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Journal Articles

Chromothripsis Orchestrates Leukemic Transformation in Blast Phase MPN through Targetable Amplification of DYRK1A

Charlotte K Brierley, Bon Ham Yip, Giulia Orlando, Harsh Goyal, Sean Wen, Jeremy Wen, Max F. Levine, Alba Rodriguez-Meira, Assunta Adamo, Matthew Bashton, Angela Hamblin, Sally-Ann Clark, Jennifer O Sullivan, Lauren Murphy, Aude-Anais Olijnik, Anitria Cotton, Shilpa Narina, Shondra Pruett-Miller, Amir Enshaei, Claire N Harrison, Mark W. Drummond, Steve Knapper, Ayalew Tefferi, Ileana antony-Debre, Supat Thongjuea, Stefan N Constantinescu, Elli Papaemmanuil, Bethan Psaila, John D. Crispino, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 993.
https://doi.org/10.1182/blood-2023-178556
Published: 2023
Journal Articles

Single-Cell Transcriptome Analysis Reveals Pathways That Drive Dyserythropoiesis in Myelodysplastic Syndromes, Which Are Targeted By Luspatercept

Onima Chowdhury, Douglas RA Silveira, Sophie Reed, Jennifer O'Sullivan, Sally-Ann Clark, Neil Ashley, Bethan Psaila, Supat Thongjuea, Adam J Mead, Lynn Quek
Journal: Blood
Blood (2022) 140 (Supplement 1): 9753–9754.
https://doi.org/10.1182/blood-2022-165865
Published: 2022
Journal Articles

Cross-Talk between Hematopoietic Cells and Fibroblast Subsets Drives Inflammation and Remodelling of the Bone Marrow Microenvironment in Myeloproliferative Neoplasms

Rong Li, Michela Colombo, Guanlin Wang, Sally-Ann Clark, Antonio Rodriguez-Romera, Yiran Meng, Abdullah Khan, Wei Xiong Wen, Nikolaos Sousos, Lauren Murphy, Christina Simoglou Karali, Korsuk Sirinukunwattana, Jennifer O'Sullivan, Ruggiero Norfo, Qian Cheng, Charlotte Brierley, Joana Carrelha, Zemin Ren, Gabriel A. Rabinovich, Vijay A Rathinam, Supat Thongjuea, Daniel Royston, Adam J Mead, Bethan Psaila
Journal: Blood
Blood (2022) 140 (Supplement 1): 1091–1092.
https://doi.org/10.1182/blood-2022-165493
Published: 2022
Journal Articles

CD34 + CD19 − CD22 + B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies

Brief Report
Clara Bueno, Susana Barrera, Alex Bataller, Valentín Ortiz-Maldonado, Natalina Elliot, Sorcha O’Byrne, Guanlin Wang, Montse Rovira, Francisco Gutierrez-Agüera, Juan L. Trincado, María González-González, Mireia Morgades, Marc Sorigué, Paloma Bárcena, Samanta Romina Zanetti, Montse Torrebadell, Nerea Vega-Garcia, Susana Rives, Mar Mallo, Francesc Sole, Adam J. Mead, Irene Roberts, Supat Thongjuea, Bethan Psaila, Manel Juan, Julio Delgado, Alvaro Urbano-Ispizúa, Josep María Ribera, Alberto Orfao, Anindita Roy, Pablo Menendez
Journal: Blood
Blood (2022) 140 (1): 38–44.
https://doi.org/10.1182/blood.2021014840
Published: 2022
Includes: Supplemental data
Journal Articles

Single-Cell Multi-Omics Reveals the Genetic, Cellular and Molecular Landscape of TP53 Mutated Leukemic Transformation in MPN

Alba Rodriguez-Meira, Haseeb Rahman, Ruggiero Norfo, Wei Wen, Agathe Chédeville, Jennifer O'Sullivan, Guanlin Wang, Aimee Paterson, Eleni Louka, Charlotte K Brierley, Warren W Kretzschmar, Francois Girodon, Zemin Ren, Matthew Bashton, Amir Enshaei, Mark W. Drummond, Florence Pasquier, Christophe Marzac, Claire N. Harrison, Isabelle Plo, Sten Eirik W Jacobsen, Supat Thongjuea, Bethan Psaila, Ileana Antony-Debre, Adam J. Mead
Journal: Blood
Blood (2021) 138 (Supplement 1): 3.
https://doi.org/10.1182/blood-2021-150191
Published: 2021
Journal Articles

Single-Cell Transcriptional Landscapes of Human Bone Marrow Reveal Distinct Erythroid Phenotypes Underpinned By Genotype in Diamond-Blackfan Anemia

Deena Iskander, MD, Guanlin Wang, PhD, Elisabeth F Heuston, PhD, Chrysi Christodoulidou, Bethan Psaila, MD PhD, Mark E Robinson, PhD, Aristeidis Chaidos, MD PhD, Pritesh Trivedi, MSc, Nikolaos Trasanidis, PhD, Alexia Katsarou, MD, Richard Szydlo, PhD, NISC Comparative SequencingProgram, Qais Al-Oqaily, MD PhD, Valentina S Caputo, PhD, Kanagaraju Ponnusamy, PhD, Anindita Roy, MD PhD, Leena Karnik, FRCPath, MRCP, Kikkeri Naresh, MD, Adam J. Mead, MD PhD, Supat Thongjuea, PhD, Marjorie Brand, PhD, Josu de la Fuente, David M. Bodine, PhD, Irene Roberts, MD PhD, Anastasios Karadimitris, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-141535
Published: 2020
Journal Articles

Single-cell analysis of bone marrow–derived CD34 + cells from children with sickle cell disease and thalassemia

Peng Hua, Noemi Roy, Josu de la Fuente, Guanlin Wang, Supat Thongjuea, Kevin Clark, Anindita Roy, Bethan Psaila, Neil Ashley, Yvonne Harrington, Claus Nerlov, Suzanne M. Watt, Irene Roberts, James O. J. Davies
Journal: Blood
Blood (2019) 134 (23): 2111–2115.
https://doi.org/10.1182/blood.2019002301
Published: 2019
Includes: Supplemental data
Journal Articles

Single Cell Whole Transcriptome Analysis Reveals Distinct Molecular Signatures of Therapy-Resistant Chronic Myeloid Leukemia Stem Cells

Alice Giustacchini, Supat Thongjuea, Petter S. Woll, PhD, Paul Sopp, Ana Duenas Perez, Nikolaos Barkas, Christopher Booth, Ruggiero Norfo, Sally-Ann Clark, Lauren Jamieson, Sten Eirik Jacobsen, Adam Mead
Journal: Blood
Blood (2015) 126 (23): 13.
https://doi.org/10.1182/blood.V126.23.13.13
Published: 2015
Journal Articles

HBS1L-MYB intergenic Variants Modulate Fetal Hemoglobin Via Long-Range MYB Enhancers

Ralph Stadhouders, BSc, Suleyman Aktuna, BSc, Supat Thongjuea, PhD, Ali Aghajanirefah, PhD, Farzin Pourfarzad, PhD, Wilfred van Ijcken, PhD, Boris Lenhard, PhD, Helen Rooks, BSc, Steve Best, PhD, Stephan Menzel, MD, Frank Grosveld, PhD, Swee Lay Thein, MBBS, DSc, Eric Soler, PhD
Journal: Blood
Blood (2013) 122 (21): 43.
https://doi.org/10.1182/blood.V122.21.43.43
Published: 2013
Journal Articles

Genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis

Athina Mylona, Charlotte Andrieu-Soler, Supat Thongjuea, Andrea Martella, Eric Soler, Ruud Jorna, Jun Hou, Christel Kockx, Wilfred van Ijcken, Boris Lenhard, Frank Grosveld
Journal: Blood
Blood (2013) 121 (15): 2902–2913.
https://doi.org/10.1182/blood-2012-11-467654
Published: 2013
Includes: Supplemental data
Journal Articles

DNA-binding factor CTCF and long-range gene interactions in V(D)J recombination and oncogene activation

Claudia Ribeiro de Almeida, Ralph Stadhouders, Supat Thongjuea, Eric Soler, Rudi W. Hendriks
Journal: Blood
Blood (2012) 119 (26): 6209–6218.
https://doi.org/10.1182/blood-2012-03-402586
Published: 2012