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Ileana Antony-Debre
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Journal Articles

AUTX703, a Novel and Potent KAT2A and KAT2B Protein Degrader, Induces Differentiation and Offers Survival Advantage in a Primary Human AML Xenograft Model

Hélène Duparc, James Neef, Janany Kandiah, Maulasri Bhatta, Agathe Chédeville, Joe DeBartolo, Sara Sinicropi-Yao, Betty Chan, Alex Constan, Christophe Marzac, Jean-Baptiste Micol, Laura Antipov, Stephane De Botton, Katharine E Yen, David S Millan, Iléana Antony-Debré, Kimberly S Straley
Journal: Blood
Blood (2024) 144 (Supplement 1): 3585.
https://doi.org/10.1182/blood-2024-208179
Published: 2024
Journal Articles

Chromothripsis Orchestrates Leukemic Transformation in Blast Phase MPN through Targetable Amplification of DYRK1A

Charlotte K Brierley, Bon Ham Yip, Giulia Orlando, Harsh Goyal, Sean Wen, Jeremy Wen, Max F. Levine, Alba Rodriguez-Meira, Assunta Adamo, Matthew Bashton, Angela Hamblin, Sally-Ann Clark, Jennifer O Sullivan, Lauren Murphy, Aude-Anais Olijnik, Anitria Cotton, Shilpa Narina, Shondra Pruett-Miller, Amir Enshaei, Claire N Harrison, Mark W. Drummond, Steve Knapper, Ayalew Tefferi, Ileana antony-Debre, Supat Thongjuea, Stefan N Constantinescu, Elli Papaemmanuil, Bethan Psaila, John D. Crispino, Adam J Mead
Journal: Blood
Blood (2023) 142 (Supplement 1): 993.
https://doi.org/10.1182/blood-2023-178556
Published: 2023
Journal Articles

Mutational Profile and Dynamics of PPM1D -Mutant Clones in the Spectrum of Myeloid Disorders

Jean Pegliasco, David Fandrei, Florence Pasquier, Nathalie Ibrahim, Maria Kfoury, Guillemette Imbert-De-Tremiolles, Nourhan Lizziek, Céline Berthon, Mael Heiblig, Delphine Lebon, Ambroise Marcais, Mathieu Meunier, Ahmad Aljijakli, Emilie Lemasle, Sylvain Chantepie, Cécile Pautas, Pierre-Yves Dumas, Stephanie Haiat, Cyril Quivoron, Ileana antony-Debre, Sophie Cotteret, Raphael Itzykson, Hervé Dombret, Nicolas Duployez, Nathalie Droin, Christophe Marzac, Elsa Bernard, Jean-Baptiste Micol
Journal: Blood
Blood (2023) 142 (Supplement 1): 4064.
https://doi.org/10.1182/blood-2023-189428
Published: 2023
Journal Articles

Single-Cell Multi-Omics Reveals the Genetic, Cellular and Molecular Landscape of TP53 Mutated Leukemic Transformation in MPN

Alba Rodriguez-Meira, Haseeb Rahman, Ruggiero Norfo, Wei Wen, Agathe Chédeville, Jennifer O'Sullivan, Guanlin Wang, Aimee Paterson, Eleni Louka, Charlotte K Brierley, Warren W Kretzschmar, Francois Girodon, Zemin Ren, Matthew Bashton, Amir Enshaei, Mark W. Drummond, Florence Pasquier, Christophe Marzac, Claire N. Harrison, Isabelle Plo, Sten Eirik W Jacobsen, Supat Thongjuea, Bethan Psaila, Ileana Antony-Debre, Adam J. Mead
Journal: Blood
Blood (2021) 138 (Supplement 1): 3.
https://doi.org/10.1182/blood-2021-150191
Published: 2021
Journal Articles

Dual role of EZH2 in megakaryocyte differentiation

Stefania Mazzi, Philippe Dessen, Mathieu Vieira, Virginie Dufour, Marie Cambot, Mira El Khoury, Iléana Antony-Debré, Brahim Arkoun, Francesca Basso-Valentina, Salwa BenAbdoulahab, Valerie Edmond, Philippe Rameau, Rachel Petermann, Monika Wittner, Bruno Cassinat, Isabelle Plo, Najet Debili, Hana Raslova, William Vainchenker
Journal: Blood
Blood (2021) 138 (17): 1603–1614.
https://doi.org/10.1182/blood.2019004638
Published: 2021
Includes: Supplemental data
Journal Articles

Palbociclib Prevents CDK4/6 Dependent-Myeloproliferation and Myelofibrosis

Helene Duparc, Delphine Muller, Ileana Antony-Debre, PhD PharmD, Caroline Marty, PhD, Najet Debili, Jean-Luc Villeval, PhD, Isabelle Plo, William Vainchenker, Laure Gilles, PhD, Hana Raslova
Journal: Blood
Blood (2020) 136 (Supplement 1): 25.
https://doi.org/10.1182/blood-2020-141092
Published: 2020
Journal Articles

Therapy Related Myeloid Neoplasm Post PARP Inhibitors: Potential Clonal Selection.

Jean-Edouard Martin, Sabine Khalife-Hachem, Thomas Grinda, Maria Kfoury, Sylvain Garciaz, Florence Pasquier, MD PhD, Jacques Vargaftig, Madalina Uzunov, MD, Amine Belhabri, MD, Sarah Bertoli, MD PhD, Nathalie Auger, Veronique Saada, Christel Guillouf, Iléana Antony-Debre, PhD, Etienne Rouleau, Flore Salviat, Olivier Caron, Patricia Pautier, Gabriel Etienne, MD PhD, Norbert Vey, MD, Filippo Rosselli, Stephane De Botton, Alexandra Leary, Christophe Marzac, MD, Jean-Baptiste Micol, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-139971
Published: 2020
Journal Articles

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Angela Su, Frank Ling, Camille Vaganay, Bryann Pardieu, Lina Benajiba, MD/PhD, Gaetano Sodaro, Justine Pasanisi, Kevin H Lin, BS, Justine Rutter, PhD, Christopher F. Bassil, Iléana Antony-Debre, PhD, Gabriela Alexe, PhD, Jean-François Benoist, MD, Yana Pikman, MD, Jun Qi, PhD, Herve Dombret, MD PhD, Claude Preudhomme, PharmD, PhD, Nina Fenouille, Hava M. Golan, Kimberly Stegmaier, MD, Camille Lobry, Kris C Wood, PhD, Raphael Itzykson, Alexandre Puissant, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 877.
https://doi.org/10.1182/blood-2019-131255
Published: 2019
Journal Articles

Clonal Hematopoiesis in the Molecular Landscape of Therapy-Related Myeloid Neoplasms in Patients Previously Treated for Gynecologic and Breast Cancers

Sabine Khalife-Hachem, Khalil Saleh, MD, Florence Pasquier, MD PhD, Anthony Tarabay, Cyril Quivoron, Sophie Cotteret, Christophe Willekens, MD, Veronique Saada, Ines-Maria Vaz-Luis, Suzette Delaloge, Alexandra Leary, Hana Raslova, PhD, Filippo Rosselli, Olivier Caron, Iléana Antony-Debre, PhD, Eric Solary, MD PhD, Stephane de Botton, MD PhD, Christophe Marzac, MD, Jean-Baptiste Micol, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3722.
https://doi.org/10.1182/blood-2019-126872
Published: 2019
Journal Articles

Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond–like syndrome

Christine Bellanné-Chantelot, Barbara Schmaltz-Panneau, Caroline Marty, Odile Fenneteau, Isabelle Callebaut, Séverine Clauin, Aurélie Docet, Gandhi-Laurent Damaj, Thierry Leblanc, Isabelle Pellier, Cécile Stoven, Sylvie Souquere, Iléana Antony-Debré, Blandine Beaupain, Nathalie Aladjidi, Vincent Barlogis, Frédéric Bauduer, Philippe Bensaid, Odile Boespflug-Tanguy, Claire Berger, Yves Bertrand, Liana Carausu, Claire Fieschi, Claire Galambrun, Aline Schmidt, Hubert Journel, Françoise Mazingue, Brigitte Nelken, Thuan Chong Quah, Eric Oksenhendler, Marie Ouachée, Marlène Pasquet, Véronique Saada, Felipe Suarez, Gérard Pierron, William Vainchenker, Isabelle Plo, Jean Donadieu
Journal: Blood
Blood (2018) 132 (12): 1318–1331.
https://doi.org/10.1182/blood-2017-12-820308
Published: 2018
Includes: Supplemental data
Journal Articles

Direct Pharmacological Inhibition of the Transcription Factor PU.1 in Acute Myeloid Leukemia

Ileana Antony-Debre, PhD, Ananya Paul, Joana Leite, Kelly Mitchell, Hye Mi Kim, Luis A. Carvajal, PhD, Tihomira Tidorova, Samuel Taylor, Kenneth Huang, Arvind Kumar, Abdelbasset A Farahat, Boris Bartholdy, PhD, Swathi-Rao Narayanagari, M.S, Jiahao Chen, Alberto Ambesi-Impiombato, Adolfo A. Ferrando, MD PhD, Ioannis Mantzaris, MD, Evripidis Gavathiotis, CPA, PhD BSc, Amit Verma, MD, Britta Will, PhD, David W Boykin, W David Wilson, Gregory MK Poon, Ulrich G. Steidl, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 858.
https://doi.org/10.1182/blood.V130.Suppl_1.858.858
Published: 2017
Journal Articles

Mutations in SRP54 Gene Cause Severe Primary Neutropenia As Well As Shwachman-Diamond-like Syndrome

Christine Bellanné-Chantelot, PharmD, PhD, Caroline Marty, PhD, Barbara Schmaltz-Panneau, PhD, Odile Fenneteau, MD, Isabelle Callebaut, PhD, Séverine Clauin, Aurélie Docet, Gandhi Damaj, MD, Thierry Leblanc, MD, Isabelle Pellier, MD, Cécile Stoven, MD, Sylvie Souquere, PhD, Iléana Antony-Debre, PhD, Blandine Beaupain, MsC, Nathalie Aladjidi, MD, Vincent Barlogis, MD, Frederic Bauduer, MD PhD, Philippe Bensaid, MD, Odile Boesflug-Tanguy, MDPhD, Claire Berger, MD, Yves Bertrand, MD, Liana Carausu, MD, Claire Fieschi, MD PhD, Claire Galambrun, MD, Aline Schmidt, MD, Hubert Journel, MD, Francoise Mazingue, MD, Brigitte Nelken, MD, Thuan Chong Quah, MD, Eric Oksenhendler, MD, Marie Ouachee, MD, Marlène Pasquet, MD, Felipe Suarez, MDPhD, Gérard Pierron, PhD, William Vainchenker, MD PhD, Isabelle Plo, PhD, Jean Donadieu, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): LBA-3.
https://doi.org/10.1182/blood.V130.Suppl_1.LBA-3.LBA-3
Published: 2017
Journal Articles

New Allosteric Inhibitors of Mutant IDH1 in Acute Myeloid Leukemia

Ujunwa Cynthia Okoye-Okafor, MS, Boris Bartholdy, PhD, Jessy Cartier, Enoch Gao, Beth Pietrak, Alan R. Rendina, Cynthia Rominger, Chad Quinn, Angela Smallwood, Ken Wiggall, Alexander Reif, Stan Schmidt, Hongwei Qi, Huizhen Zhao, Gerard Joberty, Maria Faelth-Savitski, Marcus Bantscheff, Gerard Drewes, Chaya Duraiswami, Pat Brady, Swathi-rao Narayanagari, Ileana Antony-Debre, PhD PharmD, Kelly Mitchell, Luis Carvajal, Heng Rui Wang, Laura Barreyro, PhD, Yun-Ruei Kao, Maximilian Christopeit, MD, Elisabeth Paietta, PhD, Hideki Makishima, MD PhD, Britta Will, PhD, Nestor Concha, Nicholas Adams, Benjamin Schwartz, Michael T. McCabe, PhD, Jaroslaw P. Maciejewski, MD PhD, Amit Verma, MD, Ulrich Steidl, MDPhD
Journal: Blood
Blood (2015) 126 (23): 787.
https://doi.org/10.1182/blood.V126.23.787.787
Published: 2015
Journal Articles

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia

Iléana Antony-Debré, Vladimir T. Manchev, Nathalie Balayn, Dominique Bluteau, Cécile Tomowiak, Céline Legrand, Thierry Langlois, Olivia Bawa, Lucie Tosca, Gérard Tachdjian, Bruno Leheup, Najet Debili, Isabelle Plo, Jason A. Mills, Deborah L. French, Mitchell J. Weiss, Eric Solary, Remi Favier, William Vainchenker, Hana Raslova
Journal: Blood
Blood (2015) 125 (6): 930–940.
https://doi.org/10.1182/blood-2014-06-585513
Published: 2015
Includes: Supplemental data
Journal Articles

CDK6, a new target in MLL-driven leukemia

Iléana Antony-Debré, Ulrich Steidl
Journal: Blood
Blood (2014) 124 (1): 5–6.
https://doi.org/10.1182/blood-2014-05-572917
Published: 2014
Journal Articles

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations

Brief Report
Iléana Antony-Debré, Dominique Bluteau, Raphael Itzykson, Véronique Baccini, Aline Renneville, Françoise Boehlen, Margot Morabito, Nathalie Droin, Caroline Deswarte, Yunhua Chang, Guy Leverger, Eric Solary, William Vainchenker, Rémi Favier, Hana Raslova
Journal: Blood
Blood (2012) 120 (13): 2719–2722.
https://doi.org/10.1182/blood-2012-04-422352
Published: 2012
Includes: Supplemental data
Journal Articles

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia

Dominique Bluteau, Laure Gilles, Morgane Hilpert, Iléana Antony-Debré, Chloe James, Najet Debili, Valerie Camara-Clayette, Orianne Wagner-Ballon, Veronique Cordette-Lagarde, Thomas Robert, Hugues Ripoche, Patrick Gonin, Sabina Swierczek, Josef Prchal, William Vainchenker, Remi Favier, Hana Raslova
Journal: Blood
Blood (2011) 118 (24): 6310–6320.
https://doi.org/10.1182/blood-2010-12-325555
Published: 2011
Includes: Supplemental data