Rathinam, Supat Thongjuea, Daniel Royston, Adam J Mead, Bethan Psaila
Journal: Blood
Blood (2022) 140 (Supplement 1): 1091–1092.
https://doi.org/10.1182/blood-2022-165493
Published: 2022